Senolytic Treatment Minimizes the Contribution of Excess Fat Tissue to Insulin Resistance in Mice
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - November 29, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Voxel-Based Technique to Streamline Bioprinting
At the University of Virginia researchers developed a new bioprinting technique based on voxels. Voxels are 3D cubes that form basic building blocks in computer graphics, similar to what pixels are for 2D, and have been popularized by games such as Minecraft. The new technique involves printing discrete spherical blobs of bioink (as the voxels) within a supportive matrix that then swell to merge together, forming a porous structure. Sticky bioinks can be difficult to handle and print predictably, but this new technique helps to address this issue.
Bioprinting holds enormous promise as a method to 3D print new tis...
Source: Medgadget - November 22, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Plastic Surgery Rehab Source Type: blogs
Dogs Benefit from Time Restricted Feeding
A common factor in calorie restriction, intermittent fasting, and time-restricted feeding is time spent in a state of hunger. More time spent hungry may be better, up to a point. The signaling associated with hunger upregulates cellular maintenance processes such as autophagy, known to improve health over the long term. While the biochemistry is under ever greater exploration, there is still a lot of work to be accomplished in order to map the dose-response curve for calorie intake versus time spent hungry, as well as how that dose-response curve may differ in different mammalian species. One might look at recent discussio...
Source: Fight Aging! - November 22, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How MRI-guided radiation therapy is changing the paradigm in pancreatic cancer
I truly believe we ’re at the beginning of something great in terms of fundamentally changing how we approach pancreatic cancer, the third leading cause of cancer death in the United States. With a mortality rate of roughly 80 percent, it’s been referred to as a medical emergency, yet minimal progress has been mad e in itsRead more …How MRI-guided radiation therapy is changing the paradigm in pancreatic cancer originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 14, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/michael-chuong" rel="tag" > Michael Chuong, MD < /a > < /span > Tags: Conditions Oncology/Hematology Source Type: blogs
The rise of targeted therapies: the era of the patient-focused approach
There is an urgent need for innovation in cancer treatments. Although we ’ve seen significant progress in indications for drugs treating particular diseases, cancer research data shows that 10-year survival statistics for cancers such as esophageal and lung cancer, for instance, have shown only a 10 percent increase, while pancreatic cancer has shown no significant im provement sinceRead more …The rise of targeted therapies: the era of the patient-focused approach originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 12, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/m-yair-levy" rel="tag" > M. Yair Levy, MD < /a > < /span > Tags: Meds Oncology/Hematology Source Type: blogs
Food Intolerances: A Warning of Bad Things Ahead
I’ve recently discussed how the majority of food intolerances, whether to FODMAPs, histamine, nightshades, fructose, etc., are really manifestations of dysbiosis and SIBO. Here is another way to view these phenomena: Food intolerances are your body’s signal to you that serious deterioration in your health is coming.
In other words, if all you do is choose to reduce or eliminate the offending food, you are still left with the massive disruption of your intestinal microbiome that caused the food intolerance in the first place, along with increased intestinal permeability and endotoxemia. So say you eliminate ferm...
Source: Wheat Belly Blog - November 1, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open microbiota prebiotic probiotic sibo small intestinal bacterial super gut undoctored wheat belly Source Type: blogs
poem
We described her future death as a tumor nestled amongst critical structures and way too dangerous to resect. It would have killed her. Of course this was all make believe. But she was full of ideas now. At her follow-up visit, she seemed serene and pleased. She loved her life again. She was a body again, full of indescribable mysteries. She smiled when I said her name out loud. She rested both hands on her swollen belly like a mother bearing twins.10/17/21 (Source: Buckeye Surgeon)
Source: Buckeye Surgeon - October 17, 2021 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Fight Aging! Newsletter, October 11th 2021
In conclusion, this study examined how age and the process of aging are associated with changes in the microbiome of the small intestine, using validated sampling and processing techniques. The most significant differences are higher relative abundance of the phylum Proteobacteria and decreased relative abundance of Bacteroidetes in older subjects when compared to the youngest group. The higher relative abundance of Proteobacteria appeared to affect other duodenal microbial taxa, leading to decreased microbial diversity and increased relative abundance of coliforms and of anaerobic bacteria. The small intestine is vital to...
Source: Fight Aging! - October 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Popular Science Article on Young Blood versus Old Blood in the Development of Treatments for Aging
The popular science article I'll point out today does a fair job of following the past decade or so of work arising from heterochronic parabiosis, in which the circulatory systems of a young animal and an old animal are joined. The young animal exhibits some degree of accelerated aging, while the old animal exhibits some degree of rejuvenated function. The question all along has been why exactly this happens: what are the underlying mechanisms, and can they be replicated as a basis for therapy.
The obvious first approach was to transfuse young donor blood into old recipients, as positive results would mean that the ...
Source: Fight Aging! - October 4, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 4th 2021
In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them.
Extending Life Without Extending Health: Vast Effort Directed to the Wrong Goals
https://ww...
Source: Fight Aging! - October 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senolytics as a Potential Treatment for Precancerous Lesions
It is reasonable to think that intermittent treatment with senolytics can suppress cancer incidence by killing the senescent cells that are present in precancerous lesions, whether or not they are too small to be identified by present screening techniques. This should reduce the number of cells that can potentially go on to become cancerous, and also remove the contribution of senescent cell signaling to the growth and inflammatory status of the lesion. It should not be too challenging to prove this hypothesis in animal models, but prevention of cancer in the general sense is, unfortunately, a hard sell when it comes to cl...
Source: Fight Aging! - September 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pancreatic Organoids Grown Inside Synthetic Gel
A team at MIT has developed a technique to grow organoids, both from healthy and cancerous pancreatic tissue, using a synthetic gel that predictably mimics the pancreatic extracellular environment. Compared with naturally derived materials, the synthetic gel is consistent from batch to batch, meaning that it leads to more reproducible and predictable results when growing organoids. The MIT researchers hope that the technology could advance organoid research, both pancreatic and otherwise.
Cancerous pancreatic tissues are not easy to grow and study in the lab, as they lose their cancerous characteristics relatively quick...
Source: Medgadget - September 23, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology Source Type: blogs
3D Microscopy of Whole Organs with Micrometer Detail
A team of scientists at Umeå University in Sweden came up with a way to create complex 3D maps of whole organs in incredible detail. The approach involves embedding a whole organ in agarose, a stiff gel matrix, and then using this support matrix to section the tissue into cm3 chunks.
These chunks are the perfect size for fluorescent antibody labeling of specific cell types and subsequent deep tissue imaging, using a technique such as optical projection tomography. Once the chunks are labeled and imaged, it is possible to stitch the images together on a computer to create a 3D map of the entire organ.
The researchers...
Source: Medgadget - September 20, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Pathology Source Type: blogs
