Uncovering subtle nail involvement in lichen planus with dermoscopy: a prospective, controlled study.
Conclusions: To the best of our knowledge, this is the first study focusing on uncovering subtle nail involvement in lichen planus. The presence of dilated hyponychial vascular structures in lichen planus was first described in the present study. It can be concluded that the frequency of nail involvement in lichen planus is more than known. Dermoscopic imaging of the nails of all patients with lichen planus may help establish early diagnosis and treatment to avoid permanent nail damage.
PMID: 32792882 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - August 16, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
[Ungual lesions in lupus erythematosus: A retrospective study of 14 patients].
DISCUSSION: Ungual lesions do not appear specific and do not in themselves allow diagnosis of LE. They can in fact occur in other diseases such as connective tissue disorders. However, their diagnosis is important because certain of them, such as pterygium, can lead to severe ungual dystrophia, with functional consequences. In our study, pterygium and onychoschizia appeared to be associated with cutaneous discoid lupus erythematosus and multisystemic involvement. The coexistence of peri-ungual lesions related to cutaneous lupus erythematosus and/or multisystemic involvement does not out differentiation of lupus ungual lesi...
Source: Annales de Dermatologie et de Cenereologie - August 2, 2020 Category: Dermatology Authors: Wagner C, Chasset F, Francès C, Lipsker D Tags: Ann Dermatol Venereol Source Type: research
Dorsal Pterygium and Onycholysis Associated With Bullous Pemphigoid.
PMID: 32663446 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - July 10, 2020 Category: Dermatology Authors: Iznardo H, García-Melendo C, Mir-Bonafé JF Tags: Actas Dermosifiliogr Source Type: research
Distal Phototoxic Onycholysis.
Authors: Czap C, Weckopp S
PMID: 32343652 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 30, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Nail changes induced by chemotherapeutic agents
Conclusion: Nail toxicities are common with chemotherapeutic agents, however less importance is given to nail involvement. Apart from being cosmetically significant, a few adverse effects may warrant modification of the chemotherapy. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - April 13, 2020 Category: Dermatology Authors: Neerja Saraswat Aradhana Sood Rajesh Verma Dhramesh Kumar Sushil Kumar Source Type: research
Spiderweb-like pattern: A novel dermoscopic feature in photo-onycholysis induced by doxycycline?
PMID: 31992451 [PubMed - as supplied by publisher] (Source: Therapie)
Source: Therapie - January 12, 2020 Category: Psychiatry & Psychology Authors: Chamli A, Ben Salem F, Ben Lagha I, Charfi O, Zaouak A, Fenniche S, Hammami H Tags: Therapie Source Type: research
[Ungual lesions in lupus erythematosus: A literature review].
DISCUSSION: Ungual lesions are not specific and do not permit diagnosis of LE. They can in fact occur in other diseases such as connective tissue disorders. However, their diagnosis is important because they may be the presenting sign in LE, and certain of them may be associated with more active disease. Onychomycosis is frequently a confounding factor in such immunocompromised patients.
PMID: 31812364 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - December 3, 2019 Category: Dermatology Authors: Wagner C, Chasset F, Fabacher T, Lipsker D Tags: Ann Dermatol Venereol Source Type: research
Desquamating-nonpigmenting with onycholysis fixed drug eruption in a child due to amoxicillin. Cross-reactivity study.
PMID: 31751290 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - November 20, 2019 Category: Allergy & Immunology Authors: Moya B, Vera A, Bazire R, Betancor D, Rodríguez Del Río P, Escudero C, Ibáñez MD Tags: J Investig Allergol Clin Immunol Source Type: research
Onychomycosis: An Updated Review.
CONCLUSION: Oral antifungal therapies are effective, but significant adverse effects limit their use. Although topical antifungal therapies have minimal adverse events, they are less effective than oral antifungal therapies, due to poor nail penetration. Therefore, there is a need for exploring more effective and/or alternative treatment modalities for the treatment of onychomycosis which are safer and more effective.
PMID: 31738146 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - November 19, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Retrospective Case Series on Risk Factors, Diagnosis and Treatment of Pseudomonas aeruginosa Nail Infections
ConclusionClinical examination findings of onycholysis coupled with a green or green-brown discoloration involving one or more digits and dermoscopic findings of greenish discoloration with a fading border are consistent with a diagnosis ofPseudomonas nail infection. Gentamicin topical solution is an effective, inexpensive, easy-to-use treatment for this condition. Larger randomized clinical trials are necessary to compare efficacy with other therapeutic options. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - October 7, 2019 Category: Dermatology Source Type: research
Atypical histological findings in type IV juvenile pityriasis rubra pilaris
A 7-year-old Fitzpatrick skin type IV male presented to the dermatology clinic with his mother with a seven month hx of nail changes and a mildly pruritic rash over the dorsal hands. A previous clinical visit 3 months earlier showed a negative KOH of his skin lesions and negative fungal culture of his nail clippings. The initial differential diagnosis included pachyonychia congenita, psoriasis, and tinea unguium, along with tinea corporis. On the subsequent exam, a waxy, orange palmoplantar keratoderma was noted, along with subungual hyperkeratosis and onycholysis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research
Severe nail psoriasis managed succesflly with apremilast
Psoriasis is a chronic, systemic, inflammatory disease involving skin, nails, and joints. Nail psoriasis may lead to many difficulties in daily activities including work and impairment in quality of life and may also be the cause of severe pain, anxiety and depression. A 66-year-old woman with a history of seronegative arthritis receiving methotrexate presented with severe ungual dystrophy affecting all 20 nails. Clinical examination revealed subungual hyperkeratosis, salmon patches, periungual erythema, onycholysis and nail crumbling. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research
[Evaluation of the usefulness of nail biopsy in the diagnosis of onychomycosis].
CONCLUSIONS: The overall usefulness of the biopsy was moderate for patients with more severe symptomatology, which makes its use advisable in cases of extensive onycholysis, and when discriminating colonisation from invasion is required.
PMID: 31153723 [PubMed - as supplied by publisher] (Source: Revista Iberoamericana de Micologia)
Source: Revista Iberoamericana de Micologia - May 28, 2019 Category: Biology Authors: Velásquez Agudelo V, de Bedout Gómez C, Cardona Arias JA, Cano Restrepo LE Tags: Rev Iberoam Micol Source Type: research
Onychomycosis with greenish-black discolorations and recurrent onycholysis caused by Candida parapsilosis
Publication date: Available online 16 April 2019Source: Medical Mycology Case ReportsAuthor(s): Gai Ge, Zhiya Yang, Dongmei Li, G. Sybren de Hoog, Dongmei ShiAbstractCandida parapsilosis (C. parapsilosis) has become a common pathogen, especially in immunocompromised hosts. Here, we present an immunocompetent adult with greenish-black discoloration of the right first finger nail in combination with recurrent onycholysis. C. parapsilosis was isolated from the right first finger nail and was confirmed by morphological characteristics as well as by DNA molecular analysis. Patient was successfully treated with oral itraconazole...
Source: Medical Mycology Case Reports - April 17, 2019 Category: Biology Source Type: research
Nail Involvement in Psoriatic Patients and Association with Onychomycosis: Results from a Cross-Sectional Study Performed in a Military Hospital in Tunisia
Nail psoriasis has variable prevalence and heterogeneous aspects. Many of them could mimic onychomycosis (OM). It has been suggested that patients with nail psoriasis are at high risk of OM. The aim of our study was to determine the epidemiological and clinical characteristics of nail psoriasis and to estimate the frequency and the factors associated with OM in psoriatic patients. The studied group included 163 patients with psoriasis aged 18 years or older. Epidemiological and clinical data, as well as the severity of skin and nails disease by evaluating the Psoriasis Area Severity Index (PASI) and Nail Area Psoriasis Sev...
Source: Skin Appendage Disorders - April 15, 2019 Category: Dermatology Source Type: research
