Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
NALCN is a Regulator of Cancer Metastasis
If cancers were not metastatic, did not spread themselves throughout the body, then cancer would be a much less dangerous medical condition. Tumors would be largely amenable to surgical removal, and long-term control and suppression of cancer, even at late stages, would be a feasible goal. Thus research into the biochemistry of metastasis is important. If commonalities exist in the regulation of metastasis across many cancers, interventions to suppress metastasis could lead to a sizable reduction in cancer mortality. The research here shows that cancers may hijack an existing regulatory mechanism controlling cell motility ...
Source: Fight Aging! - October 6, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - September 20, 2022.
-----This weekly blog is to explore the news around the larger issues around Digital Health, data security, data privacy, AI / ML. technology, social media and any related matters.I will also try to highlightADHA Propagandawhen I come upon it.Just so we keep count, the latest Notes from the ADHA Board were dated 6 December, 2018 and we have seen none since! It ’s pretty sad!Note: Appearance here is not to suggest I see any credibility or value in what follows. I will leave it to the reader to decide what is worthwhile and what is not! The point is to let people know what is being said / published that I have come upon, a...
Source: Australian Health Information Technology - September 20, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, September 5th 2022
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Searching for Age-Slowing Drugs in the Antidiabetic Portfolio
Data for the ability of metformin to slow aging has researchers looking at other antidiabetic drugs these days, even given that the evidence for metformin to have a meaningful impact on aging in non-diabetic animals is not great, very mixed, and even the human data for a modest addition of a few years in type 2 diabetes patients is most likely not as good as the impact of exercise and control of weight. Still, repurposing drugs to produce modest effects in a different condition has long been a going concern; regulators make it so hard to develop new drugs that it makes economic sense to repurpose existing drugs, even when ...
Source: Fight Aging! - August 31, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 15th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 14, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Overseas Health IT Links – 13th August 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://ehrintelligence.com/news/va-appoints-functional-champion-for-ehr-modernization-programVA Appoints Functional Champion for EHR Modernization ProgramThe new functional champion appointment will assist the VA EHR Modernization program as it struggles with implementation delays and cost overruns, the VA stated.BySarai RodriguezAugust 05, 2022 - The Depart...
Source: Australian Health Information Technology - August 13, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Cellular Senesence, a Key Target in the Treatment of Aging
Scores of animal studies provide compelling evidence for cellular senescence to contribute meaningfully to many age-related conditions, and yet more such studies demonstrate rapid and sizable rejuvenation via targeted removal of senescent cells in old animals using varieties of senolytic therapy. Senescent cells are created constantly in the body, the result of cells reaching the Hayflick limit on replication, tissue injury, or encountering cellular damage or toxicity. When an individual is young, these newly senescent cells are near all removed by a combination of programmed cell death and the actions of the immune system...
Source: Fight Aging! - August 10, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
mRNA Vaccines: From Tackling Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.
What is mRNA?
In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs
mRNA Vaccines: From Tackling A Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.
What is mRNA?
In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs
Fight Aging! Newsletter, June 13th 2022
In conclusion, long-term cumulative BP was associated with subsequent cognitive decline, dementia risk, and all-cause mortality in cognitively healthy adults aged ≥50 years. Efforts are required to control long-term systolic BP and pulse pressure and to maintain adequate diastolic BP.
Longer-Lived Mammals Tend to Have Lower Expression of Inflammation-Related Genes
https://www.fightaging.org/archives/2022/06/longer-lived-mammals-tend-to-have-lower-expression-of-inflammation-related-genes/
Researchers here make a few interesting observations on gene expression data from a range of mammalian species with...
Source: Fight Aging! - June 12, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cancer Correlates with Increased Risk of Later Onset of Type 2 Diabetes
Researchers here note a correlation between cancer diagnosis and greater risk of later onset of type 2 diabetes. A reasonable guess is that this is mediated by the increased burden of cellular senescence produced by chemotherapy and radiotherapy, though, as the researchers point out, the widely different risks by cancer type may indicate that tumors are metabolically active in ways that specifically promote the metabolic dysfunction that leads to type 2 diabetes.
For patients with cancer, prevalent type 2 diabetes at the date of cancer diagnosis is associated with increased cancer-specific and all-cause mortality....
Source: Fight Aging! - June 9, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Perfusion Machine Restores Donor Liver for Transplant
Clinical researchers at the University of Zurich in Switzerland have created a perfusion machine to store donor livers before transplant. We originally reported on the machine back in 2020, but now the team has announced that they stored and treated a damaged liver in the machine, which would ordinarily not be suitable for transplantation. After three days of treatment the liver was healthy enough to be implanted, and was successfully placed into a patent, who is still doing well one year later. The technique could expand the potential pool of available donor livers, as it may be possible to “refurbish” less healthy li...
Source: Medgadget - June 7, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Anesthesiology Critical Care Medicine Pathology Surgery liver transplant Liver4Life transplantation UZH_en Source Type: blogs
poem
Op Note XXIIIThe child rolled into the OR clinging to life. We opened him up. There was a warm gun steaming right there in the middle of the carnage. Bullets caterwauling. A liver shredded A spleen like beef tossed into a cage. I took off my gloves. I tore my mask. I breathed in the sulfurous fumes of the almost dead. It was a Beretta, a SIG Sauer, a Glock 19. AR 15. AR 15. I remembered that AR doesn ’t stand for automatic rifle or assault rifle. It means ArmaLite. Which is just a brand. Like Whirlpool. Like Frito Lay. It ’s important you don’t attack straw ...
Source: Buckeye Surgeon - May 26, 2022 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Fight Aging! Newsletter, May 9th 2022
In conclusion, although several favorable effects are obtained in our heterochronic non-myeloablative transplantation model, additional optimization is needed for better rejuvenation effects.
More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells
https://www.fightaging.org/archives/2022/05/more-on-gpnmb-as-a-target-for-senolytic-therapies-to-clear-senescent-cells/
You might recall that researchers recently demonstrated that vaccination against GPNMB is a senolytic strategy, reducing the harmful burden of senescent cells in aged tissues by directing the immune system to destroy these ...
Source: Fight Aging! - May 8, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
