Thyroid and shoulder diseases: the bases of a linked channel.
Authors: Vicenti G, Moretti L, De Giorgi S, Caruso I, La Malfa M, Carrozzo M, Solarino G, Moretti B Abstract The association between thyroid disorders and musculoskeletal diseases has long been suspected, but it is still debated whether they have a role in the pathogenesis of shoulder diseases. In vivo and in vitro studies describe the role of thyroid hormones in bone, cartilage and tendon biology. Retrospective studies and case reports suggest that thyroid diseases should be considered as risk factors and hold prognostic value in some of the most common causes of shoulder pain. Thus, it is advisable to search for ...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A solitary uterine relapse in T-cell Acute Lymphoblastic Leukaemia: CT features and pathologic correlation.
This report presents the CT features of a 64-year-old woman with uterine relapse of T-cell ALL, occurring 11 months after the diagnosis, as a second, unique relapse of disease. The patient was asymptomatic when a CT examination showed a homogenous thickness of the uterine wall in comparison with the previous CT examination. Histology from biopsy specimens, obtained through hysteroscopy, confirmed T-cell ALL localisation (TdT+, CD10+, CD3c+ and CD2+). The uterus could be a site of relapse in patients suffering from ALL. Even though an MRI examination could better demonstrate the disease in cases of suspected female genital ...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Endometriosis and Glanzmann ’s thrombasthenia.
We describe the cases of three sisters affected by endometriosis and GT, referred to our Department, who received different therapeutic management. PMID: 27655515 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Central apelin-13 administration modulates hypothalamic control of feeding.
Authors: Ferrante C, Orlando G, Recinella L, Leone S, Chiavaroli A, Di Nisio C, Shohreh R, Manippa F, Ricciuti A, Vacca M, Brunetti L Abstract The 77 amino prepropeptide apelin has been isolated from bovine stomach tissue and several smaller fragments, including apelin-13, showed high affinity for the orphan APJ receptor. The distribution of apelinergic fibers and receptors in the hypothalamus may suggest a role of apelin-13 on energy balance regulation, albeit the studies reporting the acute effects of apelin on feeding control are inconsistent. Considering the possible involvement of apelinergic system on hypotha...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants.
In this study, a total of 68 adult patients due to undergo HSCT for allogenic and autologous transplant were enrolled at the Stem Cell Transplant Unit. The patients were divided into two groups. One group was treated with POHC before HSCT and applications of Mucosamin® during the recovery after transplantation. The second group served as controls, with the usual treatment of Clorexidine 0.20% adopted by the department. After HSCT the same clinician, an expert in oral medicine trained for the clinical trial, evaluated symptoms of the patients’ mucositis of both groups every day. The treated patients developed less seve...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Probiotic mixture supplementation in the preventive management of trinitrobenzenesulfonic acid-induced inflammation in a murine model.
This study confirms that TNBS-induced colitis in CD-1 mice is useful for studying the mechanisms involved in IBD pathogenesis, and pre-treatment with Citogenex prevents the intestinal damage induced by TNBS. PMID: 27655518 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Age-related ultrastructural and monoamine oxidase changes in the rat optic nerve.
Authors: Taurone S, Ripandelli G, Minni A, Lattanzi R, Miglietta S, Pepe N, Fumagalli L, Micera A, Pastore FS, Artico M Abstract The aim of this paper is to study the morphology and the distribution of the monoamine oxidase enzymatic system in the optic nerve of 4 month-old Wistar (young) and 28 month-old Wistar (old) rats. The optic nerve was harvested from 20 young and old rats. The segment of optic nerve was divided longitudinally into two pieces, each 0.1 mm in length. The first piece was used for transmission electron microscopy. The second piece was stained with histochemical reaction for monoamine oxidase. T...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Newborn screening of inherited metabolic disorders: the Italian situation.
Authors: Focardi M, Pinchi V, Defraia B, Gualco B, Varvara G, Norelli GA Abstract Starting from an international overview of the current status of screening programs, the present paper focuses on the legal situation in Italy and the great differences among Italian regions. Since the introduction of tandem mass spectrometry (MS/MS) in the ‘90s the paradigm “one spot-one disease” changed. Only recently, some regions issued legislative acts to promote expanded newborn screening with MS/MS. This approach raises medico-legal and ethical issues because a fast neonatal diagnosis of an inborn error of metabolism (IEM) c...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

IgG4-related cranio-spinal hypertrophic pachymeningitis involving the internal auditory canal.
Authors: Yangue Y, Gambaracci G, Floridi P, Fiacca A, Guerriero A, Giansanti M, Scialpi M Abstract Immunoglobulin G4 (IgG4)-related hypertrophic pachymeningitis, which is a focally or diffusely thickened dura mater and lymphoplasmacytic infiltration with increased IgG4 bearing plasma cells, is a rare disease, and cases involving the whole cervical spine are even rarer. Here, we describe a case of probable IgG4-related hypertrophic pachymeningitis involving the whole cervical spine and the auditory canals in an 18-year-old male. The patient, who had a history of paresthesia and had previously experienced weakness, p...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial.
Authors: Mazza A, Cicero AF, Ramazzina E, Lenti S, Schiavon L, Casiglia E, Gussoni G Abstract Although the role of homocysteine (HCys) in secondary cardiovascular prevention has been scaled down, hyper-homocysteinemia remains a risk factor for cerebrovascular events. The aim of this study was to investigate the efficacy of nutraceuticals in lowering HCys serum levels versus a conventional vitamin supplementation in hypertensive subjects at low cardiovascular risk. One-hundred and four patients (mean age 62.8±14.5 years, 63.5% males), 52 for each treatment group, were enrolled. The study recruited patients wi...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Neonatal oxidative stress depends on oxygen blood pressure in umbilical artery.
Authors: Proietti F, De Bernardo G, Longini M, Sordino D, Scaramuzzini G, Tataranno ML, Belvisi E, Bazzini F, Perrone S, Buonocore G Abstract With advancing gestation, partial pressure of oxygen (pO2) and pH fall significantly. Hypoxia is a main factor inducing free radical generation and thereby oxidative stress (OS). Placental and fetal tissue response when oxygen becomes restricted is complex and partially known. We tested the hypothesis that changes in umbilical artery and vein blood gas concentrations modulate OS occurrence in the newborn. Seventy umbilical artery and vein plasma samples were collected from he...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A multi-centred open trial of “Dr Michaels®” (also branded as Soratinex®) topical product family in psoriasis.
A multi-centred open trial of “Dr Michaels®” (also branded as Soratinex®) topical product family in psoriasis. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):1-7 Authors: Wollina U, Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Tirant M, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Psoriasis is a chronic, recurring skin disease affecting 2-4% of the population. Genetic predisposition and precipitating factors play a role in its etiology. The disease can occur in any age or gender group. The most frequently affected areas of the body inclu...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A European prospective, randomized placebo-controlled doubleblind Study on the efficacy and safety of Dr Michaels ® (also branded as Soratinex®) product family for stable chronic plaque psoriasis.
This study shows that Dr Michaels (Soratinex®) herbal skin-care products improve mild to moderate stable chronic plaque psoriasis significantly. PMID: 27498652 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A clinical examination of the efficacy of preparation of Dr Michaels ® (also branded as Soratinex®) products in the treatment of psoriasis.
A clinical examination of the efficacy of preparation of Dr Michaels® (also branded as Soratinex®) products in the treatment of psoriasis. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):15-20 Authors: Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Wollina U, Tirant M, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Psoriasis is a chronic inflammatory disease with negative impacts both physically and psychologically. It is a common disorder affecting 2-3% of the total world population, in some cases causing changes to the nail and joints as well...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Nail psoriasis in an adult successfully treated with a series of herbal skin care products family – a case report.
We report the case of a 50-year-old male patient with recalcitrant nail dystrophies on the fingers since the age of 40, who responded successfully to Dr. Michaels® product family. The patient had a 35-year history of plaque psoriasis localised on the scalp, ears, groin, limbs, and trunk and with psoriatic arthritis. The nail symptoms consisted of onycholysis, onychomycosis, leukonychia, transverse grooves, nail plate crumbling and paronychia of the periungal skin. This case represents the efficacy and safety of the Dr. Michaels® (Soratinex® and Nailinex®) product family with successful resolution of nail dy...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Clinical evaluation of the effectiveness of “Dr Michaels®” (also branded as Soratinex®) products in the topical treatment of patients with plaque psoriasis.
Clinical evaluation of the effectiveness of “Dr Michaels®” (also branded as Soratinex®) products in the topical treatment of patients with plaque psoriasis. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):29-34 Authors: Fioranelli M, Hercogovấ J, Gianfaldoni S, Chokoeva AA, Tchernev G, Wollina U, Tirant M, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Psoriasis is generally considered as an autoimmune inflammatory cutaneous-systemic disease, with chronic course and high rate of recurrence, while its high risk of comorbidities affect the patients’ quality of li...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Successful treatment of a chronic eczema in a 48-year-old female with Dr Michaels ® (Eczitinex® and Itchinex®) product family. A case report.
We report the case of a 48-year-old female with chronic atopic eczema who responded successfully to Dr Michaels® (Eczitinex® and Itchinex®) product family. The patient had a 41-year history of atopic eczema and presented with erythematous, excoriated lesions with telangiectasia and scattered purpura (bruising) covering 90% of her body surface area. The patient also regularly suffered blepharitis with red, itchy, watery eyes. The patient was treated with Dr Michaels® (Eczitinex® and Itchinex®) ointment and herbal supplements and presented total resolution of the atopic eczema and underlying inflammat...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Dr Michaels ® (Soratinex®) product for the topical treatment of psoriasis: a Hungarian/Czech and Slovak study.
Dr Michaels® (Soratinex®) product for the topical treatment of psoriasis: a Hungarian/Czech and Slovak study. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):43-7 Authors: Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Wollina U, Tirant M, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Psoriasis is a chronic inflammatory T cell-mediated skin disease, affecting about 2% of Hungarian population. Genetic predisposition as well as environmental triggering factors, and innate immune processes play a role in its etiology. Treatment of psoriasis durin...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Successful treatment of mild to moderate acne vulgaris with Dr Michaels ® (also branded as Zitinex®) topical products family: a clinical trial.
Successful treatment of mild to moderate acne vulgaris with Dr Michaels® (also branded as Zitinex®) topical products family: a clinical trial. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):49-54 Authors: Wollina U, Tirant M, Bayer P, Coburn M, Anderson P, Donnelly B, Kennedy T, Gaibor J, Arora M, Clews L, Walmsley S, Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Acne vulgaris is an epidemic inflammatory skin disease of multi-factorial origin, frequently seen in adolescents and often persisting o...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Investigation of the efficacy and tolerability of Dr Michaels ® (also branded as Eczitinex® and Itchinex Eczitinex®) topical products in the treatment of atopic dermatitis in children.
Investigation of the efficacy and tolerability of Dr Michaels® (also branded as Eczitinex® and Itchinex Eczitinex®) topical products in the treatment of atopic dermatitis in children. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):55-63 Authors: França K, Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Wollina U, Tirant M, Bayer P, Coburn M, Anderson P, Donnelly B, Kennedy T, Gaibor J, Arora M, Clews L, Novotny F, Roccia MG, Maximov GK, Lotti T Abstract Atopic eczema is a chronic relapsing inflammatory skin disorder, characterized clinically by intensely...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Treatment of ichthyosis lamellaris using a series of herbal skin care products family.
Authors: Tirant M, Bayer P, Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Wollina U, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Lamellar ichthyosis (LI) is a genetically heterogeneous group of disorders of keratinization that are inherited in an autosomal recessive fashion, occurring in approximately 1 in 300,000 live births. The treatment of the large, dark, plate-like scales that characterize the classic manifestation of the disease are still a challenge. The aim of this study was to evaluate the efficacy and tolerability of Dr. Michaels® skin-care products for ...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Investigation of the efficacy of Dr Michaels ® (Soratinex®) family in maintaining a symptom-free state for patients with psoriasis in remission. A retrospective, comparative study.
Investigation of the efficacy of Dr Michaels® (Soratinex®) family in maintaining a symptom-free state for patients with psoriasis in remission. A retrospective, comparative study. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):73-5 Authors: Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Wollina U, Tirant M, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Psoriasis is a chronic inflammatory disease, affecting about 3% of the worldwide population. Although there are many therapeutic options available today for psoriasis, none of them can be consi...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Dr Michaels ® product family (also branded as Soratinex®) versus Methylprednisolone aceponate - a comparative study of the effectiveness for the treatment of plaque psoriasis.
Dr Michaels® product family (also branded as Soratinex®) versus Methylprednisolone aceponate - a comparative study of the effectiveness for the treatment of plaque psoriasis. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):77-81 Authors: Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Wollina U, Tirant M, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract As one of the most common dermatologic chronic-recurrent disease, variable therapeutic options are available today for management of psoriasis. Although topical high potency corticosteroids, alone ...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Successful treatment of alopecia areata with Dr. Michaels ® (Alopinex) product family.
CONCLUSION: This study demonstrates that the Dr. Michaels® StimOils, Hair Lotion and PSC 900 are an effective therapeutic option for the treatment of alopecia areata. This has important implications for resistant cases of alopecia areata where traditional systemic and topical corticosteroid therapies have failed. In addition, this treatment approach may be an attractive option for patients who have growing concern regarding side-effects of long-term corticosteroid therapy. PMID: 27498663 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Successful treatment of recalcitrant candidal intertrigo with Dr Michaels ® (Fungatinex®) product family.
Successful treatment of recalcitrant candidal intertrigo with Dr Michaels® (Fungatinex®) product family. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):89-93 Authors: Hercogovấ J, Tirant M, Bayer P, Coburn M, Donnelly B, Kennedy T, Gaibor J, Arora M, Clews L, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Wollina U, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Candidal intertrigo is an infection of the skin caused by Candida albicans that typically occurs in opposing cutaneous or muco-cutaneous surfaces. Because Candidiasis requires a damaged and moist e...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Successful treatment of facial systemic lupus erythematosus lesions with Dr Michaels ® (Soratinex®) product family. A case report.
We report the case of a 7-year-old female patient with facial lesions of SLE since the age of 5. There was no significant family history and patient had been a healthy child from birth. The child presented with a malar rash, also known as a butterfly rash, with distribution over the cheeks but sparing the nasal bridge. This case represents the efficacy of the Dr. Michaels® (Soratinex®) product family in the successful resolution of facial lesions of SLE. PMID: 27498665 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Scalp psoriasis: a promising natural treatment.
Authors: Wollina U, Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Tirant M, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Psoriasis is a lifelong chronic inflammatory disease affecting 2-3% of the worldwide population. Scalp psoriasis is a particular form of psoriasis characterized by lesions on the scalp, which may occur isolated or in association with other skin lesions. The aim of this study was to investigate the efficacy and safeness of an innovative treatment of scalp psoriasis, which is based on the topical application of natural products. Fifty adult subjects wit...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

An innovative, promising topical treatment for psoriasis: a Romanian clinical study.
Authors: Gianfaldoni S, Hercogovấ J, Fioranelli M, Chokoeva AA, Tchernev G, Wollina U, Tirant M, Novotny F, Roccia MG, Maximov GK, França K, Lotti T Abstract Psoriasis is a chronic inflammatory disease with negative impacts both physically and psychologically. It is a common disorder affecting 2-3% of the total world population, in some cases causing changes to the nail and joints as well as skin lesions. The cutaneous manifestations of psoriasis can vary in morphology and severity and therapy should be tailored accordingly. Even if today many therapeutic options are available for psoriasis treatment, none...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Efficacy and safety of Dr Michaels ® (Soratinex®) product family for the topical treatment of psoriasis: a monitored status study.
Efficacy and safety of Dr Michaels® (Soratinex®) product family for the topical treatment of psoriasis: a monitored status study. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):115-9 Authors: França K, Novotny F, Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Wollina U, Tirant M, Roccia MG, Lotti T Abstract The aim of the study was to investigate the efficacy and safety of Michaels® (Soratinex®) remedies in patients suffering from chronic plaque psoriasis in a Czech population. Seventy-five (34 female/41 male) patients, aged 18-72 years old (mean ag...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Quality of life aspects of patients with psoriasis using a series of herbal products.
This study aims to access the changes in quality of life of patients with Psoriasis using an Australian series of herbal skin-care products Dr Michaels® (Soratinex®) for psoriasis. The aim of this study is to observe and analyze the impact of Dr Michaels® product family on the quality of life of patients with psoriasis, 566 patients completed the Dermatology Quality of Life Index (DQLI) questionnaire in their initial consultation and at 3 follow up consultations, over a 6 months period. At the end of the data collection, all patients’ answers were recorded and analyzed. The Psoriasis Area and Severity (PASI) I...
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Rapid communication: a vegetable oil extract restores redox status in fibroblasts from psoriatic patients.
Authors: Barygina V, Becatti M, Mannucci A, Taddei N, Tirant M, Hercogovấ J, França K, Fioranelli M, Roccia MG, Tchernev G, Wollina U, Lotti T, Fiorillo C Abstract Psoriasis is an inflammatory skin disease that affects 2-5% of the worldwide population. It is a chronic immune-mediated hyperproliferative inflammatory skin disease of unknown etiology, characterized by the appearance of sore patches of thick, red skin with silvery scales. PMID: 27498670 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - August 10, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A prospective evaluation of outcomes of two tapered implant systems.
Authors: Andreasi Bassi M, Lopez MA, Confalone L, Gaudio RM, Lombardo L, Lauritano D Abstract The purpose of this prospective clinical study was to evaluate survival rate (SVR - i.e. fixtures still in place at the end of the observation period) and success rate (SCR - i.e. bone resorption around the implant neck) of two tapered implant systems. Both systems were equipped with a tapered connection, one requiring bone-level (BL) placement, while the other required soft-tissue-level (STL) placement. In the period between January 1996 and October 2011, 133 fixtures were inserted, 90 in females and 43 in males, with a m...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Clinical outcome of a two-piece implant system with an internal hexagonal connection: a prospective study.
Authors: Andreasi Bassi M, Lopez MA, Confalone L, Gaudio RM, Lombardo L, Lauritano D Abstract The purpose of this prospective clinical study was to evaluate the survival rate (SVR - i.e. fixtures still in place at the end of the observation period) and success rate (SCR - i.e. bone resorption around implant neck) of an implant system characterized by cylindrical and tapered implants, both provided with an internal hexagonal connection. In the period between January 1996 and October 2011, 52 implants with internal hexagonal connection were inserted in 21 females and 31 males, mean age 54±11 years. The mean po...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Maxillary sinus by-pass with tilted implants via tapered-screw bone expanders in low density bone: one year follow -up of a case series.
Authors: Andreasi Bassi M, Andrisani C, Lopez MA, Gaudio RM, Lombardo L, Lauritano D Abstract In the present paper the use of tapered-screw bone expanders (TSBEs) is proposed, in combination with the placement of tilted implants in close proximity to the anterior sinus wall, solving the problem of the reduced height of the alveolar bone in the sub-antral area. The Authors named the procedure: Tilted Implant Expansion Osteotomy (TIEO). Fifteen patients (10 females and 5 males, mean age 47.8±8.15 years) with distal edentulous maxillae were enrolled in this study. For each edentulous site 2 implants were placed...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Endoscopically controlled hydraulic sinus lift in combination with rotary instruments: one-year follow-up of a case series.
Authors: Andreasi Bassi M, Andrisani C, Lopez MA, Gaudio RM, Lombardo L, Lauritano D Abstract The aim of this study was to evaluate a sinus lift via crestal approach (SLVCA) case series, performed with rotary instruments and hydraulic pressure, analyzed under endoscopic control. Sixteen patients (11 female, 5 male, mean age 47.13±8.07 years) candidates for SLVCA were enrolled in this study. Twenty-two cylindrical two-piece implants were placed. After a suitable period of time needed for the consolidation of the graft (mean value 5.78±1.49 months), the bone augmentation was assessed by means of intraor...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Modified connective tissue punch technique to increase the vestibular/buccal keratinized tissue on flapless implant surgery: a case series.
Authors: Andreasi Bassi M, Andrisani C, Lopez MA, Gaudio RM, Lombardo L, Lauritano D Abstract The aim of this article is to show a simple and predictable technique to enhance both the vestibular/buccal (V/B) gingival thickness (GT) and keratinized tissue width (KTW) improving the soft-tissue profile after flapless implant placement. The technique proposed was named Modified Connective Tissue Punch (MCTP). Fourteen patients (6 men and 8 women) aged between 35 and 69 years (mean value 48.07±13.023 years) were enrolled in this case series. Seventeen implant sites were submitted to flapless procedure. The connec...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Guided bone regeneration by means of a preformed titanium foil: A case of severe atrophy of edentulous posterior mandible.
Authors: Andreasi Bassi M, Andrisani C, Lopez MA, Gaudio RM, Lombardo L, Carinci F Abstract The aim of this case report was to evaluate the potential of preformed titanium foil (PTF) as membrane, used together with a mouldable allograft paste, for guided bone regeneration in a case of severe mandibular posterior atrophy involving the alveolar nerve. In order to create a rigid barrier to the competitive growth of soft tissues and a stable volume for the colonization of the osteoprogenitor cells, a foil of pure titanium was pre-shaped by means of a stereolithographic model, obtained from a CT-scan of the patient. Thi...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Retrospective study on bone-level and soft-tissue-level cylindrical implants.
Authors: Lopez MA, Andreasi Bassi M, Confalone L, Gaudio RM, Lombardo L, Lauritano D Abstract The purpose of this prospective clinical study was to evaluate the survival rate (SVR - i.e. fixtures still in place at the end of the observation period) and success rate (SCR - i.e. bone resorption around implant neck) of two cylindrical implant systems. Both systems were equipped with a tapered connection, one requiring a bone-level (BL) placement, while the other a soft-tissue-level (STL) placement. In the period between January 1996 and October 2011, a total of 150 implants (76 in females and 74 in males, mean age 60&...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

The influence of “conical plus octagonal” internal connection on implant survival and success rate: a retrospective study of 66 fixtures.
Authors: Lopez MA, Andreasi Bassi M, Confalone L, Gaudio RM, Lombardo L, Lauritano D Abstract Implant oral rehabilitation has become one of the most successful dentistry techniques over the last 30 years. However, peri-implantitis is the most important complication in implant dentistry. Peri-implantits can be caused by inadequate implant-abutment connections (IAC). The aim of our study is to evaluate the influence of “conical plus octagonal” (i.e. I-Fix connection) on implant survival and success rate. All the implants included in this study were of a completely new type (I-Fix implants and abutments by FMD Falap...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Clinical outcome of 215 transmucosal implants with a conical connection: a retrospective study after 5-year follow-up.
In conclusion, Shiner XT implants are reliable tools for oral rehabilitation. PMID: 27469549 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Guided bone regeneration in distal mandibular atrophy by means of a preformed titanium foil: a case series.
Authors: Andreasi Bassi M, Andrisani C, Lopez MA, Gaudio RM, Lombardo L, Lauritano D Abstract The aim of this case series was to evaluate the clinical outcome of preformed titanium foil (PTF) to perform guided bone regeneration (GBR) in posterior mandibular atrophies. Thirteen patients (4 male; 9 female; mean age 58.85±10.16 years), with class II division C atrophy, according to Misch, were selected to perform GBR by means of PTF, using a moldable allograft paste as graft material. The devices, made of a 0.2mm thick pure titanium foil, were pre-shaped using stereolithographic models obtained from CT-scan of ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Prevention of bacterial leakage at implant-abutment connection level: an in vitro study of the efficacy of three different implant systems.
Authors: Carinci F, Lauritano D, Cura F, Lopez MA, Andreasi Bassi M, Confalone L, Pezzetti F Abstract Peri-implantitis is the main cause of implant failures. Peri-implantitis is provoked by the presence of bacterial infiltration around Implant-Abutment Connection (IAC). Reduction of bacterial leakage may be achieved by improving the accuracy and precision of the two pieces of IAC. The aim of the present in vitro study was to evaluate bacterial microleakage from the inside to the outside of the IAC, testing the efficacy of three new designs of internal conical connection (FN - nano-fix -, NQ - uNiQo - and Elisir imp...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

The use of resorbable heterologous cortical lamina as a new sinus lift floor: a technical note.
Authors: Lopez MA, Manzulli N, Casale M, Ormianer Z, Carinci F Abstract Some graft materials such as a heterologous porcine cortical lamina have an excellent capacity in creating recipient sites that can be filled with cortico-spongious collagenated bone paste that reabsorbs, allowing for the reformation of good-quality bone. In this work a technique is proposed which makes use of resorbable cortical lamina in order to create a new sinus floor that can be filled with cortico-spongious bone paste. The adequate vascularisation of the graft combined with the integration of the lamina, which does not need to be removed...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

The use of resorbable cortical lamina and micronized collagenated bone in the regeneration of atrophic crestal ridges: a surgical technique. Case series.
In this study, a technique is proposed which makes use of resorbable cortical lamina in order to create recipient sites that can be filled with micronized collagenated bone paste. The adequate vascularization of the graft combined with the integration of the lamina, which does not need to be removed, makes it possible to propose this technique as a potential alternative to those used to date. PMID: 27469553 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Oxygen high level laser therapy is efficient in treatment of chronic periodontitis: a clinical and microbiological study using PCR analysis.
Authors: Caccianiga G, Rey G, Paiusco A, Lauritano D, Cura F, Ormianer Z, Carinci F Abstract In periodontology, lasers have been suggested for the photodynamic therapy (PDT). Such therapy can be defined as the inactivation of cells, microorganisms or molecules induced by light and not by heat. The aim of our study is to assess the effect of Oxygen high-level laser therapy (OHLLT) in removing all bacterial deposits on root or implant surface by means of mechanical instrumentation and laser irradiation. OHLLT has two effects on targeted bacteria and tissues, decontamination and biostimulation. A total of 33 patients ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of laser biostimulation on the epithelial tissue for keratinized layer differentiation: an in vitro study.
Authors: Caccianiga G, Cambini A, Donzelli E, Baldoni M, Rey G, Paiusco A Abstract Gingival augmentation techniques proposed in the international literature do not exclude a surgical component, which determines consequent post-surgical discomfort and results are not always predictable. In recent years, the introduction of laser biostimulation has led to a less invasive approach, particularly in the treatment of periodontally compromised patients, limiting the surgical phase to seriously compromised cases, with regeneration techniques for the restoration of a correct periodontal tissue anatomy. The aim of this in vi...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Low-level laser therapy and invisible removal aligners.
Authors: Caccianiga G, Crestale C, Cozzani M, Piras A, Mutinelli S, Lo Giudice A, Cordasco G Abstract It seems that Low Level Laser Therapy (LLLT) stimulates orthodontic tooth movements, increasing the alveolar bone turnover. The aim of this study is to evaluate how LLLT can influence the orthodontic treatment with invisible removal aligner. A sample of 21 subjects was divided into two groups, a laser group (10 patients) and a control group (11 patients). All subjects were instructed to wear each aligner 12 hours a day for 2 weeks. Laser external bio-stimulation was given in the laser group every second week. The l...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Correlation between dysfunctional occlusion and periodontal bacterial profile.
Authors: Meynardi F, Pasqualini ME, Rossi F, Dal Carlo L, Biancotti P, Carinci F Abstract The aim of this study is to compare the evolution in bacterial profile at evident periodontitis sites following two types of treatment - oral hygiene procedures alone (Group 1) and oral hygiene plus occlusal adjustment through selective grinding (Group 2). The presence of periodontal disease was ascertained by clinical examination (redness, oedema, probe depth, bleeding-on-probing). Bacterial profiling was carried out via phase contrast microscopy on plaque samples taken from periodontitis sites in both patient groups. Bacteri...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Evaluation of the efficacy of a new oral gel as an adjunct to home oral hygiene in the management of chronic periodontitis. A microbiological study using PCR analysis.
Authors: Lauritano D, Bignozzi CA, Pazzi D, Palmieri A, Gaudio RM, Di Muzio M, Carinci F Abstract The use of chemical devices for non-surgical periodontal therapy has led to new treatment strategies aiming primarily at infection control and oral bacterial load. Over the last few decades adjunctive chemical devices has been subjected to many scientific and medical studies. The purpose of the present study was to assess the effect of a new oral gel named Parodongel on the red complex organisms using Polymerase Chain Reaction (PCR) for microbiological analysis. A total of 10 patients with a diagnosis of chronic period...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Evaluation of the efficacy of a new oral gel containing carvacrol and thymol for home oral care in the management of chronic periodontitis using PCR analysis: a microbiological pilot study.
Authors: Lauritano D, Pazzi D, Iapichino A, Gaudio RM, Di Muzio M, Lo Russo L, Pezzetti F Abstract The use of chemical devices for domestic oral hygiene in periodontal patients has led to new treatment strategies aiming primarily at a control of infection. Over the last few years, carvacrol and thymol (CT) have been subjected to many scientific and medical studies. The purpose of the present study was to assess the effect of CT on the red complex bacteria using Polymerase Chain Reaction (PCR) for microbiological analysis. Five patients with a diagnosis of chronic periodontitis in the age group>25 years, were sel...
Source: Journal of Biological Regulators and Homeostatic Agents - July 31, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research