Aspergillus Hepatic Artery Thrombosis in Liver Transplantation
We present the first cirrhotic patient who underwent liver transplantation (LT) and presented a hepatic artery thrombosis of the graft due to Aspergillus fumigatus, within the first month of LT. This culminated in graft loss, re-transplant with multiple biliary and infectious complications. To our knowledge, this is a case report of an early hepatic artery thrombosis due to Aspergillus fumigatus in an infection-free patient. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 19, 2018 Category: Biology Source Type: research

Donor-derived invasive aspergillosis after kidney transplant
We report 2 cases of kidney transplant recipients who acquired aspergillosis from a single donor. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 18, 2018 Category: Biology Source Type: research

Bilateral Candida keratitis in an HIV patient with asymptomatic genitourinary Candidiasis in Uganda
Publication date: Available online 17 July 2018Source: Medical Mycology Case ReportsAuthor(s): Simon Arunga, Teddy Kwaga, Astrid Leck, Victor H Hu, Matthew J BurtonAbstractA 35-year-old male presented with Candida keratitis in the left eye. He was HIV positive with a CD4 of 352 cells/µL. The eye quickly deteriorated, despite intensive antifungal treatment and was eviscerated. Five months later, he re-presented with Candida keratitis in his right eye. A focal source of Candida infection was suspected and a urine culture identified Candida spp, despite being asymptomatic for genitourinary candidiasis. He was subsequent...
Source: Medical Mycology Case Reports - July 17, 2018 Category: Biology Source Type: research

Disseminated Cryptococcosis in a HIV-Negative Patient: Case Report of a Newly Diagnosed Hypertensive Adult Presenting with Hemiparesis
We report a case of disseminated cryptococcosis in a 42-year old immunocompetent female. Prior to admission at Bugando Medical Centre, the patient was attended at three hospitals for hypertension and clinically diagnosed malaria. Following diagnosis of disseminated Cryptococcus at our center, she was successfully treated with fluconazole but remained with visual loss. Blood cultures should be considered in the management of any adult presenting with fever to enable early detection of the least expected differentials like in this case. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 13, 2018 Category: Biology Source Type: research

Triadelphia pulvinata: A rare invasive fungal infection in a diabetic patient
We report a case of Triadelphia pulvinata, a rare dematiaceous fungi causing invasive fungal infection in a 68 year old diabetic Iraqi female. The diagnosis was made by combining the phenotypic findings and genome sequencing. There are only 4 case reports in literature and this is probably the first from India which was treated by Liposomal Amphotericin B. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Long term survival of a dog with disseminated Aspergillus deflectus infection without definitive treatment
Publication date: Available online 10 July 2018Source: Medical Mycology Case ReportsAuthor(s): Peter F. Bennett, Jessica J. Talbot, Patricia Martin, Sarah E Kidd, Mariano Makara, Vanessa R. BarrsAbstractCanine disseminated fungal infection by Aspergillus species carries a guarded to grave prognosis as they often rapidly progress and are refractory to treatment with many euthanased soon after diagnosis. This case report describes a 2.5 year old female spayed German Shepherd Dog diagnosed with disseminated Aspergillus deflectus infection for which definitive treatment was declined by the owners. With only palliative manageme...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Successful treatment of breakthrough disseminated Trichosporon asahii fungemia in a patient with acute myeloid leukemia receiving itraconazole prophylaxis
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): Daiki Karigane, Masatoshi Sakurai, Emiko Matsuyama, Kentaro Ide, Sakiko Yamamoto-Takeuchi, Toyoko Inazumi, Sumiko KohashiAbstractWe encountered a case of a 73-year-old man with acute myeloid leukemia who developed Trichosporon asahii systemic infection while on itraconazole prophylaxis during severe neutropenia. Cryptococcal antigen was useful for diagnosis. Although itraconazole was ineffective in protecting against trichosporonosis, treatment was successful with voriconazole following liposomal amphotericin B. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Necrotizing fasciitis caused by Apophysomyces variabilis in an immunocompetent patient
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): José Y. Rodríguez, Soraya E. Morales-López, Gerson J. Rodríguez, Carlos A. Álvarez-Moreno, Walter Ocampo, Martha L. Cepeda, Miguel A. Mora-ValderramaAbstractMucormycosis caused by Apophysomyces variabilis is rarely reported in humans. A case of A. variabilis infection in an immunocompetent men after friction burns in a car accident is described. The infection presented as a rapidly progressive necrotizing infection of the skin and soft tissue, which required extensive surgical debridement and total colon...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Dermatophyte infection caused by Nannizzia gypsea: A rare case report from Madagascar
We report a rare case of dermatophyte infection of the glabrous skin (Tinea corporis) caused by Nannizzia gypsea (formerly Microsporum gypseum). A 22-year-old Malagasy female who reported close contact reportedly with cats, presented a single round lesion with a peripheral, active, squamous and pruriginous inflammatory bead. Morphologic species identification was confirmed by sequencing the internal transcribed spacer (ITS) region of the genome. Specific treatment with oral loratadine and topical miconazole cream was effective. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Diagnosis and management of a fatal case of sepsis caused by Candida parapsilosis sensu stricto in a neonate with omphalocele
We present a fatal case of persistent neonatal candidemia by Candida parapsilosis following omphalocele, without other anomalies. Despite an encouraging initial prognosis, after surgical correction and closure of the abdominal wall the case became difficult to treat, as in addition to the exposure of the patient to multiple risk factors for candidemia, antifungal therapy apparently was not adequate. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis in the setting of Acquired Immunodeficiency Syndrome (AIDS)
We present a case of a middle-aged male with AIDS and renal failure, who developed HLH secondary to disseminated histoplasmosis. Etoposide chemotherapy as recommended by the HLH 2004 Guidelines was deferred and treatment focused instead on anti-fungal therapy. Anti-retroviral therapy followed thereafter. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Mould meningitis associated with intravenous drug use
We present a rare case of mould meningitis, ventriculitis and subependymal nodules in an immunocompetent patient, having likely seeded the meninges and ventricular system through intravenous drug use. The causative mould remains undetermined. The case highlights the poor sensitivity of CSF culture and the need to consider surgical biopsy where there is diagnostic difficulty and fungal infection is being considered. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Acute paracoccidioidomycosis with duodenal and cutaneous involvement and obstructive jaundice
We report a case of PCM with duodenal and cutaneous involvement simulating cholangitis that was initially misdiagnosed as a lymphoproliferative disease. Clinicians should consider acute paracoccidioidomycosis in the differential diagnosis of jaundice and/or signs/symptoms of cholangitis developing in young patients from paracoccidioidomycosis endemic regions. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Case of Scedosporium aurantiacum infection detected in a subcutaneous abscess
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): Makoto Kondo, Hiroyuki Goto, Keiichi YamanakaAbstractThis is the case report of a Scedosporium aurantiacum infection in a subcutaneous abscess. The patient had underlying diabetes and malignant lymphoma. Scedosporium species occur widely in nature and are increasingly recognized as pathologies under specific conditions, such as in immunocompromised hosts. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with Adult Onset Still's Disease
We report a case of tracheal, laryngeal and pulmonary mucormycosis in a patient receiving immunosuppressive medication for an autoinflammatory fever syndrome. Mucormycosis was confirmed by histopathology from tracheal specimens and molecular evidence of Lichtheimia.A surgical approach was not possible because of the multifocal disease pattern and the extent of tracheal involvement. The patient was successfully treated with liposomal amphotericin B followed by posaconazole maintenance therapy. After 9 months, recurrent pulmonary mucormycosis was suspected but emerged as organizing pneumonia without evidence of active fungal...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Late presentation of Pneumocystis jirovecii pneumonia after renal transplant: A case report
We report a rare case of Pneumocystis jirovecii pneumonia in a renal transplant recipient only on maintenance immunosuppression eleven years after transplant without concomitant CMV infection or recent episodes of graft rejection. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Differential distribution patterns of Fonsecaea agents of chromoblastomycosis, exemplified by the first case due to F. monophora from Argentina
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): Marcelo Label, Luciana C. Karayan, Sybren De Hoog, Javier Afeltra, Togo Bustamante, Roxana G. VitaleAbstractChromoblastomycosis is a mutilating infection of the skin and subcutaneous tissues caused by melanized fungi belonging to the order Chaetothyriales. Proven cases of the main agent, Fonsecaea pedrosoi are mainly limited to (sub)tropical, humid climates of Latin and Central America and the Caribbean. Fonsecaea monophora has a global distribution along the equator. Cases outside the (sub)tropics have thus far mostly been considered to ...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Acute fulminant invasive pulmonary aspergillosis in an immunocompetent host: An autopsy case report
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): Yuuki Ohara, Takahiko Ito, Makoto Ito, Kyoko Yamashita, Shinya ToyokuniAbstractA 62-year-old previously healthy male who was a welder/smoker/drinker was admitted to Kani Tono Hospital for severe hypoxemia (Day 0). Initial physical and radiological examinations suggested an acute exacerbation of chronic obstructive pulmonary disease. However, respiratory failure developed rapidly, and he died on Day + 4. Aspergillus fumigatus was identified after his death, and he was diagnosed with invasive pulmonary aspergillosis. The clinical and path...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Severe acute respiratory distress syndrome in a liver transplant patient
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Nicholas M. Moore., Laurie A. ProiaAbstractThis case report presents a 46-year old man with a failed liver transplant who presented with malaise and dyspnea. Imaging studies revealed diffuse reticulonodular infiltrates and innumerable miliary nodules and a left upper lobe consolidative mass. Examination of bronchoalveolar lavage fluid demonstrated yeast cells with broad-based budding. He was diagnosed with pulmonary blastomycosis and started therapy with liposomal amphotericin. In spite of therapy, he clinically worsened, developing ...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Jessica D. Workum, Suzanne W. de Jong, Mark S. Gresnigt, Katharina L. Becker, Peter Pickkers, Frank L. van de Veerdonk, Yvonne F. Heijdra, Eva KolwijckAbstractInvasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to Aspergillus. A history of COPD, unresponsive...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Two cases of fungal keratitis caused by Metarhizium anisopliae
We present two cases of keratitis due to Metarhizium anisopliae in geographically separated areas of the United States. The isolates were microscopically similar but morphologically different and were identified by ribosomal DNA sequencing. Both isolates had low minimum inhibitory concentration (MIC) values to caspofungin and micafungin, but high MIC values to amphotericin B. The morphologic and antifungal susceptibility differences between the two isolates indicate possible polyphylogeny of the group. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Invasive pulmonary mucormycosis and aspergillosis in a patient with decompensated hepatic cirrhosis
This report also highlights the first non-diabetic case of invasive pulmonary mucormycosis with decompensated hepatic cirrhosis. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Subcutaneous abscesses caused by Trichophyton rubrum in the unilateral groin of an immunocompromised patient: A case report
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Utako Okata-Karigane, Yasuki Hata, Emiko Watanabe-Okada, Shunichi Miyakawa, Michi Ota, Yutaka Uzawa, Shigekazu Iguchi, Atsushi Yoshida, Ken KikuchiAbstractA 60-year-old Japanese man presented with multiple subcutaneous nodules in his left groin. Histologically, the nodules consisted of suppurative granulomas and abscesses not involving the hair follicles. Trichophyton rubrum TWCC57922 was detected by fungal culture and polymerase chain reaction (PCR) sequencing of the rDNA genes. We diagnosed these nodules as deeper dermal dermatophy...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Blastomycosis in a renal transplant recipient: Case of immune reconstitution inflammatory syndrome
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Alexis Guenette, Shahid Husain, Ana Konvalinka, William Geddie, Coleman RotsteinAbstractThere are limited data on blastomycosis in solid organ transplant recipients with the subsequent development of the immune reconstitution inflammatory syndrome (IRIS). Herein we describe a case of pulmonary blastomycosis in a renal transplant recipient with the development of concomitant IRIS. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

A case of pulmonary cryptococcoma due to Cryptococcus gattii in the United Kingdom
We report a case of Cryptococcus gattii infection in the UK in a 76-year-old woman on biologic therapy for intra-abdominal non-Hodgkin lymphoma. An incidental nodular lung lesion was found on a chest imaging and histology, culture and molecular mycology studies of the lobectomy specimen revealed the presence of C. gattii. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Lomentospora prolificans vertebral osteomyelitis with spinal epidural abscess in an immunocompetent woman: Case report and literature review
We report a case of L. prolificans thoracic vertebral osteomyelitis with spinal epidural abscess in a patient without apparent immunodeficiency. Clinical manifestations and radiographic findings could not distinguish from other etiologic agents. Treatment is also challenging because L. prolificans is usually resistant to antifungal agents. The patient underwent surgical debridement and has been receiving a prolonged combination of antifungal therapy to prevent an infection relapse. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Near-fatal mucormycosis post-double lung transplant presenting as uncontrolled upper gastrointestinal haemorrhage
We present a case of splenic mucormycosis post-double lung transplant, presenting as uncontrolled near-fatal upper gastrointestinal haemorrhage, to remind clinicians of the need to consider pre-transplant invasive fungal infection risk factors if an unexpected fungal infection arises in the post-transplant period. This case also highlights the valuable contribution of molecular technology for fungal identification but also the need for clinical correlation. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

A case of disseminated sporotrichosis caused by Sporothrix brasiliensis
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Blenda Fernandes, Rachel Basques Caligiorne, Dayana Monteiro Coutinho, Renata R. Gomes, Fabiana Rocha-Silva, Amanda Sanchez Machado, Emanoelle Fernandes Rutren La Santrer, Claudia Barbosa Assunção, Cássio Ferreira Guimarães, Maria Silvia Laborne, Mauricio Buzelin Nunes, Vania A. Vicente, Sybren de HoogAbstractThis paper presents a case of disseminated sporotrichosis in a 13-year-old female, originating from a rural area in Minas Gerais state, Brazil. The patient was hospitalized in Santa Casa hospital of B...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Local extensive granulomatous inflammation of the neck region and lymphangitis caused by Lichtheimia corymbifera infection in a Japanese Black calf
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): A.P.P. Teh, T. Hirai, S. Ito, Y. Hidaka, Y. Goto, H. Furukawa, J. Sawada, R. YamaguchiAbstractA 7-month-old female Japanese Black calf developed elongated, nodular mass measuring 30 × 16 cm extended from the retropharyngeal region to mid lateral neck region. Histological examination revealed granulomatous lymphangitis with non-septate fungal hyphae recognized throughout the lesions. Fungal culture, DNA sequencing and molecular phylogenetic tree analysis confirmed the sequence of Lichtheimia corymbifera. The lymphogenous r...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Candida dubliniensis abscess: A clinical case and a review of the literature
We present a case of a C. dubliniensis soft tissue abscess in a patient with uncontrolled diabetes as his only immunocompromising risk factor, treated with surgical drainage and medical management. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Multiple Organ Dysfunction Syndrome (MODS) induced by Candida krusei in an Aldabra giant tortoise (Aldabrachelys gigantea) and confirmed by electron microscopy analysis
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Maddalena Iannaccone, Petra Rita Basso, Terenzio Congiu, Paolo Cavicchio, Valentina Ulivi, Marco CampoloAbstractA young female Aldabra giant tortoise (Adabrachelys gigantea) was presented with anorexia, ataxia, severe constipation and bloating. Analysis revealed liver disease and collected biopsy diagnosed Candida krusei infection. Despite Itraconazole treatment, the tortoise got worse and died. Full necropsy was performed; microbiology showed Candida krusei presence in liver, but histopathology didn’t confirm fungal presence w...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Aspergillus endocarditis of the mitral valve with ventricular myocardial invasion, cerebral vasculitis, and intracranial mycotic aneurysm formation in a patient with hemophagocytic lymphohistiocytosis
We report a case of mitral valve aspergillus endocarditis with ventricular myocardial invasion, cerebral vasculitis and intracranial fungal aneurysm formation in a patient with hemophagocytic lymphohistiocytosis (HLH). This case illustrates the importance of prompt investigation and treatment of masses seen on an echocardiogram for rare infections such as Aspergillus endocarditis in immunocompromised patients. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Self-injury in schizophrenia as predisposing factor for otomycosis
We present a case of repeated self-induced auricular trauma in schizophrenic patient. Aural swab were collected and examined by direct microscopy and culture, revealing Aspergillus flavus. A traumatized external ear canal skin can present favourable condition for fungal growth in the psychiatric population. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Candida auris colonization in an immunocompetent patient: A new threat in medical ICU
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Shukla Das, Richa Tigga, Gargi Rai, Praveen Kumar Singh, Shyama Datt, Asha Tyagi, Narendra Pal SinghAbstractCandida auris has become a great challenge in diagnostic, therapeutic and hospital environmental adaptation. With a prevalence of 5.3% in intensive care unit (ICU) acquired candidemia in India, its colonization is very rapid which hastens hospital transmission. Strict surveillance and preventive measures need to be adopted in ICU as it can persist on dry, inanimate object, prompt adaptation and antifungal resistance can pose a ...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Vascular pythiosis of carotid artery with meningitis and cerebral septic emboli: A case report and literature review
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Maria Nina Chitasombat, Porkaew Petchkum, Suthas Horsirimanont, Pattana Sornmayura, Ariya Chindamporn, Theerapong KrajaejunAbstractVascular Pythiosis caused by Pythium insiodiosum rarely involves carotid artery. A case of concealed ruptured pseudoaneurysm of the carotid artery with neck abscesses, and cerebral septic emboli is described. Patient presented with large pulsatile neck mass that failed to response to surgery, antifungals and immunotherapeutic vaccine. Residual unresectable disease leads to death in the patient. Pythiosis ...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Incidental findings of blastomycosis lung nodules in five asymptomatic patients
In this report we describe five sporadic cases of blastomycosis in asymptomatic patients. All of these cases were initially identified as incidental findings of lung nodules on CXR or CT. To our knowledge, these are the first detailed descriptions of asymptomatic blastomycosis, occurring as sporadic disease, in the literature. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

T2Candida® to guide antifungal and lengh of treatment of candidemia in a pediatric multivisceral transplant recipient
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Iker Falces-Romero, Emilio Cendejas-Bueno, María Laplaza-González, Luis Escosa-García, Cristina Schuffelmann-Gutiérrez, Belén Calderón-Llopis, Javier Pemán, Pedro de la Oliva, Julio García-RodríguezAbstractA case of 1-year- old male multivisceral transplant recipient with candidemia diagnosed by the T2Candida® test is presented. Optimal management of the candidemia complemented the treatment of the global clinical episode. Duration of treatment might be established mu...
Source: Medical Mycology Case Reports - July 11, 2018 Category: Biology Source Type: research

Successful treatment of breakthrough disseminated Trichosporon asahii fungemia in a patient with acute myeloid leukemia receiving itraconazole prophylaxis
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): Daiki Karigane, Masatoshi Sakurai, Emiko Matsuyama, Kentaro Ide, Sakiko Yamamoto-Takeuchi, Toyoko Inazumi, Sumiko KohashiAbstractWe encountered a case of a 73-year-old man with acute myeloid leukemia who developed Trichosporon asahii systemic infection while on itraconazole prophylaxis during severe neutropenia. Cryptococcal antigen was useful for diagnosis. Although itraconazole was ineffective in protecting against trichosporonosis, treatment was successful with voriconazole following liposomal amphotericin B. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Necrotizing fasciitis caused by Apophysomyces variabilis in an immunocompetent patient
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): José Y. Rodríguez, Soraya E. Morales-López, Gerson J. Rodríguez, Carlos A. Álvarez-Moreno, Walter Ocampo, Martha L. Cepeda, Miguel A. Mora-ValderramaAbstractMucormycosis caused by Apophysomyces variabilis is rarely reported in humans. A case of A. variabilis infection in an immunocompetent men after friction burns in a car accident is described. The infection presented as a rapidly progressive necrotizing infection of the skin and soft tissue, which required extensive surgical debridement and total colon...
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Dermatophyte infection caused by Nannizzia gypsea: A rare case report from Madagascar
We report a rare case of dermatophyte infection of the glabrous skin (Tinea corporis) caused by Nannizzia gypsea (formerly Microsporum gypseum). A 22-year-old Malagasy female who reported close contact reportedly with cats, presented a single round lesion with a peripheral, active, squamous and pruriginous inflammatory bead. Morphologic species identification was confirmed by sequencing the internal transcribed spacer (ITS) region of the genome. Specific treatment with oral loratadine and topical miconazole cream was effective. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Diagnosis and management of a fatal case of sepsis caused by Candida parapsilosis sensu stricto in a neonate with omphalocele
We present a fatal case of persistent neonatal candidemia by Candida parapsilosis following omphalocele, without other anomalies. Despite an encouraging initial prognosis, after surgical correction and closure of the abdominal wall the case became difficult to treat, as in addition to the exposure of the patient to multiple risk factors for candidemia, antifungal therapy apparently was not adequate. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis in the setting of Acquired Immunodeficiency Syndrome (AIDS)
We present a case of a middle-aged male with AIDS and renal failure, who developed HLH secondary to disseminated histoplasmosis. Etoposide chemotherapy as recommended by the HLH 2004 Guidelines was deferred and treatment focused instead on anti-fungal therapy. Anti-retroviral therapy followed thereafter. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Mould meningitis associated with intravenous drug use
We present a rare case of mould meningitis, ventriculitis and subependymal nodules in an immunocompetent patient, having likely seeded the meninges and ventricular system through intravenous drug use. The causative mould remains undetermined. The case highlights the poor sensitivity of CSF culture and the need to consider surgical biopsy where there is diagnostic difficulty and fungal infection is being considered. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Acute paracoccidioidomycosis with duodenal and cutaneous involvement and obstructive jaundice
We report a case of PCM with duodenal and cutaneous involvement simulating cholangitis that was initially misdiagnosed as a lymphoproliferative disease. Clinicians should consider acute paracoccidioidomycosis in the differential diagnosis of jaundice and/or signs/symptoms of cholangitis developing in young patients from paracoccidioidomycosis endemic regions. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Case of Scedosporium aurantiacum infection detected in a subcutaneous abscess
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): Makoto Kondo, Hiroyuki Goto, Keiichi YamanakaAbstractThis is the case report of a Scedosporium aurantiacum infection in a subcutaneous abscess. The patient had underlying diabetes and malignant lymphoma. Scedosporium species occur widely in nature and are increasingly recognized as pathologies under specific conditions, such as in immunocompromised hosts. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with Adult Onset Still's Disease
We report a case of tracheal, laryngeal and pulmonary mucormycosis in a patient receiving immunosuppressive medication for an autoinflammatory fever syndrome. Mucormycosis was confirmed by histopathology from tracheal specimens and molecular evidence of Lichtheimia.A surgical approach was not possible because of the multifocal disease pattern and the extent of tracheal involvement. The patient was successfully treated with liposomal amphotericin B followed by posaconazole maintenance therapy. After 9 months, recurrent pulmonary mucormycosis was suspected but emerged as organizing pneumonia without evidence of active fungal...
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Late presentation of Pneumocystis jirovecii pneumonia after renal transplant: A case report
We report a rare case of Pneumocystis jirovecii pneumonia in a renal transplant recipient only on maintenance immunosuppression eleven years after transplant without concomitant CMV infection or recent episodes of graft rejection. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Differential distribution patterns of Fonsecaea agents of chromoblastomycosis, exemplified by the first case due to F. monophora from Argentina
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): Marcelo Label, Luciana C. Karayan, Sybren De Hoog, Javier Afeltra, Togo Bustamante, Roxana G. VitaleAbstractChromoblastomycosis is a mutilating infection of the skin and subcutaneous tissues caused by melanized fungi belonging to the order Chaetothyriales. Proven cases of the main agent, Fonsecaea pedrosoi are mainly limited to (sub)tropical, humid climates of Latin and Central America and the Caribbean. Fonsecaea monophora has a global distribution along the equator. Cases outside the (sub)tropics have thus far mostly been considered to ...
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Acute fulminant invasive pulmonary aspergillosis in an immunocompetent host: An autopsy case report
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): Yuuki Ohara, Takahiko Ito, Makoto Ito, Kyoko Yamashita, Shinya ToyokuniAbstractA 62-year-old previously healthy male who was a welder/smoker/drinker was admitted to Kani Tono Hospital for severe hypoxemia (Day 0). Initial physical and radiological examinations suggested an acute exacerbation of chronic obstructive pulmonary disease. However, respiratory failure developed rapidly, and he died on Day + 4. Aspergillus fumigatus was identified after his death, and he was diagnosed with invasive pulmonary aspergillosis. The clinical and path...
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research

Severe acute respiratory distress syndrome in a liver transplant patient
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Nicholas M. Moore., Laurie A. ProiaAbstractThis case report presents a 46-year old man with a failed liver transplant who presented with malaise and dyspnea. Imaging studies revealed diffuse reticulonodular infiltrates and innumerable miliary nodules and a left upper lobe consolidative mass. Examination of bronchoalveolar lavage fluid demonstrated yeast cells with broad-based budding. He was diagnosed with pulmonary blastomycosis and started therapy with liposomal amphotericin. In spite of therapy, he clinically worsened, developing ...
Source: Medical Mycology Case Reports - July 5, 2018 Category: Biology Source Type: research