Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Taurine is a semi-essential amino acid. Dietary taurine supplementation has been shown to modestly slow aging in mice, though as for all such interventions there is always the question of whether it will prove to be less useful in humans, and also whether these results in mice will be disproved by the much more rigorous Interventions Testing Program (ITP), once that group gets around to assessing taurine supplementation. Few of the numerous interventions thought to modestly slow aging in mice on the basis of earlier research actually held up once subjected to the ITP degree of experimental rigor.
Speculatively, taur...
Source: Fight Aging! - December 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The State Of CRISPR Clinical Trials And Their Future Potentials
CRISPR, short for “Clustered Regularly Interspaced Short Palindromic Repeats” – and more specifically CRISPR–Cas9 – relates to a gene-editing method that gained popularity in the past decade; and not for trivial reasons. Being the most efficient and accurate method to edit a cell’s genome, CRISPR holds potentials that range from treating conditions such as HIV to finding new drug targets.
While such potentials are real and are being actively investigated, you might be curious about more practical examples of CRISPR applications. By taking the US Clinical Trials registry as an example, we consider lis...
Source: The Medical Futurist - December 7, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF CRISPR therapy clinical trials gene editing Source Type: blogs
This Is Good News About A Cancer None Of Us Ever Want!
I, for one, would leap at an annual blood test to avoid this
horror!
Scientists to develop first ever blood test
for pancreatic cancer
By Joanna Panagopoulos 10:15PM November 16, 2023 Australian researchers are close to developing the first blood test for the “silent killer” pancreatic can cer. Scientists from the Walter and Eliza Hall Institute of Medical Research in Melbourne believe a (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - November 22, 2023 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rosuvastatin or Atorvastatin , Which is good and safe ?
Statins belong to a group of drugs, stolen and reengineered from the blueprint of natural Chinese red yeast rice (Monocoline K) in the late 1980s. The rest is the remarkable history in the pharma industry.
Statins directly interrupt the cholesterol synthesis by blocking HMG-CoA within the hepatocytes. It significantly lowers the LDL, fights human vascular atherosclerosis. It makes the plaque either regress, prevent progress, make it harder and in the process make them less vulnerable . There are innumerable studies that document the evidence. Statin has become a must-prescribe drug in any one with clinically establishe...
Source: Dr.S.Venkatesan MD - November 10, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha atorvastatin vs rosuvastatin avert study bmj esc jamanetwork lancet lipid association lodestar study lodestar trial bmj nejm saturn trial simvastatin statins which statin superior Source Type: blogs
Reviewing the Role of Cellular Senescence in Metabolic Disease
Senescent cells accumulate with age throughout the body. In youth the immune system promptly removes senescent cells, but this clearance slows with advancing age, leading to a growing population of lingering senescent cells. Senescent cells cease replicating and devote their efforts to the production of pro-growth, pro-inflammatory signals that become disruptive to tissue structure and function. Thus a population of senescent cells acts to actively maintain a degraded state of tissue, and their removal is immediately beneficial. Mouse studies show compelling, rapid reversals of age-related disease and extended life span re...
Source: Fight Aging! - November 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Calorie Restriction Improves Pancreatic Function in Aging Mammals
Beta cells in the pancreas produce insulin and are essential to the regulation of glucose metabolism. Dysfunction in this cell population causes diabetes, whether the origin is autoimmune destruction of beta cells (type 1 diabetes) or senescence of beta cells brought on by obesity (type 2 diabetes). Aging also impairs beta cell function through some of the same mechanisms, such as cellular senescence and constant, unresolved inflammatory signaling. The practice of calorie restriction slows aging, albeit to a greater degree in short-lived species than in long-lived species, and so it is not surprising to see that calorie re...
Source: Fight Aging! - October 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The High Cost of Type 2 Diabetes as a Lifestyle Condition
Type 2 diabetes is near entirely a lifestyle condition, and can be reversed even in later stages via suitably aggressive dietary and weight loss interventions. Obesity in early adult life is sufficient to cause type 2 diabetes via some combination of mechanisms involving excess fat in the pancreas and increased stress put upon insulin-generating beta cells resident in the pancreas, leading to greater cellular senescence and altered cell behavior. Excess visceral fat is in general harmful to the body via its metabolic activity. There are a range of ways beyond an increased burden of senescent cells by which it can produce c...
Source: Fight Aging! - October 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Soft Implant Uses AI to Deliver Drugs Despite Fibrous Encapsulation
Scientists at the University of Galway in Ireland and MIT have collaborated to create a soft robotic implant that can work to fight fibrotic encapsulation and deliver drugs despite the presence of fibrous scar tissue. The device, which the researchers have termed the FibroSensing Dynamic Soft Reservoir (FSDSR), is designed to reside in the body for extended periods and deliver drugs. However, the immune system typically recognizes such medical implants as foreign, and walls them off with a thick layer of fibrous scar tissue, limiting drug diffusion and leading to eventual failure. This new soft robotic implant can inflate ...
Source: Medgadget - October 11, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine News fibrotic encapsulation mit uniofgalway Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Beta Cell Senescence in Multiple Forms of Diabetes
The growing focus on cellular senescence as a contributing cause of aging has identified senescent cells as important agents in a range of conditions, age-related and otherwise. Interestingly, the pathology of both type 1 and type 2 diabetes appears to be mediated by senescent beta cells in the pancreas. Clearing senescent cells has been shown to be beneficial in animal models of these conditions, but it remains to be seen as to whether human patients will benefit. There are many conditions that might be treated with senolytic therapies to selectively destroy senescent cells, and only so many research groups and companies ...
Source: Fight Aging! - September 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cells Release Insulin in Response to Music
Researchers at ETH Zurich have developed an insulin delivery system that relies on music as a trigger. The unusual technology is based on calcium ion channels that typically reside in the cell membrane. Such channels are sensitive to mechanical deformation and these researchers discovered that sound waves will activate the channels. When insulin-producing cells are genetically modified to express this channel, they will experience an influx in calcium ions when music is played close by, prompting them to release insulin. The concept could be useful as a treatment for diabetes, whereby such cells, housed in a specialized ca...
Source: Medgadget - September 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine diabetes ETH Zurich Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
