Lipid peroxidation as a predictive biomarker of the early stage of cancer.
Authors: Bobrowska-Korczak B, Skrajnowska D, Kiss AK, Wrzesien R, Bielecki W, Orzoł A, Zebrowski P, Bialek S Abstract Prostate cancer continues to be a major cause of morbidity and mortality in men around the world. The data concerning the antioxidant status and the degree of lipid peroxidation at the moment of the initiation of cancer is limited. The aim of this research is to assess the effect of selected minerals (zinc, selenium, iron, copper and calcium) on the growth of the neoplastic process and the concentrations of selected biomarkers of the oxidative damage in rats with implanted prostate cancer cells. It...
Source: Journal of Biological Regulators and Homeostatic Agents - May 18, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Comparative proteomic analysis between the gingival crevicular fluid and the corresponding periodontal pocket: a preliminary study.
Authors: Bertoldi C, Bergamini S, Ferrari M, Lalla M, Bellei E, Spinato S, Tomasi A, Monari E PMID: 31088607 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - May 16, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Basal cell carcinoma of the eyelid.
Authors: Borroni D, Parekh M, Rocha De Lossada C, Adathilethu S, Marino L, Romano V PMID: 31088608 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - May 16, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Valsartan/hydrochlorothiazid е induced prostatе carcinoma in a patient who subsequently developed melanoma.
Valsartan/hydrochlorothiazidе induced prostatе carcinoma in a patient who subsequently developed melanoma. J Biol Regul Homeost Agents. 2019 May 13;33(4) Authors: Tchernev G, Temelkova I PMID: 31079442 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - May 15, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A technical note for the use of small-diameter cannula for lipoaspiration technique in aesthetic reconstructive post-oncological surgery.
Authors: Abenavoli FM, Inchingolo AD, Inchingolo AM, Dipalma G, Inchingolo F Abstract Skin cancer basal cell carcinoma (BCC) is a quite common lesion with a worldwide annual incidence between 3% and 8%. Tissue reconstruction should be biologically driven: nowadays, the naso-genial flap is one of the safest and usable flaps for the reconstruction of the labial and nasal region after invasive surgery aimed at a full BCC excision. In fact, the proximity of this flap to the area to be treated, the similar colour of the skin and the technical possibility to perform a single surgery to both harvest the flap and remove th...
Source: Journal of Biological Regulators and Homeostatic Agents - May 8, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Anti-calculus efficacy of Periogen ® oral rinse in gingivitis patients.
Anti-calculus efficacy of Periogen® oral rinse in gingivitis patients. J Biol Regul Homeost Agents. 2019 May 03;33(3) Authors: Ballini A, Cantore S, Dipalma G, De Vito D, Saini R, Saini SR, Georgakopoulos P, Gargiulo Isacco C, Inchingolo F Abstract Dental biofilm is a complex, organized microbial community that is the primary etiologic factor for plaque, the most frequently occurring oral contamination for gingivitis, dental caries and periodontal diseases. In dentistry, calculus is a form of hardened dental plaque, caused by precipitation of calcium (Ca) and phosphorous (P) ions deposited from sal...
Source: Journal of Biological Regulators and Homeostatic Agents - May 8, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Periodontal neoformations and myocarditis onset: is it more than a simple coincidence?
Authors: Abenavoli FM, Inchingolo AD, Inchingolo AM, Dipalma G, Inchingolo F PMID: 31035739 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - May 2, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effect of activated charcoal probiotic toothpaste containing Lactobacillus paracasei and xylitol on dental caries: a randomized and controlled clinical trial.
Authors: Ballini A, Cantore S, Saini R, Pettini F, Fotopoulou EA, Saini SR, Georgakopoulos IP, Dipalma G, Gargiulo Isacco C, Inchingolo F PMID: 31035741 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - May 2, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Additional 4 cases of valsartan/irbesartan-induced melanomas?
Authors: Tchernev G, Temelkova I PMID: 31032596 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 30, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effect of ticagrelor and clopidogrel on platelet aggregation function after percutaneous coronary intervention in patients with acute coronary syndrome.
In this study, phosphorylation levels of vasodilator stimulated phosphoprotein (VASP) were detected by flow cytometry (FCM) to investigate the effects of ticagrelor and clopidogrel on platelet aggregation function (PAF) after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). PMID: 30971068 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of different drainage methods on serum bile acid and hepatocyte apoptosis and regeneration after partial hepatectomy in rats with obstructive jaundice.
In conclusion, both internal and external drainage can relieve biliary obstruction. The difference in liver regeneration caused by external drainage and internal drainage may be attributed to the destruction of bile acid enterohepatic circulation, which increases hepatocyte apoptosis and affects liver regeneration. PMID: 30971329 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Analysis of imaging characteristics of patent foramen ovale-related cryptogenic stroke.
Authors: Wang H, Chu W, Kou YH, Zhang SY PMID: 30972992 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of exercise on sex hormones and expression of relevant genes in the hypothalamus in obese mice.
This study aimed to investigate the effect of different exercise loads on sex hormones and expressions of relevant genes in hypothalamus in obese mice. Sixty weaning male C57BL/6 mice were used as subjects. Among them, 15 mice were randomly classified into the normal diet group (CON group), and the remaining 45 mice into high-fat diet group (MOB group). The obesity was successfully achieved by high-fat diet 10 weeks later. Then the rats were randomly divided into three groups based on weight, namely, obesity control group (OBC group), obesity with moderate-intensity exercise group (MOBC group), and obesity with high-intens...
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

MiR-1178-3p promotes the proliferation, migration and invasion of nasopharyngeal carcinoma Sune-1 cells by targeting STK4.
Authors: Wang LQ, Deng AC, Zhao L, Li Q, Wang M, Zhang Y PMID: 30972994 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of acarbose and siglitine on blood glucose fluctuation and islet β-cell function in patients with type 2 diabetes mellitus.
Effects of acarbose and siglitine on blood glucose fluctuation and islet β-cell function in patients with type 2 diabetes mellitus. J Biol Regul Homeost Agents. 2019 Mar-Apr;33(2):365-374 Authors: Wang RR, Lv ZM, Dan YP, Chen KY, Zhang C Abstract The effects of acarbose and sitagliptin on blood glucose fluctuation and islet β-cell function in patients with type 2 diabetes mellitus (T2DM) were studied. One hundred and three patients with poorly controlled T2DM with insulin aspart 30 were selected and randomly divided into three groups: group A [continuous subcutaneous insulin infusion (CSII) t...
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

LncRNA MALAT1 promotes colorectal cancer development by sponging miR-363-3p to regulate EZH2 expression.
Authors: Xie JJ, Li WH, Li X, Ye W, Shao CF Abstract LncRNA MALAT1 is reported to play a potential role in human cancers. Hence, we investigated the effects of MALAT1 on colorectal cancer in vitro and in vivo, and further validated whether MALAT1 affected colorectal cancer development and EZH2 expression via regulating miR-363-3p. The fresh colorectal cancer tissues, adjacent non-tumor tissues, FHC, LOVO, SW620, CL40 and HCT116 cells were analyzed in this study. MALAT1, miR-363-3p and EZH2 expression levels were assessed using qRT-PCR and Western blot. Cell proliferation, migration and invasion were also measured. ...
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Changes of blood pressure, serum inflammatory factors and endothelin levels in patients with hypertension under rehabilitative aerobic exercise.
In conclusion, rehabilitative aerobic exercise can lower blood pressure and improve the overall quality of life in mild hypertension patients by inhibiting vascular inflammation and lowering plasma endothelin-1. PMID: 30972997 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Cytosine 5-hydroxymethylation regulated kit gene expression in acute myeloid leukemia.
In this study, we evaluated the role of 5mC and 5hmC levels in HL60 AML cells and bone marrow samples from AML patients for KIT gene expression to analyze 5hmC level in AML pathogenesis. Results showed that the expression and 5hmC level increased significantly of the KIT gene but the change of its 5mC level was not obvious after being treated by decitabine (DAC) in HL60 cells. IDH1 and IDH2 expression increased followed by increased KIT 5hmC level. In AML patients with IDH1 or IDH2 mutation, KIT expression and 5hmC were much lower than in those without mutation. The study indicated that the expression of KIT gene was regul...
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of different levels of soluble PD-L1 protein on the growth of Lewis lung cancer transplanted tumor.
Authors: Yang KN, Han W, Qin YJ, Chen LN Abstract To investigate the effects of different doses of soluble PD-L1 (soluble form of Programmed death ligand 1, sPD-L1) protein on Lewis lung cancer cells, flow cytometry was used to detect the expression of PD-L1 (Programmed death ligand 1) on the surface of Lewis lung cancer cell lines and the expression of PD-1 on the surface of T lymphocytes in peripheral blood and spleen cells of C57BL/6 mice. A Lewis lung cancer animal model of C57BL/6 mice was established by transplanting Lewis lung cancer cells subcutaneously. The sPD-L1 protein was injected into the abdominal ca...
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Diagnostic value of TRACP5b expression in patients with bone tumors.
Authors: Zhang Q, Cao L, Miao XD, Wu YP Abstract In order to investigate the diagnostic value of serum levels of tartrate-resistant acid phosphatase 5b (TRACP5b) in patients with bone tumors, enzyme linked immunosorbent assay (ELISA) was used to com¬pare serum levels of TRACP5b and alkaline phosphatase (ALP) in bone tumor patients (experimental group, 80 cases) and healthy controls (control group, 36 cases). It was found that the serum level of TRACP5b in the experimental group was significantly higher than that in the control group. In addition, the sensitivity and specificity of serum TRACP5b were higher than...
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Efficacy of continuous renal replacement on acute renal injury developed in severe sepsis.
This study aimed to assess the effects of continuous renal replacement therapy (CRRT) on acute renal injury caused by severe sepsis by monitoring biochemical parameters. A total of 60 patients with septic shock and acute kidney injury were included. The control group (30 cases) was treated with routine treatment and intermittent renal replacement therapy (IRRT). The experimental group (30 cases) was treated with routine treatment and continuous renal replacement therapy CRRT. The changes in inflammation and biochemical indexes and APACHE- II score were evaluated before the treatment and 1, 3, and 7days after the treatment....
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Evaluation of glucocorticoid treatment on different pathological types of primary nephrotic syndrome.
In conclusion, age, pathological type, renal tubulointerstitial damage, and RBP urinary level were related to the therapeutic effect of glucocorticoid treatment in adults and children with PNS. PMID: 30974931 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Changes in postprandial serum fibroblast growth factor 19 in newly diagnosed type-2 diabetic patients and the clinical significance.
Authors: Zhao L, Cao Y, Liu Y PMID: 30974932 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 13, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Efficacy of the Andresen activator before peak growth in class II patients.
Authors: Faccioni P, De Santis D, Luciano U, Pancera P, Sinigaglia S, Iurlaro A, Bertossi D, Lucchese A, Manuelli M, Maestrini S, Kumar N, Zotti F, Donadello D, Ricciardi G, Albanese M, Cicalese MP Abstract Andresen activator (AA) is a functional appliance used to correct Class II malocclusion in growing patients. It corrects the malocclusion stimulating mandibular growth and determining a palatoversion of the upper incisors and a vestibularization of the lower incisors. The aim of this study was to analyze the treatment efficacy of class II malocclusion due to mandibular hypodevelopment before peak growth. Fourtee...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Evaluation of pain, swelling and trismus after extraction of impacted third molars relative to the use of betamethasone in submucusal infiltration.
In this study, 4 mg single-dose submucosal betamethasone was injected in the interventional group, while in the control group nothing was injected. Postoperative measurement included pain via the VAS scale, swelling and trismus with facial measurements and maximum mouth openings, and finally nerve sensitivity. There was a significant difference between the two groups regarding trismic pain and edema. The use of a single 4 mg submucosal betamethasone injection leads to a reduction of oedema, trismus and pain in patients undergoing impacted third molar extraction. . PMID: 30966728 [PubMed - in process] (Source: Journal o...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Tooth agenesis: part 2. Orthodontic treatment and prosthetic possibilities.
Authors: De Santis D, Pancera P, Sinigaglia S, Faccioni P, Bertossi D, Luciano U, Zotti F, Kumar N, Donadello D, Manuelli M, Lucchese A, Tacchino U, Ricciardi G, Nocini R, Albanese M Abstract Dental agenesis has a great clinical significance due to its frequency during daily practice and the therapeutic problems that can arise from it. This paper will explore all the aspects to consider in order creating a proper multidisciplinary treatment plan: in particular, orthodontic, prosthetic and implantologic therapeutic alternatives are described for the rehabilitation of the different areas of the dental arches. In fact...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Bi-layered collagen nano-structured membrane prototype collagen matrix CM-10826 for oral soft tissue regeneration: an in vivo ultrastructural study on 13 patients.
Authors: De Santis D, Gelpi F, Castellani R, Palumbo C, Ferretti M, Zanotti G, Zotti F, Montagna L, Luciano U, Marconcini S, Tacchino U, Manuelli M, Nocini R, Nocini PF, Albanese M Abstract A new developed collagen matrix CM-10826 (CM) of porcine origin designed to be used as oral soft tissue substitute was investigated before and after implantation by light microscopy (LM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). In a case series biopsy specimens were harvested from thirteen patients at 10, 20, 30, 43 days after abutment surgery for uncovering dental implants. The in vivo hi...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Guidelines for achieving the best implants survival rates in the rehabilitation of the atrophic posterior maxilla.
Authors: De Santis D, Sinigaglia S, Pancera P, Faccioni P, Portelli M, Tacchino U, Manuelli M, Luciano U, Setti AP, Bursi P, Nocini R, Nocini PF, Bertossi D Abstract The first option in the rehabilitation of the posterior atrophic maxilla is the sinus lift. The aim of this study is to highlight the characteristics that a sinus lift should have to maximize the subsequent implant survival rate. 33 systematic reviews regarding sinus lift procedures, implants success and survival rates were identified through scientific archives and analysed. The obtained results indicated that a heterogeneity of sinus lift procedures ...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

An overview of guided bone regeneration.
Authors: De Santis D, Sinigaglia S, Pancera P, Faccioni P, Luciano U, Setti AP, Bursi P, Nocini R, Nocini PF, Bertossi D Abstract TGuided bone regeneration (GBR) is a surgical procedure whose purpose is to obtain, new bone, new cementum and a new periodontal attachment around a periodontally compromised tooth. In this work, an overview of the literature was performed to analyze the state of the art concerning GBR in order to draw useful conclusions for clinical practice. Twenty-nine articles regarding GBR procedures were identified through scientific archives and analyzed. The biological rationale, the graft materi...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

An overview of socket preservation.
Authors: De Santis D, Sinigaglia S, Pancera P, Faccioni P, Portelli M, Luciano U, Cosola S, Penarrocha D, Bertossi D, Nocini R, Iurlaro A, Albanese M Abstract Socket preservation is a surgical procedure whose aim is to limit the physiological resorption of the alveolar ridge that occurs after a dental extraction, in order to have sufficient bone to perform an implant placement. 16 articles regarding socket preservation procedures were identified through scientific archives and analysed. The biological rationale, the graft materials and the predictive factors are identified to help the clinicians in their practice. ...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Immediate rehabilitation of the posterior maxilla with an axial and a tilted post-extractive implant: a technical report and brief literature review.
Authors: Gelpi F, De Santis D, Bernardello F, Luciano U, Iurlaro A, Marconcini S, Nocini PF, Finotti M Abstract The atrophic posterior ridges are usually characterized by poor bone quality and quantity: this situation requires the use of bone regenerative techniques. Other alternative surgical approaches are investigated. Nowadays the use of tilted implants offers some advantages due to its feasibility. Today, bone grafting may be practical, but depends on many factors, such as the type of bone graft used (autogenous, alloplastic, or xenograft), host response, age of the patient, various complications associated wi...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Genes involved in hormone metabolism and cellular response in human ovarian granulosa cells.
Authors: Brązert M, Iżycki D, Kranc W, Borowiec B, Popis M, Ożegowska K, Bręborowicz A, Rachoń D, Nowicki M, Kempisty B Abstract Endocrinal interactions are one of the most crucial regulatory mechanisms that maintain the state of homeostasis in humans. Processes such as oogenesis, folliculogenesis, menstruation and pregnancy remain under hormonal control. A key role in folliculogenesis is played by granulosa cells. Moreover, granulosa cells take part in corpus luteum formation after ovulation. Because of that, it is important to understand the ways in which the granulosa cells, associated with those processes,...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A polycentric, randomized, double blind, parallel-group, placebo-controlled study on Lertal ®, a multicomponent nutraceutical, as add-on treatment in children with allergic rhinoconjunctivitis: phase I during active treatment.
In this study, 146 children (94 males and 52 females, mean age 9.1±1.88) were randomly assigned to Lertal® + standard treatment or Placebo + standard treatment and were visited at baseline (W0), and after 2 (W2) and 4 weeks (W4). Standard treatment consisted of continuous antihistaminic schedule. The primary endpoint was the Total Symptom Score (TSS - last 12 hours) change from the baseline to the end of the 4-week treatment. Both groups significantly (p less 0.0001 for both) reduced TSS (last 12 hours) after 4 weeks (% change: - 63.6% in Lertal®-group and - 60.7% in Placebo-group; p= n.s. intergroup analysi...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Aerobic exercise and Orexin A: role of sympathetic activity and redox system.
Authors: Monda V, Villano I, Messina A, Valenzano A, Salerno M, Santo Signorelli S, Monda M, Russo V, Sessa F, Messina G Abstract Aerobic exercise is associated with the sympathetic activation evoking adaptive responses to sustain muscle engagement. Physical exercise can cause alterations in the cardiovascular activity and cellular stress may occur which could be marked by either heart rate (HR), or galvanic skin response (GSR). Moderate plasma levels of reactive oxygen species (ROS) are considered as health markers, absolving to important roles such as adaptive cellular responses to exercise. Orexin A, a hypothala...
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Role of ADAMTS4 and ADAMTS5 during early orthodontic tooth movement.
Authors: Muraglie S, Musumeci G, Loreto C, Leonardi RM PMID: 30968682 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Megalin - a facultative marker of obesity-related glomerulopathy in children.
Authors: Ostalska-Nowicka D, Mackowiak-Lewandowicz K, Perek B, Zaorska K, Zachwieja J, Nowicki M Abstract Obesity-related glomerulopathy (ORG) is an increasingly detected syndrome present in children with obesity. Megalin, a constitutive proximal tubule cell protein, when present in urine, can be considered as a biomarker indicating renal injury in these children. PMID: 30968683 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Magnesium alginate in children with uncontrolled asthma.
Authors: Miraglia Del Giudice M, Indolfi C, Ciprandi G, Decimo F, Campana G, Umano GR, Giannetti E, Maglione M Abstract Gastroesophageal reflux disease (GERD) may be frequently associated with asthma in children and may affect asthma control. Proton pump inhibitors (PPI) are commonly prescribed in asthmatic children, despite uncertain efficacy on respiratory symptoms and risk of relevant adverse effects. PMID: 30945510 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 6, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of euphorbia kansui on the serum levels of IL-6, TNF- α, NF-κB, sTNFR and IL-8 in patients with severe acute pancreatitis.
In this study, effects of euphorbia kansui on serum levels of inflammatory factors in patients with severe acute pancreatitis were investigated, and the mechanisms underlying the role of Euphorbia kansui in the treatment of severe acute pancreatitis were discussed. 36 patients hospitalized in the Third Affiliated Hospital of Wenzhou Medical University from March 2017 to May 2018 due to severe acute pancreatitis were selected and divided into two groups using a randomized grouping method. ELISA (enzyme-linked immunosorbent assay) was used to detect expressions of various inflammatory cytokines, such as tumor necrosis factor...
Source: Journal of Biological Regulators and Homeostatic Agents - April 6, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Serum oxidative stress, inflammatory response and platelet activation in patients with vascular vertigo.
Authors: Qian SX, Gu JX, Guan QB, Zhang XL, Wang YP Abstract The aim of this study was to investigate the correlation and clinical significance of oxidative stress and inflammatory response in vascular vertigo (VV). The subjects were divided into three groups: vascular vertigo (group A), non-vascular vertigo (group B) and controls (group C). The serum levels of IL-6 (interleukins-6), SOD (superoxide dismutase), MDA (malondialdehyde) and TNF-α (tumor necrosis factor-α) and CD62P (also called P-Selectin) activation rates were determined and compared among the three groups. The levels of IL-6, TNF-α,...
Source: Journal of Biological Regulators and Homeostatic Agents - April 6, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Characterization of bacterial microbiota diversity in Tibetan pigs fed with green forage in Linzhi of the Tibet autonomous region.
This study first reported the effect of Alfalfa and Chenopodium glaucum feeding on the microbial diversity in Tibetan pigs, contributing to the forage exploitation of Tibetan pigs in the Tibet region. PMID: 30945523 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 6, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Delayed tooth replantation and inflammatory root resorption in childhood and adolescence.
Authors: Spinas E, Generali L, Mameli A, Demontis C, Martinelli D, Giannetti L Abstract Avulsion of one or more permanent teeth represents an emergency in dentistry. The main treatment is the replantation of the tooth/teeth as soon as possible to decrease possible complications. However, this is not always possible, and, in many cases, the patient undergoes a delayed replantation and subsequently prosthetic and implant treatments. PMID: 30945526 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 6, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Inhibition of the NF- κB signaling pathway on endothelial cell function and angiogenesis in mice with acute cerebral infarction.
In conclusion, IFI35 could suppress the activation of the NF-κB signaling pathway, reduce the proliferating potential of vascular endothelial cells, and lower the expression of vascular growth factors, thereby inhibiting angiogenesis in mice with acute cerebral infarction. PMID: 30945527 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 6, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Gut microbiota and immunity in common variable immunodeficiency: crosstalk with pro-inflammatory cytokines.
Authors: Franza L, Carusi V, Altamura S, Gasbarrini A, Caraffa A, Kritas SK, Ronconi G, Gallenga CE, Di Virgilio F, Pandolfi F PMID: 30942065 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 5, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Tooth avulsion with extra oral time in less than 60 minutes: two different therapeutic protocols with 13-year follow-up.
Authors: Giannetti L, Spinas E, Murri Dello Diago A Abstract The aim of this study is to assess what needs to be the priority in tooth avulsion: replantation as quickly as possible and deferred endodontic treatment, or replantation and elimination of every irritating stimulus for the periodontal ligament. PMID: 30942066 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 5, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

The use of only enamel matrix derivative allows outstanding regeneration results in periodontal intrabony defect treatment: a retrospective study.
Authors: Bertoldi C, Ferrari M, Giannetti L Abstract Periodontal tissue regeneration depends on several biological, homeostatic and regulative variables that directly induce the clinical features. The aim of this study is to compare the clinical results obtained using the enamel matrix derivative peptide (EMP) compared to the less manageable association of EMP and bovine bone xenographic (BPBM) in the treatment of deep intraosseous defects. Ten healthy patients, suffering from moderate or severe chronic periodontitis, having at least two deep and narrow intrabony defects in the same dental arch and needing surgical...
Source: Journal of Biological Regulators and Homeostatic Agents - March 30, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Vitamins B12 and D deficiencies and macro- and microelement disturbances among diabetic elderly patients.
Authors: Dziegielewska-Gesiak S, Fatyga E, Kasiarz G, Wilczynski T, Muc-Wierzgon M, Kokot T Abstract Vitamin and mineral disturbances may interfere with glucose metabolism. Elderly persons with diabetes type 2 (T2DM) are more prone to mineral disturbances and vitamin deficiencies. The aim of this study was to analyze concentrations of vitamins B12 and D and macro- and microelements among diabetic elderly patients. The study enrolled 347 patients with T2DM of whom 247 were elderly (median 76 years of age) (SenDM group) and 100 younger T2DM (median 59 years of age) (Y-DM group), and 320 patients aged 65 years and abo...
Source: Journal of Biological Regulators and Homeostatic Agents - March 30, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Bilateral ovario-hysterectomy induced osteoporotic rabbit model.
Authors: Jin ES, Kim JY, Min JK, Jeon SR, Choi KH, Lee MS, Jeong JH PMID: 30915825 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - March 29, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Bilateral ovario-hysterectomy induced osteoporotic rabbit model.
Authors: Li TT, Xu P, Bai ZG, Cui ZT, Cai XG, Zhou B PMID: 30915826 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - March 29, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Gprotein-coupled estrogen receptor 30 and extracellular signal-regulated kinase 1/2 in endometrial adenocarcinoma.
Authors: Li YM, Zhang YB, Yang HL PMID: 30915827 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - March 29, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Cytological mechanism of astragaloside IV in promoting repair of bone defects.
Authors: Lian X, Shen CC, Sun HJ, Zeng YJ Abstract To explore the possible cytological mechanism underlying the role of Astragaloside IV in promoting the repair of bone defects, osteoblasts were cultured in vitro and identified using inverted phase contrast microscopy, alkaline phosphatase (ALP) staining and alizarin red staining. PMID: 30915828 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - March 29, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research