Atopic dermatitis. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society, Polish Society of Allergology, Polish Pediatric Society and Polish Society of Family Medicine. Part I. Prophylaxis, topical treatment and phototherapy.
Authors: Nowicki RJ, Trzeciak M, Kaczmarski M, Wilkowska A, Czarnecka-Operacz M, Kowalewski C, Rudnicka L, Kulus M, Mastalerz-Migas A, Peregud-Pogorzelski J, Sokołowska-Wojdyło M, Śpiewak R, Adamski Z, Czuwara J, Kapińska-Mrowiecka M, Kaszuba A, Krasowska D, Krêcisz B, Narbutt J, Majewski S, Reich A, Samochocki Z, Szepietowski J, Woźniak K Abstract Atopic dermatitis is a chronic and recurrent inflammatory dermatosis with concomitant intensive pruritus, and is diagnosed both in children and adults. Atopic dermatitis-patients are predisposed to have bacterial, viral and fungal skin infections; they also su...
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Resistance of melanoma cells to anticancer treatment: a role of vascular endothelial growth factor.
Authors: Bogusławska-Duch J, Ducher M, Małecki M Abstract Melanoma is one of the most aggressive and resistant to treatment neoplasms. There are still many challenges despite many promising advances in anticancer treatment. Currently, the main problem for all types of treatment is associated with heterogeneity. Due to heterogeneity of cancer cells, "precise" targeting of a medicine against a single phenotype limits the efficacy of treatment and affects resistance to applied therapy. Therefore it is important to understand aetiology and reasons for heterogeneity in order to develop effective and long-las...
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Methotrexate use and NAD+/NADH metabolism in psoriatic keratinocytes.
Authors: Liszewska A, Robak E, Bernacka M, Bogaczewicz J, Woźniacka A Abstract Methotrexate inhibits tetrahydrofolic acid production and influences mitochondrial oxygen uptake and activity of several enzymes in the respiratory chain reactions, which utilize nicotinamide adenine dinucleotide-linked (NAD-linked) substrates. Hyperproliferation of keratinocytes in psoriasis requires oxidative phosphorylation, in which the reduced form of nicotinamide adenine dinucleotide (NADH) is an electron donor. One hypothesis links increased cellular metabolism to the increased NADH/NAD+ ratio; as expected, the topical applicatio...
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey.
Conclusions: Within our study population, pemphigus predominately affected females, and the most common clinical variant was PV, a subtype that frequently occurs in middle-aged individuals. MCP was the most common clinical pattern. Although MCP and higher doses of corticosteroids were needed to control pemphigus, they did not seem to influence the prognosis. PMID: 32467679 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The effects of 755 nm alexandrite laser on skin dryness and pruritus.
Conclusions: To the best of our knowledge, this is the first study researching the effects of AL on pruritus and skin dryness. Further studies with larger samples and longer follow-up periods will be able to better clarify the association. PMID: 32467680 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Endoplasmic reticulum stress links psoriasis vulgaris with keratinocyte inflammation.
Conclusions: Our findings demonstrate that PV keratinocytes have an increased ERS, which may contribute to the pathogenesis of PV. PMID: 32467681 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Serum concentration of interleukin 6 is related to inflammation and dyslipidemia in patients with psoriasis.
Conclusions: Interleukin-6 may be an indicator of inflammatory activity in psoriasis. Moreover, IL-6 may be related to lipid abnormalities in patients with this disease. PMID: 32467682 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Prevalence and severity of fatigue in psoriasis and psoriatic arthritis.
Authors: Krajewska-Włodarczyk M, Owczarczyk-Saczonek A, Placek W Abstract Introduction: Fatigue is an important and underrated symptom of many chronic diseases. Aim: The evaluation of incidence and severity of fatigue as well as the influence of selected factors on fatigue in patients with psoriasis and psoriatic arthritis (PsA). Material and methods: The study included 60 patients with PsA, 58 patients with psoriasis and 61 persons in the control group aged 35-70 years. Assessment of fatigue was conducted using a fatigue subscale from the FACIT-F questionnaire. Severity of skin lesions and arthritis was d...
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Thiol/disulphide balance in patients with psoriasis.
Conclusions: In recent years, there have been few studies on the role of oxidative stress in the etiopathogenesis of psoriasis. In this study, we investigated in psoriasis patients, thiol/disulfide balance as a new oxidative stress marker. The results were compared with a healthy control group. Our results showed that thiol/disulphide balance shifted towards disulphide in psoriasis patients. This is important as a finding that supports the role of oxidative stress in the pathogenesis of psoriasis. PMID: 32467684 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Comparison of an automated microfluidic immunoassay technology (BioIC, lab-on-chips) and ImmunoCAP assay. Lab-on-chips as a tool for specific IgE (sIgE) detection.
Authors: Szymczak-Pajor I, Pawliczak R Abstract Introduction: The measurement of clinically important specific IgE (sIgE) antibody is pivotal for both diagnosis and management of allergy. Two methods may be distinguished depending on the number of antigens tested simultaneously: singleplex and multiplex. BioIC is a multiplex, advanced, automated microfluidic immunoassay system enabling simultaneous sIgE measurement against multiple allergens. ImmunoCAP is a singleplex assay for sIgE detection and gold standard method for diagnosis of allergy. Aim: To compare and validate the diagnostic capability of a multiplex...
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Systemic corticosteroid therapy augments ex vivo release of sCD163 by peripheral blood monocytes of asthmatic patients.
Authors: Bernatowicz PL, Golec P, Bielecki P, Kowal K Abstract Introduction: The CD163 is exclusively expressed by mononuclear phagocytes as a transmembrane protein, which synthesis is regulated by anti- and pro-inflammatory signals. After shedding from the cell surface it exists in body fluids as a soluble protein (sCD163) which exerts anti-inflammatory effects. Aim: To evaluate serum concentration and ex vivo production of sCD163 by peripheral blood mononuclear cells (PBMC) in asthmatic patients treated with inhaled (ICS) or oral corticosteroids (OCS). Material and methods: The study was performed on 35 a...
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Quality of life in infants with atopic dermatitis and their families.
Authors: Djurović MR, Janković J, Ćirković A, Spirić VT, Maksimović N, Timotijević ZS, Vukićević D, Mirković Z, Vitković L, Janković S Abstract Introduction: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, with a significant effect on quality of life (QoL). Aim: To evaluate the impact of AD on QoL of Montenegrin infants and their parents and to identify predictors affecting their QoL. Material and methods: The cross-sectional study was conducted between August 2017 and July 2018 and included 186 infants with AD aged 0-4 years and their parents. The severity of diseas...
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The effect of levocetirizine and montelukast on clinical symptoms, serum level and skin expression of COX-1 and COX-2 enzymes in patients suffering from chronic autoimmune urticaria - a pilot study.
Conclusions: The effectiveness of levocetirizine and montelukast in treating CAU may be partly related to the reduction of COX-1 and COX-2 serum level and tissue expression, but further studies on a larger group of patients are needed to support this observation. PMID: 32467688 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Building age, type of indoor heating and the occurrence of allergic rhinitis and asthma.
Conclusions: Increasing building age and certain indoor heating methods are important risk factors for the occurrence of allergic rhinitis and asthma. PMID: 32467689 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Angiopoietin-like protein 2 in psoriasis: a new linkage with metabolic syndrome.
This study enrolled 180 participants divided into two groups: psoriatic group (120 patients with chronic plaque psoriasis) and control group (60 normal subjects). Psoriasis severity was determined by the psoriasis area severity index. Anthropometric measurements, lipid profile, fasting blood sugar and ANGPTL2 have been evaluated in both groups. Results: Psoriatic patients had a higher body mass index (p = 0.014), waist circumference (p
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Paraoxonase-1 and other factors related to oxidative stress in psoriasis.
Authors: Oszukowska M, Kozłowska M, Kaszuba A Abstract Introduction: Psoriasis is considered as a risk factor for atherosclerosis and contributes to myocardial infarction, ischemic heart disease and brain stroke. Aim: To estimate the atherogenic potential of psoriasis by analysing antioxidative and prooxidative factors (paraoxonase-1, α-tocopherol, uric acid, homocysteine), compare levels of these parameters between groups of psoriatic patients and healthy individuals as well as to analyse the impact of psoriasis severity and duration on the factors under the study and to define correlation between the m...
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Cross-cultural adaptation and validation of the RhinAsthma Patient Perspective (RAPP) in the Polish population.
Authors: Kupczyk M, Baiardini I, Molinengo G, Loera B, Szydłowska D, Kuna P, Canonica GW, Braido F Abstract Introduction: The RhinAsthma Patient Perspective (RAPP) was developed in Italian to assess the Health Related Quality of Life (HRQoL) impairment in patients with asthma and allergic rhinitis (AR) in daily practice. Aim: To cross-culturally validate the Polish version. Material and methods: The Polish version was administered to patients suffering from asthma and rhinitis in a prospective observational study. Polish RAPP, along with SF-12, ACT, and a Symptomatologic VAS was filled in twice, with a 4-w...
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Chromosome 11q13.5 variant as a risk factor for atopic dermatitis in children.
Conclusions: Our results indicate that the rs7927894 variant on chromosome 11q13.5 may play a role in the development of atopic dermatitis, but this effect seems to be independent of allergic sensitization and of the well-established filaggrin risk alleles, but may be modulated by gene-gene interactions. PMID: 32467693 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Pemphigus foliaceus complicated by sepsis of the aetiology of Yersinia enterocolitica after eating cheesecake.
Authors: Tomczak H, Rogacki M, Wrońska M, Malińska N, Jenerowicz D, Czarnecka-Operacz M, Adamski Z PMID: 32467694 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Skin allergic reaction to a spinal cord stimulation (SCS): an analysis of the world literature and a case report.
Authors: Woźniak-Dąbrowska K, Nowacka A, Smuczyñski W, Śniegocki M PMID: 32467695 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

A case of late onset steatocystoma multiplex.
Authors: Jiang M, Zhang M, Gu H, Chen X PMID: 32467696 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Large primary cutaneous angiosarcoma of the nose successfully treated surgically.
Authors: Mêciñska-Jundziłł K, Białecka A, Adamska U, Jundziłł A, Neska-Długosz I, Grzanka D, Witmanowski H, Czajkowski R PMID: 32467697 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Basosquamous carcinoma: epigenetic considerations in a case.
Authors: Somuncu OS, Aksoy HM, Mert B, Bicakci D, Akin D, Aksoy B PMID: 32467698 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Skin cancer in children after organ transplantation.
Authors: Imko-Walczuk B, Roskosz-Stożkowska M, Szymańska K, Kadylak D, Dębska-Ślizień A Abstract Skin cancer is the second most common complication of organ transplantation in children. The frequency of skin cancer incidence after organ transplantation is different in paediatric and adult populations. The post-transplant lymphoproliferative disease is the most common group of malignancies after organ transplantation in paediatric population. The majority of researchers who examined children with kidney, liver, heart or lungs grafts observed that the risk of skin cancer was three times higher than in the genera...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

An update on direct immunofluorescence for diagnosing dermatitis herpetiformis.
Authors: Dmochowski M, Gornowicz-Porowska J, Bowszyc-Dmochowska M Abstract This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. In certain patients presenting with the rash resembling DH, the deposition of exclusively C3 at DEJ can be found. The term "granular C3...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Sleep quality among adult patients with chronic dermatoses.
Authors: Kaaz K, Szepietowski JC, Matusiak Ł Abstract Chronic dermatoses, including atopic dermatitis, psoriasis, prurigo nodularis, chronic spontaneous urticaria and hidradenitis suppurativa, as well as accompanying subjective symptoms (itch and pain), have a great impact on patients' well-being. Skin plays an important role in the physiological sleep process. This review attempts to analyze the association between chronic dermatoses in adults and sleep quality in recent studies. Polysomnography and actigraphy are performed for the objective assessment of sleep quality. Questionnaire-based subjective evaluations ...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Ultrasonographic elastography in the evaluation of normal and pathological skin - a review.
Authors: Ambroziak M, Pietruski P, Noszczyk B, Paluch Ł Abstract The aim of this review article is to discuss the role of ultrasonographic elastography, a technique used to quantify tissue stiffness, in the evaluation of normal and pathological skin. A growing body of evidence suggests that elastography may be used for the diagnosis and monitoring of skin pathologies, in particular tumors, and fibrotic and sclerotic processes. Our knowledge about the elastographic parameters of normal skin is sparse, which together with the lack of reference values for cutaneous stiffness constitutes a serious limitation to the us...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Smoking history is negatively associated with allergen specific immunotherapy efficacy: a retrospective analysis.
Authors: Romantowski J, Specjalski K, Jakub Ł, Wasilewska E, Chełmińska M, Jassem E, Niedoszytko M Abstract Introduction: Allergen specific immunotherapy (AIT) is the only treatment modifying the course of the disease in patients allergic to airborne allergens. It has been proven to be effective in allergic populations, however individual patients vary in terms of response to the therapy. Aim: To assess the factors that might affect the efficacy of AIT. Material and methods: Patients treated with AIT for grass pollen or house dust mites were included. The efficacy of AIT was assessed with the use of Alle...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Anti-inflammatory activity of Anthemis tricolor Boiss.
Conclusions: This is the first report on anti-inflammatory activity of A. tricolor and we showed an anti-inflammatory effect of n-hexane and sesquiterpene extract of A. tricolor with UV erythema test as a result, hence A. tricolor extracts can be used for the treatment of inflammatory skin diseases due to anti-inflammatory activity. PMID: 31997994 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Dietary supplements: a great menace of our time or golden remedy? A cross-sectional study amongschool-aged children.
Conclusions: This study shows the need to educate patients about medical indications for DS use and expected benefits in the specific indications. PMID: 31997995 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Dermoscopic profile of pigmented purpuric dermatosis: new observations.
Conclusions: The characteristic dermoscopic findings of PPD have been defined in the relevant literature. Here we have identified some dermoscopic findings which have not been described previously: red circles, brown circles, rosette structures, light brown background and red background. Dermoscopic examination may facilitate the diagnostic process by reducing the use of invasive methods. PMID: 31997996 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta-analysis of case-control studies.
Authors: Ramezani M, Zavattaro E, Sadeghi M Abstract Introduction: Psoriasis is a T cell-mediated inflammatory skin disease in which fatty acids may be a link between psoriasis and its comorbidity. Aim: The present meta-analysis aimed to evaluate lipid, lipoprotein, and apolipoprotein levels in the psoriatic patients compared with the control subjects. Material and methods: Four databases, including Web of Science, Scopus, PubMed, and Cochrane Library were searched until July 2017. All records analysed were case-control studies. The quality of the questionnaires was evaluated using the Newcastle-Ottawa Scal...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Rationale for the autologous serum skin test in acute versus chronic urticaria.
Authors: Demirkan S, Baççıoğlu A Abstract Introduction: Autologous serum skin test (ASST) is a rapid, in-vivo clinical test to detect functional autoantibodies in patients with chronic spontaneous urticaria (CSU), but the rationale for its use in acute urticaria (AU) is unknown. Aim: To evaluate the efficacy of ASST among patients with AU or CSU. Material and methods: Treatment-naïve adult (age ≥ 18 years) patients with a diagnosis of AU (
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Abnormalities of heart rate turbulence and heart rate variability as indicators of increased cardiovascular risk in patients with systemic sclerosis.
Conclusions: The study confirmed the presence of HRV disturbances, including HRV circadian rhythm, as it may seem at an early stage of SSc. The HRT disorders may be characterized by the increasing changes with advancing disease. This indicates the presence of autonomic imbalance and an increased cardiovascular risk. PMID: 31997999 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Serum sphingolipid level in psoriatic patients with obesity.
Conclusions: We have demonstrated an abnormal sphingolipid profile in psoriatic patients in different weight groups. Selected CER might be the biomarkers of psoriasis severity and inflammation, may reflect lipid disturbances and contribute to the development of metabolic syndrome. PMID: 31998000 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Comparison of topical clobetasol propionate 0.05% and topical tacrolimus 0.1% in the treatment of cutaneous lichen planus.
Authors: Özkur E, Aksu EK, Gürel MS, Savaş S Abstract Introduction: The effectiveness of topical tacrolimus in the treatment of oral and genital lichen planus has been verified in many randomized studies; however, there are only few case reports in treatment of cutaneous lichen planus (CLP). Aim: We sought to compare the safety and efficacy of topical clobetasol propionate and tacrolimus ointment in the treatment of CLP. Material and methods: Retrospective analysis of patient files was performed. We enrolled patients who were diagnosed with CLP and treated with topical tacrolimus 0.1% or topical ...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Epidemiology and direct costs of atopic dermatitis in Poland based on the National Health Fund register (2008-2017).
Conclusions: The prevalence rates of AD in Poland estimated on the basis of NHF data are significantly lower than those reported in previous epidemiological studies conducted in Poland and worldwide. This may indicate that the prevalence of AD in the Polish population is underestimated or that there are no adequate disease control measures in patients with a confirmed diagnosis. PMID: 31998002 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Omalizumab usage in chronic urticaria and atopic dermatitis: data from South-East province of Turkey.
Conclusions: The decline of complaints with different treatment schemes in different patients suggests that treatment should be designed individually and that personal biomarkers playing a role in the effectiveness of the drug are important. Patients with the high IgE and eosinophil percentages and positive autologous serum test had a better treatment response to omalizumab treatment. Meanwhile, remission was found to be more frequent in atopic dermatitis patients with omalizumab treatment compared to the patients with urticaria. It may be more appropriate to choose patients based on certain criteria to ensure cost-effecti...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Clinic experience in discoid lupus erythematosus: a retrospective study of 132 cases.
Conclusions: Discoid LE, though identified long ago, remains unelucidated and there are very few studies in the literature reporting on DLE. The results indicated that smoking and chronic UV exposure are important risk factors for DLE. Moreover, although ANA positivity was high in our patients, the rate of progression to SLE was remarkably low. The results also showed that, contrary to common belief, there is no female preponderance in DLE. PMID: 31998004 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Benign tumours and tumour-like lesions in the oral cavity: a retrospective analysis.
Conclusions: In cases of oral mucosal lesions, we propose the following algorithm: the exclusion of all odontogenic and iatrogenic causes; the detection and elimination of harmful habits, parafunctions and irritants from the oral cavity especially from the vestibule of the oral cavity and from the lips; all surgical treatment should be performed only after the proper detection and elimination of causative factors to decrease the risk of recurrence; excisional biopsy or in more diffuse lesions incisional biopsy is recommended to confirm clinical diagnosis; and consideration of other factors that can modify the clinical patt...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Efficacy and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis: meta-analysis of randomized clinical trials.
Conclusions: Calcineurin inhibitors seem to be more effective and contrarily they elicit more AEs than TCS. PMID: 31998006 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Effects of the soy isoflavones, genistein and daidzein, on male rats' skin.
Conclusions: Our results provide further support for the contribution of isoflavones to defence mechanisms against oxidative stress in the skin and suggest that genistein and daidzein supplementation may provide protection against skin ageing in males. PMID: 31998007 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Three novel ATP2C1 mutations in Chinese patients with Hailey-Hailey disease.
Authors: Jia WX, Zhang WL, Zhao SJ, Li WR, Wu YD, Ma HJ, Li CR PMID: 31998008 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Acrokeratoelastoidosis as an example of marginal popular acrokeratoderma with prominent elastorrhexis.
Authors: Żychowska M, Batycka-Baran A, Baran W PMID: 31998009 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

White fibrous papulosis of the neck.
Authors: Nowicka D, Woźniak Z, Maj J, Szepietowski J PMID: 31998010 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Cutaneous manifestation of chronic lymphocytic leukemia: a case report and a literature review.
Authors: Szukalski Ł, Sysakiewicz-Buda M, Mêciñska-Jundziłł K, Białecka A, Czyż J, Czajkowski R PMID: 31998011 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Impact of allergic diseases on fertility.
Authors: Wasilewska E, Małgorzewicz S Abstract The incidence of allergic diseases has been increasing in recent decades, and currently, nearly 30% of the European population suffer from some type of allergy. Also, an increasing number of people are suffering from infertility. Both diseases are related to the hormonal and immune systems, which prompts the question as to whether there is a causal relationship between allergic disorders and the reproductive system. The purpose of this review is to evaluate whether there is a link between allergic diseases and infertility, using the available literature. PMID: 318...
Source: Advances in Dermatology and Allergology - December 18, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Immunometabolic disorders in the pathogenesis of systemic lupus erythematosus.
Authors: Tokarska K, Majsterek I, Cuchra M, Woźniacka A Abstract Systemic lupus erythematosus is a chronic autoimmune disease connected with complex and unclear disorders of the immune system, which causes inflammation of body tissues and internal organs. It leads to the formation of anti-nuclear antibodies (ANA) and immune complexes. Numerous immune system disorders and dysfunctions in the biochemical processes can occur in the course of the disease, and a wide range of abnormalities associated with cellular respiratory processes and mitochondrial function have been documented. The following paper presents the cu...
Source: Advances in Dermatology and Allergology - December 18, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Endocrine systems of the skin.
Authors: Leis K, Mazur E, Jabłońska MJ, Kolan M, Gałązka P Abstract Apart from its protective function, the skin is also both hormonally and metabolically active. Many hormones are produced in the skin and the regulation of these changes is controlled, as are other organs, by the pituitary gland and hypothalamus. Under the influence of stress factors such as ultraviolet radiation, many reactions are stimulated. After exposure to light in keratinocytes apart from eumelanin, also proopiomelanocortin, dopamine, and opioid substances - β-endorphins are produced. The skin also has a hypothalamic-pituitary-adren...
Source: Advances in Dermatology and Allergology - December 18, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The use of nasal over-the-counter agents in the evaluated Polish population. The underrated role of the pharmacist in patient education on medical treatment in patients with allergic rhinitis.
This study attempted to estimate the rates of nasal OTC use in patients diagnosed with allergic rhinitis. Material and methods: Study population was 18,578 subjects (4,192 patients diagnosed with AR and 14,386 healthy controls): children aged 6-7 years, adolescents aged 13-14 years, and adults aged 20-44 years. We used translated and validated versions of ECRHS and ISAAC questionnaires. Results: The rates of nasal decongestant use in the allergic rhinitis group were 60.4% in children, 50.7% in adolescents, and 43.0% in adults, with these figures significantly higher than in the control group (p
Source: Advances in Dermatology and Allergology - December 18, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research