A doctor ’ s journey through grief and writing [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! In this episode, we have Ryan McCarthy, an internal medicine physician, who discovered writing as a way to cope with grief. His journey started with the death of his friend Dan from pancreatic cancer, which led him to write an essay chronicling Dan’s life
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A doctor’s journey through grief and writing [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 2, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Primary Care Source Type: blogs
Manganese: The Magical Element?
The element manganese is essential for human life. It’s aptly named after the Greek word for magic, and some mysteries surrounding its role in the body still exist today—like how our bodies absorb it, if very high or low levels can cause illness, or how it might play a role in certain diseases.
Manganese is necessary for metabolism, bone formation, antioxidation, and many other important functions in the body. The element is found in strong steel, bones and enzymes, and drink cans. Credit: Compound Interest CC BY-NC-ND 4.0. Click to enlarge.
Making Much With Manganese
Structure of the human manganese s...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 26, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Proteins Source Type: blogs
Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context.
Glycine Supplementation as a Methionine Restriction Mimetic
https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/
Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restricti...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Regorafenib Is Another Potentially Senotherapeutic Tyrosine Kinase Inhibitor
Dasatinib, a tyrosine kinase inhibitor, was one of the first drugs shown to selectively destroy senescent cells and thereby reverse aspects of aging, particularly when used in combination with the plant flavonoid quercetin. Strangely, little attention was given to the question of whether other tyrosine kinase inhibitors can target senescent cells until recently. A number of these compounds have in the past undergone clinical trials, or even been approved for use by regulators, for the treatment of conditions that researchers now suspect to be connected with cellular senescence to a significant degree. Nintedanib, for examp...
Source: Fight Aging! - April 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
111 Tired Quotes You Can Relate to (But Also Get a Boost of Energy From)
If you’re tired today then maybe this post can help you.
In it I want to share relatable and timeless thoughts on tiredness. To give you some comfort. To remind you that you’re not alone in feeling this way.
But I also want to offer thoughts that can bring you a new spark of energy and motivation. And wisdom that may give you new ideas about how to tackle being tired. To hopefully be less tired in the coming weeks and months.
This is 111 of the best and most powerful tired quotes. I truly hope you’ll find something helpful here.
And if you want more useful motivation then check out this post with quotes on dealing w...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - April 11, 2023 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs
Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment.
A Vicious Cycle of Heart Failure and Dementia
https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/
The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in Type 2 Diabetes
It has been a few years since researchers suggested a role for senescent cells in mediating the damage done by excess fat tissue in the context of type 2 diabetes. Senescent cells accumulate with age, but accumulate significantly faster in people who are meaningfully overweight or obese. The inflammatory signaling produced by lingering senescent cells is disruptive of tissue structure and function throughout the body, and that includes problems in the insulin-generating regions of the pancreas that take place in diabetes patients. Interestingly, senescent cells may also be important in type 1 diabetes, a completely differe...
Source: Fight Aging! - March 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in thi...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
From grief to gratitude: How writing changed my life
Dan died, and I became a writer. I didn’t know it, but I did. Back then, I wrote one story, almost by accident, trying to make sense of my personal chaos. That essay chronicled a small-town doctor losing a beloved middle-aged friend who was rapidly fading from pancreatic cancer. It felt like being dropped into
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From grief to gratitude: How writing changed my life originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 14, 2023 Category: General Medicine Authors: Ryan McCarthy, MD Tags: Physician Primary Care Source Type: blogs
More on Transcriptional Noise in Aging
As a companion piece to a recent article questioning whether transcriptional noise actually exists as envisaged, this review paper covers what is known and unknown in this part of the field. Transcriptional noise is random variation in the first stage of gene expression, and it is thought to increase with age. It seems likely to be a consequence of the broad variety of changes and dysfunctions that occur in cellular biochemistry in old tissues, an accompaniment to faltering quality control of protein synthesis and altered epigenetics. While easily defined at the high level, transcriptional noise is challenging to measure i...
Source: Fight Aging! - March 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Semaglutide – the “ skinny jab ”
TL:DR – Semaglutide is known to US celebrities as the “skinny jab” and has apparently been the subject of a weight-loss craze. It has now been approved in the UK for weight-loss in the clinically obese.
Semaglutide is a pharmaceutical that can help control the symptoms of Type 2 diabetes for which it was first used. The nickname, the “skinny jab” comes from the drug’s activity as an appetite suppressant used in helping overweight people and the obese reduce their body weight. It is sold under the brand names Ozempic, Wegovy and Rybelsus and was originally developed by Novo Nordisk in 20...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 8, 2023 Category: Science Authors: David Bradley Tags: Health and Medicine Obesity Source Type: blogs
Fighting with perfection
Note: I originally wrote this many years ago for another site. It is not available anymore, so I am republishing it.
Diabetes is a thing surrounded by numbers. Everything is a number or is used in a calculation. We have blood sugars, units of insulin, and grams of carbohydrates. Then we take those numbers and stick them into more numbers. There is the insulin-to-carb ratio, the duration of insulin action, our correction factor, and more.
...
Source: Scott's Diabetes Blog - March 3, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Raman-Based Urine Sensor Detects Cancer Metabolites
Researchers at the Korea Institute of Materials Science (KIMS) creaetd a Raman-spectroscopy-based urine test that can detect metabolic compounds that are produced by pancreatic and prostate cancers, potentially allowing for rapid and convenient cancer screening. The technology consists of a paper strip onto which a urine sample can be added. The paper contains ‘coral-shaped’ structures that assist in amplifying the optical signal of cancer metabolites in the urine when the paper strip is illuminated with light, letting the researchers acquire spectral signals for each sample. By analyzing urine samples from cancer pati...
Source: Medgadget - February 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Oncology Pathology Source Type: blogs
The regret of leaving an old friend behind
I once knew a lady who eventually died from pancreatic cancer. She was in her early seventies at the time. Her name was Marilyn, and I went to grade school with her son Tom, so we had known each other for a long time. I was in my early thirties when the events happened. Marilyn’s
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The regret of leaving an old friend behind originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 19, 2023 Category: General Medicine Authors: Raymond Abbott Tags: Conditions Oncology/Hematology Source Type: blogs
