Analysis of long non-coding RNA expression profiles in disuse osteoporosis using microarray and bioinformatics
J Biol Regul Homeost Agents. 2021 Jul 23;35(4). doi: 10.23812/21-246-A. Online ahead of print.ABSTRACTDisuse osteoporosis (DOP) is one of the major consequences of long space flights. DOP also occurs in patients with spinal cord injuries and prolonged bedridden states that can have a severe impact on human health. Bone marrow mesenchymal stem cells (BMSCs) are multipotent stromal cells that play an important role in bone homeostasis. Long non-coding RNAs (lncRNAs) are involved in regulating osteogenic differentiation of BMSCs, and their abnormal expression might lead to the formation of orthopedic diseases. However, the sp...
Source: Journal of Biological Regulators and Homeostatic Agents - July 23, 2021 Category: Biomedical Science Authors: W Z Wei B Li J X Lin J Zhao X F Zhang X Q Wang Z Lv J Liu Source Type: research

Identification of miRNAs, mRNAs, lncRNAs, and circRNAs associated with hepatocellular carcinoma recurrence after interferon treatment
J Biol Regul Homeost Agents. 2021 Jul 23;35(4). doi: 10.23812/21-173-A. Online ahead of print.ABSTRACTTo study the molecular mechanism of interferon-alpha (IFN-α) in the treatment of hepatocellular carcinoma (HCC) and the molecular markers that can predict the therapeutic effect, differentially expressed (DE)-miRNAs, -mRNAs, -lncRNAs, and -circRNAs were screened between 12 samples collected from 4 patients who had not received treatment (control), 4 patients who had received recombinant human interferon a-2b treatment (case1), and 4 patients who had relapsed after receiving recombinant human interferon a-2b treatment...
Source: Journal of Biological Regulators and Homeostatic Agents - July 23, 2021 Category: Biomedical Science Authors: W P Zhu X G He H X Zhu L R Wang Z H Lin M Wang L Wang Source Type: research

Analysis of long non-coding RNA expression profiles in disuse osteoporosis using microarray and bioinformatics
J Biol Regul Homeost Agents. 2021 Jul 23;35(4). doi: 10.23812/21-246-A. Online ahead of print.ABSTRACTDisuse osteoporosis (DOP) is one of the major consequences of long space flights. DOP also occurs in patients with spinal cord injuries and prolonged bedridden states that can have a severe impact on human health. Bone marrow mesenchymal stem cells (BMSCs) are multipotent stromal cells that play an important role in bone homeostasis. Long non-coding RNAs (lncRNAs) are involved in regulating osteogenic differentiation of BMSCs, and their abnormal expression might lead to the formation of orthopedic diseases. However, the sp...
Source: Journal of Biological Regulators and Homeostatic Agents - July 23, 2021 Category: Biomedical Science Authors: W Z Wei B Li J X Lin J Zhao X F Zhang X Q Wang Z Lv J Liu Source Type: research

Identification of miRNAs, mRNAs, lncRNAs, and circRNAs associated with hepatocellular carcinoma recurrence after interferon treatment
J Biol Regul Homeost Agents. 2021 Jul 23;35(4). doi: 10.23812/21-173-A. Online ahead of print.ABSTRACTTo study the molecular mechanism of interferon-alpha (IFN-α) in the treatment of hepatocellular carcinoma (HCC) and the molecular markers that can predict the therapeutic effect, differentially expressed (DE)-miRNAs, -mRNAs, -lncRNAs, and -circRNAs were screened between 12 samples collected from 4 patients who had not received treatment (control), 4 patients who had received recombinant human interferon a-2b treatment (case1), and 4 patients who had relapsed after receiving recombinant human interferon a-2b treatment...
Source: Journal of Biological Regulators and Homeostatic Agents - July 23, 2021 Category: Biomedical Science Authors: W P Zhu X G He H X Zhu L R Wang Z H Lin M Wang L Wang Source Type: research

Analysis of long non-coding RNA expression profiles in disuse osteoporosis using microarray and bioinformatics
J Biol Regul Homeost Agents. 2021 Jul 23;35(4). doi: 10.23812/21-246-A. Online ahead of print.ABSTRACTDisuse osteoporosis (DOP) is one of the major consequences of long space flights. DOP also occurs in patients with spinal cord injuries and prolonged bedridden states that can have a severe impact on human health. Bone marrow mesenchymal stem cells (BMSCs) are multipotent stromal cells that play an important role in bone homeostasis. Long non-coding RNAs (lncRNAs) are involved in regulating osteogenic differentiation of BMSCs, and their abnormal expression might lead to the formation of orthopedic diseases. However, the sp...
Source: Journal of Biological Regulators and Homeostatic Agents - July 23, 2021 Category: Biomedical Science Authors: W Z Wei B Li J X Lin J Zhao X F Zhang X Q Wang Z Lv J Liu Source Type: research

Identification of miRNAs, mRNAs, lncRNAs, and circRNAs associated with hepatocellular carcinoma recurrence after interferon treatment
J Biol Regul Homeost Agents. 2021 Jul 23;35(4). doi: 10.23812/21-173-A. Online ahead of print.ABSTRACTTo study the molecular mechanism of interferon-alpha (IFN-α) in the treatment of hepatocellular carcinoma (HCC) and the molecular markers that can predict the therapeutic effect, differentially expressed (DE)-miRNAs, -mRNAs, -lncRNAs, and -circRNAs were screened between 12 samples collected from 4 patients who had not received treatment (control), 4 patients who had received recombinant human interferon a-2b treatment (case1), and 4 patients who had relapsed after receiving recombinant human interferon a-2b treatment...
Source: Journal of Biological Regulators and Homeostatic Agents - July 23, 2021 Category: Biomedical Science Authors: W P Zhu X G He H X Zhu L R Wang Z H Lin M Wang L Wang Source Type: research

Bacteria and oral cavity: a new story to tell
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):1-6. doi: 10.23812/21-3supp1-1.ABSTRACTPeriodontal diseases include a mild and reversible form named gingivitis (GI), and periodontitis (PD) that is the main cause of tooth loss in adults. GI, that affects gums and coronal junctional epithelium, as well as periodontitis, that is characterized by loss of connective tissue attachment, are caused by a persistent inflammatory response promoted by alteration of periodontal biofilm. The aim of the study was to test whether the prevalence of each species was associated with a particular clinical condition. Periodontal evalu...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: D Mucchi Source Type: research

Hormones and dentistry: a two-way relationship
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):7-12. doi: 10.23812/21-3supp1-2.ABSTRACTStem cells of dental pulp (SCDPs) are multipotent stem cells with the potential to differentiate into various cell types. For this reason, they have been proposed as an alternative source for mesenchymal stem cells. Somatostatin (ST) is a peptide hormone with an inhibitory effect on several endogenous hormones. The aim of our study is to investigate whether somatostatin can promote or inhibit differentiation of SCDPs in osteoblasts and bone tissue. SCDPs were extracted from third molars of healthy subjects and were treated with...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: D Mucchi Source Type: research

Hyaluronic acid and its use in dentistry
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):13-18. doi: 10.23812/21-3supp1-3.ABSTRACTThe purpose of this paper is to evaluate the role of hyaluronic acid in bio-revitalization (HABR) by testing several extracellular matrix biological parameters in cultured dermal fibroblasts. To this aim, fibroblastic expressed genes after exposition to three HABR medical devices were evaluated. Cells were seeded on a layer of three different medical devices containing 6.2, 10 and 20 mg/ml of HABR for 24 h. Real Time Polymerase Chain Reaction was performed to investigate gene expressions. Genes encoding HABR synthesis and degr...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: D Mucchi Source Type: research

Patient's perception of intraoral scanning: a comparison between traditional and digital dental impression
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):19-28. doi: 10.23812/21-3supp1-4.ABSTRACTThe purpose of this work was to assess the discomfort perceived by the patient during the intraoral scan procedure using the iTero Scanner. A sample of 33 patients was selected on the basis of parameters that identify a complete dentition. All treated patients underwent a traditional polyvinylsiloxane impression with double procedure and an intraoral scan in the same session. Subsequently they were given a questionnaire concerning the discomfort perceived by both procedures. Once the completed questionnaires were obtained, pre...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: A Giancotti G Mampieri F Paoncelli M Greco C Arcuri Source Type: research

Upper-lip laser frenectomy with a diode laser in a pediatric patient: a case report
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):29-35. doi: 10.23812/21-3supp1-5.ABSTRACTThe case report aims to describe the parameters of performing upper labial frenectomy with the use of diode laser beams without infiltrated local anaesthesia. A 6-year-old patient was referred by the orthodontist for assessment of the upper anterior labial frenum. The dental treatment plan reported only the presence of caries on deciduous teeth and seals on the first permanent molars. The clinical examination reported the presence of a high attachments of labial frenum with a pathologically attachment and the presence of a dia...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: N Bianchi C Lorenzi A Pinto A Laureti P Carosi Source Type: research

The role of periodontal bacteria, Porphyromonas Gingivalis, in Alzheimer's disease pathogenesis and aggravation: a review
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):37-45. doi: 10.23812/21-3supp1-6.ABSTRACTThe aim of this study was to establish the role of Porphyromonas gingivalis in Alzheimer's disease. An electronic search of publications was established from three electronic databases: Cochrane, PubMed and Web of Science. The search strategy used a combination of controlled vocabulary and free-text words. Inclusion and exclusion criteria were defined by the authors before the start of the study. The inclusion criteria were: all studies published in English language; in vitro analysis; in vivo on animals and postmortem biopsie...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: C Lorenzi N Bianchi A Pinto V Mazzetti C Arcuri Source Type: research

Guided endodontic microsurgery in apicoectomy: a review
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):47-55. doi: 10.23812/21-3supp1-7.ABSTRACTThe purpose of this review was twofold. The first aim was to show predictable protocols of guided endodontic microsurgery (EMS) and to describe its clinical outcomes. The second aim was to verify the accuracy of this technique compared to the traditional pathway. An electronic search of publications was established from two electronic databases, Cochrane and PubMed, by two independent researchers. The search strategy used a combination of controlled vocabulary and free-text words. Inclusion and exclusion criteria were defined ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: F Lio G Mampieri V Mazzetti A Leggeri L Arcuri Source Type: research

The health of soft tissues around four dental implants loaded immediately supporting a 4-year-old fixed screw-retained prosthesis
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):57-66. doi: 10.23812/21-3supp1-8.ABSTRACTThe aim of this study was to assess the soft tissues health around the implant/abutment interfaces of fixed screw-retained prosthesis supported by four dental implants after at least 1-year in function. All the implants were placed between December 1, 2015 and April 30, 2019. Digital implant surgical planning was performed for all the complete-arch rehabilitations and then full-guided surgery was performed. The fixed-interim prostheses were delivered the day of the surgery and replaced by definitive prostheses after the healin...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: F Carosi L Ottria F Lio A Laureti P Papi Source Type: research

Microbial leakage evaluation of warm gutta - percha techniques
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):67-75. doi: 10.23812/21-3supp1-9.ABSTRACTThe aim of this study is to compare bacterial leakage of MicroHeat and continuous wave with and without endodontic sealer. Thirty-eight single-rooted extracted mandibular premolars were selected and randomly divided into four experimental groups (n=8) and two control groups (n=3). Teeth were prepared with Mtwo NiTi files and obturated with MicroHeat or System B with or without endodontic sealer. Three teeth were used as positive controls (Ct+) and three intact teeth served as negative controls (Ct-). All samples were tested fo...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: A Libonati V Di Taranto E Montemurro G Gallusi Source Type: research

Radiographic and electronic working length comparison. An < em > in vivo < /em > study of three Electronic Apex Locator devices
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):77-85. doi: 10.23812/21-3supp1-10.ABSTRACTThe aim of this study is to compare the working length measured with Root ZX (EAL1), Propex II (EAL2) and Endo Analyzer Model 8005 (EAL3) with radiographic measurements during endodontic treatment. Fifty single canal teeth scheduled for endodontic treatment were selected for the study. After endodontic access preparation, pulp chamber was irrigated with 5mL of 5% sodium hypochlorite (NaOCl). The canal was scouted with a size 10 K-file introduced slightly over the apex to verify the canal patency. The working length (WL) was m...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: V Di Taranto A Libonati E Montemurro G Gallusi Source Type: research

Reduction of radiations exposure in endodontics: comparative analysis of direct (GX S-700, Gendex) and semidirect (VistaScan Mini View, D ürr) digital systems
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):87-94. doi: 10.23812/21-3supp1-11.ABSTRACTThe importance of intraoral periapical radiography is crucial as it represents a fundamental mean of evaluation and diagnosis for supporting bone and teeth hard tissues diseases and pathologies. Even though conventional film technology is still widespread, presently there are many digital radiography alternatives. Direct digital systems are devices with an intraoral sensor wired or paired wireless with a computer. These devices do generate an image immediately during exposure and acquisition. The semi direct digital systems i...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: A Libonati G Gallusi E Montemurro V Di Taranto Source Type: research

Craniofacial and occlusal features of individuals with Turner Syndrome: A cephalometric study
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):95-106. doi: 10.23812/21-3supp1-12.ABSTRACTCraniofacial features of 18 individuals with Turner Syndrome (TS) were compared with age and gender matched healthy individuals. Dental history, panoramic radiograph, dental casts and cephalometric measurements were assessed. The dental casts analysis showed a significantly higher PH/PW ratio in individuals with TS under GH therapy compared to healthy individuals (p=0.004; paired t-test). This data objectively supported the definition of a high-narrow palate. The ANB angle and the Wits index were similar in the two group, sh...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: A Bagattoni L Lardani A Vanni T Costi Source Type: research

Impact of self-ligating orthodontic brackets on dental biofilm and periodontal pathogens in adolescents
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):107-115. doi: 10.23812/21-3supp1-13.ABSTRACTThe aim of the present prospective study was to evaluate periodontal health and subgingival microbiological alterations in adolescents treated with fixed self ligating orthodontic brackets in comparison to subject without any orthodontic appliance. A total of 40 adolescents (23 females and 17 males; mean age: 13.2 ± 3.2 years) were included: 30 subjects with self ligating brackets (test group) and 10 patients without orthodontic appliances (control group). Follow-ups were as follows: T1 (1 month), T2 (3 months), T3 (...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: E Carli M Pasini L Lardani G Giuca M Miceli Source Type: research

Oral manifestations in paediatric patients with hepatobiliary diseases: a review
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):117-125. doi: 10.23812/21-3supp1-14.ABSTRACTIt is well known that greenish pigmentation of the teeth is seen in children following remission of severe jaundice and clinical and serum bilirubin, a degradation product of haemoglobin, may be permanently trapped in forming dental hard tissues causing discolouration and enamel and dentine hypoplasia. Neonatal jaundice is the most common cause of hyperbilirubinemia and pigmentation of the deciduous teeth is the consequence of this condition. Various hepatobiliary pathologies may have a clinical finding in the oral cavity; ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: M R Giuca L Lardani S Ligori E Carli G Giuca M Miceli Source Type: research

Critical investigation of the pre-surgical anatomic factors that influence the aesthetic result in post-extractive implantology and immediate prosthetic
This article presents some key factors to analyze and follow in order to achieve a predictable and acceptable aesthetic result. The creation of a predictable peri-implant aesthetics requires adequate preservation of the bone and soft tissues around the teeth that will be extracted and a correct positioning of the 3D implant. Furthermore, aesthetic success requires the creation of a correct transmucosal path, during the provisional prosthetic phases, which must be replicated and maintained with the definitive crowns.PMID:34289672 | DOI:10.23812/21-3supp1-15 (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: M Di Girolamo F Cecchetti L Volpe L Baggi D Mazza M Turco S Volpe Source Type: research

Guided sinus lift: virtual planning of surgical templates for lateral access
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):139-145. doi: 10.23812/21-3supp1-16.ABSTRACTThe sinus lift with lateral approach is a regenerative technique nowadays considered predictable to increase the height of bone in the atrophic posterior maxilla. Knowledge of sinus anatomy and evaluation of risk factors are the basis of regenerative and rehabilitative surgical success. The positioning and size of the lateral antrostomy represent critical factors in the execution of regenerative surgery, due to the difficulty in transferring radiological information to the lateral wall of the maxillary sinus even for skille...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: F Cecchetti M Spuntarelli D Mazza M Di Girolamo L Baggi Source Type: research

Endodontic retreatment and bioceramics: A case report
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):147-153. doi: 10.23812/21-3supp1-17.ABSTRACTThe success rate in endodontic retreatment can be significantly boosted by using materials that guarantee both intimate adhesion to the canal walls and long-term stability. Bioceramic cements used in root filling show interesting properties including extraordinary sealing capacities, antimicrobial activity that stimulates periapical healing and the continuous production of hydroxyopathitis for a long time. This case report deals with the application of bioceramic cement in endodontic retreatment. The Bioroot RCS (Septodont)...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: F Cecchetti M Spuntarelli R Zaccone D Mazza M Di Girolamo L Baggi Source Type: research

A new factor involved during childbirth labor: the importance of having a good dental occlusion
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):155-166. doi: 10.23812/21-3supp1-18.ABSTRACTIt is widely recognized that the physiology of childbirth labor largely depends on the interaction between three factors: a) the force generated by uterine contractions; b) the structure and characteristics of the birth canal and c) the fetus. Harmony between these three variables determines the initiation of maternal dynamic phenomena and the establishment of an optimal maternal-fetal balance in which both warrant for a correct delivery timing. The present study considered the above known factors and assessed if any other ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: C Maggioni S Saccomanno J P Meerssman R F Mastrapasqua A Pirino F Scoppa Source Type: research

Complications of oral piercing: a review of the literature and two case reports
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):167-178. doi: 10.23812/21-3supp1-19.ABSTRACTThe practice of piercing has been used since ancient times, and nowadays is coming back in fashion among adolescents and young adults. Teenagers wearing oral piercings are frequently observed during routine examination, and there are, also, recurrent harmful consequences attributed to the devices. Unfortunately, piercings are usually placed by unlicensed individuals, lacking the appropriate anatomical knowledge, and therefore unable to provide sufficient information regarding the potential risks, especially when compared to...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: S Saccomanno I Ieria R J Manenti S Giancaspro P Pirelli Source Type: research

Proposal of use of the autotransplantation of the third molar as space maintainer in growing patients: a review of literature and a clinical case
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):179-184. doi: 10.23812/21-3supp1-20.ABSTRACTThe review of literature shows that 48,22% of the autotranspated teeth were orthodontically treated. A 13-year-old male patient presented a destructive decay in the element 3.6, which was underoccluded. To maintain the arch space and the quantity of bone necessary for a potential implant, it was decided to perform an autotransplantation of the impacted element 3.8. Tooth autotransplantation is a valid and durable alternative to the prosthetic and the implant solutions with high success rate.PMID:34289677 | DOI:10.23812/21-3...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: S Saccomanno D Lagan à S Saran A De Stefani P Pirelli G Bruno A Gracco Source Type: research

Does a short lingual frenulum affect body posture? Assessment of posture in the sagittal plane before and after laser frenulotomy: a pilot study
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):185-195. doi: 10.23812/21-3supp1-21.ABSTRACTThe factors that characterize posture are neurophysiological, biomechanical, psychoemotional. Neurophysiological factors concern the modulation of tone, muscle tone is the result of a series of neuropsychological processes within the tonic-postural system. The tonic-postural system can become unbalanced for various reasons, including a tight lingual frenum. The aim of this pilot study was to evaluate the benefits of frenulectomy by laser on body posture and on the scapular (shoulders) anteroposterior movement. Twenty-four h...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: S Saccomanno A Pirino G Bianco L C Paskay R Mastrapasqua F Scoppa Source Type: research

The relationship between TMJ symptoms and orthodontic treatments: a survey on 236 orthodontic patients
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):197-204. doi: 10.23812/21-3supp1-22.ABSTRACTThe study analyzes how and if temporomandibular joint symptoms are influenced by different types of orthodontic therapy. Two-hundred-and-thirty-six adult orthodontic patients treated by different clinicians, were asked to complete a survey in which factors as the age, the gender and the type of device were considered. The questions were about the typical symptoms of temporomandibular disorders, in particular headache, bruxism, clenching, pain while opening the mouth and joint's noise. It was highlighted if these symptoms ch...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: S Saccomanno D Lagan à R Mastrapasqua S Giancaspro R J Manenti S Saran Source Type: research

Comparative analysis of the peri-implant tissue response of standard versus short implants in smoker, non-smoker and former smoker patients: a one-year retrospective study
This study was a comparative analysis of three groups of patients. Patients were eligible if they needed an implant in the posterior areas of the maxilla and mandible, both with a sufficient amount of bone, using implants that are standard or with small heights, and using small implants so that they could avoid any regenerative bone therapy aimed at increasing vertical size. The clinical and X-ray assessment was performed after 4/6 months (T1) and after one year (T2). The main results were recordings of clinical aspects such as presence of inflammation, color and gum appearance assessments, and X-ray assessment differentia...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: C Manilia L Mancini R Giffi V Bisegna D Marcattili Source Type: research

Fibre post cementation: instrumental analysis
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):213-218. doi: 10.23812/21-3supp1-24.ABSTRACTThe loss of dental substance due to the presence of decay, to wide conservative repairs, to the preparation of prosthetics or to enamel-dentine fractures, often causes an important structural weakening in the element that is endodontically treated (1-15). It is therefore necessary to use endocanal posts in the coronal reconstruction. Mineral fibre posts and epoxy resins that are available at present, fixed with resinous cements, thanks to their excellent integration, exceed the concept of reconstruction, meant as assembly o...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: R J Manenti A P Lomurno S Giancaspro L Mancini Source Type: research

Qualitative and quantitative analysis of the CTX in relation to the period of intake of bisphosphonates: A systematic review
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):219-227. doi: 10.23812/21-3supp1-25.ABSTRACTThe aim of this systematic review was to determinate the true value of C-terminal crosslinking telopeptide test (CTX) in patient who takes Bisphosphonate. A comprehensive search of studies published up to March 2020 and listed in the PubMed/MEDLINE and Cochrane Library databases, was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) guidelines. The search identified 99 publications; 6 studies were finally deemed eligible for inclusion according to the study criteri...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: M Milani R J Manenti D Marcattili R Marino A P Lomurno Source Type: research

Early childhood caries in Tirana, Albania
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):228. doi: 10.23812/21-3supp1-26.ABSTRACTEarly Childhood Caries (ECC) is a destructive form of caries that affects the temporary teeth and may be present in children of very young age as early as teeth erupt. The distinctive characteristic of caries in this age is that it affects initially a limited number of teeth which if not treated in time spread rapidly across all deciduous teeth. The purpose of this study is to determine the prevalence and severity of early childhood caries in children 3-5 years old in the public kindergartens in Tirana.PMID:34289683 | DOI:10.23...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: A Alushi R J Manenti M Mema P Rasicci E Petro Source Type: research

Bacteria and oral cavity: a new story to tell
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):1-6. doi: 10.23812/21-3supp1-1.ABSTRACTPeriodontal diseases include a mild and reversible form named gingivitis (GI), and periodontitis (PD) that is the main cause of tooth loss in adults. GI, that affects gums and coronal junctional epithelium, as well as periodontitis, that is characterized by loss of connective tissue attachment, are caused by a persistent inflammatory response promoted by alteration of periodontal biofilm. The aim of the study was to test whether the prevalence of each species was associated with a particular clinical condition. Periodontal evalu...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: D Mucchi Source Type: research

Hormones and dentistry: a two-way relationship
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):7-12. doi: 10.23812/21-3supp1-2.ABSTRACTStem cells of dental pulp (SCDPs) are multipotent stem cells with the potential to differentiate into various cell types. For this reason, they have been proposed as an alternative source for mesenchymal stem cells. Somatostatin (ST) is a peptide hormone with an inhibitory effect on several endogenous hormones. The aim of our study is to investigate whether somatostatin can promote or inhibit differentiation of SCDPs in osteoblasts and bone tissue. SCDPs were extracted from third molars of healthy subjects and were treated with...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: D Mucchi Source Type: research

Hyaluronic acid and its use in dentistry
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):13-18. doi: 10.23812/21-3supp1-3.ABSTRACTThe purpose of this paper is to evaluate the role of hyaluronic acid in bio-revitalization (HABR) by testing several extracellular matrix biological parameters in cultured dermal fibroblasts. To this aim, fibroblastic expressed genes after exposition to three HABR medical devices were evaluated. Cells were seeded on a layer of three different medical devices containing 6.2, 10 and 20 mg/ml of HABR for 24 h. Real Time Polymerase Chain Reaction was performed to investigate gene expressions. Genes encoding HABR synthesis and degr...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: D Mucchi Source Type: research

Patient's perception of intraoral scanning: a comparison between traditional and digital dental impression
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):19-28. doi: 10.23812/21-3supp1-4.ABSTRACTThe purpose of this work was to assess the discomfort perceived by the patient during the intraoral scan procedure using the iTero Scanner. A sample of 33 patients was selected on the basis of parameters that identify a complete dentition. All treated patients underwent a traditional polyvinylsiloxane impression with double procedure and an intraoral scan in the same session. Subsequently they were given a questionnaire concerning the discomfort perceived by both procedures. Once the completed questionnaires were obtained, pre...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: A Giancotti G Mampieri F Paoncelli M Greco C Arcuri Source Type: research

Upper-lip laser frenectomy with a diode laser in a pediatric patient: a case report
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):29-35. doi: 10.23812/21-3supp1-5.ABSTRACTThe case report aims to describe the parameters of performing upper labial frenectomy with the use of diode laser beams without infiltrated local anaesthesia. A 6-year-old patient was referred by the orthodontist for assessment of the upper anterior labial frenum. The dental treatment plan reported only the presence of caries on deciduous teeth and seals on the first permanent molars. The clinical examination reported the presence of a high attachments of labial frenum with a pathologically attachment and the presence of a dia...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: N Bianchi C Lorenzi A Pinto A Laureti P Carosi Source Type: research

The role of periodontal bacteria, Porphyromonas Gingivalis, in Alzheimer's disease pathogenesis and aggravation: a review
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):37-45. doi: 10.23812/21-3supp1-6.ABSTRACTThe aim of this study was to establish the role of Porphyromonas gingivalis in Alzheimer's disease. An electronic search of publications was established from three electronic databases: Cochrane, PubMed and Web of Science. The search strategy used a combination of controlled vocabulary and free-text words. Inclusion and exclusion criteria were defined by the authors before the start of the study. The inclusion criteria were: all studies published in English language; in vitro analysis; in vivo on animals and postmortem biopsie...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: C Lorenzi N Bianchi A Pinto V Mazzetti C Arcuri Source Type: research

Guided endodontic microsurgery in apicoectomy: a review
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):47-55. doi: 10.23812/21-3supp1-7.ABSTRACTThe purpose of this review was twofold. The first aim was to show predictable protocols of guided endodontic microsurgery (EMS) and to describe its clinical outcomes. The second aim was to verify the accuracy of this technique compared to the traditional pathway. An electronic search of publications was established from two electronic databases, Cochrane and PubMed, by two independent researchers. The search strategy used a combination of controlled vocabulary and free-text words. Inclusion and exclusion criteria were defined ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: F Lio G Mampieri V Mazzetti A Leggeri L Arcuri Source Type: research

The health of soft tissues around four dental implants loaded immediately supporting a 4-year-old fixed screw-retained prosthesis
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):57-66. doi: 10.23812/21-3supp1-8.ABSTRACTThe aim of this study was to assess the soft tissues health around the implant/abutment interfaces of fixed screw-retained prosthesis supported by four dental implants after at least 1-year in function. All the implants were placed between December 1, 2015 and April 30, 2019. Digital implant surgical planning was performed for all the complete-arch rehabilitations and then full-guided surgery was performed. The fixed-interim prostheses were delivered the day of the surgery and replaced by definitive prostheses after the healin...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: F Carosi L Ottria F Lio A Laureti P Papi Source Type: research

Microbial leakage evaluation of warm gutta - percha techniques
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):67-75. doi: 10.23812/21-3supp1-9.ABSTRACTThe aim of this study is to compare bacterial leakage of MicroHeat and continuous wave with and without endodontic sealer. Thirty-eight single-rooted extracted mandibular premolars were selected and randomly divided into four experimental groups (n=8) and two control groups (n=3). Teeth were prepared with Mtwo NiTi files and obturated with MicroHeat or System B with or without endodontic sealer. Three teeth were used as positive controls (Ct+) and three intact teeth served as negative controls (Ct-). All samples were tested fo...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: A Libonati V Di Taranto E Montemurro G Gallusi Source Type: research

Radiographic and electronic working length comparison. An < em > in vivo < /em > study of three Electronic Apex Locator devices
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):77-85. doi: 10.23812/21-3supp1-10.ABSTRACTThe aim of this study is to compare the working length measured with Root ZX (EAL1), Propex II (EAL2) and Endo Analyzer Model 8005 (EAL3) with radiographic measurements during endodontic treatment. Fifty single canal teeth scheduled for endodontic treatment were selected for the study. After endodontic access preparation, pulp chamber was irrigated with 5mL of 5% sodium hypochlorite (NaOCl). The canal was scouted with a size 10 K-file introduced slightly over the apex to verify the canal patency. The working length (WL) was m...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: V Di Taranto A Libonati E Montemurro G Gallusi Source Type: research

Reduction of radiations exposure in endodontics: comparative analysis of direct (GX S-700, Gendex) and semidirect (VistaScan Mini View, D ürr) digital systems
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):87-94. doi: 10.23812/21-3supp1-11.ABSTRACTThe importance of intraoral periapical radiography is crucial as it represents a fundamental mean of evaluation and diagnosis for supporting bone and teeth hard tissues diseases and pathologies. Even though conventional film technology is still widespread, presently there are many digital radiography alternatives. Direct digital systems are devices with an intraoral sensor wired or paired wireless with a computer. These devices do generate an image immediately during exposure and acquisition. The semi direct digital systems i...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: A Libonati G Gallusi E Montemurro V Di Taranto Source Type: research

Craniofacial and occlusal features of individuals with Turner Syndrome: A cephalometric study
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):95-106. doi: 10.23812/21-3supp1-12.ABSTRACTCraniofacial features of 18 individuals with Turner Syndrome (TS) were compared with age and gender matched healthy individuals. Dental history, panoramic radiograph, dental casts and cephalometric measurements were assessed. The dental casts analysis showed a significantly higher PH/PW ratio in individuals with TS under GH therapy compared to healthy individuals (p=0.004; paired t-test). This data objectively supported the definition of a high-narrow palate. The ANB angle and the Wits index were similar in the two group, sh...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: A Bagattoni L Lardani A Vanni T Costi Source Type: research

Impact of self-ligating orthodontic brackets on dental biofilm and periodontal pathogens in adolescents
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):107-115. doi: 10.23812/21-3supp1-13.ABSTRACTThe aim of the present prospective study was to evaluate periodontal health and subgingival microbiological alterations in adolescents treated with fixed self ligating orthodontic brackets in comparison to subject without any orthodontic appliance. A total of 40 adolescents (23 females and 17 males; mean age: 13.2 ± 3.2 years) were included: 30 subjects with self ligating brackets (test group) and 10 patients without orthodontic appliances (control group). Follow-ups were as follows: T1 (1 month), T2 (3 months), T3 (...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: E Carli M Pasini L Lardani G Giuca M Miceli Source Type: research

Oral manifestations in paediatric patients with hepatobiliary diseases: a review
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):117-125. doi: 10.23812/21-3supp1-14.ABSTRACTIt is well known that greenish pigmentation of the teeth is seen in children following remission of severe jaundice and clinical and serum bilirubin, a degradation product of haemoglobin, may be permanently trapped in forming dental hard tissues causing discolouration and enamel and dentine hypoplasia. Neonatal jaundice is the most common cause of hyperbilirubinemia and pigmentation of the deciduous teeth is the consequence of this condition. Various hepatobiliary pathologies may have a clinical finding in the oral cavity; ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: M R Giuca L Lardani S Ligori E Carli G Giuca M Miceli Source Type: research

Critical investigation of the pre-surgical anatomic factors that influence the aesthetic result in post-extractive implantology and immediate prosthetic
This article presents some key factors to analyze and follow in order to achieve a predictable and acceptable aesthetic result. The creation of a predictable peri-implant aesthetics requires adequate preservation of the bone and soft tissues around the teeth that will be extracted and a correct positioning of the 3D implant. Furthermore, aesthetic success requires the creation of a correct transmucosal path, during the provisional prosthetic phases, which must be replicated and maintained with the definitive crowns.PMID:34289672 | DOI:10.23812/21-3supp1-15 (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: M Di Girolamo F Cecchetti L Volpe L Baggi D Mazza M Turco S Volpe Source Type: research

Guided sinus lift: virtual planning of surgical templates for lateral access
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):139-145. doi: 10.23812/21-3supp1-16.ABSTRACTThe sinus lift with lateral approach is a regenerative technique nowadays considered predictable to increase the height of bone in the atrophic posterior maxilla. Knowledge of sinus anatomy and evaluation of risk factors are the basis of regenerative and rehabilitative surgical success. The positioning and size of the lateral antrostomy represent critical factors in the execution of regenerative surgery, due to the difficulty in transferring radiological information to the lateral wall of the maxillary sinus even for skille...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: F Cecchetti M Spuntarelli D Mazza M Di Girolamo L Baggi Source Type: research

Endodontic retreatment and bioceramics: A case report
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):147-153. doi: 10.23812/21-3supp1-17.ABSTRACTThe success rate in endodontic retreatment can be significantly boosted by using materials that guarantee both intimate adhesion to the canal walls and long-term stability. Bioceramic cements used in root filling show interesting properties including extraordinary sealing capacities, antimicrobial activity that stimulates periapical healing and the continuous production of hydroxyopathitis for a long time. This case report deals with the application of bioceramic cement in endodontic retreatment. The Bioroot RCS (Septodont)...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: F Cecchetti M Spuntarelli R Zaccone D Mazza M Di Girolamo L Baggi Source Type: research

A new factor involved during childbirth labor: the importance of having a good dental occlusion
J Biol Regul Homeost Agents. 2021 May-Jun;35(3 Suppl. 1):155-166. doi: 10.23812/21-3supp1-18.ABSTRACTIt is widely recognized that the physiology of childbirth labor largely depends on the interaction between three factors: a) the force generated by uterine contractions; b) the structure and characteristics of the birth canal and c) the fetus. Harmony between these three variables determines the initiation of maternal dynamic phenomena and the establishment of an optimal maternal-fetal balance in which both warrant for a correct delivery timing. The present study considered the above known factors and assessed if any other ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2021 Category: Biomedical Science Authors: C Maggioni S Saccomanno J P Meerssman R F Mastrapasqua A Pirino F Scoppa Source Type: research