Brassinosteroid biosynthesis, stress resistance in plants, and application of brassinosteroids in plant biotechnology.
Authors: Ali MM, Zhang WP, Ihsan MA, Zafar H, Rauf QA, Akhtar MK Abstract Brassinosteroids (BRs) are newly discovered plant hormones that protect the plants from biotic and abiotic stress. Plants produce these hormones at all times, however, the quantity and location of their production vary. It has been demonstrated that BRs help the plants to regulate their response to stress conditions and make them more resistant to pest attack, extreme hot or cold environment, water scarcity, and salinity, among other types of stress. Manipulation of genes involved in the synthesis of BRs in different plants is a feasible stra...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Correlation between rheumatoid arthritis and immunological changes in a rheumatoid arthritis rat model.
This study aimed to investigate the characteristics of the immunological profile of the cells of the synovial membrane and the expression of IL-10 and IL-17 in a rheumatoid arthritis rat model in order to provide a targetdirected treatment for immunological control. Eighty female Wistar rats were randomly divided into a rheumatic arthritis model group (model group) and a control group, 40 animals per group. After the successful rheumatoid arthritis rat model was obtained, 10 animals were sacrificed from each group every week starting from the third week till the sixth week and the expression levels of CD3, CD21, and CD68 i...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

miR-200b promotes cell proliferation and invasion in t-cell acute Lymphoblastic leukemia through NOTCH1.
In this study, we evaluated the impact of miR-200b in T-ALL cell proliferation, survival and invasion using gain and loss of function approaches. Human Jurkat cells, a widely used in-vitro T-ALL cell model, were transfected with miR-200b mimic or miR-200b inhibitor. miR-200b mimics substantially inhibited Jurkat cell proliferation and invasion while significantly stimulating cell apoptosis compared to the control miRNA-treated cells. In contrast, Jurkat cells treated with anti-miR200 demonstrated induction of cell growth and invasion but repression of cell apoptosis. Such effect was accompanied by the corresponding alterat...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Carbon monoxide modulates melatonin synthesis in porcine pineal Cells in vitro: a preliminary study.
Authors: Romerowicz-Misielak M, Dzięgielewska-Gęsiak S, Koziorowska A, Kusak O, Górka A, Broda D, Waszkiewicz EM, Koziorowski M Abstract Two main isoforms of heme oxygenase (HO-1 and HO-2), the main enzyme of heme metabolism, were identified in the pineal gland. This suggests possible interactions between the melatonin synthesis pathway and the HO system. The aim of this study was to investigate the participation of carbon monoxide (CO), an HO by-product, on the melatonin synthesis pathway. Tests were carried using primary cell cultures of porcine pineal glands. The tricarbonyldichlororuthenium (II) dimer ...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Influence of serum HMGB1 level on the incidence of respiratory Distress syndrome in neonates.
In conclusion, the level of HMGB1 in the sera of newborns can better predict the occurrence and death of NRDS, and can therefore be considered as a marker for its diagnosis, evaluation and prognosis. PMID: 30574754 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effect of propranolol on proliferation and apoptosis of hemangioma endothelial cells in infants and young children.
In conclusion, the level of HMGB1 in the sera of newborns can better predict the occurrence and death of NRDS, and can therefore be considered as a marker for its diagnosis, evaluation and prognosis. PMID: 30574755 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Supplementation with L-arginine affects its metabolizing pathways in rat liver subjected to bile duct ligation.
This study was conducted in order to contribute to the understanding of the enrolment of L-arginine supplementation in cholestatic liver function. This was carried out by estimation of serum and liver tissue arginase activity, along with liver tissue citrulline, nitric oxide (NO) and polyamine concentrations. Rats subjected to BDL were treated for nine days with L-arginine (150 mg/kg) or remained without any treatment. Animals from two control groups were either subjected to medial laparotomy (sham/opened group) or were without any surgical treatment and received only L-arginine. Application of L-arginine prevented a signi...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Continuous nursing intervention on recovery of diabetic patients.
Authors: Chi S, Liu JL, Kang HC, Lv DM Abstract The aim of this study was to probe the influence of continuous nursing intervention on recovery of diabetic patients. From October 2016 to June 2017, 80 diabetic patients who received treatment in our hospital were selected and randomly divided into an intervention group and a control group. The intervention group received continuous nursing care including indirect follow-up, health education and home visit. The self-care ability and blood sugar of the two groups were compared three months later. The score of self-care ability in the intervention group was 89.64&plusm...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Contributions of VSX1 gene to keratoconus.
Authors: Kalasidou G, Frydas I, Kozei A, Syrmakesi P, Loukovitis E, Sfakianakis K, Balidis M, Zachariadis Z, Tranos P, Kozeis N, Anogeianakis G Abstract Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial degenerative corneal disorder, with incidence of approximately 1 per 2000 of the population. KC follows an autosomal recessive or dominant pattern of inheritance and is, apparently, associated with genes which interact with environmental, genetic and/or other factors. The present report focuses on the VSX1 gene, for which there is general agreement that it is involved in KC and other corneal p...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

The p75 neurotrophin receptor in cells of oral mucosal epithelium.
Authors: Bryja A, Jankowski M, Dyszkiewicz-Konwińska M, Piotrowska-Kempisty H, Antosik P, Bukowska D, Bruska M, Nowicki M, Kempisty B Abstract The p75 neurotrophin receptor (p75NTR) can play different roles in cells. This protein can on the one hand act in the regulation of cell growth and survival, while being an apoptosis inducing factor in different contexts. p75NTR regulates cell cycle not only in nerve cells but also in epithelial oral mucosal cells. In the former, neurotrophin-p75NTR signaling affects cell growth and survival. Recent studies showed that p75NTR is expressed in basal cells of oral mucosal epit...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Correlation between SPARC, TGF β1, Endoglin and angiogenesis mechanism in lung cancer.
Correlation between SPARC, TGFβ1, Endoglin and angiogenesis mechanism in lung cancer. J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6):1525-1531 Authors: Wang B, Zhang Z, Tang J, Tao H, Zhang Z Abstract To study the relationship between Secreted protein, acidic and rich in cysteine (SPARC), Transforming growth factorβ1 (TGFβ1), Endoglin and angiogenesis in lung cancer, 40 cases of lung cancer specimens and 40 adjacent normal lung tissues specimens were collected and 10 cases from each were selected for preparation of tissue chip. CD34 (endothelial cell marker), Endoglin human α-Smoo...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Comparative assessment of atherosclerosis of rabbit femoral artery by Duplex Ultrasound Scanning, Optical Coherence Tomography and Fractional Flow Reserve.
In conclusion, hemodynamic significance of lesions assessed by FFR was only related with percent diameter stenosis measured by DUS. PMID: 30574761 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Correlation of hypertension and F2RL3 gene methylation with Prognosis of coronary heart disease.
In conclusion, the methylation of F2RL3 can affect the prognosis of different types of acute coronary syndrome and is closely related to mortality. PMID: 30574762 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Efficacy of commercial vaccines against the prevalent strains of Newcastle disease and avian influenza (h9n2) infections in broilers in Pakistan.
Authors: Irshad I, Aslam A, Tipu MY, Ashraf K Abstract TThe efficacy of the two commonly used commercial vaccines for Newcastle disease (ND) and low path avian influenza (LPAI) H9N2 were evaluated against field virus in broiler chicks. One hundred one-dayold commercial broiler chicks were divided into four groups (A to D) with an equal number of birds per group. Group A and B were vaccinated against H9N2 and NDV, respectively, at day 7 of age while group C served as positive infected control for H9N2 and group D for NDV. Serum samples from birds in all groups were tested for presence of antibodies against H9N2 and ...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Electrospun probiotics: an alternative for encapsulation.
Authors: Akbar Z, Zahoor T, Huma N, Jamil A, Ayesha H, Kumar Irudayaraj JM Abstract Electrospinning has emerged as a potential method to fabricate nonwoven nanofibers. It has application in different fields of biomedicine as it has potential to carry antimicrobial and bioactive agents. The present investigation was conducted to optimize the process conditions and determine the viability of probiotics after being electrospun in fibers. Poly(vinyl alcohol) (PVA) was utilized as electrospun material because it possesses generally recognized as safe (GRAS) status and in dry form it acts as a high oxygen barrier and has...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Pedicled palatal flap for surgical repair of oro-nasal fistula.
Authors: Rauso R, Tartaro G, Califano L, Rugge L, Chirico F, Colella G Abstract Oronasal fistula can occur secondary to various pathologies, but cleft surgery is the most common. The authors propose a pedicled palatal flap technique for surgical repair of small oronasal fistula (0.5-0.8 cm), derived from their experience in the treatment of 7 patients between March 2003 and December 2007. In one case, the fistula was induced by prolonged snorting of cocaine. In the other cases, the fistulas developed after excision of a benign tumor of the palate. For the cocaine-induced fistula, failure of the repair attempt was a...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Percutaneous headless screws and wide-awake anesthesia to fix metacarpal and phalangeal fractures: outcomes of the first 56 cases.
Authors: Nucci AM, Del Chiaro A, Addevico F, Raspanti A, Poggetti A Abstract Phalangeal (P) and metacarpal (MC) fractures are very common injuries, with potentially disabling, residual impairment, deformities or stiffness. Conservative treatment represents the strategy of choice in most cases, but in unstable fractures and/or high-demanding patients, surgical fixation could be required. Ideally, the best treatment choice will be the intramedullary fixation systems, if possible without the implant protruding from the skin. Intramedullary headless screw fixation could be the reliable option to achieve a primary fixat...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Assessment of nutritional status and therapy in emergency Medicine settings.
Authors: Giorgetti GM, De Toma P, Di Pietro E, Khazrai YM, Fabiocchi F, Trotta MC, Mirante E, Barletta P, Castaldo E, Elisei W, Picchio M, Tursi A Abstract Hospital malnutrition is becoming a clinical concern. Our aim was to determine the prevalence of hospital malnutrition through Nutritional Risk Screening 2002 (NRS) and to evaluate nutritional risk through a prospective study. Nutritional status was assessed collecting anthropometric parameters together with the data relating to the diseases in the medical records of patients admitted to the Department of Emergency Medicine of the "Sant'Eugenio" Hospit...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Additive manufacturing and biomimetic materials in oral and maxillofacial surgery: a topical overview.
In conclusion, new biomaterials are increasingly being studied as possible therapeutic remedies. Advances in tissue engineering are leading to the development of new scaffolds useful for bone regeneration and therefore potentially valid for applications in maxillofacial surgery. PMID: 30574768 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effect of self-adjusting file and WaveOne reciprocating file on the filling ability of oval-shaped canals with thermoplasticized gutta-percha.
Authors: Generali L, Cavani F, Righi E, Murri Dello Diago A, Spinas E, Giannetti L Abstract The aim of the study was to compare the effect of Self-Adjusting Files (SAF) and WaveOne Primary file with syringe and needle irrigation on the filling ability of oval-shaped root canals obturated with thermoplasticized gutta-percha. Twenty-four single root teeth with single oval-shaped root canals were distributed into two experimental homogeneous groups. One group was instrumented and cleansed using the SAF system while in the other group the WaveOne system with syringe and needle irrigation was used. After instrumentation...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A novel technique to prevent sinus membrane collapse during maxillary sinus floor augmentation without bone graft: technical note.
Authors: Scarano A, Murmura G, Mastrangelo F, Lorusso F, Greco Lucchina A, Carinci F Abstract Different surgical techniques have been developed to reconstruct the posterior maxilla without bone graft. A barrier membrane usually placed internal to the sinus, without stabilizer or bone window, pushed inside the sinus cavity as the ''roof'' of the sinus cavity to preserve the space and help bone regeneration has been used with success. In the present technical report, the heterologous cortical lamina is used for the mechanical support of sinus membranes. The membrane is placed through two lines of 2-3 mm, mesial and d...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Efficacy of a combined sea salt-based oral rinse with xylitol against dental plaque, gingivitis, and salivary Streptococcus mutans load.
Authors: Cantore S, Ballini A, Saini R, De Vito D, Altini V, Saini SR, Pustina-Krasniqi T, Xhajanka E, Gargiulo Isacco C, Dipalma G, Inchingolo F Abstract the succession of dental plaque development can lead to serious complications, such as caries, gingivitis, and periodontitis. The control of dental plaque on tooth surfaces is vital for the prevention of dental plaque related diseases. In this context, antimicrobial agents may serve as a valuable complement to mechanical plaque removal. Therefore the present study was aimed to evaluate the action of a combined rinsing solution containing different antimicrobials ...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Serum 25-hydroxy vitamin D levels in essential hypertension.
Authors: Granato T, Anastasi E, Viggiani V, Occhiuzzi F, Angeloni A, Gradini R, Suppa M Abstract Vitamin D may have prognostic value in hypertension patients and, in addition to conventional biomarkers, could be a valuable tool for disease management. The aim of this study was to assess the association of vitamin D status in patients with essential hypertension and to evaluate its prognostic utility. Forty-eight consecutive patients (40 Caucasian and 8 Asian) aged between 30 and 80 years (mean 61.5, range 34-84 years), were enrolled in the study. The main exclusion criteria were age less than 18 years, kidney failu...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Spider Zygoma: a new implant rehabilitation technique for atrophic maxilla.
We present a new minimally-invasive approach, called "Spider Zygoma", consisting of implant-supported prosthesis with the addition of customized maxillofacial plates and screws on surface of zygomatic bone. A 3D-model of the edentulous upper jaw was used as preoperative model. Two customized bone plates were created and used as guide for placement of implants and zygomatic screws. Although this is only a pilot study, this new surgical technique seems to be safe and accurate, confirmed by the maintenance of good aesthetic and functional results after 5-year follow-up. PMID: 30574773 [PubMed - in process] (Sour...
Source: Journal of Biological Regulators and Homeostatic Agents - December 25, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Analysis of changes in hepatic gene expression and tissue architecture of heart and kidney in association with diet-induced obesity in Rattus norvegicus.
Authors: Batool T, Akhtar T, Asghar A, Khawar MB, Sheikh N Abstract Obesity is an epidemic issue associated with low-grade inflammation and in most of the cases with poor iron condition that influences nearly every community. The present research experiment was designed to inspect the consequences of obesity on the micro architecture of heart and kidney tissues as well as on the expression of mRNA of some hepatic genes like Hepcidin, Transferrin and TNF-α in association with their role in iron regulation and proinflammatory responses in the body. Two tentative groups of Rattus norvegicus (each supplied with d...
Source: Journal of Biological Regulators and Homeostatic Agents - December 19, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Short-term effects of a dietary supplement on lower urinary tract symptoms.
Authors: Cosentino V, Militello A, Lauria G Abstract Benign prostatic hyperplasia (BPH) is one of the most common conditions affecting men over 40 years of age, typically manifesting itself with lower urinary tract symptoms (LUTS). Recently, research interest has focused in discovering a viable nutraceutical alternative to the drugs that are currently the first line of treatment for BPH. The aim of this study was to investigate the efficacy and safety of a dietary supplement containing curcumin, beta-sitosterol and oligomeric proanthocyanidins in a group of BPH/LUTS patients. One-hundred men with LUTS caused by BPH...
Source: Journal of Biological Regulators and Homeostatic Agents - December 8, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Differential expression of CYP2j2 gene and protein in Camelus dromedarius.
This study is considered the first report investigating the differential expression profiles of the CYP2J2 mRNA and protein in the liver, heart, and kidney of Camelus dromedarius. A total of 30 samples were used to determine the expression of both CYP2J2 mRNA and protein using qRT-PCR and western blotting methods, respectively. The mRNA level of CYP2J2 was significantly elevated in the liver compared to that in the heart and kidney. The tissue distribution of the CYP2J2 protein was coherent to its transcript level in the kidney, but not in the liver and heart samples. The difference between the CYP2J2 mRNA and protein dist...
Source: Journal of Biological Regulators and Homeostatic Agents - November 2, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Role of macrophages in the pathogenesis of atherosclerosis and aortocoronary graft disease.
Authors: Perek B, Kowalska K, Kempisty B, Nowicki A, Jankowski M, Nawrocki MJ, Malińska A Abstract Atherosclerosis and disease of graft implanted to bypass occluded coronary or peripheral arteries are similar processes. Patency of implanted grafts is of paramount importance in respect to long-term outcomes. Although few cell types participate in atherosclerotic plaque formation, macrophages play a crucial role. In this article we review the fate of monocytes that infiltrate vessel wall following endothelium damage, and then undergo transformation to macrophages (identified as CD68 positive cells) and eventually le...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

IL-33 mediates allergy through mast cell activation: Potential inhibitory effect of certain cytokines.
Authors: Tettamanti L, Kritas SK, Gallenga CE, D'Ovidio C, Mastrangelo F, Ronconi G, Caraffa A, Toniato E, Conti P Abstract Mast cells (MCs) are hematopoietic immune cells commonly found in adjacent to blood vessels in the lamina propria of airway mucosa. They are important in allergic reactions since the cross-linking of their surface high affinity receptor FceRI induces activation of these cells, and provokes the synthesis, degranulation and release of inflammatory mediators including arachidonic acid-derived eicosanoids (de novo synthesized), stored enzyme mediators, and inflammatory TH1 and TH2 cytokines, and c...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Balance between epithelial and stromal marker expression and distribution in primary culture model of porcine endometrium during real-time cell proliferation..
In this study, we used molecular analysis techniques, such as RT-qPCR and immunocytochemistry, to analyze the expression and distribution of cytokeratin 18 and panCytokeratins 8, 18 and 19 and vimentin in porcine luminal endometrial epithelial cells, coupled with analysis of their behavior in RTCA. The results have confirmed the presence of epithelial, as well as stromal cell markers in the cells, varying in levels at different stages of culture. They have also given insight into the modes of proliferation and differentiation of studied cells in in vitro culture, as well as providing additional proof for the possible mesen...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Azithromycin influences airway remodeling in asthma via the PI3K/Akt/MTOR/HIF-1 α/VEGF pathway.
In this study, we investigated the protective effect of azithromycin on airway remodeling through the phosphoinositol-3 kinase/Akt/mechanistic target of rapamycin kinase/hypoxia-inducible factor 1α (HIF-1α)/vascular endothelial growth factor (VEGF) pathway. We observed that a long course of azithromycin could significantly reduce airway reactivity and ovalbulmin-induced pathological alterations in asthmatic mice. Gene expression analysis confirmed that HIF-1α and VEGF were significantly down-regulated following a long course of azithromycin administration. PMID: 30334401 [PubMed - in process] (Source:...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Enzyme linked receptor protein signaling pathway is one of the ontology groups that are highly up-regulated in porcine oocytes before in vitro maturation.
Authors: Borys S, Brązert M, Jankowski M, Kocherova I, Ożegowska K, Celichowski P, Nawrocki MJ, Kranc W, Bryja A, Kulus M, Jeseta M, Pieńkowski W, Bręborowicz A, Bukowska D, Antosik P, Pawelczyk L, Skowroński MT, Brüssow KP, Bruska M, Zabel M, Nowicki M, Kempisty B Abstract Before being able to fully participate in the processes associated with its function as a female gamete, the oocyte needs to undergo a range of changes to achieve its mature form. These morphological, biochemical and metabolomic processes are induced by the somatic tissues surrounding the oocyte, through the expression of specific tran...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Expression of IL-17A, E, and F and their receptors in non-small-cell lung cancer.
In this study, we systematically analysed immunoreactivity for IL-17A, IL-17E and IL-17F and their relevant receptors in the lung sections from non-small cell lung cancer (NSCLC) and normal control. Immunoreactivity for IL-17A, IL-17F, IL-17RA and IL- 17RC, but not IL-17RB was significantly elevated in NSCLC compared with controls, while IL-17E was reduced. The median numbers of infiltrating lymphocytes and neutrophils and global macrophage (CD68) immunoreactivity of phagocytes were also elevated in NSCLC compared with control tissue sections. Furthermore, correlation between the expression of IL-17A and its receptors IL-1...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Cross-talk between apelin and vasopressin in response to different osmotic stimuli in type 2 diabetic rats.
This study aims to investigate the interaction between apelin and AVP in osmotic regulation in type 2 diabetes mellitus (T2DM), and to explore the underlying mechanism. Forty-eight adult male albino rats were divided into six groups: control (isotonic, ip 0.9% NaCl; hypotonic, ip distilled water; hypertonic, ip 2% NaCl) groups and T2DM (isotonic, hypotonic, hypertonic) groups. Serum levels of AVP, apelin, Na, glucose, serum and urine osmolarity were measured; kidney samples were taken for Aquaporin 2 channels (AQP2) and epithelial sodium channel gamma subunit (ENaCγ) gene expression. Hypothalamic tissue sections were...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Genes involved in regulation of cellular metabolic processes, signaling and adhesion are the markers of porcine buccal pouch mucosal cells long-term primary cultured in vitro.
In this study we analysed a complete transcriptome of long-term in vitro cultures of porcine buccal pouch oral mucosa cells. Using a microarray approach, we focused on genes associated with cellular metabolic processes, signalling and adhesion, from 4 gene ontology groups: "Positive regulation of cellular component movement", "Positive regulation of cellular process", "Positive regulation of intracellular signal transduction" and "Single organism cell adhesion". Nineteen genes (CCL8, CXCL2, PLK2, DUSP5, PTGS2, LIF, CCL2, ATP1B1, REL, ITGB3, SCARB1, UGCG, PDPN, LYN, ETS1, FCER1G, TGFB...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Xuebijing enhances neuroprotective effects of ulinastatin on transient cerebral ischemia via Nrf2-are signal pathways in the hippocampus.
Authors: Hu HX, Zhu MQ, Sun YC, Ma C, Wang X, Liu XL Abstract Prior studies have demonstrated that ulinastatin (UTI) plays a beneficial role in regulating cerebral ischemic injury evoked by cardiac arrest (CA). It is noteworthy to find interventions that can enhance effects of this drug and thereby increase its clinical application. Xuebijing (XBJ) is comprised of extracts from Chinese herbs and has been widely used in China as an anti-endotoxicity drug for the treatment of sepsis and ischemic disorders associated with multiple organ dysfunction syndrome. Thus, in this study we examined the effects of a combination...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of female sex hormones on chemotherapeutic paclitaxel-induced neuropathic pain and involvement of inflammatory signal.
Authors: Wang YC, Li N, Zhao Y, Zhang LJ Abstract Paclitaxel is used for the treatment of several types of cancers. However, one of its significant limiting complications is painful peripheral neuropathy during therapy. Gender is considered to play a role in modifying pain intensity. The present study examined the effects of female sex hormones on paclitaxel-induced neuropathic pain and the engagement of inflammatory signal of sensory nerves. Ovariectomies were performed on rats and subsequent hormone replacement with the combination of 17β-estradiol and progesterone was given. ELISA was used to determine the ...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Detection of serum procalcitonin and hypersensitive C-reactive protein in patients with pneumonia and sepsis.
Authors: Liu GB, Cui XQ, Wang ZB, Wen L, Duan HL Abstract Sepsis, a systemic inflammatory response syndrome induced by infection, has high rates of morbidity and mortality. Pneumonia is a major cause for sepsis; however, pneumonia complicated by sepsis is a difficult clinical diagnosis. To assess the clinical relevance of serum procalcitonin (PCT) and hypersensitive C-reactive protein (hs-CRP) in early diagnosis of pneumonia complicated by sepsis, 220 patients with pneumonia who were admitted to hospital from July 2015 to July 2016 were enrolled in this study. The patients were divided into non-sepsis (N=82), mild ...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

GLP-1, a powerful physiological incretin: an update.
Authors: Malik J, Roohi N Abstract Food intake, especially carbohydrates, release incretin, which is an endocrine transmitter. Among the various endocrine modulators, Glucagon-like peptide 1 (GLP-1) is more effective in stimulating the release of insulin and more powerful regulator of physiological functions. Mainly (GLP-1) receptors are expressed in lungs, α and β cells of pancreatic islets and the nervous system. Peripheral tissues, gastrointestinal tract and extra pancreatic tissues i.e., vascular smooth muscle, kidney and heart, also contain high affinity receptors for GLP-1. The aim of this systemat...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effect of nerve root block guided by ultrasound on cervicogenic pain and its influence on immune function.
This study aimed to observe the effect of ultrasound-guided nerve root block in the treatment of cervicogenic pain and its influence on immune function. A total of 30 patients (group A) with cervical discogenic pain (CDP) were treated by selective cervical nerve root block and 30 patients (group B) with CDP were treated with cervical spinal block under the X-ray C-arm guidance. The two groups of patients were examined with regard to the analgesic effect by Numerical Rating Scale (NRS), and the changes in the preoperative and postoperative range of motion in the neck (ROM). In addition, weekly pain attacks and the duration ...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis.
In conclusion, we demonstrated that expression of PIG3 is frequently reduced in GC tissue, and PIG3 suppressed human GC growth through p53- mediated apoptosis. PIG3 may act as a potential diagnostic marker and a potential therapeutic target of GC. PMID: 30334411 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Phylogeny and comparative modeling of phytochelatin synthase from Chlorella sp. as an efficient bioagent for detoxification of heavy metals.
In this study, a phylogram was generated to study evolutionary relationships of PCS from various organisms. It was revealed that PCS from green algae and plants are orthologs as both have evolved from a common ancestor. PCS from cyanobacteria appeared in two different clades showing that they have followed different lineages during evolution. Structural modeling was also carried out by building a 3D model of PCS from Chlorella variabilis using software Modeller v9.16. The predicted structure will be helpful for protein engineering strategies and to understand its interactions with other proteins. The biological biosorption...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

High sensitivity C-reactive protein as a cardiovascular risk marker in independent community-living elderly persons.
Authors: Płóciniczak A, Dzięgielewska-Gęsiak S, Brożek A, Blacha A, Nowicki M, Formanowicz D Abstract An alarming fact is that increasing numbers of cardiovascular disease (CVD) events occur more often among elderly individuals without previous occurrence of CVD. There are numerous modifiable risk factors such as dyslipidemia,-and inflammatory markers, as well as cardiovascular events risk charts, in the identification and prevention of cardiovascular morbidity and mortality among elderly population. Thus, the aim of this study was to analyze some CVD risk factors as well as international CVD risk charts...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Changes in electrolytes and uric acid excretion during and after a 100 km run.
Authors: Wołyniec W, Ratkowski W, Kasprowicz K, Małgorzewicz S, Aleksandrowicz E, Witek K, Grzywacz T, Żmijewski P, Renke M Abstract Physical activity leads to changes in water and electrolyte homeostasis and to enhanced purine metabolism. The typical abnormalities observed after exercise are hyperkaliemia, hyper- or hyponatremia and hyperuricemia. The possible explanations of hyperuricemia are: increased metabolism and decreased elimination of uric acid. Changes in uric acid excretion are commonly observed in disturbances of sodium and water homeostasis. The aim of this study was to evaluate changes in electrol...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Tumor potential in rat wounds after short- and long-term administration of platelet-rich plasma: an update.
Authors: Spartalis E, Tsilimigras DI, Ntanasis-Stathopoulos I, Spartalis M, Moris D Abstract Comment on: Omar NN, et al. Tumor potential in rat wounds after short- and long-term administration of platelet-rich plasma. J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):889-899. Platelet-Rich Plasma (PRP) is a promising concentrate. But are there any disadvantages or contraindications regarding its application? Is the use of PRP indicated in wounds of patients undergoing resection for cancer. The presence of growth factors could promote tumor proliferation and recurrence. It is of the utmost importance to recognize any ...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Artemisinin ameliorates the symptoms of experimental autoimmune myasthenia gravis by regulating the balance of TH1 cells, TH17 cells and Treg cells.
Authors: Chen W, Li FF, Li C, Sui JK, Meng QF, Li XL, Li H, Li CH, Li YB Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by fatigue and muscle weakness. Artemisinin and its derivatives were reported to be experimentally used to treat autoimmune diseases, such as systemic lupus erythematosus (SLE) and experimental allergic encephalomyelitis (EAE). Here, we tested the effects of artemisinin on experimental autoimmune myasthenia gravis (EAMG). Our data confirmed that artemisinin markedly ameliorated the symptoms of EAMG rats. There was a decreased level of tumor necrosis factor-α (TNF-&alp...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of different degrees of depression on inflammatory response and immune function in patients with ovarian cancer.
Authors: Su JP, Liu HF, Zhang HL, He YJ, Nie Y Abstract The aim of this study was to explore the effect of depression of different degrees on inflammatory response and immune function in patients with ovarian cancer. One hundred and eight cases of ovarian cancer according to the Federation Internationale of Gynecologie and Obstetrigue (FIGO) stage II~III who visited the Gynecology Department of Affiliated HongQi Hospital of MuDanJiang Medical University between September 2015 and May 2017 were enrolled in the study. After being hospitalized, they were divided into two groups according to their Beck Depression Inven...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Relationship between sleep disorders and lymphocyte subsets and cytokines in patients with lung cancer.
In conclusion, monitoring of T-lymphocyte subsets and IL-6 levels in patients is enhanced during radiotherapy. Clinically effective programs of radiotherapy for lung cancer improve the body's immune status. PMID: 30334418 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Treatment mechanism of tolerogenic dendritic cells on rheumatoid arthritis.
This study aims to explore the possible mechanism of treatment of collagen-induced rheumatoid arthritis (RA) by tolerogenic dendritic cells (tDCs). Different methods were used to induce and cultivate tDCs, and suitable conditions for tDC cultivation were explored. The experimental RA induced by collagen in mouse was treated by the obtained tDCs, and the possible mechanism was explored. The serum concentration of TNF-α, IFN-β, IL-4 and anti-type II collagen antibody were detected by ELISA. The anti-type II collagen antibody of mice without treatment was higher than that without disease onset, while the Blank-DC g...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Vitamin D receptor gene polymorphisms and prostate cancer.
Authors: Braczkowski RS, Kwiatkowski R, Danikiewicz A, Górczyńska-Kosiorz S, Trautsolt W, Braczkowska B, Grzeszczak W Abstract Prostate cancer (PC) is the most common cancer among men worldwide and its pathogenesis is complex. The development of PC depends on family and environmental factors. Vitamin D can be associated with both of these factors. Its reduced serum concentration has been reported in a number of tumors. However, in the case of PC, the study results are conflicting. Polymorphism of VDR gene may also be involved in the development of this cancer. The aim of the study was to compare the frequen...
Source: Journal of Biological Regulators and Homeostatic Agents - October 20, 2018 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research