Effects of tumor-associated macrophages on the proliferation and migration of esophageal cancer-associated lymphatic endothelial cells.
Authors: Chen JY, He LI, Zhang HX, Sun MM, Chen KS Abstract The aim of this study was to explore whether M2 macrophages can be transformed into M1 macrophages, and to investigate the effect of different types of macrophages on the proliferation, migration and ring-forming ability of esophageal cancer-related lymphatic endothelial cell (LEC). Human monocytic leukemia cell line (THP-1 cell) was induced to differentiate to M1 macrophages (M1 group) and M2 macrophages (M2 group), and co-cultured with esophageal cancer-associated LEC. The individual esophageal cancer co-cultured with LEC was used as control. Different t...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effect of CuSO4 and nano copper on serum antioxidant capacity in Weaned piglets.
Authors: Chang Z, Zhang H, Dong H, Mehmood K, Ijaz M, Ahmad HI, Naeem MA, Wu Q, Nabi F, Zhu H Abstract Copper is the most essential trace element in the animal body. Nano-sized copper particles have been widely used in a number of different animal species in modern medicinal practice. The present study was designed to examine the effect of dietary copper sulfate/(CuSO4) and nano copper supplementation on serum antioxidant capacity of weaning piglets. A total of 28 Duroc piglets (21 days, and weighing ~7 kg) were randomly divided into three equal groups. The control group (n=4) was administered with a normal standar...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Thymoquinone protects against cerebral small vessel disease: Role of antioxidant and anti-inflammatory activities.
Authors: Guan D, Li Y, Peng X, Zhao H, Mao Y, Cui Y Abstract Cerebral small vessel disease (CSVD) is a leading cause of progressive decline of cognition and a major risk factor for stroke. Thymoquinone (TQ) is the major biological component of Nigella sativa (N. sativa) and its extracts. We explored the possible protective effect of TQ against CSVD in strokeprone spontaneously hypertensive SHRsp rats. Morris water maze and novel object recognition tests were conducted to evaluate memory and cognitive function. mRNA expression of inflammatory factors were determined and oxidative stress was evaluated. We showed that...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Cysteinyl leukotrienes C4 and D4 downregulate human mast cell expression of toll-like receptors 1 through 7.
This study determined the effect of CysLT on toll-like receptor (TLR) expression by the human mast cell line LAD2. Real-time PCR analysis determined that LTC4, LTD4 and LTE4 downregulated mRNA expression of several TLR. Specifically in human CD34+-derived human mast cells (HuMC), LTC4 inhibited expression of TLR1, 2, 4, 5, 6 and 7 while LTD4 inhibited expression of TLR1-7. Montelukast blocked LTC4-mediated downregulation of all TLR, suggesting that these effects were mediated by activation of the CysLT1 receptor (CysLT1R). Flow cytometry analysis confirmed that LTC4 downregulated surface expression of TLR2 which was blocke...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Study on physiological and psychological comprehensive nursing of elderly tumor patients after surgery.
In conclusion, effective nursing intervention played a crucial role in the postoperative recovery of elderly tumor patients by reducing pain and anxiety degrees, which improved the patients’ satisfaction with the nursing. PMID: 29685002 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Long non-coding RNA SNHG16 contributes to glioma malignancy by competitively binding miR-20a-5p with E2F1.
In conclusion, SNHG16 promotes glioma tumorigenesis by sponging miR-20a-5p, leading to the enhancement of its endogenous targets E2F1. The data provides a new clue for the role of SNHG16/miR-20a-5p/E2F1 in the development of glioma. PMID: 29685003 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Clinical value of combined tests for tumor markers for gastric cancer.
Authors: Xu MX, Cui HJ, Yao TL, Gui YF Abstract To study the clinical diagnostic value of treating gastric cancer (GC) with combined tests for tumor markers (CEA, CA199, CA242 and CA724), fifty healthy subjects, 50 patients with GC at different stages and 50 patients with benign GC were randomly selected from our hospital. These subjects were divided into a normal group A, an experimental group B and a control group C. Venous blood was drawn and tested for four serum tumor markers. The SPSS 18.0 analytic system was then used to analyze the data. Tumor markers for GC at different stages, different pathological patte...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Prevalence of Degnala disease in bovine along with screening of toxigenic fungi isolated from contaminated rice straw.
Authors: Nazar M, Khan MS, Ijaz M, Anjum AA, Sana S, Setyawan EMN, Saleem MI, Ahmad I Abstract Toxigenic potential of different candidate fungi, isolated from rice straw feed of Degnala disease affected bovines was analyzed along with species, age, gender and seasonal prevalence. Of 1,536 cases, 104 (6.77%) showed positive signs with a significant association (p less than 0.05) between this disease and rice straw feeding, in buffaloes, and bovine aged over 1 year in the winter season. Complete blood count showed a marked increase in erythrocyte sedimentation rate and all white blood cells numbers, except lymphocyte...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Spoligotyping analysis of Mycobacterium tuberculosis with TB-sprint technology.
Authors: Ali S, Sola C, Harrison M, Tahir M, Sheed Khan A, Mumtaz M, Chimara E, Hassan F Abstract Spoligotyping is a highly reproducible, fast polymerase chain reaction (PCR)-based approach for identification of different strains of Mycobacterium tuberculosis through genotyping of Mycobacterium tuberculosis complex (MTB). Molecular typing of MTB is helpful for understanding and controlling TB epidemics. Spoligotyping was performed on 166 strains of MTB collected from 25 districts of Khyber Pakhtunkhwa, Pakistan. Results were analyzed using online database, SITVIT2, developed by the Institute Pasteur de Guadeloupe, ...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Neuroprotection of ulinastatin on transient cerebral ischemia via antioxidative mechanisms.
Authors: Hu HX, Xu DH, Ju WN, Ma C, Wang X, Liu XL Abstract Ulinastatin [also called urinary trypsin inhibitor (UTI)] has beneficial effects on cerebral ischemic injury evoked by cardiac arrest (CA). However, the underlying mechanisms are unknown. The purpose of this report was to determine the involvement of antioxidative signal pathway of the hippocampus in effects of UTI in the process of neurological functions after transient cerebral ischemia. CA was induced by asphyxia followed by cardiopulmonary resuscitation in rats. Western blot analysis and ELISA were used to examine expression of Nrf2-antioxidant respons...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Medicamentous thrombolysis disguises pulmonary thromboembolism as a cause of death.
In this study, we conclude that PTE is generally overlooked as the principal diagnosis and the cause of death. Rightful postmortem diagnosis could lead to increased vigilance and a change in management in many of such cases, which could result in improved survival. Motivated by providing better awareness of PTE, this study aimed to illustrate unrecognized PTE and pathological findings that were masked by thrombolytic drugs. PMID: 29685008 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Sudden-onset unilateral ptosis induced by pituitary Macroadenoma, with false-positive jolly and neostigmine tests.
Authors: Shen GX, Wu KJ, Chen Z, Gao YF, Nan GX Abstract The development of ptosis as a consequence of pituitary tumor is an exceptionally rare occurrence. Here, we describe the case of sudden-onset unilateral ptosis induced by pituitary macroadenoma. The condition was characterized by false-positive Jolly and neostigmine tests. These findings mimic oculomotor nerve palsy and make the correct diagnostics rather challenging. The case points to the fact that patients with acquired ptosis need detailed neuroophthalmological examination. PMID: 29685009 [PubMed - in process] (Source: Journal of Biological Regulators...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Expressions and clinical significance of factors related to acute coronary syndrome.
We examined the correlations between the levels of MMP-2 and IL-18 and cardiac risk factors in ACS. Logistic regression analysis was performed to screen for factors that predict ACS. Both MMP-2 and IL-18 concentrations were increased in the ACS group compared to the SAP group or control group (P less than 0.01). Especially, MMP-2 and IL-18 were highly expressed in the patients with ST elevated myocardial infarction (STEMI). Both serum levels of MMP-2 and IL-18 in the single-, double- and triple-vessel lesion group were higher compared to the control group (P less than 0.01). MMP-2 levels were positively correlated with IL-...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Glucocorticoids in combination with ursodesoxycholic acid in the treatment of autoimmune hepatitis.
Authors: Li WY, Yang XS, Wang YC Abstract Autoimmune hepatitis (AH) is usually manifested as chronic hepatitis in clinics; it may evolve to liver cirrhosis, hepatic failure, and even death if treatment is delayed. To investigate the clinical efficacy of glucocorticoids in combination with ursodesoxycholic acid in the treatment of glucocorticoids in combination with ursodesoxycholic acid, one hundred and twenty patients with AH who were admitted to the hospital from February 2014 and February 2016 were selected and randomly divided into an observation group and a control group using random number table. Patients in ...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Evaluating the utility of autoantibodies for disease activity and relapse in giant cell arteritis.
Authors: Kuret T, Lakota K, Hočevar A, Burja B, Čučnik S, Sodin-Semrl S Abstract In patients with giant cell arteritis (GCA), autoantibodies against cytoskeletal elements, cardiolipin, neutrophil cytoplasmic antigens, ferritin, endothelial and smooth muscle cells have been reported, however no updated reviews are available evaluating their clinical utility. Methodology of detection is important, especially for quantitative assays, e.g. enzyme-linked immunoassays and multiplex beadbased immunoassays, while semiquantitative assays contribute valuable data on isoforms, epitope mapping and cellular localization. Mos...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Status of cathelicidin IL-37, cytokine TNF, and vitamin D in patients with pulmonary tuberculosis.
This study aims to evaluate the serum concentrations of LL-37 in individuals with active pulmonary tuberculosis (TB) and to determine whether any correlations between peptide LL-37, tumor necrosis factor (TNF) and vitamin D serum levels exist. A total of 46 adults with pulmonary TB were recruited for the study. Sixty-one controls were randomly selected as control group. Serum concentrations of cathelicidin LL-37, vitamin D (25(OH)D), as well as TNF, were measured using an enzyme-linked immunosorbent assay (ELISA) kit. The mean (± SEM) level of LL-37 was significantly higher in the TB group (7.45±1.58) compare...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Correlation analysis of CD4 gene polymorphism and blood routine Indexes in pigs (Sus scrofa).
This study indicates that CD4 gene is significantly associated with partial blood routine indexes in pigs, and it can be considered as a candidate gene for the study of porcine disease resistance. PMID: 29685014 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Importance of basophils in eosinophilic asthma: the murine counterpart.
Authors: Poddighe D, Mathias CB, Brambilla I, Marseglia GL, Oettgen HC Abstract Several experimental studies in mice showed that basophils participate in the initiation of Th2 adaptive immune response, in addition to the effector phase. However, the role of basophils in allergic airway inflammation is less clear. The aim of this experiment was to assess the importance of basophils in recruiting inflammatory cells and, in particular, eosinophils in a murine model of asthma induced by Aspergillus fumigatus allergens. Additionally, bronchial reactivity was evaluated. Basophil depletion resulted in a reduction of infla...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Correlation between childhood eczema and specific IgG antibody level.
Authors: Liu Y, Yan H, Shao F, Li QH, Cui M Abstract Eczema, a common pediatric dermatosis with unclear pathogenesis, can seriously affect the life quality of children due to its recurrence and long course. Recent study has found that food specific IgG (sIgG) might be involved in the course of eczema. To analyze the correlation between childhood eczema and sIgG and evaluate the role of avoiding taking intolerance food in the treatment of childhood eczema, this study enrolled 216 children with eczema who were admitted to the Taian Maternal and Child Health Care Hospital, Shandong, China, between August 2014 and Octo...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Posterior hemivertebra resection in combination with screw rod internal fixation in the treatment of pediatric congenital scoliosis.
In conclusion, posterior hemivertebra resection in combination with screw rod internal fixation is a highly efficient and safe treatment which can significantly relieve the clinical symptoms and cause few complications. PMID: 29685017 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Three-vessel-trachea view in the diagnosis of fetal cardiac great vessel malformation.
Authors: Chen KB, Gu Q, Xia T, Lu X, Zhang ZD Abstract Fetal cardiac great vessel malformation is attracting increasing attention in the prenatal ultrasonic diagnosis of fetal congenital heart disease. To investigate the clinical diagnostic values of three-vessel-trachea view (3VT view) in the ultrasonic diagnosis of this malformation, the present study analyzed the echocardiographic examination results of 77 fetuses with great vessel malformation, retrospectively analyzed the echocardiographic characteristics in the three-vessel-trachea view, and followed up the enrolled cases. The results suggest that great vesse...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effect of branched chain amino acids on perioperative temperature, glucose level and fat metabolism in patients with gastrointestinal tumors.
This study aimed to investigate the effect of branched chain amino acids (BCCAs) on perioperative temperature, glucose and fat metabolism in patients with gastrointestinal tumors. Fifty-six patients undergoing gastrointestinal tumor surgery were included in the study and randomly divided into two groups of 28 patients each: an experimental and a control group. During surgery, the experimental group received 5.64mL·Kg-1·h-1(4KJ·Kg-1·h-1) of BCCAs intravenously, through an infusion pump, and the control group received an equal volume of NaCl 0.9%. Vital signs were continuously monitored during the...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Ability of computed tomography to predict right heart strain on an echocardiogram in patients with acute pulmonary embolus.
This study aimed to investigate the predictive value of computed tomography pulmonary angiogram (CTPA) findings of right heart strain in patients with computed tomography (CT)-proven PE for the diagnosis of right heart strain by echocardiogram (ECHO). The institutional review board (IRB) approved retrospective chart review of the adult emergency department patients diagnosed with an acute PE between 2012 and 2016. A total of 128 patients diagnosed with RHS by CT who had received an ECHO during their hospitalization were included in the study. Descriptive statistics were run for the variables of interest. The majority of pa...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Detection of hand-foot-mouth disease and its spatial-temporal Epidemiological characteristics with GIS platform.
Authors: Xu XJ, Tang Z, Zeng LR, Luo H, Chen QY, Li L, Lou Q, He XJ Abstract The aim of this study is to investigate the main category of hand-foot-mouth (HFM) virus and analyze the distribution characteristics and susceptible population of HFM disease in China. Infants who have had HFM disease for less than 7 days were selected from the First Affiliated Hospital of Guangxi Medical University, Guangxi, China. Various specimens were collected from the infants, and EV71 and CA16 nucleic acid detections were performed using fluorescence quantitative assay. The positive results of the specimens were compared to determi...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Role of fungal-induced stress in biochemical and phytochemical profiling of Peganum harmala.
Authors: Afzal M, Shahid M, Riaz M, Saleem MA, Wattoo JI, Zeshan B, Naveed M Abstract The current study was designed to evaluate bioactive compounds under the influence of biotic stress on seedlings of Peganum harmala. Biologically active compounds were determined by using different techniques. The HPLC and GC-MS analyses detected the significant amount of phenolic acids and active biological compound. Total protein content, activity of proteases, α-amylases, catalases and peroxidases were observed to be accelerated under fungal stress. The seedling extracts exhibited prominent antifungal and antimicrobial ac...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Extracorporeal shockwave therapy versus exercise program in patients with low back pain: short-term results of a randomised controlled trial.
Authors: Notarnicola A, Maccagnano G, Gallone MF, Mastromauro L, Rifino F, Pesce V, Covelli I, Moretti B Abstract The physiotherapy treatment of low back pain (LBP) with physical stimulation offers different possibilities of application. Until now, the physical therapies used in LBP are laser therapy, ultrasonotherapy and currents. We conducted a clinical trial in order to verify whether shockwave therapy, which is very effective in treating tendinopathies and fracture consolidation delays, leads to clinical and electromyographic improvement in patients affected by LBP. We randomized thirty patients affected by LBP...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Oral Lichen planus.
Authors: Giannetti L, Dello Diago AM, Spinas E Abstract Oral Lichen planus (OLP) is the most frequent mucosal localization of Lichen planus, affecting about 1-2% of the population. It is associated with skin lesions in 60-70% of cases, while occurring as the only manifestations in 15-25% of patients. Six clinical forms of OLP are identified: reticular (the most common), plaque, papular, atrophic, vesicles/bullous and erosive. The evolution is chronic, especially in the erosive form. A 1% incidence of squamous-cell carcinoma has been reported, thus considering OLP as a potential premalignant condition. The etiopatho...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Comparison of coronal leakage of different root canal filling techniques: an ex vivo study.
Authors: Libonati A, Di Taranto V, D Agostini C, Santoro MM, Di Carlo D, Ombres D, Gallusi G, Favalli C, Marzo G, Campanella V Abstract The aim of this study was to compare the quality of the coronal seal, using an in vitro bacterial invasion test, of three different root canal filling systems. Twenty-seven freshly extracted mandibular premolars were selected and divided into three experimental groups (G1, G2 and G3 n=7) and two control groups (Ct+ and Ct- n=3). All teeth in the experimental groups were prepared using NiTi Mtwo rotating instruments and then the endodontic treatments were completed using the three-t...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effect of biophysical therapy on articular pain in a primary care setting compared to ibuprofen and placebo: a randomized controlled trial.
Authors: Foletti A, Egan CG, Baron P Abstract Articular pain is one of the most frequent complaints practitioners face in their daily work. With an aging population, many patients have multiple comorbidities that are associated with the presence of chronic diseases, while others experience allergies, side effects or do not respond to standard medications or procedures. Therefore, there is an urgent need for new effective and safe strategies to manage articular pain, especially in its chronic manifestations. This randomized controlled trial was designed to assess the efficacy of a single therapy session using a biop...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Clinical course of severe colitis: a comparison between Crohn ’s Disease and ulcerative colitis.
Clinical course of severe colitis: a comparison between Crohn’s Disease and ulcerative colitis. J Biol Regul Homeost Agents. 2018 Mar-Apr;32(2):415-423 Authors: Sinagra E, Orlando A, Scalisi A, Mocciaro F, Criscuoli V, Oliva L, Maisano S, Giunta M, La Seta F, Solina G, Rizzo AG, Leone A, Tomasello G, Cappello F, Cottone M Abstract Few data are available about the clinical course of severe colonic Crohn’s disease (CD). The aim of this study is to describe the clinical course of severe Crohn’s colitis in a patient cohort with isolated colonic or ileocolonic CD, and to compare it with the clinical cour...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Gastric reflux: the therapeutical role of Marial ® .
Gastric reflux: the therapeutical role of Marial® . J Biol Regul Homeost Agents. 2018 04 26;32(4) Authors: Aragona SE, Mereghetti G, Ciprandi G Abstract The worldwide relevance of gastroesophageal reflux disease (GERD) has had a considerable increase in recent years. The guidelines for the diagnosis and treatment of GERD are well consolidated and continuously updated. Recently, the extra-esophageal manifestations of reflux have been considered from a multidisciplinary point of view, so the symptoms of the laryngo-pharyngeal reflux (LPR) have been precisely defined. At present, a new Medical Compoun...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Emerging from gastroesophageal reflux (EMERGE): an Italian survey - I the viewpoint of the gastroenterologist.
In conclusion, the current experience demonstrated that GERD may be managed considering a patient-centred work-up by using the GIS questionnaire. GIS score may be able to define the medication choice that includes also the new medical compound Marial®. PMID: 29687693 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient.
In conclusion, the current survey demonstrated that patients with GERD perceived a significant improvement of GERD symptoms measured by the RSI questionnaire. Marial® was as effective as PPI plus add-on. PMID: 29687694 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Correlation between the reflux finding score and the GERD impact scale in patients with gastroesophageal reflux disease.
Authors: Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G, EMERGE Study Group: A. Arrigoni, D. Artuso, M. Astegiano, C. Azzinnari, E. Battaglia, C. Belcari, E. Bendia, P. Benedicenti, M. Bianchetti, G. Brandimarte, I. Buoncompagni, M. Cabras, S. Camilleri, G. Capece, S. Caronna, C. Cassieri, F. Castaldo, T. Catalano, C. Citarella, F. D’Amore, G. D’Alia, F. D’Arpa, A. Dattola, N. De Bortoli, A. De Medici, S. Di Marzo, R. Di Mitri, A. Di Napoli, V. D’Onofrio, L. Dughera, W. Elisei, G. Errico, L. Familiari, P. Familiari, R. Frasca, A. Frunzio, M. Gatti, S. Genova, S. Grosso, R. Gullotta, D.R. ...
Source: Journal of Biological Regulators and Homeostatic Agents - April 26, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Etiological periodontal treatment with and without low-level laser therapy on IL-1 β level in gingival crevicular fluid: an in vivo multicentric pilot study.
Etiological periodontal treatment with and without low-level laser therapy on IL-1β level in gingival crevicular fluid: an in vivo multicentric pilot study. J Biol Regul Homeost Agents. 2018 Mar 26;32(2) Authors: Mastrangelo F, Dedola A, Cattoni F, Ferrini F, Bova F, Tatullo M, Gherlone E, Lo Muzio L Abstract Cytokine proteins may have important roles during different human physiological and pathological processes. In the oral cavity, the bone loss and periodontal tissue pathology was related to inflammatory process activation. The aim of the present study was to assess the effects of etiological ...
Source: Journal of Biological Regulators and Homeostatic Agents - March 27, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

IL-1 haplotype analysis in periodontal disease.
Authors: Ballini A, Cantore S, Dedola A, Santacroce L, Laino L, Cicciù M, Mastrangelo F Abstract Numerous studies have established statistical associations of the IL-1 gene cluster polymorphisms with various inflammatory diseases. Deriving from that, the present study was intended to determine whether single-nucleotide polymorphisms (SNPs) in these gene are also associated with periodontal disease in a Linkage disequilibrium analysis. This investigation also created two haplotype blocks, both consisting of two different SNPs. Recent theoretical analyses indicate that research with an interpretation of period...
Source: Journal of Biological Regulators and Homeostatic Agents - March 27, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

New scientific synergies to manage patients with severe Rhinitis: allergy diagnosis and treatment for ENT specialists.
Authors: Masieri S, Cavaliere C, Incorvaia C, Frati F Abstract INTRODUCTION: Allergic rhinitis (AR) is a global health problem because of its steadily increasing incidence and prevalence that currently concerns about 30% of the world’s population. Although AR is not a disease that reduces the life expectancy, it is a disorder with a major impact on the quality of life of patients, resulting from an impaired social life, school performance and work productivity. Furthermore, AR produces significant costs for its treatment. PMID: 29552865 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Human nasal immune system: a special site for immune response establishment.
Authors: Porzia A, Cavaliere C, Begvarfaj E, Masieri S, Mainiero F Abstract The mucosal immune system located in correspondence to the olfactory organs in adult humans is not well identifiable but has proven important in establishing an effective immune response against inhaled antigens, including the generation of Helper 1 (TH1)- and TH2-cells, cytotoxic T lymphocytes (CTLs), plasma cells (PCs) and memory B cells. It is constituted by a diffused network of cells of epithelial and immune origin, as well as organized lymphoid tissue, where each component has a role in the initiation and maintenance of a long-lasting...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Mechanisms of allergic diseases in Otorhinolaryngology.
Authors: Ridolo E, Martignago I, Masieri S Abstract Allergic Rhinitis (AR) is an IgE-mediated hypersensitivity disease caused by inhalation of an allergen to which the patients is sensitized. Etiopathogenesis of AR comprises a sensitization phase, an immediate phase and a late phase. In the sensitization phase, inhaled allergens are processed in peptides and come into contact with the nasal mucosa cells. Antigen-Presenting Cells (APCs), especially represented by Dendritic Cells (DCs), capture them through the interaction with their own MHC class II complexes and migrate to lymph nodes. Then, allergenic peptides are...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Pollens causing allergy and their monitoring by aerobiology and phenology.
Authors: Travaglini A, Masieri S, Cavaliere C, Brighetti MA Abstract Allergies caused by inhalant allergens, particularly pollens, are steadily increasing in urban centers. It is known that atmospheric pollution is strongly related to the inflammatory disease of the upper and lower airways but it is equally important in the development of sensitization towards pollens. Particulate Matter (PM), sulfur dioxide (SO2) and nitrogen dioxide (NO2) have an enhancement function on the persistence of pollens in the air, increasing the concentration and duration of pollinosis. It is therefore essential to use air quality cont...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

The skin prick test.
Authors: Frati F, Incorvaia C, Cavaliere C, Di Cara G, Marcucci F, Esposito S, Masieri S Abstract The skin prick test (SPT) is the most common test for the diagnosis of allergy. SPT is performed by pricking the skin, usually in the volar surface of the forearm, with a lancet through a drop of an allergen extract and is usually the first choice test in the diagnostic workup for allergic diseases because of its reliability, safety, convenience and low cost. SPT is minimally invasive and has the advantage of testing multiple allergens in 15 to 20 min. In children, SPT is far less disturbing than venipuncture and is us...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Laboratory tests for allergy diagnosis.
Authors: Savi E, Peveri S, Cavaliere C, Masieri S, Montagni M Abstract The introduction of highly purified natural and recombinant single allergenic molecules represented an important improvement in the diagnosis of IgE sensitization. The identification of specific IgE against cross-reacting molecules such as profilin, lipid transfer proteins, calcium binding proteins or against “genuine molecules”, represents an added value and allows to distinguish between true and false polysensitization. In vitro tests add information to recognize patients with sensitization to genuine molecules that cause allergic diseases a...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

ENT tests for assessing the allergic patient.
Authors: Cavaliere C, Rosati D, Messineo D, Masieri S Abstract Allergic rhinitis (AR) is a disease that afflicts a large percentage of the world population. It concerns both allergists and otolaryngologists, therefore it is important for both specialists to be aware of the characteristics of a patient who suffers from AR. Often, patients complain of nasal breathing difficulty only, initially not reporting any other symptoms typical of AR. In this brief review, the most important investigations, physical examination, nasal endoscopy, nasal peak flow and rhinomanometry, are described. All these investigations allow u...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Nasal cytology.
Authors: Gelardi M, Cavaliere C, Jannuzzi L Abstract Nasal cytology represents a useful, inexpensive and easy-to-apply diagnostic method to better detail the phenotypic characteristics of rhinitis. In fact, it allows to detect and quantify the cell population within the nasal mucosa at a given time. The technique involves sampling, processing and microscope reading. Sampling requires the collection of cells from the surface of nasal mucosa that is usually done by a sterile disposable curette. Samples should be collected from the middle portion of the inferior turbinate where the ratio ciliate/mucinous cells is expe...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Role of imaging in allergic rhinology.
Authors: Messineo D, Masieri S, Cavaliere C Abstract Rhinitis is an underestimated clinical condition, which has a considerable impact on the quality of life of the affected patients. The subject of this review focuses on three fundamental aspects: the development of knowledge concerning anatomic landmarks, the development of radiological imaging technology, and developments that can make a difference in the treatment of allergic rhinitis. The anatomical study of paranasal sinuses has been conducted since the time of the ancient Egyptians. Development of radiological equipment from the early 1900s has helped to imp...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Allergic conjunctivitis: current concepts on pathogenesis and management.
Authors: Sacchetti M, Abicca I, Bruscolini A, Cavaliere C, Nebbioso M, Lambiase A Abstract Allergic conjunctivitis (AC) includes a wide spectrum of clinical entities characterized by different incidence, age of onset, natural course, clinical outcome and response to treatment. Taken together, they represent one of the most frequent ocular surface diseases affecting more than 30% of the young-adult population and show an increasing incidence over the years. Moreover, comorbidities with other systemic atopic conditions such as asthma, atopic dermatitis and rhinitis require a multidisciplinary approach. Recent ...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Allergic rhinitis.
Authors: Incorvaia C, Cavaliere C, Frati F, Masieri S Abstract Allergic rhinitis (AR) was long considered a quite trivial disease, but the advance in epidemiological and clinical knowledge, with a major role for Allergic rhinitis and its Impact on Asthma (ARIA) initiative, substantially changed the scene. Now we know that AR has significant effects on patients’ quality of life and also has a relevant economic burden. The ARIA phenotypes related to the duration of symptoms and to the severity of AR are very useful in establishing the optimal strategy in each patient with AR, also according to the kind of allergens ...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Asthma associated to rhinitis.
Authors: Incorvaia C, Masieri S, Cavaliere C, Makri E, Sposato B, Frati F Abstract A large amount of data show that AR and asthma are associated both epidemiologically and clinically, introducing the definition of “united airway disease”. The mechanisms underlying such association were initially suggested to start from the nose, including the loss of the protective and homeostatic effects of nasal function, the activation of a naso-bronchial reflex and the spread of allergic inflammation from the nose to the lower airways. Later, other factors such as microbial stimuli and systemic inflammatory mechanisms, involv...
Source: Journal of Biological Regulators and Homeostatic Agents - March 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Is static friction affected by aging and amount of elastomeric ligatures in orthodontic sliding mechanics? An in-vitro investigation.
Is static friction affected by aging and amount of elastomeric ligatures in orthodontic sliding mechanics? An in-vitro investigation. J Biol Regul Homeost Agents. 2018 Mar 15;32(2 Suppl. 2): Authors: Portelli M, Lucchese A, Lo Giudice A, Militi A, Spinuzza P, Bellocchio AM, Nucera R, Croce S, Ghilardi G, Manuelli M Abstract In straight-wire mechanics, friction can significantly influence the forces expressed by wires. The aim of this study is to assess whether the aging and the sum of elastomeric ligatures affect the static friction during orthodontic space closure. A 0.017x 0.025-in SS was drawn throu...
Source: Journal of Biological Regulators and Homeostatic Agents - March 17, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Haematopoiesis: “living in the shadow” of stem cell differentiation.
Authors: Jankowski M, Dyszkiewicz-Konwińska M, Magas M, Skorupski M, Gorecki G, Bukowska D, Antosik P, Jeseta M, Bruska M, Nowicki M, Zabel M, Kempisty B Abstract Haematopoiesis is one of the most well understood stem-cell associated processes. It is a process in which pluripotent hematopoietic stem cells (HSCs) self-proliferate and differentiate into all types of blood cells. The process takes place in marrow of the flat bones in adults, however its location changes several times through embryonic and foetal development. Given the broad range of blood cells and the major differences in their build and function, t...
Source: Journal of Biological Regulators and Homeostatic Agents - March 6, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research