Cancer Correlates with Increased Risk of Later Onset of Type 2 Diabetes

Researchers here note a correlation between cancer diagnosis and greater risk of later onset of type 2 diabetes. A reasonable guess is that this is mediated by the increased burden of cellular senescence produced by chemotherapy and radiotherapy, though, as the researchers point out, the widely different risks by cancer type may indicate that tumors are metabolically active in ways that specifically promote the metabolic dysfunction that leads to type 2 diabetes. For patients with cancer, prevalent type 2 diabetes at the date of cancer diagnosis is associated with increased cancer-specific and all-cause mortality. Yet, despite potential health implications, there is limited knowledge on whether cancer is also a risk factor for type 2 diabetes. We investigated the incidence of type 2 diabetes following a cancer diagnosis and evaluated the influence of new-onset type 2 diabetes in patients with cancer on overall survival. We included 51,353 incident cancer case subjects diagnosed from 2004 to 2015 living in the Greater Copenhagen area without type 2 diabetes. We sampled all 112 million tests from 1.3 million individuals, performed by the Copenhagen General Practitioners' Laboratory, contained in the Copenhagen Primary Care Laboratory Database (CopLab) (2015-57-0121) from 2000 to 2015, data for which were merged with data on incident cancer from the Danish Cancer Registry. The median follow-up time was 2.34 years for all case subjects and 4.41 years for cancer-fr...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs