Biological drugs in the treatment of atopic dermatitis - current recommendations of the Polish Dermatological Society, the Polish Society of Allergology, the Polish Pediatric Society and the Polish Society of Family Medicine.
Authors: Nowicki RJ, Trzeciak M, Rudnicka L, Szepietowski J, Kulus M, Kupczyk M, Mastalerz-Migas A, Peregud-Pogorzelski J, Jahnz-Różyk K, Narbutt J, Czarnecka-Operacz M, Czajkowski R, Grubska-Suchanek E, Krasowska D, Kręcisz B, Kowalewski C, Lesiak A, Olszewska M, Samochocki Z, Śpiewak R, Wilkowska A Abstract Atopic dermatitis (AD) is secondary to genetic, immunological and microbiological disorders as well as epidermal barrier defects, which are the main targets of therapy. The disease proceeds with periodic exacerbations. Its development and course are influenced by numerous environmental and individual...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Pathogenesis of psoriasis in the "omic" era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis.
Pathogenesis of psoriasis in the "omic" era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis. Postepy Dermatol Alergol. 2020 Oct;37(5):625-634 Authors: Szczerkowska-Dobosz A, Krasowska D, Bartosińska J, Stawczyk-Macieja M, Walczak A, Owczarczyk-Saczonek A, Reich A, Batycka-Baran A, Czajkowski R, Dobrucki IT, Dobrucki LW, Górecka-Sokołowska M, Janaszak-Jasiecka A, Kalinowski L, Nowicki RJ, Płoska A, Purzycka-Bohdan D, Radulska A, Reszka E, Samotij D, Siekierzycka A, Slominski AT, Slominski RM, Sobalska-Kwapis M, Strapagiel D, S...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Objectification of the nasal patency assessment techniques used in nasal allergen provocation testing.
Authors: Krzych-Fałta E, Samoliński BK Abstract Topical allergen application in nasal provocation testing (NPT) is associated with remarkably rapid changes in nasal patency. Thus, selecting the techniques of assessing the extent of nasal obstruction (as one of the responses to topical allergen application) is an important component of NPT. The study attempted to systematize and evaluate the techniques selected for assessing nasal patency during NPT based on a review of relevant literature. We reviewed the literature on the attempts to standardize the objective techniques for assessing nasal patency and their use ...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The microbiome and its impact on food allergy and atopic dermatitis in children.
Authors: Łoś-Rycharska E, Gołębiewski M, Grzybowski T, Rogalla-Ładniak U, Krogulska A Abstract Food allergy (FA) affects 4-10% of children, especially children with atopic dermatitis (AD). During infancy the gut microbiome may determine both the course of FA and tolerance to food allergens. Analogically, the skin microbiome changes in the course of AD. Most studies have associated FA with a lower abundance and diversity of Lactobacillales and Clostridiales, but greater numbers of Enterobacterales, while AD in children has been associated with lower numbers of Staphylococcus epidermidis and S. hominis but an ab...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Another face of dermal fillers.
Authors: Witmanowski H, Błochowiak K Abstract Potential complications related to dermal fillers depend on the type of the fillers and the site of their application. The classification of dermal filler complications can be divided into early and late, and into minor and major events. According to their mechanism, they can be divided into non-ischaemic and ischaemic complications. The aim of this study is to present possible complications related to dermal fillers, to explain their aetiology and to propose preventive management and treatment. Non-ischaemic complications can be technique-dependent and include the rea...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Novel therapies for advanced skin carcinomas.
Authors: Modrakowska P, Balik K, Maj M, Bajek A Abstract Advanced skin carcinomas are a serious therapeutic problem. The statistical analysis shows a continuous increase in the incidence of both melanoma and non-melanoma skin cancers. Traditional therapies are characterized by low effectiveness and patients overall survival is not affected by them. By understanding the molecular pathways that lead to the neoplastic transformation and thanks to the knowledge of the immune system, it is possible to use personalized medicine in novel therapies for advanced skin carcinomas. PMID: 33240003 [PubMed] (Source: Advances...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Diagnosis of Papillon-Lef èvre syndrome: review of the literature and a case report.
Diagnosis of Papillon-Lefèvre syndrome: review of the literature and a case report. Postepy Dermatol Alergol. 2020 Oct;37(5):671-676 Authors: Adamski Z, Burchardt D, Pawlaczyk-Kamieńska T, Borysewicz-Lewicka M, Wyganowska-Świątkowska M Abstract Papillon-Lefëvre syndrome (PLS), classified as ectodermal dysplasia, is an autosomal recessive condition related to the cathepsin C (CTSC) gene mutation. The first clinical symptoms, occurring most commonly between the ages of 1 and 4, are palmoplantar hyperkeratosis and also periodontitis resulting in the loss of most or all teeth in the same seq...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Dermoscopic features in different dermatopathological stages of cutaneous melanomas.
Conclusions: Presence of pseudopods, a multicomponent pattern, white regression structures, atypical blood vessels and nodules on dermoscopy suggest invasive (high stage) melanoma. PMID: 33240005 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children.
Authors: Bobrowska-Korzeniowska M, Brzozowska A, Jerzyńska J, Stelmach W, Stelmach I Abstract Introduction: The usefulness of total specific resistance (sRtot) and interrupter resistance (Rint) as a bronchodilator reversibility test (BT) alternative to forced expiratory volume in 1 s (FEV1) in asthma diagnosis in children has not been established. Aim: To compare different applied definitions of airflow obstruction in children measuring response to the bronchodilator by spirometry, plethysmography and the interrupter technique in asthmatic children. Material and methods: It was a prospective, real-life, no...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Synergistic effect of fennel essential oil and hydrogen peroxide on bacterial biofilm.
Conclusions: Combination of fennel essential oil containing nearly 80% trans-anethole and H2O2 represents a potential for further basic and applied research on wound management. PMID: 33240007 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Skin lesions caused by Orthopoxvirus in children.
Conclusions: In the case of unclear necrotising skin lesions in children, the primary diagnosis always includes bacterial dermatitis. However, if the patient has come into contact with animals, diagnosis of OPV infection should also be considered. PMID: 33240008 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Differences in subjective and objective evaluation of hyperhidrosis. Study among medical students.
Authors: Dobosz Ł, Stefaniak T, Halman J, Piekarska A Abstract Introduction: Hyperhidrosis is a condition that significantly impairs patients' quality of life. Qualification for treatment in most cases is based only on subjective evaluation of symptoms without objective confirmation. Aim: To evaluate the differences between subjective and objective evaluation of sweating among medical students. Material and methods: There were 179 participants involved in the study. Subjective evaluation of sweating was conducted using the Hyperhidrosis Disease Severity Scale and Numeric Rating Scale in 4 body areas: the f...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Interleukin 22 and 6 serum concentrations decrease under long-term biologic therapy in psoriasis.
Authors: Olejniczak-Staruch I, Narbutt J, Bednarski I, Woźniacka A, Sieniawska J, Kraska-Gacka M, Śmigielski J, Lesiak A Abstract Introduction: Psoriasis, affecting approximately 2% of the worldwide population, is a chronic, inflammatory skin disease in which overexpression of proinflammatory cytokines is observed. Most of the available data on the influence of antipsoriatic therapy on the cytokine serum concentration are inconsistent and based on short-term observations. Aim: To evaluate the influence of long-term biologic therapy with tumor necrosis factor α (TNF-α) blockers (adalimumab, etanerc...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Examples of adverse effects after biological therapy.
This article presents cases of 4 patients who have been administered biological treatment and in whom there have been observed, inter alia, the occurrence of hypersensitivity reactions in the form of acute urticaria as well as skin lesions of erythema multiforme nature or positive antinuclear antibodies titre. The symptoms experienced by the presented patients posed no direct threat to life and the benefits of the drugs' administration had a significant therapeutic importance. PMID: 33240011 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Serum and local IL-4, IL-5, IL-13 and immunoglobulin E in allergic rhinitis.
Conclusions: Regardless of the obvious differences of the concentrations of the cytokines studied in our groups, oftentimes no significant difference is observed. More studies should be conducted in order to show the role of IL-4, -5, -13, and IgE in the pathogenesis and severity of the disease. PMID: 33240012 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Anti-endothelial cell antibodies are associated with apoptotic endothelial microparticles, endothelial sloughing and decrease in angiogenic progenitors in systemic sclerosis.
Conclusions: We found an association between AECAs and the severity of endothelial damage in SSc based on higher levels of total EMPs and CECs. In our study, AECAs were associated with apoptosis of ECs rather than their activation. We also identified a possible role of AECAs in the impairment of vascular repair in SSc as evidenced by significantly fewer angiogenic EPCs. PMID: 33240013 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Analysis of molecular and clinical parameters of 4-year adalimumab therapy in psoriatic patients.
Conclusions: TNF-α seems to be a useful marker to evaluate the efficacy of therapy and occurring resistance to the medicine. A complex mechanism for the regulation of the analysed gene expression was underlined, which involved the potential role of miRNAs. PMID: 33240014 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Adrenocorticotropin/cortisol ratio - a marker of psoriasis severity.
Conclusions: Our results support the role of HPA axis dysfunction in the complex pathogenesis of psoriasis, showing a positive correlation between morning ACTH/cortisol ratio and disease severity. ACTH/cortisol ratio can be regarded as a new biochemical marker of psoriasis severity worth further studies. PMID: 33240015 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Sensitisation to airborne allergens as a risk factor for allergic rhinitis and asthma in the Polish population.
Conclusions: AR and asthma shared common risk factors, independently of age. Sensitisation to airborne allergens was significantly associated with asthma and, even more strongly, with AR, across all age groups. The AR was the strongest risk factor for allergic asthma in the youngest group. Persistent AR increased asthma risk more than intermittent AR in all age groups. PMID: 33240016 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Cutaneous and systemic granulomatosis in ataxia-telangiectasia: a clinico-pathological study.
Conclusions: In the setting of combined immunodeficiency in A-T, cutaneous and systemic granulomatosis reflects a granulomatous reaction pattern, as a result of inappropriate immune regulation. PMID: 33240017 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Evaluation of the effects of hair colouring products on the oxidative status in rats.
Conclusions: Knowing the facts about these products, which are easily accessible to every individual in society and are considered to be innocent, will prevent possible harm. PMID: 33240018 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Biostimulative effect of laser on growth of mesenchymal stem/stromal cells in vitro.
Conclusions: The presented results indicate that both lasers, Er:YAG and diode can be used to stimulate stem/stromal cell growth in vitro. The biostimulative effect of laser therapy on stromal cells may be used in the future in aesthetic dermatology in combined laser and cell therapy. PMID: 33240019 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Clinical picture and treatment of cutaneous lesions in patients with neurofibromatosis type 1.
Conclusions: Due to the polymorphism of the clinical picture and unpredictable course of the disease, there is no one standard of treatment of patients with Recklinghausen disease. Excision of tumours in the early stage of their development gives better functional and aesthetic results. PMID: 33240020 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Prevalence and potential risk factors of urticaria in the Polish population of children and adolescents.
Conclusions: A higher incidence of urticaria in the younger age group may suggest an upward trend in the incidence of this disease in the near future. The incidence of chronic urticaria in children turned out to be higher than in the European population. As our research results show, the incidence of urticaria in children and adolescents does not depend on exposure to polluted air. PMID: 33240021 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The prevalence of IgE-dependent sensitizations to selected trophoallergens and airborne allergens in the population of children and adolescents of the north-eastern region of Poland.
Conclusions: Measurement of skin prick test reactivity to different allergens is a useful and commonly used method in epidemiological studies for the assessment of allergic sensitization and changes in selected populations. The obtained results confirmed the need for systematic epidemiological research into allergic sensitization and allergic diseases among children and adolescents in Poland. PMID: 33240022 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Prognostic factors of patients with mycosis fungoides.
Authors: Bahalı AG, Su O, Cengiz FP, Emiroğlu N, Ozkaya DB, Onsun N Abstract Introduction: Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma. Prognostic factors may help to evaluate the course of the disease and may also be useful in selecting appropriate treatment plans for patients. Aim: To investigate the potential prognostic factors of MF and their correlations with MF stage. Material and methods: We evaluated the records of patients with MF who were followed in our lymphoma clinic between 1998 and 2015. Age, sex, disease stage, peripheral blood eosinophilia, eosinoph...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris.
Authors: Pektas SD, Cinar N, Duman DD, Kara A, Batu J, Karakas-Celik S, Aksoy DY Abstract Introduction: Ghrelin has anti-inflammatory and immunomodulatory activities. Data about the role of ghrelin and ghrelin polymorphisms in the development of acne vulgaris in post-adolescent male patients are limited. Aim: To evaluate the role of serum androgens, insulin resistance, ghrelin and ghrelin polymorphisms in severe acne vulgaris. Material and methods: Thirty-five post-adolescent male patients with a mean age of 28.0 ±5.4 years and 33 age-and BMI-matched controls were enrolled. Serum androgens, lipids, i...
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Syphilis and HIV infection in patients with hepatitis A: a preliminary study from one centre in Poland.
Authors: Bura M, Bura A, Mozer-Lisewska I PMID: 33240025 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Clinical manifestations of diffuse large B-cell lymphoma in the skin and subcutaneous tissue a case series study.
Authors: Dulik K, Kamińska-Winciorek G, Swoboda R, Kwiatkowska-Pamula A, Giebel S PMID: 33240026 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Acute onset of necrolytic migratory erythema mimicking an erythema multiforme.
Authors: Juśko N, Kłosowicz A, Kaleta K, Gałązka K, Kapińska-Mrowiecka M PMID: 33240027 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 27, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Angioedema. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society (PTD) and Polish Society of Allergology (PTA).
Authors: Nowicki RJ, Grubska-Suchanek E, Porêbski G, Kowalski ML, Jahnz-Różyk K, Matuszewski T, Rudnicka L, Kulus M, Barañska-Rybak W, Czajkowski R, Doniec Z, Kowalewski C, Krêcisz B, Lange M, Narbutt J, Olszewska M, Sokołowska-Wojdyło M, Szczerkowska-Dobosz A, Śpiewak R, Trzeciak M, Wilkowska A Abstract Angioedema is a non-inflammatory oedema of the subcutaneous tissue and/or mucosal membranes. It most commonly coexists with urticaria wheals and is considered to be a deep form of urticaria. Less commonly, it occurs in isolation and can take two basic forms: acquired angioedema and her...
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis.
Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis. Postepy Dermatol Alergol. 2020 Aug;37(4):452-467 Authors: Owczarczyk-Saczonek A, Purzycka-Bohdan D, Nedoszytko B, Reich A, Szczerkowska-Dobosz A, Bartosiñska J, Batycka-Baran A, Czajkowski R, Dobrucki IT, Dobrucki LW, Górecka-Sokołowska M, Janaszak-Jasiecka A, Kalinowski L, Krasowska D, Radulska A, Reszka E, Samotij D, Słominski A, Słominski R, Sobalska-Kwapis M, Stawczyk-Macieja M, Strapagiel D, Szczêch J, Żmijewski M, Nowicki RJ Abstract Psoriasis is ...
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Non-alcoholic fatty liver disease in patients with psoriasis: therapeutic implications.
Authors: Klujszo EH, Parcheta P, Witkowska AB, Krecisz B Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing a more severe form of the disease with poorer outcomes. The components of the metabolic syndrome - obesity, lipid abnormalities, hypertension, and type 2 diabetes - significantly correlate with NAFLD progression. The inflammatory state present in psoriasis plays a significant role in development of NAFLD and the metabolic syndrome. All patients with psoriasis a...
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Low-level laser therapy in the treatment of recurrent aphthous stomatitis and oral lichen planus: a literature review.
Authors: Ślebioda Z, Dorocka-Bobkowska B Abstract Recurrent aphthous stomatitis (RAS) and oral lichen planus (OLP) present inflammatory, recurrent diseases of the oral mucosa with not fully understood aetiology. Despite numerous attempts to discover an effective treatment for RAS and OLP, the current main treatment strategies are largely confined to the reduction of symptoms. Low-level laser therapy (LLLT) is of interest as a novel treatment modality. The aim of the paper was to discuss the mechanism of action and the biological effects of LLLT and to critically review and summarize recent clinical reports on the ...
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Frontal fibrosing alopecia: a disease that remains enigmatic.
Authors: Lis-Święty A, Brzezińska-Wcisło L Abstract Frontal fibrosing alopecia (FFA) is recognized to represent a generalized process of inflammatory scarring alopecia. Apart from the classic form affecting the frontal hairline, there are a range of disease manifestations involving loss of eyebrows and of eyelashes, loss of peripheral body hair, fibrosing alopecia in a pattern distribution, facial and extrafacial skin, mucous membrane, and nail involvement. Classic linear, diffuse "zigzag", pseudo "fringe sign", androgenetic alopecia-like, cockade-like, ophiasis-like and incomplete patterns ...
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Dermoscopic diagnosis of subungual hematoma: new observations.
Conclusions: We detected two new findings which have not been described previously for subungual hematoma: the first one is "blue-white colour" which is known as an important clue to melanoma. The second one is granular leukonychia localized on the hematoma. We suggest that in any case of the nail discoloration, a thorough dermoscopic examination should be performed. Moreover, progression of the colour change to the distal edge should be observed to ensure that a possible melanoma is not overlooked. PMID: 32994768 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Endothelial dysfunction in patients with systemic sclerosis.
Authors: Pacholczak-Madej R, Kuszmiersz P, Bazan-Socha S, Kosałka-Wêgiel J, Iwaniec T, Zarêba L, Kielczewski S, Rams A, Walocha JA, Musiał J, Dropiñski J Abstract Introduction: Patients with systemic sclerosis experience endothelial dysfunction and damage even in the absence of clinical manifestations. Aim: To evaluate various methods for assessing the endothelial function for their applicability to clinical practice. Material and methods: Forty-two patients (7 men and 35 women) with systemic sclerosis and 36 controls (11 men and 25 women) matched for age, sex, body mass index, smoking ...
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The role of pentraxin 3 in pemphigus vulgaris.
Conclusions: PTX3 was found to be increased in PV and PTX3 could be a useful indicator of disease activity in PV. PMID: 32994770 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Sensitisation to lipid transfer proteins in pollen - allergic adults with food allergy.
Conclusions: Antigen-specific IgE antibodies to LTP components were identified in 24% of the subjects. In subjects with LTP allergy, adverse skin reactions were the most common after consumption of sensitising foods. Peach was the most common food allergen triggering these reactions. The Artemisia vulgaris component Art v 3 was the precursor of LTP allergy in our study population: the highest incidence and the highest mean levels of asIgE were demonstrated for this component. PMID: 32994771 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

In silico analysis of CpG islands and miRNAs potentially regulating the JAK-STAT signalling pathway.
Conclusions: The epigenetic mechanisms of the regulation of the JAK-STAT signalling pathway gene expression constitute a promising new therapeutic strategy for treatment of those diseases, during which disorders are observed in gene expression models of the analysed signalling pathway. PMID: 32994772 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Oral premedication in patients with a history suggesting hypersensitivity to iodinated contrast media.
Conclusions: Premedication with cetirizine and prednisone before radiologic procedures proved to be efficient in patients with a history suggesting hypersensitivity to iodinated contrast media. There was no significant difference in efficacy related to the dose of prednisone (20 mg vs. 50 mg). PMID: 32994773 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Factors affecting the concentration of soluble tumour necrosis factor- α receptor type I in the blood serum of patients with localized scleroderma.
Conclusions: The obtained results suggest a potential role of sTNFαR1 in the pathogenesis of localized scleroderma. PMID: 32994774 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Diagnostic accuracy of reflectance confocal microscopy for pigmented skin lesions presenting dermoscopic features of cutaneous melanoma.
Conclusions: It can be estimated that double evaluation of melanocytic lesions by dermoscopy and reflectance confocal microscopy may allow up to 62% of unnecessary excisions to be avoided. PMID: 32994775 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Caspase-3, p53 and Bcl-2 expression in basal cell carcinoma of the eyelid.
Conclusions: The caspase-3 level was lower in the BCC group. This result suggests that these enzymes can play a significant role in carcinogenesis of eyelid BCC. PMID: 32994776 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Prevalence of allergic rhinitis and asthma in Poland in relation to pollen counts.
Conclusions: Our findings do not confirm the hypothesis of a positive association between pollen exposure and the prevalence of allergic rhinitis and asthma. PMID: 32994777 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Efficiency of long-term high-dose intravenous ascorbic acid therapy in locally advanced basal cell carcinoma - a pilot study.
Conclusions: Our results suggest that IVA is well tolerated in a small group of patients with extensive BCCs. However, in the era of smoothened (Smo) receptor inhibitors, it may only be considered as an adjuvant therapy in treatment-resistant cases. PMID: 32994778 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Bronchial asthma control degree and the temperament structure according to the Eysenck model.
Conclusions: The structure of temperament of a person with poor control of bronchial asthma can be characterized. Patients with poor asthma control have a higher level of neuroticism, psychoticism and propensity to lie, compared with the healthy population and subjects with good or partial bronchial asthma control. PMID: 32994779 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Effect of Oreodoxa oleracea Jacq. pollen protein allergen in albino mice.
Conclusions: The present study is the first study to evaluate the allergenic potential of Oreodoxa oleracea in mice. The findings revealed that Oreodoxa oleracea which is profoundly planted in pubic areas for aesthetic purposes possess allergenic effect. PMID: 32994780 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Usefulness of three-dimensional digital image analysis for objective evaluation of the efficacy of non-facial port-wine stain treatment with large spot 532 nm laser.
Conclusions: Both objective and subjective analysis indicated that the large spot 532 nm laser is highly effective in the treatment of the neck and trunk. 3D color and area objective analysis provides an accurate tool to measure the efficacy of PWS treatment. PMID: 32994781 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Assessment of selected parameters of the circulatory system in patients undergoing oral aspirin challenge.
Conclusions: No clinically significant cardiac arrhythmias were recorded during OAC. The changes observed in the records of blood pressure and ECG monitoring show that OAC performed in accordance with the current guidelines does not pose a high risk to the patient's health and life as a result of cardiovascular reactions. PMID: 32994782 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - October 2, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research