Fight Aging! Newsletter, October 4th 2021

In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them.

Extending Life Without Extending Health: Vast Effort Directed to the Wrong Goals
https://www.fightaging.org/archives/2021/09/extending-life-without-extending-health-vast-effort-directed-to-the-wrong-goals/

It is very hard to coax a damaged machine into continued operation without repairing the damage. It is expensive and time-consuming, the machine works poorly, and fails catastrophically only a little later than it would have done without all of that effort. Keeping damaged machines running is exactly the goal of near all work on treating age-related disease, however. Very few projects are focused on addressing the cell and tissue damage that causes aging. Anything other than repairing or otherwise reversing that damage will produce only marginal gains, at great expense.

This has been well demonstrated. With the best will in the world, an enormous amount of effort has been put towards helping older people by treating age-related dis...

Source: Fight Aging! - October 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs