Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
Unconditional cash transfers, health and savings
Econ Hum Biol. 2024 Mar 15;53:101373. doi: 10.1016/j.ehb.2024.101373. Online ahead of print.ABSTRACTThis paper examines the relationship between a national unconditional cash transfers (UCTs) program, health and savings. We theoretically and empirically show that motives to save can be strong when cash transfers promote health outcomes. We first present a theoretical model that considers lifecycle-consumption savings decisions, where households derive utility from consumption and leisure time at working age, as well as old-age consumption and old-age longevity that positively depend on health spending. We then empirically ...
Source: Economics and Human Biology - March 26, 2024 Category: Biology Authors: Sefa Awaworyi Churchill Nasir Iqbal Saima Nawaz Siew Ling Yew Source Type: research
Retraction Note: Environmental factors affecting the frequency of road traffic accidents: a case study of sub-urban area of Pakistan
Environ Sci Pollut Res Int. 2024 Mar 26. doi: 10.1007/s11356-024-33079-2. Online ahead of print.NO ABSTRACTPMID:38528229 | DOI:10.1007/s11356-024-33079-2 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - March 26, 2024 Category: Environmental Health Authors: Hafiz Mohkum Hammad Muhammad Ashraf Farhat Abbas Hafiz Faiq Bakhat Saeed A Qaisrani Muhammad Mubeen Shah Fahad Muhammad Awais Source Type: research
Retraction Note: Environmental factors affecting the frequency of road traffic accidents: a case study of sub-urban area of Pakistan
Environ Sci Pollut Res Int. 2024 Mar 26. doi: 10.1007/s11356-024-33079-2. Online ahead of print.NO ABSTRACTPMID:38528229 | DOI:10.1007/s11356-024-33079-2 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - March 26, 2024 Category: Environmental Health Authors: Hafiz Mohkum Hammad Muhammad Ashraf Farhat Abbas Hafiz Faiq Bakhat Saeed A Qaisrani Muhammad Mubeen Shah Fahad Muhammad Awais Source Type: research
Unconditional cash transfers, health and savings
Econ Hum Biol. 2024 Mar 15;53:101373. doi: 10.1016/j.ehb.2024.101373. Online ahead of print.ABSTRACTThis paper examines the relationship between a national unconditional cash transfers (UCTs) program, health and savings. We theoretically and empirically show that motives to save can be strong when cash transfers promote health outcomes. We first present a theoretical model that considers lifecycle-consumption savings decisions, where households derive utility from consumption and leisure time at working age, as well as old-age consumption and old-age longevity that positively depend on health spending. We then empirically ...
Source: Economics and Human Biology - March 26, 2024 Category: Biology Authors: Sefa Awaworyi Churchill Nasir Iqbal Saima Nawaz Siew Ling Yew Source Type: research
Tick-borne Rickettsia, Anaplasma, Theileria, and enzootic nasal tumor virus in ruminant, PET, and poultry animals in Pakistan
ConclusionThis study reveals that there is a considerably wider range of TBPs held in Pakistan that take in various contagious zoonotic pathogens than was previously thought. This information advances TBP epidemiology and will contribute to upgrade future control measure. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 26, 2024 Category: Microbiology Source Type: research
Global burden and trends of acute viral hepatitis among children and adolescents from 1990 to 2019: a systematic analysis of the Global Burden of Disease Study 2019
ConclusionEffective vaccines and treatments for hepatitis B and C offer eradication opportunities. Broadening diagnostic and therapeutic coverage is vital to address disparities in service provision for children and adolescents. (Source: Hepatology International)
Source: Hepatology International - March 26, 2024 Category: Infectious Diseases Source Type: research
Assessment of pheniramine in alternative biological matrices by liquid chromatography tandem mass spectrometry
In this study, pheniramine was quantified in both conventional and alternative specimens of twenty chronic drug abusers, aged 16 –50 years, who were positive for pheniramine in comprehensive toxicological screening for drugs by gas chromatography with mass spectral detection in positive electron impact mode. Pheniramine was extracted from biological specimens using solid phase extraction and liquid chromatography tandem ma ss spectrometry was employed for quantification. Chromatographic separation was carried out on a Poroshell120EC-18 (2.1 mm × 50 mm × 2.7 µm) column using water-acetonitrile in formic acid (0...
Source: Forensic Science, Medicine, and Pathology - March 26, 2024 Category: Forensic Medicine Source Type: research
"The Critical Services Are Out of Reach": Diabetes Management and the Experiences of South Asian Immigrants in Ontario
This study provides support for the fact that even in Canada's universal healthcare system, disparities exist, particularly for ethnic minorities, and that a universal prescription drug coverage component is a crucial step forward to ensure equitable access to health services utilization for all.PMID:38523416 | DOI:10.1177/21501319241240635 (Source: Primary Care)
Source: Primary Care - March 25, 2024 Category: Primary Care Authors: Minal Waqar Vincent Z Kuuire Source Type: research
Prospective Analysis of Lipid Variations in Hyperthyroid Subjects from Lahore, Pakistan
Biomed Res Int. 2021 Sep 3;2021:9936782. doi: 10.1155/2021/9936782. eCollection 2021.ABSTRACTPerturbations in the actions of T3 and T4 influence the normal metabolic pathways. Responsiveness of lipid biomarkers like LDL-C, HDL-C, TC, TG, Apo-A, and Apo-B after rehabilitation of thyroid profile attaining euthyroid state was determined. A total of 179 age-matched subjects of both genders were recruited for this research. Sixty healthy controls, thirty-four subclinical, fifty overt hyperthyroid, and thirty-five follow-up subjects having 3 months of Carbimazole therapy were enrolled. Biochemical analysis was performed by chemi...
Source: Biomed Res - March 25, 2024 Category: Research Authors: Muhammad Amir Iqbal Shaaf Ahmad Tamseela Mumtaz Zahra Naseem Javeria Malik Husna Ahmad Nabila Roohi Source Type: research
Level of polychlorinated biphenyls in tumor and blood serum of breast cancer patients and control subjects from Punjab, Pakistan
Sci Total Environ. 2024 Mar 23:171908. doi: 10.1016/j.scitotenv.2024.171908. Online ahead of print.ABSTRACTThe current study examined the level of Polychlorinated biphenyls (PCBs) in tumor and blood serum of female breast cancer patients and control individuals recruited from Punjab, Pakistan. Breast tumor and blood serum from 40 patients and only blood serum from ten control subjects were obtained and concentration of 32 PCB congeners was analyzed through Gas chromatography coupled with Mass spectrophotometry. Sociodemographic variables of the patients along with essential clinical and haematological parameters were taken...
Source: Cancer Control - March 25, 2024 Category: Cancer & Oncology Authors: A Khalid N A Abbasi N Jamil J H Syed S R Ahmad A Qadir Source Type: research
