An acute phase reaction from zoledronate mimicking symptoms seen in opioid withdrawal: a case report
CONCLUSION: Zoledronate, well known for causing acute phase reactions, was likely the cause of withdrawal-like symptoms. Acute phase reactions with bisphosphonates mostly occur in the first infusion, and the incidence decreases with subsequent infusions. Symptoms typically occur 24-72 h post-infusion, and last at most for 72 h. Cognitive bias led the primary team to be concerned with opioid withdrawal rather than investigating other causes for the patient's presentation. Therefore, providers should thoroughly investigate potential etiologies and rule them out accordingly to provide the best care. Health care providers shou...
Source: Addiction Science and Clinical Practice - May 1, 2024 Category: Addiction Authors: Pankti P Acharya Crystal Joseph Source Type: research
Effects of Empagliflozin on vascular and skeletal mineralization in Hyperlipidemic mice
Vascul Pharmacol. 2024 Apr 29:107376. doi: 10.1016/j.vph.2024.107376. Online ahead of print.ABSTRACTCardiovascular disease and osteoporosis, major causes of morbidity and mortality, are associated with hyperlipidemia. Recent studies show that empagliflozin (EMPA), an inhibitor of sodium-glucose cotransporter-2 (SGLT2), improves cardiovascular health. In preclinical animal studies, EMPA mitigates vascular calcification in the males but its effects in the females are not known. Thus, we used female mice to test the effects of EMPA on calcification in the artery wall, cardiac function, and skeletal bone. By serial in vivo mic...
Source: Vascular Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sophia Kalanski Stuti Pradhan Andy Hon Yuxuan Xia Nora Safvati Juan Carlos Rivera Mimi Lu Linda L Demer Yin Tintut Source Type: research
Development of Transdermal Formulation Based on Nanotechnology and Elucidation of Its Drug Delivery Pathways
Yakugaku Zasshi. 2024;144(5):505-510. doi: 10.1248/yakushi.23-00178-1.ABSTRACTTransdermal drug delivery is a formulation in which the drug is absorbed through the skin for systemic action. Its advantages include avoidance of first-pass effects, sustained drug supply, and ease of administration and discontinuation. Drugs administered transdermally transfer into the blood circulation through the stratum corneum, epidermis, and dermis. The stratum corneum on the skin surface plays a barrier function in skin absorption. Therefore, developing of transdermal drug delivery systems requires innovations that overcome the barrier fu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Hiroko Otake Noriaki Nagai Source Type: research
Risks of suboptimal and excessive thyroid hormone replacement across ages
ConclusionSuboptimal and excessive LT4 replacement of the preventable non-communicable disease hypothyroidism requires more focus from the healthcare system and from the global political systems to prevent the personally devastating and socioeconomically challenging consequences. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review
CONCLUSION: MACS is no longer considered an asymptomatic disorder; repeated hormonal and functional tests are crucial to prevent multiorgan damage.PMID:38686896 | DOI:10.2174/0118715303266569231129101847 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Stephanie Farah Leah Nasr Jocelyne Eid Fares Source Type: research
Effect of Low Protein Diet on Bone Structure of Young Wistar Mice
Conclusion:</b> A low protein diet decreased the body weight of the rats, also causing impaired bone growth characterized by decreasing femur weight. The low protein diet also caused osteoporosis in the bones.PMID:38686732 | DOI:10.3923/pjbs.2024.113.118 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Faysal Kastella Filiani Natalia Salim Hanna Goenawan Ronny Lesmana Rita Maliza Rahimi Syaidah Aziiz Mardanarian Rosdianto Vita Murniati Tarawan None Setiawan Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review
CONCLUSION: MACS is no longer considered an asymptomatic disorder; repeated hormonal and functional tests are crucial to prevent multiorgan damage.PMID:38686896 | DOI:10.2174/0118715303266569231129101847 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Stephanie Farah Leah Nasr Jocelyne Eid Fares Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review
CONCLUSION: MACS is no longer considered an asymptomatic disorder; repeated hormonal and functional tests are crucial to prevent multiorgan damage.PMID:38686896 | DOI:10.2174/0118715303266569231129101847 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Stephanie Farah Leah Nasr Jocelyne Eid Fares Source Type: research
Effect of Low Protein Diet on Bone Structure of Young Wistar Mice
Conclusion:</b> A low protein diet decreased the body weight of the rats, also causing impaired bone growth characterized by decreasing femur weight. The low protein diet also caused osteoporosis in the bones.PMID:38686732 | DOI:10.3923/pjbs.2024.113.118 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Faysal Kastella Filiani Natalia Salim Hanna Goenawan Ronny Lesmana Rita Maliza Rahimi Syaidah Aziiz Mardanarian Rosdianto Vita Murniati Tarawan None Setiawan Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review
CONCLUSION: MACS is no longer considered an asymptomatic disorder; repeated hormonal and functional tests are crucial to prevent multiorgan damage.PMID:38686896 | DOI:10.2174/0118715303266569231129101847 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Stephanie Farah Leah Nasr Jocelyne Eid Fares Source Type: research
