Langerhans cell histiocytosis with nail changes and multisystem disease: a case report.
We describe a 2-year-old boy with onycholysis, subungual hyperkeratosis, and hemorrhages on his fingernails. He also had hepatosplenomegaly and pulmonary involvement. The diagnosis of Langerhans cell histiocytosis was made by histopathologic examination of skin and liver.The role of nail involvement as an unfavorable prognostic sign is still unclear and this paper concludes that nail involvement in Langerhans cell histiocytosis is a possible sign of multisystemic involvement.
PMID: 27617727 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - September 13, 2016 Category: Dermatology Authors: De Jesus Semblano Bittencourt M, Moraes Dias C, Lima Lage T, Magno Parijós A, Brito Mesquita L, Haber Carvalho A Tags: Dermatol Online J Source Type: research
Nail abnormalities in patients with vitiligo
Conclusions: Nail abnormalities were more prevalent in vitiligo patients than in controls. Systematic examination of the nails in such patients is useful because nail abnormalities are frequent. However, the causes of such abnormalities require further study. Longitudinal ridging and leukonychia were the most common abnormalities observed in this study. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - August 30, 2016 Category: Dermatology Source Type: research
Nail psoriasis in an adult successfully treated with a series of herbal skin care products family a case report.
We report the case of a 50-year-old male patient with recalcitrant nail dystrophies on the fingers since the age of 40, who responded successfully to Dr. Michaels® product family. The patient had a 35-year history of plaque psoriasis localised on the scalp, ears, groin, limbs, and trunk and with psoriatic arthritis. The nail symptoms consisted of onycholysis, onychomycosis, leukonychia, transverse grooves, nail plate crumbling and paronychia of the periungal skin. This case represents the efficacy and safety of the Dr. Michaels® (Soratinex® and Nailinex®) product family with successful resolution of nail dystrophies an...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Incidence, clinical manifestations and clipping of nail psoriasis in the dermatology center of the Hospital Universitário Evangélico de Curitiba
Conclusions: Patients with nail psoriasis are usually men, with worse quality of life and higher chance of psoriatic arthritis. The correlation between the nail involvement of psoriasis and psoriatic arthritis in hands confirms the association between these two forms. The clinical diagnosis of nail psoriasis did not correlate with the histological diagnosis. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - July 14, 2016 Category: Dermatology Source Type: research
[Dermatomiositis and evans syndrome associated with HTLV-1 infection].
Authors: Loja-Oropeza D, Zavala-Flores E, Vilca-Vasquez M
Abstract
A 55-year-old female patient, born in Ayacucho, with a history of dermatomyositis for 3 years, who received irregular treatment with prednisone. Two months prior to admission, she presented with autoinmune hemolytic anemia and idiopathic thrombocytopenic purpura. The patient received methylprednisolone pulse therapy and packed red blood cells transfusions. Upon admission, she was drowsy, with a poor overall status, marked weight loss, dehydration, with presence of livedo reticularis in her lower extremities, and onychodystrophy and onycholy...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - July 8, 2016 Category: Global & Universal Tags: Rev Peru Med Exp Salud Publica Source Type: research
Spontaneous, painful nail haemorrhages and onycholysis in a patient at high altitude.
PMID: 27571727 [PubMed - in process] (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - June 30, 2016 Category: Journals (General) Authors: Marbus SD, van Vugt M Tags: Neth J Med Source Type: research
Answer to Photo Quiz: Spontaneous, painful nail haemorrhages and onycholysis in a patient at high altitude.
Authors:
PMID: 27571728 [PubMed - in process] (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - June 30, 2016 Category: Journals (General) Tags: Neth J Med Source Type: research
Risk factors, clinical variants and therapeutic outcome of retronychia: a retrospective study of 18 patients
ConclusionIn our opinion, ischaemic damage is the main cause of retronychia. Evaluation of clinical variants is mandatory to propose appropriate treatment. The limitations of this study include the retrospective design. (Source: European Journal of Dermatology)
Source: European Journal of Dermatology - June 30, 2016 Category: Dermatology Source Type: research
Psoriatic nail involvement and its relationship with distal interphalangeal joint disease
Abstract
Psoriatic nail disease and distal interphalangeal (DIP) arthritis both are common manifestations of psoriatic arthritis (PsA). Several clinical characteristics are allegedly associated with DIP joint damage, particularly nail psoriasis. However, there is little evidence to substantiate this phenomenon. The purpose of this study is to investigate the relationship between DIP involvement, nail psoriasis and other parameters. A cross-sectional study involved 45 patients from local rheumatology clinic. Four hundred fifty psoriatic fingernails scored, and the radiographs of all these fingers were revi...
Source: Clinical Rheumatology - May 31, 2016 Category: Rheumatology Source Type: research
Laser and light therapies for the treatment of nail psoriasis
In this study, the efficacies of light and laser therapies are systematically reviewed. Light therapies involve ultraviolet light (with or without photosensitizers) or intense pulsed light. Alternatively, laser therapy in nail psoriasis is primarily administered using a 595‐nm pulsed dye laser. These modalities have demonstrated significant improvement in psoriatic nail lesions, and even complete resolution in some cases. Both laser and light modalities have also been tested in combination with other systemic or topical therapeutics, with variable improvement in efficacy. Both laser and light therapies are generally well...
Source: Journal of the European Academy of Dermatology and Venereology - May 25, 2016 Category: Dermatology Authors: Eric L. Maranda, Austin H. Nguyen, Victoria M. Lim, Farhaan Hafeez, Joaquin J. Jimenez Tags: Review Article Source Type: research
Hair and nail adverse events during treatment with targeted therapies for metastatic melanoma
Conclusion
Hair and nail side effects during targeted therapy for melanoma are not rare. The early recognition and cure of such side effects by dermatologists is of benefit to ensure the need for dose reduction or drug discontinuation. (Source: European Journal of Dermatology)
Source: European Journal of Dermatology - April 30, 2016 Category: Dermatology Source Type: research
Nail alterations during pregnancy: a clinical study
This study investigated the frequency and nature of nail changes occurring during pregnancy in 312 healthy, 18–40‐year‐old pregnant women in gestation weeks 16–40. After a routine obstetric examination at the obstetrics and gynecology clinic at the study institution, all subjects submitted to an examination of all fingernails and toenails. Only nail alterations that had developed during pregnancy were recorded. Any nail changes that had occurred before the start of gestation were not considered. Data were presented as percentages. The Shapiro–Wilk and chi‐squared tests were used to make categorical comparisons....
Source: International Journal of Dermatology - April 21, 2016 Category: Dermatology Authors: Seval Erpolat, Ayla Eser, Ikbal Kaygusuz, Hatice Balci, Aydin Kosus, Nermin Kosus Tags: Clinical Trial Source Type: research
592 Fingernail photo-onycholysis resulting from aminolevulinic acid-photodynamic therapy with blue light for treatment of actinic keratoses on face
We report a case of fingernail photo-onycholysis in a patient who was treated with PDT-ALA for perioral AKs on the face. A 65 year old female presented with all fingernails noticeably lifted from the nail bed 72 hours post PDT-ALA treatment of AKs on the face. Negative fungal culture results ruled out onychomycosis. It is hypothesized that the patient touched her face with her nails during incubation prior to PDT-ALA treatment under blue light, collecting ALA under her fingernails and exposing them to sunlight post treatment in her garden. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 20, 2016 Category: Dermatology Authors: K.M. Paci, R. Todd Bell, B. Goldstein Tags: Photobiology Source Type: research
Various simultaneous nail changes due to valproic acid use.
We present a 50-year-old man who had onycholysis, roughness of the nail surface and brownish-yellow discoloration of both fingernails and toenails, which remarkably ameliorated upon cessation of valproic acid.
PMID: 26983583 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - March 17, 2016 Category: Toxicology Authors: Solak B, Oztas Kara R, Erdem T Tags: Cutan Ocul Toxicol Source Type: research
[Cosmetic nail products].
Abstract
Cosmetic embellishment of fingernails involves the use of substance that harden either after the evaporation of solvents (varnishes) or after polymerisation (artificial acrylic nails, gel tips, glue-on artificial nails). Pathological reactions to cosmetics usually occur at a remote site for varnishes, and, most commonly, in situ with polymerising substances. Unvarnished artificial nails do not affect pulse oximetry readings, and in theory, patients are not required to remove them. However, a real problem of contamination via artificial nails exists. Increased carriage of pathological Gram-negative...
Source: Annales de Dermatologie et de Cenereologie - March 14, 2016 Category: Dermatology Authors: Baran R, Goettmann S, André J Tags: Ann Dermatol Venereol Source Type: research
