Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2 diabetes. Limited mechanism-based strategies exist to alleviate insulin resistance. Here, using single-cell transcriptomics, we identify a small, critically important, but previously unexamined cell population, p21Cip1 highly expressing (p21high) cells, which accumulate in adipose tissue with obesity. By leveraging a p21-Cre mouse model, we demonstrate that intermittent clearance of p21high cells can both prevent and alleviate insulin resistance in obese mice. Exclusive inactivation of the NF-κB pathway within p21high cells, without killing them, attenuates insulin resistance. Moreover, fat transplantation experiments establish that p21high cells within fat are sufficient to cause insulin resistance in vivo. Importantly, a senolytic cocktail, dasatinib plus quercetin, eliminates p21high cells in human fat ex vivo and mitigates insulin resistanc...
Org. Biomol. Chem., 2022, Accepted Manuscript DOI: 10.1039/D1OB02428K, PaperSiuli Das, Rakesh Mondal, Amit Kumar Guin, Nanda D Paul Herein, we report ligand-centered redox controlled Zn(II)-catalyzed multicomponent approaches for synthesizing pyrimidines and triazines. Taking advantage of the ligand-centered redox events, using a well-defined Zn(II)-catalyst (1a) bearing (E)-2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline (L1a) as... The content of this RSS Feed (c) The Royal Society of Chemistry
As of Friday, CHRISTUS St. Vincent is in the final planning stages of the 72,000-square-foot regional cancer center and prepping for neighborhood notification meetings in February. A groundbreaking should follow six months afterward.
Hi all, I have this patient on our unit who is in their early 20s. She presents as having severe borderline personality disorder but has a strong family history of bipolar disorder I as well. She was medication naive at presentation save for venlafaxine. The only odd thing about her is that she has persistent tachycardia into the 120s and has since her arrival. She's not dehydrated. She has negative ANA and CRP. Do you think there could be something organic underlying her mix of BPD +/-... Read more
Home - FLCCC | Front Line COVID-19 Critical Care Alliance The 'I-MASK+ Prophylaxis and Early Outpatient Treatment Protocol for COVID-19' and the 'MATH+ Hospital Treatment Protocol for COVID-19' are physiologic-based combination treatment regimen created by the FLCCC Alliance, a group of leaders in critical care medicine. All component medicines in our... covid19criticalcare.com These quacks have a bunch of bull**** pseudoscience on this website aimed at fueling our terminally stupid Karens. They even have a section dedicated t...
Current med student who was set on Rads before this elective rotation. However, I hate the rotation I am on. I have to just watch a resident read scans for 4-5 hrs. It is so boring that I dread going in everyday. I honestly have no idea what they are telling me half the time either. I like the tech apsect though, and the fact that it is all mental power and the only difference b/w you and ur peers is thinking. Is this normal to hate this rotation... did you guys enjoy ur radiology rotations... Read more
ConclusionsRegardless of a patient ’s baseline symptom severity, CBT and ADM-c both prevent depressive relapse substantially better than medication discontinuation. Given the shorter duration of treatment and equivalent longer-term outcomes, treatment with CBT might be considered a first choice for adults with depression.
The objective of this study is to evaluate the life course effects of racism on depressive symptoms in young Black women and to identify particularly sensitive periods. Guided by life-course theory and using logistic regression, we analyzed baseline data on racism frequency and stress from racism at two time periods (before age 20 and during the 20s) and follow-up data (at approximate 20-month intervals) on depressive symptoms (using a modified 11-item Center for Epidemiologic Studies Depression Scale, CES-D) among 1612 Black women participants aged 23 –34 years living in Detroit, MI. Of the 1612 women, 65% repo...
The White House is pushing ahead with efforts to prod people to get COVID-19 shots after the Supreme Court put a halt to the administration’s sweeping vaccinate-or-test plan for large employers
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