Current methods for the assessment of skin microcirculation: Part 1.
Authors: Neubauer-Geryk J, Hoffmann M, Wielicka M, Piec K, Kozera G, Brzeziński M, Bieniaszewski L Abstract Microcirculation accounts for about 99% of blood vessels in adults and mediates between the arterial and venous parts of the cardiovascular system, both structurally and functionally. Skin microcirculation consists of two vascular plexuses: superficial and deep. Microcirculation includes vessels with a diameter of less than 150 μm, i.e. arteries, small veins, lymphatic vessels and arteriovenous anastomoses, which build the microcirculation unit. Skin microcirculation may be affected both in systemic patho...
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

New guidelines for the treatment of seasonal allergic rhinitis.
Authors: Emeryk A, Emeryk-Maksymiuk J, Janeczek K Abstract The paper discusses the classification and forms of allergic rhinitis with a special focus on seasonal allergic rhinitis (SAR). The general principles of SAR management are presented, including the role of nasal glucocorticoids, nasal and oral antihistamines, and antileukotrienes. Based on the latest guidelines, the current rules for the selection of drugs in the therapy of SAR are given, paying special attention to the initial treatment. The aim of the paper is to present updated guidelines for the pharmacological management of patients with seasonal aller...
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Assessment of hair nickel and chromium levels in patients with a fixed orthodontic appliance: a systematic review and meta-analysis of case-control studies.
Conclusions: The slightly elevated hair levels of Ni and Cr in patients undergoing fixed orthodontic treatment suggest that changing the components of fixed orthodontic appliances can be considered as an acceptable solution in the future. PMID: 31333341 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Evaluation of ocular findings in patients with lichen planus.
Authors: Ozlu E, Teberik K Abstract Introduction: Lichen planus (LP) is a chronic, inflammatory disease of unknown etiology. Aim: To evaluate the tear functions and the retinal and choroidal thickness (CT) in patients with LP. Material and methods: In total, 33 patients and 30 healthy controls were enrolled. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer 1 test (with anesthesia), tear break-up time (TBUT) test, intraocular pressure (IOP), axial length (AL), and central corneal thickness (CCT). The measurements of retinal thickness (RT) and CT were obtai...
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Differences in skin lesions of endogenous and exogenous Cushing's patients.
Conclusions: Since Cushing's syndrome is a rare disease and it is often diagnosed later in life, data on the frequency of skin findings are limited and sparse in the literature. In the comparison of endogenous Cushing's and exogenous Cushing's groups, acne, hypertrichosis, and fungal infections were found more frequently in the exogenous Cushing's group and hirsutism more frequently in the endogenous Cushing's group. PMID: 31333343 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Investigation of the relationship between atopy and psoriasis.
Conclusions: The findings suggested that atopy was not common in the patients with psoriasis and supported the concept that atopy protects against such autoimmune diseases such as psoriasis. PMID: 31333344 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Prevalence of allergic diseases in children with inflammatory bowel disease.
Conclusions: Children with IBD should be constantly monitored by medical professionals, not only due to the underlying disease but also due to a possible concomitant allergic disease. PMID: 31333345 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Assessment of autonomic nervous system functions and cardiac rhythms in patients using isotretinoin.
Conclusions: This study is very important because SSR results show that increasing the existing sympathetic activity in acne vulgaris after isotretinoin usage could explain the exacerbation in acne lesions for the first month, and according to the ECG results the medication did not cause cardiac side effects. PMID: 31333346 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Analysis of Hymenoptera venom allergy in own material. Clinical evaluation of reactions following stings, in patients qualified for venom immunotherapy.
Conclusions: The treatment after the sting in a significant percentage of episodes still deviates from the recommendations of the guidelines, especially in the field of adrenaline recommendations for patients in case of a resting by an insect. PMID: 31333347 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The effect of fennel essential oil and trans-anethole on antibacterial activity of mupirocin against Staphylococcus aureus isolated from asymptomatic carriers.
Authors: Kwiatkowski P, Pruss A, Masiuk H, Mnichowska-Polanowska M, Kaczmarek M, Giedrys-Kalemba S, Dołęgowska B, Zielińska-Bliźniewska H, Olszewski J, Sienkiewicz M Abstract Introduction: Staphylococcus aureus constitutes the most pathogenic species within the staphylococcal genus. Humans remain the major reservoirs of this pathogen which colonizes mostly anterior nares of healthy individuals. Aim: To investigate the effect of fennel essential oil (FEO) and trans-anethole (tA) on antibacterial activity of mupirocin (MUP) against S. aureus strains isolated from asymptomatic carriers. Material and method...
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Evaluation of selected mechanisms of immune tolerance in psoriasis.
Authors: Owczarczyk-Saczonek A, Czerwińska J, Orylska M, Placek W Abstract Introduction: Psoriasis is an autoimmune disease with an excessively aberration of the Th17/Treg balance and deficiency of anti-inflammatory cytokines. Aim: Evaluation of Treg markers expression in the lesional and perilesional psoriatic skin and serum anti-inflammatory cytokines in male psoriatic patients compared to healthy men. Material and methods: Treg markers (FoxP3+, CD4, CTLA-4, CD25/IL-2R, CD39/ENTPD1, IL-7R/CD127, CD3) and tissue expression of protective cytokines (IL-10, IL-35, TGF-β) in the lesional and perilesional...
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis.
Conclusions: The results of our study indicate that leptin levels might correlate with disease activity and subtype in SSc patients. PMID: 31333350 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Organizational model for the management of patients with chronic allergic conditions.
Conclusions: The authors propose an organizational model incorporating the position of a healthcare educator (HE) as a coordinator in the process of managing chronic allergic conditions in adult patients within the Polish healthcare system. Adult patient education by the HE would include introducing the principles of secondary and tertiary prevention in order to improve the quality of life in patients with chronic allergic conditions. PMID: 31333351 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Venom allergy treatment practices in Poland in comparison to guidelines: next edition of the national audit.
Conclusions: In the most important procedures, there is a very high compliance with the guidelines. In the areas where the guidelines are not precise, we observed a large spread of results. PMID: 31333352 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Right atrial myxoma: a potential accelerator of pulmonary hypertension in the course of systemic sclerosis. The role of interleukin-6.
Authors: Peregud-Pogorzelska M, Lewandowski M, Trzcińska-Butkiewicz B, Brzosko M PMID: 31333353 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Ectrodactyly-ectodermal dysplasia-clefting syndrome with unusual cutaneous vitiligoid and psoriasiform lesions due to a novel single point TP63 gene mutation.
Authors: Wawrzycki B, Pietrzak A, Chodorowska G, Filip AA, Petit V, Rudnicka L, Dybiec E, Rakowska A, Sobczyńska-Tomaszewska A, Kanitakis J PMID: 31333354 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Congenital multiple juvenile xanthogranuloma.
Authors: Cichewicz A, Białecka A, Męcińska-Jundziłł K, Adamska U, Białecki M, Neska-Długosz I, Grzanka D, Czajkowski R PMID: 31333355 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Primary skin manifestation of non-small-cell lung cancer - a case study.
Authors: Grzywa-Celińska A, Szmygin-Milanowska K, Emeryk-Maksymiuk J, Celiński R, Sobieszek G, Siwiec J, Krusiński A, Milanowski J PMID: 31333356 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Brain metastasis from ocular malignant melanoma: a case report of a brain secondary lesion occurring 5 years after the primary lesion treatment.
Authors: Śniegocki M, Smuczyński W, Woźniak-Dąbrowska K, Nowacka A PMID: 31333357 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Confirming acetylsalicylic acid hypersensitivity as a cause of chronic urticaria by desensitization.
Authors: Puźniakowska KM, Gawinowska M, Chełmińska M PMID: 31333358 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Molecular background of skin melanoma development and progression: therapeutic implications.
Authors: Olbryt M Abstract Melanoma is the most aggressive skin cancer with an increasing number of cases worldwide and curable mostly in its early stage. The improvement in patients' survival in advanced melanoma has been achieved only recently, due to development of new biological drugs for targeted therapies and immunotherapy. Further progress in the treatment of melanoma is clearly dependent on the better understanding of its complex biology. This review describes the most important molecular mechanisms and genetic events underlying skin melanoma development and progression, depicts the way of action of newly d...
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Wound healing complications in oncological patients: perspectives for cellular therapy.
Authors: Deptuła M, Zieliński J, Wardowska A, Pikuła M Abstract Various types of cancer are nowadays a serious medical and social problem and a great challenge for modern medicine. The majority of anticancer therapy is based on traditional chemotherapy and radiotherapy. Both of these highly non-specific types of treatment have a number of serious side effects including wound healing complications. Radiotherapy and chemotherapy mostly affect rapidly dividing skin cells (e.g. keratinocytes), as well as fibroblasts, melanocytes, endothelial and immune cells. Currently, there are many strategies to improve wound hea...
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Polish Society of Allergology statement on the diagnosis and treatment of severe, difficult-to-control bronchial asthma.
Authors: Kupczyk M, Bartuzi Z, Bodzenta-Łukaszyk A, Kulus M, Kuna P, Kupryś-Lipińska I, Mazurek H Abstract Severe asthma requires at least high doses of inhaled corticosteroids (ICS) in combination with a long-acting β-agonist (LABA) or systemic corticosteroids (SCS) for more than 50% of days/year to avoid loss of control, or remains uncontrolled despite the treatment described above. The diagnosis of severe asthma should be confirmed in a reference centre as it requires careful differential diagnosis and the exclusion of factors hindering the achievement of optimal control. Severe asthma represents a signi...
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Positive effect of ozonotherapy on serum concentration of soluble interleukin-2 receptor and neopterin in patients with systemic sclerosis.
Conclusions: Ozonotherapy had a beneficial influence on the immune response in patients with scleroderma. Balneotherapy may be considered as an additional therapeutic option, but further research is required. PMID: 31320847 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Does influenza subtype H1N1 have a place in the etiology of pityriasis rosea?
Conclusions: According to the results of this study, we can say that influenza subtype H1N1 does not play a role in PR etiology. PMID: 31320848 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Analysis of circulating soluble programmed death 1 (PD-1), neuropilin 1 (NRP-1) and human leukocyte antigen-G (HLA-G) in psoriatic patients.
Conclusions: Increased concentrations of sNRP-1 and unchanged values of sHLA-G and sPD-1 concentrations may be indicative of impaired immune tolerance mechanisms in psoriasis. PMID: 31320849 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

CAG polymorphism in the androgen receptor gene in women may be associated with nodulocystic acne.
Conclusions: The CAG trinucleotide repeat count in the ARG may be associated with acne, without hirsutism findings. PMID: 31320850 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Investigation of galectin-3, lipocalin 2, retinol binding protein (RBP), small dense low-density lipoprotein (sdLDL) in patients with hirsutism.
Authors: Yavuz IH, Ozaydin-Yavuz G, Çokluk E, Kurtoğlu Z, Bilgili SG Abstract Introduction: Hirsutism is defined as excessive terminal hair in androgen-dependent areas in women. Adipose tissue is no longer regarded as a storage site for triglycerides or as a source of free fatty acids but is currently emerging as a key constituent of energy metabolism secreting numerous enzymes, cytokines, growth factors, and hormones. Aim: To evaluate serum levels of galectin-3 (Gal3), lipocalin-2 (LCN2), retinol binding protein (RBP), and small dense low-density lipoprotein (sdLDL) in patients with hirsutism and patie...
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Clinical characteristics and epidemiology of chronic urticaria: a nationwide, multicentre study on 1091 patients.
Authors: Jankowska-Konsur A, Reich A, Szepietowski J, Polish Chronic Urticaria Working Group Abstract Introduction: Urticaria is one of the most common skin diseases. Depending on the length of symptoms, acute (lasting less than 6 weeks) and chronic urticaria (CU) (> 6 weeks) are distinguished. According to the current European guidelines, CU is divided into inducible urticaria (IU) and chronic spontaneous urticaria (CSU). Aim: To assess the epidemiology and clinical characteristics of CU in Poland. Material and methods: This was a nationwide, multicentre, cross-sectional, questionnaire-based study perfo...
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Syphilis in Poland is on the rise and underreported.
Conclusions: Our work shows that there is a remarkable underreporting of syphilis in the mandatory epidemiological surveillance system in Poland, involving also hospitalized patients. The use of the data of NHF in the surveillance of syphilis in Poland is proposed. PMID: 31320853 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Systemic and environmental risk factors for recurrent aphthous stomatitis in a Polish cohort of patients.
Authors: Ślebioda Z, Dorocka-Bobkowska B Abstract Introduction: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease without a clearly defined etiology. Aim: To analyze the influence of systemic diseases, medications, smoking and a family history of RAS on the prevalence and the course of the condition in Polish patients with RAS. Material and methods: Seventy-eight patients with RAS and 72 subjects without a history of RAS were enrolled in the study. All participants underwent a detailed oral examination and a full blood count. The results were statistically analyzed with Statistica 10 (St...
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Factors affecting the choice of therapeutic regimens in asthma and chronic obstructive pulmonary disease patients and patient adherence to the therapies prescribed.
Conclusions: The most common treatments for asthma and COPD in Poland are inhaled glucocorticosteroids and long-acting β2 agonists. The main factors influencing treatment decisions are the current GINA and GOLD recommendations as well as patients' age, comorbidities, and price of treatment. PMID: 31320855 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Effects of omalizumab therapy on peripheral nerve functions: short observational study.
Conclusions: Omalizumab therapy caused no peripheral neuropathy in any of our patients but altered the latency, amplitude, and velocity values of the peripheral nerves. PMID: 31320856 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Efficacy of ciclesonide in the treatment of patients with asthma exacerbation.
Conclusions: Treating with high doses of ciclesonide is characterised by a quick and potent anti-inflammatory effect as well as prompt clinical improvement along with the proper safety profile in patients experiencing asthma exacerbations. PMID: 31320857 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient.
Conclusions: Angiomyofibroblastoma should be included in the differential diagnosis of inguinal hernia. This is the fourteenth case of angiomyofibroblastoma diagnosed in males. PMID: 31320858 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The effect of Nd:YAG laser therapy on cutaneous leishmaniasis compared to intralesional meglumine antimoniate.
This study aimed to investigate the effect of Nd:YAG laser therapy (NDY) on cutaneous leishmaniasis in comparison with meglumine antimoniate (MA). Therefore, researchers are seeking to use a more effective, faster and less complicated method. Material and methods: This study was conducted as a clinical trial on 16 patients with cutaneous leishmaniasis treated simultaneously as follows: one lesion with Glucantime and another with NDY laser in the Ahvaz Jundishapur University of Medical Sciences in 2016-2017. Then, the demographic data, number of treatment sessions, mean duration of illness before the start of treatment,...
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Dermoscopy of frictional asymptomatic darkening of the extensor surfaces.
Authors: Tan C, Xia L PMID: 31320860 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Symmetric acral annular erythema: a variant of erythema annulare centrifugum, necrolytic acral erythema or a distinct clinical entity?
Authors: Reszke R, Woźniak Z, Reich A PMID: 31320861 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Surgery combined with photodynamic therapy in the treatment of disfiguring acne inversa: the efficacy of reconditioning.
Authors: Bu W, Huang L, Chen X, Fang F PMID: 31320862 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Omalizumab therapy in a patient with severe asthma and co-existing chronic obstructive pulmonary disease.
Authors: Kupryś-Lipińska I, Pałczyński C, Molinska J, Kuna P PMID: 31320863 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Acute form of acne inversa in an 18-week pregnant patient: a case study.
Authors: Plagens-Rotman K, Przybylska R, Gerke K, Jaracz K, Serafinowska J, Sadowska-Przytocka A, Adamski Z, Czarnecka-Operacz M PMID: 31320864 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - July 21, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Asthma and exercise-induced respiratory disorders in athletes. The position paper of the Polish Society of Allergology and Polish Society of Sports Medicine.
Authors: Gawlik R, Kurowski M, Kowalski M, Ziętkowski Z, Pokrywka A, Krysztofiak H, Krzywański J, Bugajski A, Bartuzi Z Abstract Exercise-induced respiratory symptoms describe acute airway narrowing that occurs as a result of exercise. It includes exercise-induced bronchoconstriction (EIB) and exercise-induced asthma (EIA) issues. To provide clinicians with practical guidelines, a multidisciplinary panel of stakeholders was convened to review the pathogenesis of EIB/EIA and to develop evidence-based guidelines for the diagnosis and treatment. Recommendations for the diagnosis and treatment of EIB were developed. ...
Source: Advances in Dermatology and Allergology - March 13, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?
Authors: Blicharz L, Rudnicka L, Samochocki Z Abstract Atopic dermatitis is a common, recurrent pruritic dermatosis with a complex pathogenesis. It has been associated with disordered patterns of immunological response and impaired epithelial barrier integrity. These features predispose the patients to robust colonization of skin lesions by Staphylococcus aureus. Virulence factors of S. aureus (e.g. superantigens, α- and δ-toxin, protein A) have been shown to exacerbate and perpetuate the course of atopic dermatitis. Novel therapeutic options with potential for restoring natural microbiome composition a...
Source: Advances in Dermatology and Allergology - March 13, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

The safety of isotretinoin treatment in patients with bone fractures.
Authors: Miziołek B, Bergler-Czop B, Stańkowska A, Brzezińska-Wcisło L Abstract Isotretinoin is widely applicable in dermatology, although it may develop severe side effects in the skeletal system. An intention of this review was to establish the safety of oral isotretinoin in patients with bone fractures. Both MEDLINE/Pubmed and SCOPUS databases were searched to investigate the influence of isotretinoin on the skeletal system. The drug shows a strong osteoporotic activity in rats whereas this effect is milder in humans. Biochemical markers of bone turnover remain unchanged except for serum calcium in patients ...
Source: Advances in Dermatology and Allergology - March 13, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Advantages in diagnosis of giant cell arteritis by ultrasound.
Authors: Wojczal J, Kozera G, Luchowski P, Neubauer-Geryk J Abstract Giant cell arteritis is the most common systemic vasculitis. It selectively affects large- and medium-sized arteries. Arterial wall inflammation leads to luminal occlusion and tissue ischemia, which cause the clinical manifestations of this vasculitis. Susceptible sites include the vascular bed of the cranial nerves and scalp including the temporal arteries, optic nerve, masseter muscles, and the posterior circulation of the central nervous system. Involvement can extend to the aorta and its primary and secondary branches, including the subclavian...
Source: Advances in Dermatology and Allergology - March 13, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

New variants in COL5A1 gene among Polish patients with Ehlers-Danlos syndrome: analysis of nine cases.
Conclusions: Our study is the first COL5A1 gene molecular investigation conducted among cEDS patients from Central Eastern Europe. Besides new COL5A1 variant findings, we gained molecular confirmation of clinical diagnosis of cEDS. In some cases, specific and adequate evaluation and classification of EDS patients based only on clinical features, may be difficult. PMID: 30858776 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 13, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Real-world effectiveness and safety of omalizumab in patients with uncontrolled severe allergic asthma from the Czech Republic.
Conclusions: The results of this subgroup analysis support the evidence that add-on omalizumab therapy is effective and well tolerated for management of patients with uncontrolled persistent AA in the Czech Republic. Global evaluation of treatment effectiveness assessment is a reliable predictor of long-term response to omalizumab treatment. PMID: 30858777 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 13, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Cerebral and skin microcirculatory dysfunction in type 1 diabetes.
Authors: Kozera GM, Neubauer-Geryk J, Wolnik B, Szczyrba S, Wojczal J, Nyka WM, Bieniaszewski L Abstract Introduction: An increase in cerebral pulsatility index (PI), measured by transcranial Doppler, reflects the presence of cerebral microangiopathy. A decrease in distance between skin capillaries (DISTANCE) and an increase in the ratio between the area of capillaries and total area of examined skin (COVERAGE), revealed by capillaroscopy, reflects skin microangiopathy. However, little is known about the association between the cerebral and skin microvasculature function in patients at risk of microcirculatory dysf...
Source: Advances in Dermatology and Allergology - March 13, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Type D personality, anxiety sensitivity, social anxiety, and disability in patients with acne: a cross-sectional controlled study.
Authors: Sereflican B, Tuman TC, Tuman BA, Parlak AH Abstract Introduction: Acne has long been associated with many psychiatric comorbidities. Aim: To determine anxiety and depression levels, social phobia frequency, social anxiety level, subjective stress perception, anxiety sensitivity, disability, and the frequency of type D personality in patients with acne. Material and methods: In total, 61 patients with acne aged> 16 years and 61 age, gender, and educationally matched healthy volunteers were included in the study. The patients and healthy controls were evaluated using the Diagnostic and Statistica...
Source: Advances in Dermatology and Allergology - March 13, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

New indications for topical ivermectin 1% cream: a case series study.
Conclusions: Topical ivermectin was well tolerated and beneficial for treatment of mild and moderate PD, SD and AV. PMID: 30858780 [PubMed] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 13, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research