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Multi-strain probiotics ameliorates Alzheimer's-like cognitive impairment and pathological changes through the AKT/GSK-3 β pathway in senescence-accelerated mouse prone 8 mice
CONCLUSIONS: Multi-strain probiotics treatment can ameliorate cognitive impairment and pathological change in SAMP8 mice, including neural damage, Aβ and Tau pathology, and neuroinflammation. This effect is associated with the regulation of the phosphorylation of the AKT/GSK-3β pathway.PMID:38548184 | DOI:10.1016/j.bbi.2024.03.031 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 28, 2024 Category: Neurology Authors: Qian Xiao-Hang Chen Si-Yue Tang Hui-Dong Source Type: research

Exploring the diversity of vaginal microbiota between healthy women and cervical cancer patients in India
Conclusion. Differences in the vaginal microbiome between healthy and ICC women could help in the early prediction of cervical cancer risk and thus in designing prevention strategies.PMID:38546452 | DOI:10.1099/jmm.0.001819 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 28, 2024 Category: Microbiology Authors: Ashwini Kamble Shilpa Naik Manju Talathi Deepali Jadhav Meena Sakharkar Jian Yang Om Prakash Ruchika Kaul-Ghanekar Source Type: research

Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations
This article summarizes the current scientific evidence on the effects of supplementation with prebiotics, probiotics, and synbiotics on high-risk human papillomavirus (HPV) infections, precancerous lesions, and various stages of cervical cancer development and treatment while also examining the underlying molecular pathways involved. Our findings indicate that a higher dietary fiber intake is associated with a reduced risk of HPV infection, while certain probiotics have shown promising results in clearing HPV-related lesions. Additionally, certain strains of probiotics, prebiotics such as inulin and fructo-oligosaccharide...
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research

Effect of a probiotic and an antibiotic on the mobilome of the porcine microbiota
Conclusion: There is no positive effect of adding probiotics to an antibiotic treatment when these treatments are administered simultaneously. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - March 28, 2024 Category: Genetics & Stem Cells Source Type: research

Kombucha Tea-associated microbes remodel host metabolic pathways to suppress lipid accumulation
by Rachel N. DuMez-Kornegay, Lillian S. Baker, Alexis J. Morris, Whitney L. M. DeLoach, Robert H. Dowen The popularity of the ancient, probiotic-rich beverage Kombucha Tea (KT) has surged in part due to its purported health benefits, which include protection against metabolic diseases; however, these claims have not been rigorously tested and the mechanisms underlying host response to the probiotics in KT are unknown. Here, we establish a reproducible method to maintainC.elegans on a diet exclusively consisting of Kombucha Tea-associated microbes (KTM), which mirrors the microbial community found in the fermenting culture...
Source: PLoS Genetics - March 28, 2024 Category: Genetics & Stem Cells Authors: Rachel N. DuMez-Kornegay Source Type: research

Agro-ecosystem of honeybees as source for native probiotic yeasts
AbstractProbiotic microorganisms are used to improve the health and wellness of people and the research on this topic is of current relevance and interest. Fifty-five yeasts, coming from honeybee ’s ecosystem and belonging toCandida,Debaryomyces,Hanseniaspora,Lachancea,Metschnikowia,Meyerozyma,Starmerella andZygosacchromyces genera and related different species, were evaluated for the probiotic traits. The resistance to gastrointestinal conditions, auto-aggregation, cell surface hydrophobicity or biofilm formation abilities as well as antimicrobial activity against common human pathogenic bacteria were evaluated. The saf...
Source: World Journal of Microbiology and Biotechnology - March 28, 2024 Category: Microbiology Source Type: research

Bacillus subtilis SOM8 isolated from sesame oil meal for potential probiotic application in inhibiting human enteropathogens
While particular strains within the Bacillus species, such as Bacillus subtilis, have been commercially utilised as probiotics, it is critical to implement screening assays and evaluate the safety to identify pot... (Source: BMC Microbiology)
Source: BMC Microbiology - March 28, 2024 Category: Microbiology Authors: Zhongtian Zhao, Wenrui Li, The Thien Tran and Say Chye Joachim Loo Tags: Research Source Type: research

The Beneficial Role of Lactobacillus paracasei subsp. paracasei NTU 101 in the Prevention of Atopic Dermatitis
In this study, Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101) was orally administered for a duration of 4 weeks, followed by the induction of AD using ovalbumin (OVA) in a mouse model. The skin condition of the stimulated site was observed during the induction period. Subsequently, the serum immunoglobulin E (IgE) content, splenocyte T cell typing, and skin histological interpretation were examined to evaluate the efficacy of NTU 101 in alleviating AD symptoms in allergen-exposed animals. The findings indicated that administering NTU 101 beforehand effectively alleviated skin symptoms in animals with AD. It red...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Chin-Feng Liu Tsung-Wei Shih Chun-Lin Lee Tzu-Ming Pan Source Type: research

The Beneficial Role of Lactobacillus paracasei subsp. paracasei NTU 101 in the Prevention of Atopic Dermatitis
In this study, Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101) was orally administered for a duration of 4 weeks, followed by the induction of AD using ovalbumin (OVA) in a mouse model. The skin condition of the stimulated site was observed during the induction period. Subsequently, the serum immunoglobulin E (IgE) content, splenocyte T cell typing, and skin histological interpretation were examined to evaluate the efficacy of NTU 101 in alleviating AD symptoms in allergen-exposed animals. The findings indicated that administering NTU 101 beforehand effectively alleviated skin symptoms in animals with AD. It red...
Source: Mol Biol Cell - March 27, 2024 Category: Molecular Biology Authors: Chin-Feng Liu Tsung-Wei Shih Chun-Lin Lee Tzu-Ming Pan Source Type: research