Challenges in Performing Nail-Fold Capillaroscopy during COVID-19
Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 18, 2021 Category: Dermatology Source Type: research

Bibliometric Analysis of the 50 Most Cited Publications in Hidradenitis Suppurativa
Conclusions: Recent advances in HS research have focused on investigating HS pathogenesis and drug development, highlighting disease comorbidities, and improving evidence-based care. Studies in pathogenesis have translated into a paradigm shift in medical treatment from antibiotics to incorporation of targeted therapies in recent years. Encouraging growth of HS research in countries outside of North America and Europe may help to optimize HS care globally.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 18, 2021 Category: Dermatology Source Type: research

Flame Hair: Auxiliary Trichoscopic Finding in Radiotherapy-Induced Alopecia
We describe a case of an AE induced by radiotherapy, emphasizing the trichoscopic findings.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 18, 2021 Category: Dermatology Source Type: research

Through a Nail Darkly
Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 17, 2021 Category: Dermatology Source Type: research

Nonscarring Alopecia and Hypopigmented Lesions May Be Unusual Signs of Secondary Syphilis
We present a case of a 22-year-old patient in whom these symptoms were associated with positive spirochete reactions, which allowed making a diagnosis of syphilitic alopecia coexisting with leukoderma syphiliticum. Skin lesions and hair loss resolved after the treatment with benzathine benzylpenicillin. Trichoscopy in syphilitic alopecia is nonspecific, but the absence of features typical for alopecia areata such as exclamation mark hairs may be important on an early stage of the clinical workup.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 17, 2021 Category: Dermatology Source Type: research

The Impact of Shampoo Wash Frequency on Scalp and Hair Conditions
Conclusions: Two different studies led to the same conclusion: higher wash frequency is both beneficial and more preferred to lower wash frequency among the Asian populations studied. Concerns related to “overcleaning” were unfounded both objectively and subjectively.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 15, 2021 Category: Dermatology Source Type: research

Subclinical Onychomycosis in Apparently Healthy Adults
Conclusion: We found 4 patients with yeasts, 3 with hyphae, and 1 patient with a combined infection with both yeasts and hyphae (3.1%). These add up to 25% of the clinically apparent healthy nails. Our results show that we still have much to learn from the initial stages of onychomycosis and that our population probably has higher incidence of this nail disease, so we must be alert to subtle nail changes. As our participants signed an informed consent, we will contact those that resulted positive for follow up consultations.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 10, 2021 Category: Dermatology Source Type: research

Hypopigmentation of the Eyebrows in Frontal Fibrosing Alopecia
Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 10, 2021 Category: Dermatology Source Type: research

Comment on Follicular Inflammation and Fibrosis in Pattern Hair Loss
Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 8, 2021 Category: Dermatology Source Type: research

Thirty Years (and More) of Hair Research Societies
The contributions of the core hair research societies and their members over the past 30 years have advanced the field of hair research and the understanding and treatment of hair disorders and normal hair growth.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 8, 2021 Category: Dermatology Source Type: research

Distinctions in the Management, Patient Impact, and Clinical Profiles of Pachyonychia Congenita Subtypes
Conclusion and Discussion: Patients with different PC subtypes have distinct clinical nail presentations and psychosocial impact. Genetic testing should be used to confirm PC diagnoses. Further characterization of PC, especially the rarer subtypes, may allow for more individualized patient education.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - February 5, 2021 Category: Dermatology Source Type: research

Scalp Erosions that Do Not Heal: The Diagnostic Value of Trichoscopy
Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - January 27, 2021 Category: Dermatology Source Type: research

Progressive Primary Plate-Like Osteoma Cutis of the Scalp
Osteoma cutis (OC) or cutaneous ossification refers to uncommon bone formation in the skin. Primary OC develops without any predisposing factor or pre-existing lesion, whereas secondary OC sets out as a dystrophic ossification following traumatic, cicatricial, and neoplastic factors or other cutaneous inflammations. Herein, we report a rare case of long-standing progressive primary OC of the scalp resected in 3 sessions with no recurrence after 1 year.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - January 27, 2021 Category: Dermatology Source Type: research

Follicular Granular Parakeratosis: A Case Report, Literature Review, and Proposed Classification
Granular parakeratosis (GP) is a distinctive acquired keratotic dermatosis that is usually presented with brownish-red hyperkeratotic papules and plaques in the intertriginous areas. Follicular involvement in GP could be either extending lesions from interfollicular epithelium or originating primarily from the follicular epithelium. The latter was named follicular GP and is considered an extremely rare condition. To our knowledge, there has been one reported case so far in the literature. We herein report the second case of follicular GP in a 52-year-old Thai man presenting with multiple tiny filiform hyperkeratotic papule...
Source: Skin Appendage Disorders - January 26, 2021 Category: Dermatology Source Type: research

Congenital Curved Nail of the Fourth Toe with Subungual Hyperkeratosis
We report a case of CNFT with thickening and hyperkeratosis at the hyponychium and peripheral nail bed that was successfully treated using a novel surgical technique. A 7-year-old Japanese boy had a clawed nail with thickening and hyperkeratosis at the hyponychium and peripheral nail bed on his bilateral fourth toes. His chief complaint was pain. The nails of the bilateral fourth toes curved plantarly and exhibited thickening and hyperkeratosis of the hyponychium and peripheral nail bed. A surgical approach was planned to improve the condition. The distal phalanges that deviated and formed a point toward the nail bed were ...
Source: Skin Appendage Disorders - January 22, 2021 Category: Dermatology Source Type: research

The Impact of Nail Psoriasis and Treatment on Quality of Life: A Systematic Review
At least 80% of patients with psoriasis will have nail involvement during their lifetimes. Understanding quality of life (QoL) impact of this condition and associated treatments is of utmost importance. Study objectives were to review the available literature describing patient-reported QoL outcomes in nail psoriasis and relationship with disease severity and treatment. A literature search was performed for English-language articles published prior to August 1, 2020. Articles were included in the review if primary data and validated patient-reported outcome measures assessing QoL were presented, and nail involvement was sp...
Source: Skin Appendage Disorders - January 22, 2021 Category: Dermatology Source Type: research

Psoriasis Exacerbation after < b > < i > Candida < /i > < /b > Antigen Immunotherapy Injection
Conclusion:Candida antigen injection may cause psoriasis exacerbation, as TNF α and subsequent T-helper 1 induction is crossroad in both psoriasis andCandida antigen immunotherapy. Therefore, we report this case to state that besides the effectiveness ofCandida antigen for wart therapy, caution should be considered if used in patients who are susceptible to psoriasis with meticulous follow-up or better to apply an alternative treatment option.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - January 21, 2021 Category: Dermatology Source Type: research

Adalimumab in the Management of Isotretinoin-Induced Acne Fulminans: Report of a Case
We report a case of isotretinoin-induced AF (IIAF) in a 12-year-old boy resistant to traditional therapies (oral steroids and isotretinoin). The patient was successfully treated with adalimumab that can be considered an effective off-label option in the treatment of resistant IIAF in children.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - January 21, 2021 Category: Dermatology Source Type: research

Meeting Calendar
Skin Appendage Disord 2021;7:82 (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - January 19, 2021 Category: Dermatology Source Type: research

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Skin Appendage Disord 2021;7:82 (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - January 19, 2021 Category: Dermatology Source Type: research

A Rare Case of Osteoinvasive Amelanotic Melanoma of the Nail Unit
Conclusion: A heightened index of suspicion for a malignant process is necessary when standard of care fails to lead to improvement or resolution. In these instances, biopsy should be seriously considered.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - December 23, 2020 Category: Dermatology Source Type: research

Occipital Fibrosing Alopecia in a Young Male: A Case Report
Conclusion: Both LPP and FFA mostly affect the anterior-mid scalp of females. However, recent reports on FFA also in premenopausal women and men should make physicians aware of atypical features of this disease and unusual clinical presentation.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - December 17, 2020 Category: Dermatology Source Type: research

Multiple Koenen Tumors, a Rare Entity: Combination Treatment with 1% Topical Sirolimus Electrofulguration and Excision
We report a case of long-standing, multiple Koenen tumors affecting all twenty nails in an elderly female who was successfully treated with a combination of topical sirolimus 1%, surgical excision, and electrofulguration.Case Report: A 57-year-old lady presented with multiple, asymptomatic periungual, and subungual tumors affecting all twenty nails since 27 years. Cutaneous examination revealed confetti macules, ash-leaf macule, and shagreen patch over trunk. Nail biopsy was compatible with Koenen ’s tumor. Computerized tomography of brain showed diffuse patchy sclerosis. The tumors were treated with topical sirolimu...
Source: Skin Appendage Disorders - December 16, 2020 Category: Dermatology Source Type: research

Trichotillomania Incognito: Two Case Reports and Literature Review
Trichotillomania is a compulsive disorder characterized by repetitive hairpulling. It is an important cause of patchy alopecia, especially in children between 9 and 13 years of age. The aim of this paper is to report 2 pediatric cases presenting with trichotillomania without patches. This condition may be extremely distressful, impacting psychosocial development of children. In these case reports, we reinforce the relevance of trichoscopy in hair disorder evaluation, which allowed early recognition to better advise and conduct these unique pediatric cases.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - December 15, 2020 Category: Dermatology Source Type: research

Hypotrichosis with Juvenile Macular Dystrophy in Saudi Arabia: A Case Report
We describe herein a family member with alopecia since birth associated with severe visual impairment in their early life. We suspect the diagnosis of hypotrichosis with juvenile macular dystrophy. Genetic testing confirms the clinical suspension. We emphasize the importance of genetic testing for proper genetic counseling.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - December 15, 2020 Category: Dermatology Source Type: research

Excellent Response of Dermatophytoma and Nail Splitting to Nail Plate Debridement Plus Topical Ciclopirox Olamine 1% Solution
Onychomycosis often presents as thickened, discolored nails. Usually, one or both great toenails are affected. Eventually, the nail plate becomes friable and may split and break up, often due to trauma or invasion of the plate by dermatophytes that have keratolytic properties. Dermatophytoma is a unique feature of onychomycosis that occurred by abundant fungal filaments and spores forming a fungal ball under the nail plate. It is often refractory to traditional therapy. Based on the clinical and mycological examination, a case of onychomycosis in a 45-year-old woman presented as dermatophytoma with longitudinal nail splitt...
Source: Skin Appendage Disorders - December 9, 2020 Category: Dermatology Source Type: research

Rapid Response to Certolizumab Pegol in Hidradenitis Suppurativa: A Case Report
Conclusion: Certolizumab pegol is a humanized antigen-binding fragment of a monoclonal antibody which binds to TNF-alpha. However, certolizumab pegol is only approved for plaque psoriasis in dermatology; it is likely to be a promising effective agent for HS, especially in challenging cases.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - December 9, 2020 Category: Dermatology Source Type: research

Repigmentation of White Forelock in a Familial Case of Piebaldism Reported via Teledermatology in the COVID-19 Era
We describe a case of white forelock repigmentation in an infant with piebaldism, thanks to a photograph sent by the patient ’s mother to our dermatology clinic, during COVID-19 pandemic.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - December 9, 2020 Category: Dermatology Source Type: research

Androgenetic Alopecia in a Patient with Klinefelter Syndrome: Case Report and Literature Review
Conclusion: Our patient had a good response to oral minoxidil, finasteride, and low-level light therapy.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - December 7, 2020 Category: Dermatology Source Type: research

Panitumumab-Induced Paronychia: A Case Report and a Brief Review of the Literature
Panitumumab is a recombinant, fully humanized IgG2 monoclonal antibody targeting the epidermal growth factor receptor (EGFR). Panitumumab is indicated for patients with metastatic colorectal cancer with progressive refractory disease. Targeted therapies are well known to be well tolerated; however, they may induce toxicities that are distinct from those of classical chemotherapeutic agents. For instance, EGFR inhibitors (EGFRIs) are associated with some specific dermatological adverse effects, one of which is nail toxicity. Since panitumumab is fully humanized, unlike most of the other EGFRIs, it has been reported to have ...
Source: Skin Appendage Disorders - December 3, 2020 Category: Dermatology Source Type: research

Eyebrow Regrowth in Patients with Frontal Fibrosing Alopecia Treated with Low-Dose Oral Minoxidil
Conclusion: Low-dose OM could be a promising adjunctive therapy for treatment of the eyebrows in patients with FFA, particularly in early disease.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - December 2, 2020 Category: Dermatology Source Type: research

Presence of Trichodynia Symptoms in Hair Diseases and Related Factors
Discussion: The frequency of trichodynia was significantly higher in women in comparison to that in men. Symptoms of trichodynia were significantly more common in patients with cicatricial alopecia in comparison to that in the other 4 diagnostic categories. There was no significant difference between the 4 diagnostic categories in terms of trichodynia severity.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - December 2, 2020 Category: Dermatology Source Type: research

Subungual Invasive Squamous Cell Carcinoma with Doubtful Underlying Bone Invasion: A Treatment Proposal
Conclusion: We propose that when an invasive sSCC is present and an MRI is doubtful of bone invasion, before amputating, a bone biopsy should be performed.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - November 24, 2020 Category: Dermatology Source Type: research

Nail Disease: Clinical Decisions among Portuguese Dermatologists and Family Physicians
Onychomycosis is one of the most common nail disorders and may be difficult to distinguish from other causes of nail dystrophy, based on clinical grounds alone. With this study, we aimed to describe the use of fungal testing by dermatologists and family physicians in their daily current practice, analyze their respective familiarity with nail disease diagnosis, and ultimately treatment decision-making by both groups. An online survey was distributed among Portuguese dermatologists, trainees, and family physicians by email. The survey focused on the diagnostic impression, use of diagnostic methods to confirm a fungal infect...
Source: Skin Appendage Disorders - November 18, 2020 Category: Dermatology Source Type: research

Contents Vol. 6, 2020
Skin Appendage Disord 2020;6:I –VI (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - November 13, 2020 Category: Dermatology Source Type: research

Acknowledgment to Referees for Skin Appendage Disorders 2020
Skin Appendage Disord 2020;6:394 (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - November 13, 2020 Category: Dermatology Source Type: research

Meeting Calendar
Skin Appendage Disord 2020;6:393 (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - November 13, 2020 Category: Dermatology Source Type: research

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Skin Appendage Disord 2020;6:393 (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - November 13, 2020 Category: Dermatology Source Type: research

Treatment of Chemotherapy-Induced Subungual Pyogenic Granuloma with Topical Timolol Solution
Conclusion: This case highlights the promising use of timolol solution for therapeutically challenging PGs, such as those of subungual regions. This option may be particularly useful for individuals who are vulnerable to multiple PGs secondary to chemotherapy who wish to avoid repeated procedural interventions.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - November 10, 2020 Category: Dermatology Source Type: research

Squamous Cell Carcinoma Arising in Ungual Lichen Planus: Report and Review
Conclusions: The occurrence of SCC in nail LP is rare. LP is not “premalignant” per se, but SCC might rarely arise in LP scars.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - November 5, 2020 Category: Dermatology Source Type: research

Chloronychia in Healthcare Workers in COVID-19 Times
Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - November 3, 2020 Category: Dermatology Source Type: research

Demographic and Clinical Features of 1,641 Patients with Alopecia Areata, Alopecia Totalis, and Alopecia Universalis: A Single-Center Retrospective Study
Conclusion: AA is affecting approximately 2% of the general population without any sex, race, or age group predilection. In this study, we found a lower prevalence of AA in the pediatric age group in comparison with adults. This finding may support the hypothesis of the increasing prevalence of AA over time. The higher ratio of AA regarding this study may support that the frequency of AA and subtypes varies between regions.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - October 28, 2020 Category: Dermatology Source Type: research

Subungual Elastofibroma
Cutaneous elastofibroma is part of the connective tissue nevus complex. Two subungual cases remotely similar to the one presented here have been described before. This patient presented with an unusual form of subungual elastofibroma of the big toe, which was surgically removed. Histopathology revealed a connective tissue tumor extremely rich in very fine elastic fibers. Their relationship to oxytalan and elaunin fibers is discussed as is the potential association of this nail bed lesion with the onychodermis.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - October 26, 2020 Category: Dermatology Source Type: research

Trichotillomania in Children and the Different Approaches between Dermatological and Behavioral Health Professionals at an Urban Tertiary Care Center
Conclusions: TTM patients choose to present to behavioral health or dermatology; however, there are distinctive differences between the two cohorts. With behavioral and pharmacologic treatment options, a relationship between dermatologists and behavioral health specialists is necessary for multifactorial management of TTM.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - October 26, 2020 Category: Dermatology Source Type: research

KID Syndrome and Hidradenitis Suppurativa: A Rare Association Responding to Surgical Treatment
Conclusion: Despite the technical difficulties related to surgery, namely, cutaneous superinfections, frequent dehisce of the suture, and closure by secondary intention, the authors strongly recommend the surgical approach in these patients.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - October 26, 2020 Category: Dermatology Source Type: research

Hidradenitis Suppurativa in a Patient Affected by Mayer-Rokitansky-K ├╝ster-Hauser Syndrome: Insight into the Role of Hormones in HS
Conclusion: HS usually appears after puberty, exhibits premenstrual flare, improves in pregnancy, and worsens postpartum, which indicates a role of hormones and particularly of androgens in its pathophysiology. Contrasting data are reported in the literature. Our case wants to strengthen the idea that hormones could play an important role, probably with other endogenous or exogenous factors. Multidisciplinary investigations will clarify which part is played by each factor in the pathogenesis of HS.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - October 19, 2020 Category: Dermatology Source Type: research

Efficacy and Tolerability of a Shampoo Containing Broad-Spectrum Cannabidiol in the Treatment of Scalp Inflammation in Patients with Mild to Moderate Scalp Psoriasis or Seborrheic Dermatitis
Conclusion: Replacing current shampooing practices with a broad-spectrum cannabidiol-containing shampoo significantly reduces both severity and symptoms of scalp inflammation within 2 weeks, with excellent tolerability and treatment satisfaction in subjects with mild to moderate scalp psoriasis or seborrheic dermatitis.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - October 19, 2020 Category: Dermatology Source Type: research

A Case of Linear Alopecia of the Scalp
Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - October 16, 2020 Category: Dermatology Source Type: research

Efficacy and Safety of Intralesional Bleomycin in the Management of Ungual Warts
Conclusions: A total of 250 periungual and subungual warts were treated in 80 patients. An average of 2.61 sessions per patient was required for complete resolution. Moderate pain was reported by 65 patients (81.2%), and transitory perilesional hyperpigmentation was observed in 155 lesions (62%). Severe pain and necrosis developed in 3 lesions (1.2%) that were reversible without any residual scarring and deformity. We conclude that intralesional bleomycin is an effective and safe therapeutic modality for ungual warts.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - October 14, 2020 Category: Dermatology Source Type: research

The Role of Trichoscopy in Keratosis Follicularis Spinulosa Decalvans: Case Report and Review of the Literature
Conclusion: In our article, we underlined the importance of trichoscopy for the diagnosis of this hair disease, with also a review of the literature on diagnosis and treatment.Skin Appendage Disord (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - October 12, 2020 Category: Dermatology Source Type: research