Scanning electron, 3D-confocal and stereotactic microscopies morpho-structural analysis of antibiotic-loaded cement porosity in three different formulations.
Authors: Fenga D, Vermiglio G, Traina F, Favaloro A, Rosa MA Abstract Chronic osteoarticular infections such as osteomyelitis or periprosthetic joint infection (PJI) have become a growing problem over the years. The “gold standard” in local antibiotic administration is still the antibiotic-loaded acrylic bone cement (ALABC) which is used in both prophylaxis, because it has been shown it can reduce the risk of infection and used in therapy during a “two-stage surgery” in PJI or in chronic osteomyelitis. We performed morphological analysis of three different formulations of antibiotic-loaded c...
Source: Journal of Biological Regulators and Homeostatic Agents - December 2, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Posterolateral bundle reconstruction of the anterior cruciate ligament to restore rotational stability of the knee.
Authors: Vadalà G, Petrillo S, Buschini F, Papalia R, Denaro V Abstract Only 5-10% of partial tears of the anterior cruciate ligament (ACL) are symptomatic, especially in high demand individuals or in patients practicing sports requiring rotational motions.. A certain preoperative diagnosis of this condition is challenging and often needs the combination of clinical examination, magnetic resonance imaging (MRI) and knee-laxity tool measurements. However, the arthroscopic examination of the torn ACL bundle is the most important factor in decision-making. Evidence in various studies have shown that the preserv...
Source: Journal of Biological Regulators and Homeostatic Agents - December 2, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A new surgical positioning system for robotic assisted minimally invasive spine surgery and transpedicular approach to the disc.
Authors: Vadalà G, Accoto D, Russo F, Portaccio I, Rossini M, Valentini S, Papalia R, Denaro V Abstract Minimally Invasive Spine Surgery (MISS) procedures for the treatment of spinal pathologies have experienced exponential growth due to improved techniques and decreased trauma to the patient. Several MISS procedures that require the use of a trans-pedicular cannula as a guiding tool for pedicle screw placement, delivery of biomaterials to the vertebral body or injection of biologics to the disc space have been described. Although these are clear advantages of MISS, the limited dissection and exposure may re...
Source: Journal of Biological Regulators and Homeostatic Agents - December 2, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Biomaterials as bone graft substitutes for spine surgery: from preclinical results to clinical study.
This study aims to evaluate the efficacy of the ceramic biomaterial SintLife® putty for bone replacement in patients treated by posterolateral fusion for degenerative spine disorders. HA biomaterials were effective in promoting the in vitro growth of hMSCs and their osteogenic differentiation. In the animal model, SintLife® putty has been effective in generating neo-formed bone tissue with morphological and structural features similar to those of the pre-existing bone. The post-market surveillance analysis has not reported any intra-operative nor early or late post-operative adverse events. Seven patients are curre...
Source: Journal of Biological Regulators and Homeostatic Agents - December 2, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Targeted muscle reinnervation for improved control of myoelectric upper limb prostheses.
Authors: Vadalà G, Di Pino G, Ambrosio L, Diaz Balzani L, Denaro V Abstract Targeted muscle reinnervation (TMR) is a novel surgical technique developed to improve the control of myoelectric upper limb prostheses. Nerves transected by the amputation, which retain their original motor pathways even after being severed, are redirected to residual denervated muscles that serve as target for consequent reinnervation. Once the process is complete, reinnervated muscles will contract upon voluntary activation of transferred nerves while attempting to move missing regions of the amputated limb, generating EMG signals...
Source: Journal of Biological Regulators and Homeostatic Agents - December 2, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

The effect of anti-IgE therapy in knee osteoarthritis: a pilot observational study.
Authors: Aquili A, Farinelli L, Bottegoni C, Antonicelli L, Gigante A Abstract Osteoarthritis is a whole-joint disease and its pathogenesis remains poorly understood. Recent evidence proposed the importance of the innate immune system as trigger of synovium inflammation following the degeneration of cartilage. Moreover, synovial mast cells (MCs) might be correlated with pain and disability reported by patients. Anti IgE therapy represents a new class of MCs stabilizing agent, licensed for people with asthma and chronic urticaria. Therefore, we studied if the stabilizing effect of anti IgE would improve the pain and...
Source: Journal of Biological Regulators and Homeostatic Agents - November 29, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Clinical and radiographic short mid-term outcomes of primary total stabilizer knee arthroplasty.
Authors: Bonicoli E, Piolanti N, Giuntoli M, Polloni S, Ciapini G, Parchi PD, Scaglione M Abstract A successful Total Knee Arthroplasty (TKA) requires stability, but rarely in primary TKA, a prosthesis with more constraint than a posterior-stabilizer (PS) is necessary. In patients with severe varus/valgus deformities with incompetent collateral ligaments or in knees that cannot be adequately balanced after ligaments release, a total-stabilizer (TS) prosthesis may be required. The purpose of our retrospective study is to evaluate clinical and radiographic outcomes at short mid-term follow-up in patients treated with...
Source: Journal of Biological Regulators and Homeostatic Agents - November 29, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A systematic review on delayed absorption of subretinal fluid after scleral buckling for rhegmatogenous retinal detachment.
Authors: Fu JL, Shi G, Liu ZX, Su GF, Kang ZC Abstract Rhegmatogenous retinal detachment is a vision-threatening disease and is treated by either scleral buckling or pars planar vitrectomy. Rapid absorption of the subretinal fluid (SRF) helps in the early recovery of the vision. The absorption of SRF after the scleral buckling procedure is rapid, provided that the retinal break or breaks are closed at or after surgery. However, in some patients with rhegmatogenous retinal detachment, complete absorption of the SRF occur several weeks or months after the surgery. In this review, we discuss the factors influencing th...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Autophagy inhibition increased the anti-tumor effect of cisplatin on drug-resistant esophageal cancer cells.
This study was designed to observe the effect autophagy has on the occurrence of esophageal cancer cell drug resistance against cisplatin and investigate its molecular mechanism in order to provide new details and strategies for the clinical treatment of esophageal cancer, especially cisplatin treatment. The detection methods used in this study were 3-(4,5-dimethylthiazd-2-yl)-2,5-dipheny-ltetrazolium bromide (MTT) colorimetric assay, clone survival technique, small interfering RNA (siRNA) transfection, and Western blot. Autophagy is a protection mechanism of drug-resistant cells processed by cisplatin, and maintains the c...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Sibelium in combination with dibazole in the treatment of angioneurotic headache.
Authors: Liu LL, Li X, Chang G, Wang ZG, Zhang SJ, Ju XN Abstract Angioneurotic headache is a common nerve headache featured by intermittence, repetition, paroxysm and aggravation, which can severely affect the sufferer’s quality of life. Currently, there are multiple drugs which can be used for relieving this type of headache, and the effectiveness and safety of drugs have been a subject of interest in clinical practice. To observe the effects of sibelium in combination with dibazole and offer a basis for the clinical treatment, 136 patients with angioneurotic headache who were admitted to hospital between F...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Evolving safety practices in the setting of modern complex operating room: role of nurses.
Authors: Niu L, Li HY, Tang W, Gong S, Zhang LJ Abstract Operating room (OR) nursing previously referred to patient care provided during the intra-operative phase and the service provided within the OR itself. With the expansion of responsibilities of nurses, OR nursing now includes pre-operative and post-operative periods, therefore peri-operative nursing is accepted as a nursing process in OR in the contemporary medical literature. Peri-operative nurses provide care to the surgical patients during the entire process of surgery. They have several roles including those of manager or a director, clinical practitione...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Proliferative, anti-apoptotic and immune-enhancing effects of L-arginine in culture of skin fibroblasts.
Authors: Kocic H, Arsic I, Stankovic M, Tiodorovic D, Ciric V, Kocic G Abstract Semi-essential amino acid L-arginine may be of fundamental importance in various intracellular and intercellular pathways related to skin repair and wound healing. Our current study was aimed to explore the effect of L-arginine on skin fibroblast (L929) signaling pathways involved in cell proliferation (Akt-pAkt kinase, Erk/pErk1/2 kinase, JNK/pJNK kinase and pStat-1), apoptosis (Bcl2 and Bax) and immune defense (NF-κB and CD26). Significant upregulation of Erk (p
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Small incision releasing of transverse carpal ligament in diagnosis and treatment of mild carpal tunnel syndrome.
Authors: Chen L, Liu HQ, Yang F, Liu Y, Zhang ZX, Liu ZG, Li RJ Abstract Carpal tunnel syndrome (CTS) is a medical condition due to compression of the median nerve as it travels through the wrist at the carpal tunnel. Few studies have been carried out to examine the effectiveness of mini-open technique for carpal tunnel release using minor wrist skin crease incision in patients with mild CTS. Therefore, the present study was designed to improve the neurophysiological parameters for the diagnosis of mild CTS, and to examine the effectiveness of small incision surgery for the clinical treatment of mild CTS. To this e...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Potential risk of developing herpes simplex encephalitis in patients treated with sildenafil following primary exposure to genital herpes.
Authors: Goren A, Mccoy J, Kovacevic M, Situm M, Lonky N Abstract Herpes simplex encephalitis (HSE) is associated with significant mortality and morbidity. As a consequence of HSE, up to 75% of infected individuals die or experience irreversible neurological damage. While the pathogenesis of the disease is unknown, it is traditionally hypothesized that the viral infection occurs by neuronal transmission directly from peripheral sites. Non-neuronal modes of infection have generally been overlooked as the brain is protected by the blood-brain-barrier (BBB). The BBB poses an effective barrier to pathogens as well as t...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Protective effects of Smyrnium cordifolium boiss essential oil on pentylenetetrazol-induced seizures in mice: involvement of benzodiazepine and opioid antagonists.
Authors: Abbasi N, Mohammadpour S, Karimi E, Aidy A, Karimi P, Azizi M, Asadollahi K Abstract Smyrnium cordifolium as a wild plant is used in traditional medicine in Iran for the treatment of anxiety and insomnia. The anticonvulsant effect of this plant has not been studied to date, therefore this study aimed to evaluate the anticonvulsant effects of its essential oil and curzerene on seizure. Essential oil of the Smyrnium cordifolium plant was prepared by the hydro-distillation method. Gas chromatography and gas chromatography-mass spectroscopy analysis of the essential oil revealed its main components. Anticonvul...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Combined detection of tumor markers and serum inflammatory factors in the diagnosis and treatment of gynecologic oncology.
Authors: Wang HP, Wu HY, Wang Y, Wang L Abstract In recent years, gynecologic cancer has become the third leading cause of death for women world-wide. Serum tumor markers and inflammatory factors have been shown to be useful in the diagnosis of gynecological tumors. Therefore, the clinical value of the combined detection of tumor markers and serum inflammatory factors in the diagnosis of gynecologic oncology was studied. One hundred patients with gynecological tumors admitted to our hospital were selected as the tumor group, and 50 healthy volunteers were selected as the control group. According to clinical diagnos...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Targeted ultrasound molecular imaging in mouse atherosclerotic plaque model.
This study aims to assess the early diagnosis of mouse atherosclerotic plaque through targeted ultrasound molecular imaging. Forty Apolipoprotein E-deficient (ApoE-/-) mice and 40 C57BL/6 wild type mice were randomly divided into 4 groups, 20 mice per group. Mice included in the study group were fed with high cholesterol diet for 20 weeks, after which the targeted ultrasound microbubbles were prepared. The mice with atherosclerotic plaque were studied with targeted ultrasound molecular imaging in comparison with red oil O staining. The results of targeted ultrasound molecular imaging of atherosclerotic plaque indicate that...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Antioxidant potential analysis of P. ostreatus, P. sajor-caju, P. sapidus and P. columbinus.
Authors: Irshad A, Shahid M, Asghar M, Khan JA Abstract The present study was conducted to evaluate the antioxidant activity of ethanol, n-hexane, dichloromethane, ethyl acetate and water extracts of four different Pleurotus spps. P. ostreatus, P. sajor-caju, P. sapidus and P. columbinus. The extraction was performed by classical organic solvent extraction (COSE). The extracts of Pleurotus spps. contained appreciable levels of total phenolic contents (TPC) (0.95-19.49 GAE, mg/g) and total flavonoid contents (0.85-3.73 CE, mg/g). All Pleurotus spps. also contained considerable DPPH radical scavenging activity, showi...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Aortic dissection with acute non-st-segment elevation myocardial infarction as the first manifestation.
Authors: Wang ZY, Wang YJ, Liu XL, Zhao X, Mao CY Abstract Acute chest pain caused by aortic dissection or acute myocardial infarction (AMI) is one of the most serious medical emergencies and requires very quick differential diagnosis to seize the best time for treatment. Aortic dissection and acute myocardial infarction are manifested with similar symptoms, making it difficult to differentially diagnose these two conditions. The present case was initially misdiagnosed as an acute non-ST-segment elevation myocardial infarction (NSTEMI) with left aortic disease, and then diagnosed by coronary angiography examination...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Influence of glucose metabolism on cognitive function of patients with acute small-artery occlusion.
Authors: Zhai LP, Zhang XL, Guan QB, Yu B, Wang YP, Shen HP, Yu XX, Wang DD, Zhu Y Abstract The aim of this study was to evaluate the influence of abnormal glucose metabolism on cognitive function of patients with acute small-arterial occlusion (SAO). The present study included 1,211 patients, with small-artery occlusion according to the Trial of Org 10172 in acute stroke treatment (TOAST) classification, admitted between March 2014 and December 2016 to The Second Hospital of Jiaxing. According to cognitive function, the patients were divided into a group of normal cognitive function, a mild cognitive impairment gr...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Electromagnetic fields with frequencies of 5, 60 and 120 Hz affect the cell cycle and viability of human fibroblast BJ in vitro.
Authors: Koziorowska A, Romerowicz-Misielak M, Filipek A, Koziorowski M Abstract The impact of electromagnetic field (EMF) on humans has been described in numerous studies, but many questions are still unanswered. The aim of the experiment described in this study was to evaluate the effect of EMF on the viability of human fibroblast BJ in vitro and the percentage of cells in different phases of the cell cycle (G1/G0, S, G2/M) after 2 hours of exposure to sinusoidal continuous and pulsed EMFs with frequency of 5 Hz, 60 Hz and 120 Hz at a magnetic induction of 2,5 mT. The viability of BJ cells exposed to an EMF was e...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Serum level of cathelicidin LL-37 in patients with active tuberculosis and other infectious diseases.
Authors: Majewski K, Agier J, Kozłowska E, Brzezińska-Błaszczyk E Abstract A growing body of evidence indicates the role of cathelicidin LL-37, a member of the antimicrobial peptide family, in host innate defense mechanisms. The important role of this peptide in infectious diseases is also suggested, however, to date, data relating to LL-37 expression in the course of bacterial infections are far from complete. Therefore, the aim of the present study was to determine LL-37 serum levels in adult patients with pulmonary tuberculosis (TB). For comparison, circulating LL-37 levels in patients with pneumonia induced ...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of lipopeptide carboxymethyl chitosan nanoparticles on Staphylococcus aureus biofilm.
In conclusion, lipopeptide carboxymethyl chitosan nanoparticles had a good inhibition and scavenging effect on the formation of Staphylococcus aureus biofilm and the growth of surface-attached bacteria. PMID: 28956426 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Sleep disorders of acute thalamic stroke and its influence on plasma IL-17.
Authors: Li Q, Zhao X, Gong DH, Geng YM, Zhang HL, Bi PX Abstract The aim of this study was to investigate the relationship between sleep disorders in acute thalamus stroke patients and plasma IL-17 levels and the mechanism through which inflammatory reactions develop in stroke. The study included two groups of patients: an experimental group consisting of 30 patients with thalamus stroke who received treatment at the Affiliated Hong Qi Hospital of Mu Dan Jiang Medical University during October 2015 to October 2016 and a control group consisting of 15 healthy volunteers. All the subjects included in the study were ...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Expression and clinical significance of rhubarb on serum amylase and TNF-alpha of rat model of acute pancreatitis.
Authors: Zhang WF, Li ZT, Fang JJ, Wang GB, Yu Y, Liu ZQ, Wu YN, Zheng SS, Cai L Abstract The aim of this study was to evaluate the therapeutic effect of rhubarb extract on acute pancreatitis. Ninety-six healthy Sprague Dawley rats, weighing 301±5.12 g were randomly divided into 4 groups: sham surgery (group A), acute pancreatitis model (group B), acute pancreatitis with normal saline (group C), and acute pancreatitis model with rhubarb (group D). The levels of serum amylase (AMY) and TNF-α were measured at 1st, 6th, 12th and 24th hour after modeling, and the pancreatic tissue were used to observe the ...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Is lingual tonsil a preferential target for processing sublingually administered materials?
Authors: Masieri S, Incorvaia C, Cavaliere C, Di Cara G, Frati F Abstract The oral cavity is a site of pivotal importance in the immune response to foreign antigens, ensuring tolerance induction to harmless agents but reactivity to potentially noxious antigens. Tolerance or reactivity are driven by a number of secondary lymphoid organs, all belonging to the Waldeyer ring, that include adenoids, tubal, palatine and lingual tonsils. Waldeyer’s ring tissues were acknowledged as implicated not only in the adaptive immune system but also in the innate immune system modulation, involving the toll-like receptors. In...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Cyberknife ® system: a new therapeutic strategy for sinonasal solitary extramedullary plasmacytomae.
We present the first case of sinonasal-EMP treated with CyberKnife®-stereotactic radiotherapy (SRT) with a complete remission without adverse events. Based on the post-therapeutic results and healthy tissue preservation, we believe that CyberKnife®-SRT represents a good therapeutic option for the treatment of sinonasal-EMP. PMID: 28958136 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Short-term effect of shockwave therapy, temperature controlled high energy adjustable multi-mode emission laser or stretching in Dupuytren ’s disease: a prospective randomized clinical trial.
Short-term effect of shockwave therapy, temperature controlled high energy adjustable multi-mode emission laser or stretching in Dupuytren’s disease: a prospective randomized clinical trial. J Biol Regul Homeost Agents. 2017 Jul-Sep;31(3):775-784 Authors: Notarnicola A, Maccagnano G, Rifino F, Pesce V, Gallone MF, Covelli I, Moretti B Abstract Dupuytren’s disease is a debilitating disease of the hand characterized by nodules on the surface of the palm with progressive loss of finger extension. The chosen forms of treatment are infiltrative and surgical. Conservative treatment could be usefu...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Clusterin serum level: how does it affect psoriatic patients?
Authors: Buquicchio R, Foti C, Loconsole F, Polimeno L, Ventura MT Abstract Psoriasis is a chronic inflammatory skin disease with systemic involvement that might predispose to many psoriasis-related comorbidities, such as metabolic syndrome and cardiovascular disorders. Clusterin (Clu), also known as apolipoprotein J (ApoJ), is a highly conserved disulfide-linked heterodimeric glycoprotein implicated in a great variety of physiological and pathophysiological processes including lipid transportation, tissue remodeling, senescence, cell interaction, stress response, inflammation, apoptosis, diabetes mellitus and meta...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Multicenter prospective crossover study on new prosthetic opportunities in post-laryngectomy voice rehabilitation.
Authors: Serra A, Spinato G, Spinato R, Conti A, Licciardello L, Di Luca M, Campione G, Tonoli G, Politi D, Castro V, Maniaci A, Maiolino L, Cocuzza S Abstract The aim of this study was to assess the clinical experience of three Italian centers using the third generation Provox Vega prosthesis, in terms of device life and voice outcome, comparing the results with the second generation Provox 2 prosthesis in the same sample. A prospective multicenter crossover study was performed in three phases. In the first phase we performed a reassessment, for enrollment purposes, of patients who were categorized into four diffe...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: a clinical and histopathological evaluation.
Authors: Inchingolo F, Cantore S, Dipalma G, Georgakopoulos I, Almasri M, Gheno E, Motta A, Marrelli M, Farronato D, Ballini A, Marzullo A Abstract Bisphosphonates are antiresorptive pharmacological agents used in the treatment of osteoporosis. Recently, osteonecrosis of the jaw has been recognized as a potential side effect in patients on long-term bisphosphonate therapy. This condition, popularly called bisphosphonate-related osteonecrosis of the jaw (BRONJ), has been rechristened as MRONJ (medication-related osteonecrosis of the jaw) to accommodate the increasing number of cases of osteonecrosis of jaws associat...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Oral manifestations of inflammatory bowel disease.
This article discusses the most recent findings on the oral manifestations of IBD with a focus on bacterial modulations and immune changes. It also includes an overview on options for management of the oral lesions of IBD. PMID: 28958141 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Serum 25-hydroxy vitamin D concentration in acute coronary syndrome.
Authors: Anastasi E, Suppa M, Viggiani V, Tartaglione S, Angeloni A, Granato T Abstract Vitamin D may have prognostic value in cardiovascular disease (CVD) patients and, in addition to conventional biomarkers, could be a valuable tool for disease management. The aim of this study was to assess the association of vitamin D status in patients with acute coronary syndrome (ACS) and to evaluate its prognostic utility. The levels of 25(OH) vitamin D were correlated with troponin T hs. Forty-eight consecutive outpatients (40 Caucasian and 8 Asian) aged between 40 and 70 years (mean 61.5, range 43-77 years) were enrolled ...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Assessment of pN-GAL as a marker of renal function in elite cyclists during professional competitions.
Authors: Andreazzoli A, Fossati C, Spaccamiglio A, Salvo R, Quaranta F, Minganti C, Di Luigi L, Borrione P Abstract Glomerular filtration rate (GFR) has been shown to be lower than physiological values during exercise with a strong negative correlation with exercise intensity. Among new markers of renal function, neutrophil gelatinase-associated lipocalin (NGAL) seems to be very promising. It is an early, sensitive and specific marker of acute kidney injury (AKI) with two isoforms: plasma NGAL (pNGAL) and urinary NGAL (uNGAL). The aim of the present study was to assess acute variations in NGAL plasma levels after p...
Source: Journal of Biological Regulators and Homeostatic Agents - September 30, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Activation and inhibition of adaptive immune response mediated by mast cells.
Authors: Toniato E, Frydas I, Robuffo I, Ronconi G, Caraffa Al, Kritas SK, Conti P Abstract Adaptive immune response plays an important role against bacteria and parasites, a reaction that also involves mast cell (MC) activation which participates in innate and adaptive immunity. In allergic reactions there is a TH2 immune response with generation of allergen-specific IgE antibodies. In MCs, IgE cross-link FcRI high affinity receptor and activate tyrosine kinase proteins, leading to stimulation of NF-κB and AP-1 resulting in the release of a number of cytokines/chemokines and other compounds. Through their pr...
Source: Journal of Biological Regulators and Homeostatic Agents - September 29, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Hepatic insulin-like growth factor receptor is upregulated by activation of the GSK3B-FOXO3 pathway after partial hepatectomy.
Authors: E CY, Cai Y, Sun BZ, Guan LY, Jiang T Abstract Liver regeneration after partial hepatectomy (PH) is a complex and well-elaborated biological process whereby synchronized cell proliferation is induced in response to the loss of liver mass. Insulin-like growth factor 1 (IGF1) signaling, which plays a crucial role in normal growth and development, is involved in the process of liver regeneration. To assess the changes in the levels of serum IGF1 and hepatic IGF1 receptor (IGF1R), we established a mouse model for PH. This also allowed us to further explore the mechanisms that participate in the regulation of l...
Source: Journal of Biological Regulators and Homeostatic Agents - September 29, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Study of three types of desensitizers in dentin bonding strength.
Authors: Cheng L, Wang S, Che YH, Qian M Abstract One hundred and twenty human molars without decay (premolars and complete third molars) freshly extracted for orthodontic purposes were used in the study to explore the impact of application of three kinds of desensitizers on self-etching/all-etching bond strength of dentin. The roots were ground along the cementoenamel junction (CEJ), the residual crowns were divided into two parts along mesial and distal direction, and the enamel layer was removed. The dentin was ground into standard pieces of 3x3x3 mm and then polished using alumina waterproof abrasive paper. Two...
Source: Journal of Biological Regulators and Homeostatic Agents - September 29, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Expression of connexins in porcine buccal pouch mucosa cells during real-time long-term cell proliferation in vitro: a primary culture approach.
In this study we investigated the expression of connexins Cx36, Cx37, Cx40, Cx43, and Cx45 mRNAs during real-time cellular proliferation in vitro. The oral mucosa cells were isolated from 80 pubertal crossbred Landrace gilts. The cells were transferred into primary in vitro culture (IVC) and cultured for 30 days. The cells were collected to RNA isolation after 7, 15 and 30 days of IVC and were checked for their real-time proliferative status using real-time cell analysis (RTCA). We found an increased expression of Cx43 mRNA after 30 days of IVC as compared to control (P
Source: Journal of Biological Regulators and Homeostatic Agents - September 29, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Study of GSK3b inhibitors SB415286 and SB216763 to improve osteoblastic differentiation on microstructured titanium.
Authors: Lumetti S, Calciolari E, Parisi L, Toffoli A, Mazzotta S, Ferrillo S, Ierardo G, Macaluso GM, Galli C, Manfredi E Abstract Rough titanium surfaces enhance cell response to activation of Wnt canonical signalling, a pathway required for osteoblast differentiation. The present study investigated the effects of GSK3β-inhibitors SB216763 and SB415286 on osteoblastic differentiation on titanium surfaces with different topography and wettability. Osteoblastic MC3T3 cells were plated on smooth (Pickled), sand-blasted/acid-etched (SLA) or hyper hydrophilic SLA (modSLA) titanium discs and transfected with a rep...
Source: Journal of Biological Regulators and Homeostatic Agents - September 29, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

MIR-92 stimulates VEGF by inhibiting von Hippel-Lindau gene product in epithelial ovarian cancer.
Authors: Guo FJ, Shao YP, Wang YP, Jin YM, Liu SS, Wang QY Abstract The molecular mechanisms underlying regulation of vascular endothelial growth factor (VEGF) in epithelial ovarian cancer (EOC) remain poorly defined. VEGF, a potent angiogenic factor, is up-regulated in a variety of cancers and contributes to angiogenesis in tumor tissues. The level of VEGF correlates with progression of malignancy. We previously reported that miR-92 is abnormally elevated in the plasma of EOC patients. Here, we tested the hypothesis that miR-92 inhibits von Hippel-Lindau gene product (VHL), a tumor suppressor gene, and in turn de-...
Source: Journal of Biological Regulators and Homeostatic Agents - September 29, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Amoxicillin and clavulanate potassium in treating children with suppurative tonsillitis.
Authors: Chen LE, Shen YZ, Jiang DY, Feng GL, Zhang XL, Wang YF Abstract To evaluate clinical effects of amoxicillin and clavulanate potassium in the treatment of children with suppurative tonsillitis, 146 children with suppurative tonsillitis were randomly divided into a ceftezole sodium group and an amoxicillin and clavulanate potassium group. The two groups were given anti-infection treatment using different drugs. Symptomatic treatment was carried out once symptoms such as fever appeared. Five to seven days were taken as one treatment course. Blood routine examination and the detection of C-reactive protein (CR...
Source: Journal of Biological Regulators and Homeostatic Agents - September 29, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of central fibroblast growth factor 21 (FGF21) in energy balance.
Authors: Recinella L, Leone S, Ferrante C, Chiavaroli A, Di Nisio C, Martinotti S, Vacca M, Brunetti L, Orlando G Abstract Fibroblast growth factor 21 (FGF21) is known as a major metabolic regulator of glucose and lipid homeostasis. Continuous intracerebroventricular (i.c.v.) administration of FGF21 was found to modulate feeding and energy expenditure in rats with diet-induced obesity, suggesting a central effect by the peptide. In this context, in the present work, we studied the effects of a single central FGF21 administration (0.5-5 µg) on feeding and energy expenditure by evaluating locomotor activity, in...
Source: Journal of Biological Regulators and Homeostatic Agents - September 13, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Crocus sativus, Serenoa repens and Pinus massoniana extracts modulate inflammatory response in isolated rat prostate challenged with LPS.
Authors: Chiavaroli A, Recinella L, Ferrante C, Locatelli M, Macchione N, Zengin G, Leporini L, Leone S, Martinotti S, Brunetti L, Vacca M, Menghini L, Orlando G Abstract Prostatitis is a common prostate disease that could be promoted by bacterial or non-bacterial infectious agents. In addition, inflammatory pathways involved in prostatitis have been increasingly studied, and herbal extracts endowed with anti-inflammatory effects are under investigation, individually or in combination, for their efficacy in alleviating the burden of inflammation, with possible improvements in symptoms. Serenoa repens (Serenoa), in ...
Source: Journal of Biological Regulators and Homeostatic Agents - September 13, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

In vitro protective effects of resveratrol and stilbene alkanoic derivatives on induced oxidative stress on C2C12 and MCF7 cells.
In this study, a series of stilbene hybrids 1-9, previously reported as peroxisome proliferator-activated receptor (PPAR) agonists, were assessed at micromolar concentrations using MTT cell viability assay in C2C12 and MCF7 cell lines. The modulation of oxidative stress was also evaluated by measuring the protective effects on reactive oxygen species (ROS) production induced or not by oxidative stimulus. Among these, compounds 2 and 8 showed significant radical scavenging activity. PMID: 28889799 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - September 13, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Effects of central fibroblast growth factor 21 and irisin in anxiety-like behavior.
In conclusion, in the present study we demonstrated behavioral effects induced by central FGF-21 and irisin injections that could involve increased DA signaling in the prefrontal cortex. PMID: 28890831 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - September 13, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Colorectal cancer: an update on the effects of lycopene on tumor progression and cell proliferation
Authors: Carini F, David S, Tomasello G, Mazzola M, Damiani P, Rappa F, Battaglia L, Cappello F, Jurjus A, Gerges Geagea A, Jurjus R, Leone A Abstract Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such as fruits and vegetables; however, data on Lycopene are still rare. Studies on HT-29 colorectal cancer cells and on animal mod...
Source: Journal of Biological Regulators and Homeostatic Agents - August 3, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Colorectal cancer and inflammatory bowel diseases: effects of diet and antioxidants.
Authors: Carini F, Tomasello G, Jurjus A, Geagea A, Al Kattar S, Damiani P, Sinagra E, Rappa F, David S, Cappello F, Mazzola M, Leone A Abstract It is well established that oxidative stress is common in inflammatory bowel diseases (IBDs). Accordingly, antioxidants are recommended for treatment. The aim of this study is to compare the effects of antioxidants contained in the various types of tea on symptoms and evolution of IBD and colorectal cancer (CRC). Analysis of the literature revealed that the theaflavin-3, 30-digallate (TFDG) contained in black tea, and epigallocatechin-3-O-gallate (EGCG) contained in green ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 22, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Treatment of skin defects with growth factors and biodegradable collagen carrier: histological evaluation in animal model.
Authors: Menchini Fabris GB, Nocini PF, Gelpi F, Lotti J, Favero V, Zanotti G, Jurlaro A, Rosskopf I, Lotti T, Barone A, Castegnaro G, De Santis D Abstract The aim of the present study is to evaluate the effects on skin regeneration of a new collagen matrix (CM-10826) when used in different combination with or without growth factors, using skin regeneration without membrane as control. An area of 10x15 cm on rabbit back was shaved and three circular wounds on test side were covered with a differently soaked membrane. The first wound was soaked with Epidermal Growth Factor (EGF, 26mg/130mL) (Test EGF), the second wi...
Source: Journal of Biological Regulators and Homeostatic Agents - July 15, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Buccal bone dimensions and aesthetic outcome at maxillary incisors replaced by conventional dental implants. A case series with a 5-year follow-up.
Authors: Menchini Fabris GB, Marconcini S, Barone A, Velasco Ortega E, Bressan E, Balleri P Abstract In the aesthetic field, successful replacement of a tooth with a dental implant requires blend and harmony within the existing dentition. The influence of the dimension of buccal bone at implant sites on aesthetic outcomes and the relation between buccal bone horizontal and vertical dimensions are unclear. The aim of the present study is to investigate the correlation between buccal bone thickness, buccal bone level and aesthetic outcome in conventionally placed implants – placed five or more years previously ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 15, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Cutaneous manifestations in Steinert ’s disease. Apropos of four clinical cases.
Cutaneous manifestations in Steinert’s disease. Apropos of four clinical cases. J Biol Regul Homeost Agents. 2017 07 13;31(2 Suppl. 2) Authors: Cona F, Lotti J, Fioranelli M, Roccia MG, Lotti T, Guarneri C Abstract Myotonic dystrophy type 1 (MD1) (OMIM 160900, Steinert disease) is the most common muscular disease, with an estimated worldwide prevalence ranging from 0.5 to 18/10,000 (1). MD1 is an autosomal dominant multisystem disorder that affects skeletal and smooth muscles as well as eyes, heart, endocrine system, and central nervous system. Available data on skin and adnexal involvement that ...
Source: Journal of Biological Regulators and Homeostatic Agents - July 15, 2017 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research