American Tegumentary Leishmaniasis
A 49-year-old male patient, alcoholic, smoker, and cocaine user presented with a 3-month history of mucocutaneous ulcers. He was facing psychological, social, and behavioral consequences brought about by the lesions' repulsive features. Positive findings on physical examination included two skin ulcers with raised indurated border, an ulcerovegetative lesion on the lower lip, and an erythematous ill-defined plaque on the fifth left finger with onycholysis (Figure 1). Histopathology showed dense inflammatory infiltrate consisting of plasma cells, lymphocytes, and macrophages, presenting formation of epithelioid cell granu...
Source: The Journal of Emergency Medicine - March 7, 2018 Category: Emergency Medicine Authors: Fred Bernardes Filho, Rodolfo Mendes Queiroz, Breno Nery Tags: Visual Diagnosis in Emergency Medicine Source Type: research
Nail changes in alopecia areata: an update and review
Abstract
Nail changes are a common feature of alopecia areata (AA) and are a significant source of cosmetic disfigurement and functional impairment. This review provides an update of the prevalence, clinical and histopathological features, pathogenesis, differential diagnosis, clinical course, prognosis, and management of nail changes in patients with AA. Searches for peer‐reviewed journal articles were conducted using the PubMed/MEDLINE database with the search terms “nail changes alopecia areata,” “alopecia areata nails,” and specific searches on “trachyonychia alopecia areata” and “pitting alopecia areat...
Source: International Journal of Dermatology - January 10, 2018 Category: Dermatology Authors: Khatiya Chelidze, Shari R. Lipner Tags: Review Source Type: research
PATEO syndrome: periarticular thenar erythema with onycholysis.
PMID: 29283012 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - December 28, 2017 Category: Cancer & Oncology Authors: Rzepecki AK, Franco L, McLellan BN Tags: Acta Oncol Source Type: research
Case report: photo ‐onycholysis after PUVA treatment for hypopigmented mycosis fungoides with response to topical steroid
We report a case of a 16‐year‐old male patient with skin type VI with onycholysis following PUVA treatment for hypopigmented mycosis fungoides. Symptoms resolved with the application of topical steroid.
Melanin in the nail bed in patients with skin type VI has been suggested to afford some protection against photo‐onycholysis. We report a case of a 16‐year‐old male patient with skin type VI with onycholysis following PUVA treatment for hypopigmented mycosis fungoides. Symptoms resolved with the application of topical steroid. (Source: Clinical Case Reports)
Source: Clinical Case Reports - December 22, 2017 Category: General Medicine Authors: Paul Jie Wen Tern, Julia Gass Tags: Case Report Source Type: research
Clinical and serological characteristics of nail psoriasis in Indian patients: A cross-sectional study
Conclusions: In Indian patients with nail psoriasis, severity of nail involvement was found to be poorly correlated with the extent of cutaneous disease. In addition the impact of nail disease on patient's quality of life was found to be minimal. This suggests the need for a quality of life questionnaire suited to the Indian population. Serological markers were raised overall in the study patients and more so in the patients with concomitant arthritis. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - October 16, 2017 Category: Dermatology Authors: Deepashree Daulatabad Chander Grover Bineeta Kashyap Amit Kumar Dhawan Archana Singal Iqbal R Kaur Source Type: research
Acquired Idiopathic True Transverse Leukonychia.
Abstract
A 34-year-old man from Djibouti presented with a 14-year history of relapsing and remitting transverse white bands on the fingernails with sparing of the toenails. Examination revealed several transverse, white bands following the contour of the lunula on seven of his fingernails that did not fade upon compression of the digits (Figure). There was no onycholysis. No other skin lesions were noted. The patient reported having lived for 4 years (2000-2004) in a house that had well water as its primary water supply. This 4-year period was a stressful point in our patient's life. During that time, he h...
Source: Skinmed - September 3, 2017 Category: Dermatology Authors: Hadi A, Stern D Tags: Skinmed Source Type: research
Onychomycosis Laboratory Diagnosis: Review
AbstractPurpose of ReviewOnychomycosis is a growing global health problem. Proper diagnosis is important in order to avoid the risks of unnecessary treatments. This review summarizes the laboratory techniques currently available for the diagnosis of onychomycosis with the advantages and disadvantages of each test.Recent FindingsResearch is underway to prove the clinical utility of other diagnostic techniques such as PAS-stained nail biopsies and molecular tests as viable alternatives for the diagnosis of onychomycosis with promissory results.SummaryDermoscopy can be helpful to differentiate onychomycosis from traumatic ony...
Source: Current Fungal Infection Reports - July 8, 2017 Category: Infectious Diseases Source Type: research
A prospective randomized controlled trial of hydrating nail solution for prevention or treatment of onycholysis in breast cancer patients who received neoadjuvant/adjuvant docetaxel chemotherapy
ConclusionsHydrating nail solution significantly reduced the incidence of docetaxel-induced onycholysis in BC patients (NCT02670603). (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 3, 2017 Category: Cancer & Oncology Source Type: research
Skin findings in autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls.
Conclusions: Our findings indicate that the presence of skin findings in a majority of thyroid patients significantly differs for certain cutaneous manifestations with respect to controls, autoimmune etiology, and thyroid functional status.
PMID: 28618767 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - June 18, 2017 Category: General Medicine Tags: Turk J Med Sci Source Type: research
Green nail syndrome
A 40-year-old woman presented to the dermatology outpatient department with greenish black discoloration of the nail plate of the right thumb and the index finger that occurred within a month (Figure 1). The patient had no significant medical history, had not received any medication, or had not experienced any previous fingernail injuries. As she is a homemaker, her hands are exposed to water, detergents and soaps for long periods. Bacteriologic culture of nail scrapings was positive forPseudomonas aeruginosa andCandida glabrata. Based on the clinical and pathological findings, the patient was diagnosed as having green nai...
Source: QJM - June 13, 2017 Category: Internal Medicine Source Type: research
Periarticular Thenar Erythema and Onycholysis Syndrome: A Manifestation of Taxane-Induced Cutaneous Toxicity
Publication date: Available online 1 June 2017 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): E. Rodríguez-Lomba, I. Molina-López, R. Suárez-Fernández, O. Baniandrés-Rodríguez (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - June 2, 2017 Category: Dermatology Source Type: research
Uneven flat feet and closed shoes produce toenail clinical changes that mimic all types of onychomycosis
Asymmetric gait toenail unit syndrome (AGNUS), first introduced in 2012, described toenails identical to those seen in dermatophyte and opportunistic onychomycosis, yet fungus free. AGNUS results from the asymmetry of plantar surfaces, affecting gait biomechanics causing minute toenail trauma while walking in closed shoes. Nail abnormality in AGNUS includes distal subungual onycholysis, subungual hyperkeratosis, leukonychia, endonyx, nail plate damage, increased curvature of the nail plate, retronychia and pincer nail. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 31, 2017 Category: Dermatology Source Type: research
Onycholysis and Eyelash Trichomegaly After Pan-FGFR Inhibitor Use
This case report describes severe onycholysis and eyelash trichomegaly following the use of new selective pan-FGFR inhibitors. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 24, 2017 Category: Dermatology Source Type: research
Acral lesions with an underlying internal malignancy
A 58-year-old Hispanic woman with cholangiocarcinoma of the common bile duct resected 1 year before consultation (Fig 1) presented with a 1-month history of bilateral, asymptomatic, fissured, hyperkeratotic purple-red plaques on her first and second fingers and xanthonychia and onycholysis of all fingernails (Fig 2). There was no significant irritant or allergen exposure. Clobetasol propionate 0.05% with occlusion once daily and emollients had no effect. Lesions spread toward the fifth finger and dorsal surfaces of her hands. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 16, 2017 Category: Dermatology Authors: Gabriela Botta, Jorge Navarrete, Luc ía Sanjinés, María Mazzei, Caroline Agorio Tags: JAAD online Source Type: research
