A Man With Sudden Onset of Gastroparesis
By HANS DUVEFELT Leo Dufour is not a diabetic. He is in his mid 50s, a light smoker with hypertension and a known hiatal hernia. He has had occasional heartburn and has taken famotidine for a few years along with his blood pressure and cholesterol pills. Over the past few months, he started to experience a lot more heartburn, belching and bloating. Adding pantoprazole did nothing for him. I referred him to a local surgeon who did an upper endoscopy. This did not reveal much, except some retained food in his stomach. A gastric emptying study showed severe gastroparesis. The surgeon offered him a trial of metoclopra...
Source: The Health Care Blog - September 16, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Primary Care Hans Duvefelt Source Type: blogs

The 9 Trends Shaping the Future of Pharma
The drug sends a message to a caregiver after the patient swallowed it. The doctor prescribes virtual reality treatments for migraines. Do you think it is science fiction? You are mistaken. Just let me familiarize you with the top 10 trends shaping the future of pharma. And if you want to have a more in-depth analysis of the topic, read our related ebook, Technologies Shaping the Future of Pharma! Technologies Shaping the Future of Pharma We designed this e-book to serve as a collection of relevant examples, best practic...
Source: The Medical Futurist - August 26, 2021 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Future of Pharma 3d printing artificial intelligence augmented reality digital health Innovation nanotechnology Personalized medicine pharmacology virtual reality VR gc4 pharmacies pharmacogenetics Source Type: blogs

The 10 Trends Shaping the Future of Pharma
The drug sends a message to a caregiver after the patient swallowed it. The doctor prescribes virtual reality treatments for migraines. Do you think it is science fiction? You are mistaken. The pharma industry has taken a big swung into digital transformation. All participants invest in digital health topics. But as with all trending issues, and there is a lot of fuss that is hard to see through. As the medical community increasingly acknowledges the importance of digital health, the cultural shift we so often talk about is still a way to go. To change that, the first step is always getting to know what’s coming. ...
Source: The Medical Futurist - August 26, 2021 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Future of Pharma 3d printing artificial intelligence augmented reality digital health Innovation nanotechnology Personalized medicine pharmacology virtual reality VR gc4 pharmacies pharmacogenetics Source Type: blogs

Answer to Case 650
Answer to theParasite Case of the Week 650: MaleAscaris lumbricoidesAs nicely stated by Florida Fan, " Ah Ha, once more the male round worm finds its way out. Judging by the curved tail and the size, it ’s a male Ascaris lumbricoides. The female is longer and larger with a straight tail. Hopefully this is the only one in the patient, and though terrifying, it’s good riddance for the host. " A. lumbricoidesfemales can be up to 35 cm long (range of fully mature females is 20-35 cm), whereas males are slightly smaller at 15-30 cm long. Adults usually reside in the small intestine, but can occasionally migra...
Source: Creepy Dreadful Wonderful Parasites - August 23, 2021 Category: Parasitology Source Type: blogs

Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns. First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Strength Training and Aerobic Exercise Reduce Cancer Mortality
Researchers here note that undertaking strength training and aerobic exercise acts to reduce mortality due to cancer, to a similar degree as these activities are known to reduce all cause mortality in later life. The mechanisms involved are likely diverse, but it is worth noting that (a) muscle tissue is metabolically active in beneficial ways, such that more muscle is better than less muscle, (b) better immune function is linked to exercise, and immune surveillance is critical to cancer prevention, and (c) exercise helps to reduce chronic inflammation, where chronic inflammation helps to drive the establishment and develo...
Source: Fight Aging! - August 17, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The pancreas of the future?
Hidden in the epigastric region of the abdomen concealed by a curtain of peritoneum is a moody, often forgettable little organ. Of course, the term organ is a somewhat generous description for this rather overqualified gland. The pancreas has its own set of rules as it mischievously lurks behind the stomach waiting for its cueRead more …The pancreas of the future? originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 5, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/thomas-l-amburn" rel="tag" > Thomas L. Amburn < /a > < /span > Tags: Tech Gastroenterology Source Type: blogs

A case for changing the way we talk about obesity
You are finger. No, I have fingers. You are leg. No, I have legs. You are pancreas. No, I have a pancreas. You are fat. Hmm … Now let’s try this with disease processes: You are diabetes. No, I have diabetes. You are cancer. No, I have cancer. You are anorexia. No, I have anorexia.Read more …A case for changing the way we talk about obesity originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 16, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/jill-becker" rel="tag" > Jill Becker, MD < /a > < /span > Tags: Conditions Obesity Source Type: blogs

Up, Please
By KIM BELLARD When I think of elevator operators, I think of health care. Now, it’s not likely that many people think about elevator operators very often, if ever.  Many have probably never seen an elevator operator.  The idea of a uniformed person standing all day in an elevator pushing buttons so that people can get to their floors seems unnecessary at best and ludicrous at worse.  But once upon a time, they were essential, until they weren’t.  Healthcare, don’t say you haven’t been warned.  Elevators have been around in some form for hundreds of years, and by the 19th century were using steam o...
Source: The Health Care Blog - July 13, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology elevator operators elevators Kim Bellard Source Type: blogs

Dose Reductions
This’ll be quick.  My talquetamab and Pomalyst doses have been reduced due to the effects on my pancreas.  I started a few weeks ago on 4 mg of Pom.  Now I’m taking 3 mg.  Talquetamab was administered at 400 micrograms/kg, and now I’ll be getting 135.  I was feeling as though I’d had a punch … The post Dose Reductions appeared first on Beth Morgan Multiple Myeloma Treatment Blog. (Source: beth's myeloma blog)
Source: beth's myeloma blog - July 9, 2021 Category: Cancer & Oncology Authors: Beth Tags: pomalidomide Pomalyst Talquetamab Zometa Source Type: blogs

Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Introducing Developmental Signaling into Adults in Order to Produce Regeneration
Is it possible to safely introduce developmental signaling characteristic of the developing embryo and fetus into an aged adult in order to spur greater regeneration of tissues? The past decades of work on embryonic stem cell therapies and induced pluripotent stem cell therapies, and the slow investigation of how most of these therapies produce their benefits via cell signaling, suggest that this goal is in principle possible. Similarly, research into species capable of proficient regeneration, such as salamanders and zebrafish, suggests broad similarities between the biochemistry of organ development and the biochemistry ...
Source: Fight Aging! - June 17, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Reports of the Death of Diamyd's T1D Intervention Have Been Greatly Exaggerated
Remember Diamyd Medical?  I wrote about the company and even interviewed one of the company execs (Peter Zerhouni, who was then Director of Business Development) back in 2010 (see that post athttps://blog.sstrumello.com/2010/05/interview-with-diamyd-medical-ab.html). A year later, I wrote another post about it not being dead yet (seehttps://blog.sstrumello.com/2011/06/teplizumab-and-dpt-1-not-dead-yet.html), but it later appeared to actually be dead, and I basically lost interest.As it turns out, the Swedish biotech firm known as Diamyd Medical isn ' t dead after all! Diamyd Medical was founded by the Swedish entrepre...
Source: Scott's Web Log - June 14, 2021 Category: Endocrinology Source Type: blogs

Reports of the Death of Diamyd's T1D Intervention Have Been Greatly Exaggerated
RememberDiamyd Medical?  I wrote about the company and even interviewed one of the company execs (Peter Zerhouni, who was then Director of Business Development) back in 2010 (see that post athttps://blog.sstrumello.com/2010/05/interview-with-diamyd-medical-ab.html). A year later, I wrote another post about it not being dead yet (seehttps://blog.sstrumello.com/2011/06/teplizumab-and-dpt-1-not-dead-yet.html), but it later appeared to actually be dead, and I basically lost interest.As it turns out, the Swedish biotech firm known as Diamyd Medical isn ' t dead after all! Diamyd Medical was founded by the Swedish entrepren...
Source: Scott's Web Log - June 14, 2021 Category: Endocrinology Source Type: blogs

Health effects of partial hydrogenation of vegetable oils
Partially hydrogenated vegetable oils contain trans fatty acids which are different from the natural fatty acids in vegetable oils and animal fat [1]. Fatty acids in partially hydrogenated vegetable oils are 14 cis and trans isomers of octadecenoic and octadecadienoic acids that are formed during hydrogenation. Trans fatty acids cause inflammation and calcification of arterial walls. They also inhibit cyclooxygenase needed for conversion of arachidonic acid to prostacyclin, a compound beneficial for the vascular tree. There are reformulations of hydrogenated fat containing the essential fatty acid linoleic acid which get...
Source: Cardiophile MD - April 25, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs