Natural Killer Cells Oppose In Vivo Reprogramming
We report that natural killer (NK) cells significantly limit reprogramming, both in vitro and in vivo. Cells and tissues in the intermediate states of reprogramming upregulate the expression of NK-activating ligands, such as MULT1 and ICAM1. NK cells recognize and kill partially reprogrammed cells in a degranulation-dependent manner. Importantly, in vivo partial reprogramming is strongly reduced by adoptive transfer of NK cells, whereas it is significantly increased by their depletion. Notably, in the absence of NK cells, the pancreatic organoids derived from OSKM-expressing mice are remarkably large, suggesting that ablat...
Source: Fight Aging! - May 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Wireless Implant for Anti-Cancer Photodynamic Therapy
Researchers at Texas A&M University created a wireless device that aims to illuminate and destroy residual tumor cells left after cancer resection. The device can be used by surgeons to illuminate the tumor bed after resection. It works in combination with a photosensitizer drug that is administered before the procedure and accumulates in tumor cells, making them vulnerable to the lethal effects of the delivered light. The small device can also be implanted within the body, potentially to provide longer term photodynamic therapy and guard against cancer recurrence.
For many cancers, surgery is the primary treatment,...
Source: Medgadget - April 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Radiology Surgery TAMU Source Type: blogs
Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bacteria Promote Cancer Metastasis
Given the onset of a particular type of cancer, why does that cancer become a much worse prospect for only some individuals? Why are some people more prone to metastasis, for example? A perhaps underappreciated factor is the interaction of infectious agents with the tumor microenvironment, as researchers discuss here. Exposure to pathogens, and particularly persistent pathogens, may be a good explanation for many areas of medicine in which only some people bearing all of the traditional risk factors go on to develop the worst outcomes.
Microbes play a critical role in affecting cancer susceptibility and tumor prog...
Source: Fight Aging! - April 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cryomesh System for Long Term Pancreatic Islet Storage
Researchers at the University of Minnesota developed a cryopreservation system that allows for long-term pancreatic islet cold storage. Islets can be implanted in patients with diabetes, and can even be curative in this context, but the technique has been hampered by a lack of techniques to store donor islets beyond 24-72 hours. This latest technique, which uses a cryomesh system to remove excess cryopreservation fluid from the islets before freezing and new methods to rewarm the frozen islets, has been shown to safely store the tissue for as long as nine months.
Pancreatic islet transplantation has the potential...
Source: Medgadget - March 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Surgery universityofminnesota Source Type: blogs
Prescribing Unapproved Medical Devices? The Case of DIY Artificial Pancreas Systems
Joseph T.F. Roberts (University of Birmingham), Victoria Moore (University of Manchester), Muireann Quigley (University of Birmingham), Prescribing Unapproved Medical Devices? The Case of DIY Artificial Pancreas Systems, 21(1) Med. L. Int ’l. 42-68 (2021): In response to slow progress regarding technological... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - March 26, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Muscle Strengthening Activities in Later Life Correlate with Reduced Mortality
Past studies have demonstrated reduced mortality as a result of strength training in older individuals. Muscle tissue is metabolically active, involved in a range of processes in the body, such as insulin metabolism and control of inflammation. Here this review paper, researchers note the correlation between activities that strengthen muscle and lower mortality in epidemiological data. It is worth thinking about for those of us tempted to let the exercise schedule lapse as life moves on.
Physical inactivity is a global public health problem. Regular engagement in muscle-strengthening activities (eg, resistance tra...
Source: Fight Aging! - March 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Raspberry Pi Health Care
By KIM BELLARD
Like many of you, I have been intently following the war in Ukraine, cheering for President Zelensky and the Ukrainian people, while hoping it doesn’t end up in WW3. I thought about trying to write about it, then I saw that Raspberry Pi just turned ten, and I thought, yeah, that’s more my speed.
And, of course, easier to relate to healthcare.
For most of us, a computer is our smartphone, tablet, or laptop. We buy them already designed and built, complete with an operating system and other useful software. There’s an almost unlimited range of other software that can easily be...
Source: The Health Care Blog - March 1, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health Electronic Health Record Kim Bellard Rasberry Pi Source Type: blogs
Fight Aging! Newsletter, January 31st 2022
In conclusion, the effects of MR on the gut barrier were likely related to alleviation of the oscillations of inflammation-related microbes. MR can enable nutritional intervention against age-related gut barrier dysfunction.
Clearing Senescent Cells from the Neural Stem Cell Niche Rapidly Improves Neurogenesis in Old Mice
https://www.fightaging.org/archives/2022/01/clearing-senescent-cells-from-the-neural-stem-cell-niche-rapidly-improves-neurogenesis-in-old-mice/
Neurogenesis is the generation of new neurons in the brain, and their integration into existing neural circuits. It is essential to learning a...
Source: Fight Aging! - January 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Short In Vivo Reprogramming Treatment Reverses Age-Related Omics Changes in Mice
Researchers here demonstrate that, in mice, many biological markers of aging (in the epigenome, transcriptome, and metabolome) are made more youthful by a short in vivo exposure to the Yamanaka factors capable of reprogramming cells into induced pluripotent stem cells. That process also resets epigenetic marks on the genome to a youthful configuration, improving mitochondrial function, among other benefits. In this case, the goal of a short treatment is to minimize any possible cell conversion, keeping the reprogramming exposure short enough to only change epigenetic markers, gene expression, and cell behavior to be more y...
Source: Fight Aging! - January 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Nanotherapy for Immunosuppression May Lead to Diabetes Treatment
Researchers at Northwestern University developed a nanoparticle delivery system for a common immunosuppressant drug that increases the potential of pancreatic islet transplantation as a viable long-term treatment for Type I diabetes. The technology targets the drug to act on the antigen presenting cells of the immune system, rather than T cells. This results in a more selective immunosuppression with fewer side-effects and better long-term viability for transplanted islets, which are typically attacked and destroyed by the immune system. The researchers hope that the technology could pave the way for islet transplantation ...
Source: Medgadget - January 20, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine diabetes northwestern Source Type: blogs
The Anatomy Of A Good Digital Health Company
Transparent communication, clinically-validated technologies, addressing real-life clinical needs; these might sound like no-brainer components to a digital health company since they are working in the healthcare sector. It is also a rapidly expanding one where investments were heavily channeled into during the pandemic.
However, some estimate that 90% of digital health startups will go bust or be ‘acqui-hired’ within a few years of being founded. If digital health represents the future of medicine and healthcare, it is important to understand why this is the case.
We previously dissected the reasons as to ...
Source: The Medical Futurist - January 20, 2022 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Artificial Intelligence in Medicine Bioethics Digital Health Research E-Patients Future of Medicine Future of Pharma Personalized Medicine Portable Medical Diagnostics Science Fiction Telemedicine & Smartphones clinical trial communi Source Type: blogs
Best Practices In Digital Health: 9 Keys To Build A Future-Ready Organisation
Transparent communication, clinically-validated technologies, addressing real-life clinical needs; these might sound like no-brainer components to a digital health company since they are working in the healthcare sector. It is also a rapidly expanding one where investments were heavily channeled into during the pandemic.
However, some estimate that 90% of digital health startups will go bust or be ‘acqui-hired’ within a few years of being founded. If digital health represents the future of medicine and healthcare, it is important to understand why this is the case.
We previously dissected the reasons as to ...
Source: The Medical Futurist - January 20, 2022 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Artificial Intelligence in Medicine Bioethics Digital Health Research E-Patients Future of Medicine Future of Pharma Personalized Medicine Portable Medical Diagnostics Science Fiction Telemedicine & Smartphones clinical trial communi Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
