The effect of Schizophyllan on the differentiation of osteoclasts and osteoblasts
In this study, its effects on bone cells, particularly osteoclasts and osteoblasts, were examined. We demonstrated that SPG dose-dependently inhibited osteoclastogenesis and reduced gene expression associated with osteoclast differentiation. SPG also decreased bone resorption and F-actin ring formation. This inhibition could have been due to the downregulation of transcription factors c-Fos and nuclear factor of activated T cells 1 (NFATc1) via the MAPKs (JNK and p38), IκBα, and PGC1β/PPARγ pathways. In coculture, SPG lowered osteoclastogenic activity in calvaria-derived osteoblasts by reducing macrophage colony-stimul...
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Soo-Ho Kim Keun Ha Park Jun Lee Seoung Hoon Lee Jeong-Hwa Baek Source Type: research
Intermittent administration of PTH for the treatment of inflammatory bone loss does not enhance entheseal pathological new bone formation
CONCLUSION: Experimental animal models of AS treated with iPTH show improvement in trabecular bone density, but not entheseal pathological bone formation，indicating it may be a potential treatment for inflammatory bone loss does in AS.PMID:38603833 | DOI:10.1016/j.bbrc.2024.149888 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Shuai Zhang Wenjun Hao Dongying Chen Siwen Chen Zihao Li Fangling Zhong Haitao Wang Jianru Wang Zhaomin Zheng Zhongping Zhan Guo Dai Hui Liu Source Type: research
Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility
Conclusions
Residential greenness was associated with higher bone mineral density and decreased risk of incident osteoporosis. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Tan, T., Tang, L., Guo, X., Li, T., Tian, Y., Ouyang, Z. Tags: Editor's choice, Press releases, ARD Lay summaries, ARD, Osteoporosis Source Type: research
Molecules, Vol. 29, Pages 1741: A 70% Ethanol Neorhodomela munita Extract Attenuates RANKL-Induced Osteoclast Activation and H2O2-Induced Osteoblast Apoptosis In Vitro
This study explores the protective impact of Neorhodomela munita ethanol extract (EN) on osteoporosis by modulating critical pathways in osteoclastogenesis and apoptosis. Raw264.7 cells and Saos-2 cells were used for in vitro osteoclast and osteoblast models, respectively. By utilizing various in vitro methods to detect osteoclast differentiation/activation and osteoblast death, it was demonstrated that the EN’s potential to inhibit RANKL induced osteoclast formation and activation by targeting the MAPKs-NFATc1/c-Fos pathway and reducing H2O2-induced cell death through the downregulation of apoptotic signals....
Source: Molecules - April 11, 2024 Category: Chemistry Authors: Seongtae Jeong Il-Kwon Kim Hanbyeol Moon Hojin Kim Byeong-Wook Song Jung-Won Choi Sang Woo Kim Seahyoung Lee Dong-Sik Chae Soyeon Lim Tags: Article Source Type: research
The association between prealbumin concentration at admission and mortality in elderly patients with hip fractures: a cohort study
ConclusionThe prealbumin concentrations at admission were nonlinearly associated with long-term mortality in geriatric hip fractures, and 162.2 mg/L could be considered a prognostic factor of mortality risk. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - April 11, 2024 Category: Orthopaedics Source Type: research
