Conditioned medium of human mesenchymal stem cells affects stem cell senescence in osteoporosis
In this study, we aimed to compare the effects of conditioned medium (hMSCs-CM) from early and late passage hMSCs on cellular senescence and to verify the benefits of CM from early passage hMSCs in mitigating the progression of osteoporosis through the prevention of cellular senescence. We investigated the distinct endocrine effects of early (P5) and late (P17) passage hMSCs in vitro, as well as the preventive benefits of early passage hMSCs-CM in osteoporosis model triggered by ovariectomy. Our results indicate that long-term cultured hMSCs contributed to the progression of inflammatory transcriptional programs in P5 hMSC...
Source: Biochemical and Biophysical Research communications - April 15, 2024 Category: Biochemistry Authors: Kehong Liu Kiyoshi Sakai Junna Watanabe Jiao Dong Hiroshi Maruyama Xinheng Li Hideharu Hibi Source Type: research
Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use
CONCLUSION: The 3 Hz stimulation offered the greatest physiological challenge and was perceived as more acceptable for long term use among people with SCI.PMID:38619192 | DOI:10.1080/10790268.2024.2338295 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 15, 2024 Category: Orthopaedics Authors: Michael A Petrie Shauna Dudley-Javoroski Kristin A Johnson Jinhyun Lee Olga Dubey Richard K Shields Source Type: research
Rheumatology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0678. Online ahead of print.ABSTRACTMany patients with rheumatologic conditions receive care from physicians other than rheumatologists. Here we note key findings from 6 studies in rheumatology published in 2023 that offer valuable insights for internal medicine specialists and subspecialists outside of rheumatology. The first study investigated the effect of low-dose glucocorticoids on patients with rheumatoid arthritis (RA) over 2 years and challenged existing perceptions about the risks of glucocorticoids in this setting. The second study focused on the updated guideline for...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Kafaf Jalali Lisa A Mandl Source Type: research
Starvation Osteoporosis in Shoah Survivors: Emphasis on Descendant Generations
Isr Med Assoc J. 2024 Apr;26(4):207-210.NO ABSTRACTPMID:38616663 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: George M Weisz Source Type: research
Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use
CONCLUSION: The 3 Hz stimulation offered the greatest physiological challenge and was perceived as more acceptable for long term use among people with SCI.PMID:38619192 | DOI:10.1080/10790268.2024.2338295 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 15, 2024 Category: Orthopaedics Authors: Michael A Petrie Shauna Dudley-Javoroski Kristin A Johnson Jinhyun Lee Olga Dubey Richard K Shields Source Type: research
Rheumatology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0678. Online ahead of print.ABSTRACTMany patients with rheumatologic conditions receive care from physicians other than rheumatologists. Here we note key findings from 6 studies in rheumatology published in 2023 that offer valuable insights for internal medicine specialists and subspecialists outside of rheumatology. The first study investigated the effect of low-dose glucocorticoids on patients with rheumatoid arthritis (RA) over 2 years and challenged existing perceptions about the risks of glucocorticoids in this setting. The second study focused on the updated guideline for...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Kafaf Jalali Lisa A Mandl Source Type: research
Starvation Osteoporosis in Shoah Survivors: Emphasis on Descendant Generations
Isr Med Assoc J. 2024 Apr;26(4):207-210.NO ABSTRACTPMID:38616663 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: George M Weisz Source Type: research
Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use
CONCLUSION: The 3 Hz stimulation offered the greatest physiological challenge and was perceived as more acceptable for long term use among people with SCI.PMID:38619192 | DOI:10.1080/10790268.2024.2338295 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 15, 2024 Category: Orthopaedics Authors: Michael A Petrie Shauna Dudley-Javoroski Kristin A Johnson Jinhyun Lee Olga Dubey Richard K Shields Source Type: research
Starvation Osteoporosis in Shoah Survivors: Emphasis on Descendant Generations
Isr Med Assoc J. 2024 Apr;26(4):207-210.NO ABSTRACTPMID:38616663 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: George M Weisz Source Type: research
