Ppx1 putative exopolyphosphatase is essential for polyphosphate accumulation in < em > Lacticaseibacillus paracasei < /em >
Appl Environ Microbiol. 2024 Apr 15:e0229023. doi: 10.1128/aem.02290-23. Online ahead of print.ABSTRACTThe linear polymer polyphosphate (poly-P) is present across all three domains of life and serves diverse physiological functions. The enzyme polyphosphate kinase (Ppk) is responsible for poly-P synthesis, whereas poly-P degradation is carried out by the enzyme exopolyphosphatase (Ppx). In many Lactobacillaceae, the Ppk-encoding gene (ppk) is found clustered together with two genes encoding putative exopolyphosphatases (ppx1 and ppx2) each having different domain compositions, with the gene order ppx1-ppk-ppx2. However, th...
Source: Applied and Environmental Microbiology - April 15, 2024 Category: Microbiology Authors: Daniela Corrales Cristina Alc ántara Manuel Z úñiga Vicente Monedero Source Type: research
Effects of < em > Lactobacillus paracasei < /em > N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research
Gut microbiota and female health
World J Gastroenterol. 2024 Mar 28;30(12):1655-1662. doi: 10.3748/wjg.v30.i12.1655.ABSTRACTThe gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer, and ovarian cancer etc. Despite this, there has been limited discussion on the underlying mechanisms. This editorial explores the three potential mechanisms throug...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Meng-Yao Wang Li-Xuan Sang Si-Yu Sun Source Type: research
Effects of < em > Lactobacillus paracasei < /em > N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research
Gut microbiota and female health
World J Gastroenterol. 2024 Mar 28;30(12):1655-1662. doi: 10.3748/wjg.v30.i12.1655.ABSTRACTThe gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer, and ovarian cancer etc. Despite this, there has been limited discussion on the underlying mechanisms. This editorial explores the three potential mechanisms throug...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Meng-Yao Wang Li-Xuan Sang Si-Yu Sun Source Type: research
Next-generation probiotics: the upcoming biotherapeutics
Mol Biol Rep. 2024 Apr 15;51(1):505. doi: 10.1007/s11033-024-09398-5.ABSTRACTRecent and continuing advances in gut microbiome research have pointed out the role of the gut microbiota as an unexplored source of potentially beneficial probiotic microbes. Along the lines of these advances, both public awareness and acceptance of probiotics are increasing. That's why; academic and industrial research is dedicated to identifying and investigating new microbial strains for the development of next-generation probiotics (NGPs). At this time, there is a growing interest in NGPs as biotherapeutics that alter the gut microbiome and a...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Omnia Momtaz Al-Fakhrany Engy Elekhnawy Source Type: research
A Palearctic view of a bat fungal disease
Conserv Biol. 2024 Apr 15:e14265. doi: 10.1111/cobi.14265. Online ahead of print.ABSTRACTThe fungal infection causing white-nose disease in hibernating bats in North America has resulted in dramatic population declines of affected species, since the introduction of the causative agent Pseudogymnoascus destructans. The fungus is native to the Palearctic, where it also infects several bat species, yet rarely causes severe pathology or the death of the host. Pseudogymnoascus destructans infects bats during hibernation by invading and digesting the skin tissue, resulting in the disruption of torpor patterns and consequent emac...
Source: Conservation Biology - April 15, 2024 Category: Biology Authors: F Whiting-Fawcett A S Blomberg T Troitsky M B Meierhofer K A Field S J Puechmaille T M Lilley Source Type: research
Ppx1 putative exopolyphosphatase is essential for polyphosphate accumulation in < em > Lacticaseibacillus paracasei < /em >
Appl Environ Microbiol. 2024 Apr 15:e0229023. doi: 10.1128/aem.02290-23. Online ahead of print.ABSTRACTThe linear polymer polyphosphate (poly-P) is present across all three domains of life and serves diverse physiological functions. The enzyme polyphosphate kinase (Ppk) is responsible for poly-P synthesis, whereas poly-P degradation is carried out by the enzyme exopolyphosphatase (Ppx). In many Lactobacillaceae, the Ppk-encoding gene (ppk) is found clustered together with two genes encoding putative exopolyphosphatases (ppx1 and ppx2) each having different domain compositions, with the gene order ppx1-ppk-ppx2. However, th...
Source: Applied and Environmental Microbiology - April 15, 2024 Category: Microbiology Authors: Daniela Corrales Cristina Alc ántara Manuel Z úñiga Vicente Monedero Source Type: research
Effects of < em > Lactobacillus paracasei < /em > N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research
Gut microbiota and female health
World J Gastroenterol. 2024 Mar 28;30(12):1655-1662. doi: 10.3748/wjg.v30.i12.1655.ABSTRACTThe gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer, and ovarian cancer etc. Despite this, there has been limited discussion on the underlying mechanisms. This editorial explores the three potential mechanisms throug...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Meng-Yao Wang Li-Xuan Sang Si-Yu Sun Source Type: research
Gut microbiota and female health
World J Gastroenterol. 2024 Mar 28;30(12):1655-1662. doi: 10.3748/wjg.v30.i12.1655.ABSTRACTThe gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer, and ovarian cancer etc. Despite this, there has been limited discussion on the underlying mechanisms. This editorial explores the three potential mechanisms throug...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Meng-Yao Wang Li-Xuan Sang Si-Yu Sun Source Type: research
Effects of < em > Lactobacillus paracasei < /em > N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research
Effects of < em > Lactobacillus paracasei < /em > N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research
Gut microbiota and female health
World J Gastroenterol. 2024 Mar 28;30(12):1655-1662. doi: 10.3748/wjg.v30.i12.1655.ABSTRACTThe gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer, and ovarian cancer etc. Despite this, there has been limited discussion on the underlying mechanisms. This editorial explores the three potential mechanisms throug...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Meng-Yao Wang Li-Xuan Sang Si-Yu Sun Source Type: research
Gut microbiota and female health
World J Gastroenterol. 2024 Mar 28;30(12):1655-1662. doi: 10.3748/wjg.v30.i12.1655.ABSTRACTThe gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer, and ovarian cancer etc. Despite this, there has been limited discussion on the underlying mechanisms. This editorial explores the three potential mechanisms throug...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Meng-Yao Wang Li-Xuan Sang Si-Yu Sun Source Type: research
