Cryptococcosis due to Cryptococcus gattii VGII in southeast Brazil: The One Health approach revealing a possible role for domestic cats
Publication date: Available online 17 April 2019Source: Medical Mycology Case ReportsAuthor(s): Fábio Brito-Santos, Rosani Santos Reis, Rowena Alves Coelho, Rodrigo Almeida-Paes, Sandro Antonio Pereira, Luciana Trilles, Wieland Meyer, Bodo W.e, Márcia dos Santos Lazéra, Isabella Dib Ferreira GremiãoAbstractTwo cats infected by C. gattii, presented lesions on the nasal region and respiratory signs. Strains were typed as molecular type VGII, mating type alpha, MLST subtypes ST442 and ST185. Since Rio de Janeiro is known as an endemic area for C. neoformans VNI, these cases might be a warning for a...
Source: Medical Mycology Case Reports - April 19, 2019 Category: Biology Source Type: research

Onychomycosis with greenish-black discolorations and recurrent onycholysis caused by Candida parapsilosis
Publication date: Available online 16 April 2019Source: Medical Mycology Case ReportsAuthor(s): Gai Ge, Zhiya Yang, Dongmei Li, G. Sybren de Hoog, Dongmei ShiAbstractCandida parapsilosis (C. parapsilosis) has become a common pathogen, especially in immunocompromised hosts. Here, we present an immunocompetent adult with greenish-black discoloration of the right first finger nail in combination with recurrent onycholysis. C. parapsilosis was isolated from the right first finger nail and was confirmed by morphological characteristics as well as by DNA molecular analysis. Patient was successfully treated with oral itraconazole...
Source: Medical Mycology Case Reports - April 17, 2019 Category: Biology Source Type: research

Vision loss in an AIDS patient with cryptococcal meningitis
We report a case of acute bilateral visual loss secondary to Cryptococcal meningitis. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - April 16, 2019 Category: Biology Source Type: research

Cryptococcal meningitis after ART: Need for proper baseline evaluation in the era of ‘Test & Treat’
We report a case of severe cryptococcal meningitis presenting following the commencement of ART. There is clear benefit in the early commencement of ART among HIV infected patients and to prevent patients lost to follow-up as aimed with the ‘Test & Treat’ approach. However, this approach needs to be balanced against the risk of IRIS and its associated morbidity and mortality when those patients are not being properly evaluated for opportunistic infections being present without overt symptoms. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - April 16, 2019 Category: Biology Source Type: research

Rasamsonia sp: An emerging infection amongst chronic granulomatous disease patients. A case of disseminated infection by a putatively novel Rasamsonia argillacea species complex involving the heart
Publication date: Available online 16 April 2019Source: Medical Mycology Case ReportsAuthor(s): Ahmed Babiker, Nupur Gupta, Connie F.C. Gibas, Nathan P. Wiederhold, Carmita Sanders, James Mele, Hongxin Fan, Alina Iovleva, Ghady Haidar, Carolyn FernandesAbstractChronic granulomatous disease (CGD) is a heterogeneous condition due to defects in NADPH oxidase characterized by granuloma formation and increased susceptibility to invasive infections, in particular moulds. The use of broad-spectrum, mould-active antifungal prophylaxis has improved mortality. However rare resistant moulds have emerged as important pathogens. Diagno...
Source: Medical Mycology Case Reports - April 16, 2019 Category: Biology Source Type: research

Hypersensitivity pneumonitis of a bagpipe player: Fungal antigens as trigger?
Publication date: Available online 26 March 2019Source: Medical Mycology Case ReportsAuthor(s): Katharina Ziegler, Marcus Joest, Nesrin Turan, Dirk Schmidt, Peter-Michael Rath, Joerg SteinmannAbstractHere we present a 79-year old man with chronic hypersensitivity pneumonitis probably caused by fungal contamination of a bagpipe. Several samples were taken from the patient's bagpipe. Four potential fungal antigens (Exophiala phaeomuriformis, Kwoniella europaea, Pyrenochaeta unguis-hominis and Aureobasidium melanogenum) as potential trigger of hypersensitivity pneumonitis were identified. A serum ELISA test with Exophiala pha...
Source: Medical Mycology Case Reports - March 27, 2019 Category: Biology Source Type: research

Chronic Candida dubliniensis meningitis in a lung transplant recipient
We report a case of a possible donor derived Candida dubliniensis infection in a lung transplant recipient, who initially presented with empyema that was treated successfully, but subsequently developed chronic meningitis. Diagnosis was delayed due to the low yield of CSF cultures, and was confirmed with fungal PCR and BD glucan assay. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - March 27, 2019 Category: Biology Source Type: research

Disseminated Scedosporium apiospermum central nervous system infection after lung transplantation: A case report with successful recovery
We present a CF-patient with disseminated Scedosporium apiospermum infection after lung transplantation. The patient had skin, surgical wound, spinal cord, and brain involvements. She recovered fully after prolonged course of voriconazole treatment. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - March 16, 2019 Category: Biology Source Type: research

Infection of burn wound by Aspergillus fumigatus with gross appearance of fungal colonies
Publication date: Available online 15 March 2019Source: Medical Mycology Case ReportsAuthor(s): Anh – Tram Que, Ngoc - Minh Thai Nguyen, Ngoc – Anh Do, Nhu-Lam Nguyen, Ngoc – Dung Tran, Tran – Anh LeAbstractThe morbidity of invasive aspergillosis in burn patients is low but the diagnosis is difficult and the mortality rate is high. A severe burned patient at the Vietnam National Institute of Burn was suspected of fungal wound infection (FWI) with fungal growth on the wound. The diagnosis of FWI caused by Aspergillus fumigatus was made by isolation and histological examination. This may be the first ...
Source: Medical Mycology Case Reports - March 15, 2019 Category: Biology Source Type: research

Central line associated blood stream infection (CLABSI) due to Exophiala dermatitidis in an adult patient: Case report and review
We describe an E. dermatitidis CLASBI. The strain was identified by morphological and molecular methods. E. dermatitidis CLASBI is highly uncommon, but seems to be increasing. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - March 4, 2019 Category: Biology Source Type: research

A black mould death: A case of fatal cerebral phaeohyphomycosis caused by Cladophialophora bantiana
We present a case of fatal cerebral phaeohyphomycosis in a 67-year-old Caucasian man. Diagnosis was achieved by histopathological examination of brain tissue followed by conventional culture and molecular identification. We highlight diagnostic and treatment challenges involved. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - March 1, 2019 Category: Biology Source Type: research

Cranial aspergillosis in a patient receiving ibrutinib for chronic lymphocytic leukemia
We present a case of cerebral abscesses caused by Aspergillus felis in a patient receiving ibrutinib for chronic lymphocytic leukemia. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - February 28, 2019 Category: Biology Source Type: research

First bloodstream infection due to Prototheca zopfii var. hydrocarbonea in an immunocompromised patient
Publication date: Available online 16 February 2019Source: Medical Mycology Case ReportsAuthor(s): Norma Beatriz Fernández, Constanza Giselle Taverna, Matías Vivot, Susana Córdoba, Lucia ParavanoAbstractHere we describe a bloodstream infection due to P. zopfii var. hydrocarbonea in a patient with acute lymphoblastic leukemia. Identification was performed by DNA sequencing of the D1/D2 domain of 26s ribosomal DNA and by MALDI-TOF MS technique. Antifungal susceptibility tests against amphotericin B, fluconazole, itraconazole, and voriconazole showed the following MIC values, respectively: 0.25 mg/L, 128 ...
Source: Medical Mycology Case Reports - February 17, 2019 Category: Biology Source Type: research

Peritonitis by Exophiala dermatitidis in a pediatric patient
Publication date: Available online 15 February 2019Source: Medical Mycology Case ReportsAuthor(s): Rosângela L. Pinheiro, Regielly C.R. Cognialli, Rodolfo C. Barros, Tyane de A. Pinto, Mariana F.M. Cunha, Tony T. Tahan, Morgana F. Voidaleski, Renata R. Gomes, Guilherme N. Becker, Lucas V. Andrade, Flavio Queiroz-Telles, G. Sybren de Hoog, Renata R. Sakiyama, Vânia A. VicenteAbstractFungal peritonitis is frequent on peritoneal dialysis, with rare cases by Exophiala dermatitidis. A 25-month-old female admitted to the pediatric ICU with acute renal failure was submitted to peritoneal dialysis. After 10 days patien...
Source: Medical Mycology Case Reports - February 15, 2019 Category: Biology Source Type: research

An instance of excellent response of subcutaneous zygomycosis to itraconazole monotherapy
We report a case of 4-year-old male child from Chhattisgarh, who presented with a painless, non-tender, large, subcutaneous swelling of 4 months duration on the right upper arm, which was initially misdiagnosed as benign spindle cell tumor and advised surgical resection. But the fungal culture of the affected tissue grown Basidiobolus ranarum and the child responded very well to itraconazole therapy only. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - February 14, 2019 Category: Biology Source Type: research

An atypical cause of sporotrichosis in a cat
Publication date: Available online 16 January 2019Source: Medical Mycology Case ReportsAuthor(s): Jeffrey Thomson, Darren J. Trott, Richard Malik, Bradley Galgut, Milton M. McAllister, Judith Nimmo, Doug Renton, Sarah E. KiddAbstractA nine-year-old domestic cat from Melbourne, Australia, presented with a non-ulcerated nodule on its nasal bridge. A fungal infection of the subcutis was diagnosed based on histopathology and culture of a white mould, which was identified as Sporothrix pallida complex by ITS1–5.8S-ITS2 and β-tubulin gene sequencing. The cat was treated by cytoreduction, itraconazole and subsequently ...
Source: Medical Mycology Case Reports - January 18, 2019 Category: Biology Source Type: research

Two cases of Emergomyces pasteurianus infection in immunocompromised patients in the Netherlands
We report two cases of Emergomyces pasteurianus infection in the Netherlands. Both patients were immunocompromised and had pulmonary symptoms. The first patient died due to a pulmonary infection with Es. pasteurianus, concomitant listeriosis, Pseudomonas aeruginosa sepsis and invasive pulmonary aspergillosis. The second patient had pulmonary and subcutaneous lesions, and recovered completely after treatment with posaconazole for 14 months. In both cases, diagnosis of Es. pasteurianus was made with internal transcribed spacer rRNA PCR and culture. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - January 15, 2019 Category: Biology Source Type: research

Endobronchial fusariosis in a child following bilateral lung transplant
We present a case of endobronchial fusariosis following bilateral sequential lung transplantation for idiopathic pulmonary arterial hypertension in a 13 years old boy who was treated successfully with posaconazole and nebulized amphotericin B. We discuss the role of nebulized amphotericin B in treating invasive pulmonary fungal disease in children. To our knowledge, this is the first pediatric case of endobronchial fusariosis reported in the literature. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - January 15, 2019 Category: Biology Source Type: research

Chronic Candida Osteomyelitis of Hard Palate and Nose: A diagnostic quandary
Publication date: Available online 14 January 2019Source: Medical Mycology Case ReportsAuthor(s): Darwin Kaushal, Anuradha Sharma, Amber Kesarwani, Jitu Mani KalitaAbstractCandida induced osteomyelitis is infrequent. There is scarcity of literature on this entity in maxillofacial region and thus there is possibility to mismanage such cases. We are presenting a case of chronic maxillofacial Candida tropicalis osteomyelitis causing palatal and septal perforation with saddle nose deformity in a young lady with commencement and progression of disease process over two pregnancies. Diagnosis was established by histopathology and...
Source: Medical Mycology Case Reports - January 15, 2019 Category: Biology Source Type: research

Successful treatment of severe aplastic anemia with syngeneic stem cell transplantation in the setting of active disseminated mucormycosis
Publication date: Available online 12 January 2019Source: Medical Mycology Case ReportsAuthor(s): Jean El-Cheikh, Ali Atoui, Nour Moukalled, Nohra Ghaoui, Haidar El Darsa, Souha S. Kanj, Ali BazarbachiAbstractSevere aplastic anemia (SAA) is a hematological disease resulting in pancytopenia due to bone marrow failure. Treatment consists of immunosppressive therapy, or allo-SCT. Patients with aplastic anemia are predisposed to invasive fungal infections due to mucormycosis. Till now, syngeneic SCT in the context of active mucormycosis infection for patients with severe aplastic anemia is lacking in the literature.Here, we re...
Source: Medical Mycology Case Reports - January 13, 2019 Category: Biology Source Type: research

Magnusiomyces clavatus infection in a child after allogeneic hematotopoetic stem cell transplantation: diagnostic and therapeutic implications
We report a case of Magnusiomyces clavatus fungemia with pulmonary, renal and skin localizations in a 6-year-old boy with prolonged neutropenia because of three allogeneic hematopoietic stem cell transplantations. The infection was controlled by aggressive and strictly monitored combination therapy with voriconazole and liposomial-ampthotericine-B along with durable recover from neutropenia. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - December 22, 2018 Category: Biology Source Type: research

Multiple cerebral abscesses in a renal transplant recipient: Two swords in one scabbard!
Publication date: Available online 21 December 2018Source: Medical Mycology Case ReportsAuthor(s): Vivek Sood, Navin Pattanashetti, Shefali Gupta, Shivprakash M. Rudramurthy, Raja Ramachandran, K.L. GuptaAbstractAlthough rare, both Cladophialophora bantiana (C. bantiana) and Toxoplasma gondii have been known to be associated with brain abscess in renal transplant recipients (RTRs), however co-infection has never been reported till date. In the present case, 40 years old renal transplant recipient on curtailed immunosuppressive therapy presented with progressive headache and altered sensorium. The computed tomography of hea...
Source: Medical Mycology Case Reports - December 22, 2018 Category: Biology Source Type: research

Chronic Progressive Disseminated Histoplasmosis in a Renal Transplant Recipient
We report an unusual case of disseminated histoplasmosis in a renal transplant recipient manifesting with a chronic progressive course over several years. After starting treatment with itraconazole, the patient showed marked improvement in his symptoms and had clinical resolution (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - December 22, 2018 Category: Biology Source Type: research

Azole resistance of Malassezia pachydermatis causing treatment failure in a dog
Publication date: Available online 21 December 2018Source: Medical Mycology Case ReportsAuthor(s): Martina Angileri, Mario Pasquetti, Michela De Lucia, Andrea PeanoAbstractA 5-year-old neutered female toy Poodle chronically treated with systemic and topical azoles to control recurrent Malassezia dermatitis/otitis was presented because of the loss of treatment efficacy. Minimum Inhibitory Concentrations (MICs) obtained in vitro for various azoles (especially itraconazole and ketoconazole) against Malassezia strains isolated from the dog were increased by several-fold compared with MICs obtained for control isolates. These r...
Source: Medical Mycology Case Reports - December 22, 2018 Category: Biology Source Type: research

Cutaneous sporotrichosis in a stray cat from Thailand
Publication date: Available online 21 December 2018Source: Medical Mycology Case ReportsAuthor(s): Lerpen Duangkaew, Chompoonek Yurayart, Orawan Limsivilai, Charles Chen, Chaiyan KasorndorkbuaAbstractThis is a case report of feline sporotrichosis in a 3-year-old male intact DSH stray cat in Bangkok, Thailand. Cytology and histopathology revealed Sporothrix yeast-like organisms in ulcerative cutaneous lesions. Fungal culture and sequence analysis of ITS region of rDNA confirmed the diagnosis and the causative agent as Sporothrix schenckii. This is the first case report of feline sporotrichosis in the country. The case repor...
Source: Medical Mycology Case Reports - December 22, 2018 Category: Biology Source Type: research

Acute renal injury cause by confirmed Psilocybe cubensis mushroom ingestion
Publication date: Available online 22 December 2018Source: Medical Mycology Case ReportsAuthor(s): Emily Austin, Hilary S. Myron, Richard K. Summerbell, Connie MackenzieAbstractPsilocybe mushrooms are consumed for their hallucinogenic properties. Fortunately, there are relatively few adverse effects associated with their consumption. This is the first reported case of acute kidney injury (AKI) secondary to confirmed ingestion of Psilocybe cubensis mushroom.A 15-year-old male he developed symptomatic AKI 36 hours post-ingestion of Psilocybe cubensis mushrooms. He was admitted to hospital with hypertension, nausea and a...
Source: Medical Mycology Case Reports - December 22, 2018 Category: Biology Source Type: research

Immune Reconstitution Inflammatory Syndrome Associated with Disseminated Histoplasmosis and TNF-alpha Inhibition
Publication date: Available online 22 December 2018Source: Medical Mycology Case ReportsAuthor(s): Theodore Wright, Basak Coruh, David Fredricks, Nina KimAbstractEndemic fungal infections are a significant problem for patients on TNF-alpha inhibitors. Immune reconstitution inflammatory syndrome, IRIS, can present in patients with waning TNF-alpha inhibition and an endemic fungal infection. There may be a potential role that TNF-alpha inhibitors can play in mitigating IRIS related to disseminated endemic fungal infections. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - December 22, 2018 Category: Biology Source Type: research

Brain abscess caused by Cladophialophora bantiana: Total remission after full resection and short-course Voriconazole treatment
We report on a brain abscess in an immunocompetent man caused by Cladophialophora bantiana, a black mold known to prefer the brain for abscess-formations with a mortality rate up to 65%. The published cases so far show different therapeutical approaches and outcomes, whereby a standardized treatment could not yet be established. We report on a case of Cladophialophora bantiana brain abscess with total remission of the abscess after full resection and a short antifungal treatment. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - December 12, 2018 Category: Biology Source Type: research

Trichophyton benhamiae and T. mentagrophytes target guinea pigs in a mixed small animal stock
We present a case of a small animal stock infected with two Trichophyton species. T. benhamiae was isolated from 15 out of 26 (58%) guinea pigs including two morphologically different phenotypes. Eight guinea pigs were infected with T. benhamiae and T. mentagrophytes simultaneously. The animals showed alopecia and crusts or no clinical signs at all. T. benhamiae was not detected in rats, rabbits and mice kept in the same stock. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - December 1, 2018 Category: Biology Source Type: research

Breaking the Mold: A case of pulmonary mucormycosis treated with isavuconazole
Publication date: Available online 1 December 2018Source: Medical Mycology Case ReportsAuthor(s): Jonathan Huggins, Ayman Al Jurdi, Renuka GuptaAbstractPulmonary mucormycosis is a rare opportunistic invasive fungal infection that disproportionately affects immunocompromised hosts and carries high morbidity and mortality. It is traditionally treated with combined pharmacologic and surgical modalities. Here we present a case of pulmonary mucormycosis in a patient whose disease burden precluded surgical management, and in whom acute kidney injury necessitated therapy with an alternative to the recommended pharmacologic antifu...
Source: Medical Mycology Case Reports - December 1, 2018 Category: Biology Source Type: research

Saccharomyces cerevisiae fungemia in a critically ill patient with acute cholangitis and long term probiotic use
We report a case of a 74-year-old man admitted for acute cholangitis taking a probiotic supplement containing the subtype Saccharomyces boulardii. He later developed S. cerevisiae fungemia that was successfully treated with Micafungin and Fluconazole. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - November 14, 2018 Category: Biology Source Type: research

Palate ulcer, uvular destruction and nasal septal perforation caused by Sporothrix brasiliensis in an HIV-infected patient
We report a dramatic presentation of Sporothrix brasiliensis infection, with destruction of the nasal septum, soft palate, and uvula of an HIV-infected woman. She was successfully treated with amphotericin B deoxycholate followed by itraconazole. Sporotrichosis remains a neglected opportunistic infection in patients with AIDS and awareness of this potentially fatal infection is of utmost importance. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - November 14, 2018 Category: Biology Source Type: research

Chronic pulmonary aspergillosis following pulmonary embolism
We describe a case of CPA in a 79-year-old female following bilateral pulmonary emboli. The clinical implications are numerous, including the dilemma of anticoagulation. This link suggests that a lower threshold for suspecting CPA following pulmonary embolus is required, even in the absence of other respiratory disease. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - November 11, 2018 Category: Biology Source Type: research

Treatment of cerebral mucormycosis with drug therapy alone: A case report
We report on an elderly male patient with headache and right-side weakness. Imaging studies revealed multiple space-occupying lesions in the parietal and occipital cerebral regions. Biopsy revealed broad aseptate ribbon-like structures branching at right angles, suggestive of mucormycosis. Improvement was observed after medical therapy with 20 weeks of liposomal amphotericin B (5 mg/kg/day) combined with posaconazole, followed by posaconazole (400 mg twice a day) alone for 1 month. The patient recovered without neurological deficits; however, multidrug-resistant bacteraemia and hospital-acquired pneumonia occurre...
Source: Medical Mycology Case Reports - October 29, 2018 Category: Biology Source Type: research

Deep cutaneous Trichosporon asahii infection in a patient recovering from toxic epidermal necrolysis
We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 27, 2018 Category: Biology Source Type: research

Purpuriocillium lilacinum infection in captive loggerhead sea turtle hatchlings
Publication date: Available online 25 October 2018Source: Medical Mycology Case ReportsAuthor(s): Clarisse Máximo Arpini, Yhuri Cardoso Nóbrega, Vinícius Davel Castheloge, Daniel Santos Neves, Carlos Eduardo Tadokoro, Gisela Lara da Costa, Manoel Marques Evangelista Oliveira, Marcelo Renan de Deus SantosAbstractThis paper reports a case of Purpureocillium lilacinum infection in seven loggerhead sea turtle (Caretta caretta) hatchlings kept in an aquarium under inadequate condition. The fungus was isolated from skin and pulmonary lesions. Metilene blue and NaCl solutions, Schinus terebinthifolius and euc...
Source: Medical Mycology Case Reports - October 25, 2018 Category: Biology Source Type: research

Aspergillus Endocarditis Diagnosed by Fungemia Plus Serum Antigen Testing
Publication date: Available online 25 October 2018Source: Medical Mycology Case ReportsAuthor(s): Timothy J. Hatlen, Scott G. Filler, Arnold Bayer, Sonia Shah, Shivani Shodhan, Tam T. VanAbstractFungal endocarditis remains an uncommon clinical diagnosis, though is likely to become more frequent due to the global increase in transplantations and cardiac valvular surgery. A case of prosthetic valve endocarditis due to Aspergillus fumigatus is described that was diagnosed with serologic fungal markers and confirmed with positive blood cultures, an uncommon finding. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 25, 2018 Category: Biology Source Type: research

Invasive fungal infection by Aspergillus flavus in immunocompetent hosts: a case series and literature review
Publication date: Available online 25 October 2018Source: Medical Mycology Case ReportsAuthor(s): Ana María Garcia-Giraldo, Barbara Lucia Mora, Jorge Mario Loaiza-Castaño, Jorge Andrés Cedano, Fernando RossoAbstractInvasive aspergillosis usually affects immunocompromised hosts with variable manifestations depending on the site of infection. In this article, we present two cases of invasive Aspergillosis in two non-immunocompromised patients; both cases had a paranasal sinuses infection, with intraorbital and intracranial extension, requiring surgery and antifungal treatment with Voriconazole. These cas...
Source: Medical Mycology Case Reports - October 25, 2018 Category: Biology Source Type: research

Exophiala psychrophila: a new agent of chromoblastomycosis
We report a woman who was treated before with mycological cure, but she experience a relapse requiring treatment again. Direct microscopic examination and skin biopsy with culture were necessary to identify a Exophiala psychrophila, and for our knowledge this is the first case reported. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 25, 2018 Category: Biology Source Type: research

Posaconazole and isavuconazole induced hypomagnesaemia
Publication date: Available online 28 September 2018Source: Medical Mycology Case ReportsAuthor(s): John Burston, Mark Robertson, Sebastian van Hal, Angie N. Pinto (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 5, 2018 Category: Biology Source Type: research

Aspergillus fumigatus endocarditis in an Indigenous Australian male without classic risk factors
We present the case of an “immunocompetent” Indigenous Australian male with culture confirmed Aspergillus brain abscesses complicating bilateral endocarditis. The reported mortality rate for Aspergillus endocarditis approaches 100%. Despite sub-optimal therapy this patient survived beyond expectation. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 22, 2018 Category: Biology Source Type: research

Blastoschizomyces capitatus pneumonia in a patient with untreated chronic lymphocytic leukemia
We report a case of pulmonary infection by B. capitatus in a patient with untreated chronic lymphocytic leukemia. Although the patient had a complete recovery, we believe that this report will alert clinicians to consider B. capitatus as possible cause of severe pneumonia in untreated CLL. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 22, 2018 Category: Biology Source Type: research

Invasive rhinocerebral mucormycosis in a patient with liver cirrhosis leading to fatal massive stroke
Publication date: Available online 21 September 2018Source: Medical Mycology Case ReportsAuthor(s): Taher Sabobeh, Kamran Mushtaq, Ahmed Elsotouhy, Adham A. Ammar, Sameera RashidAbstractImmunocompromised status is associated with invasive fungal infections including mucormycosis. These infections are challenging to treat and associated with high overall mortality.Here we report a fatal case of invasive mucormycosis in a cirrhotic, diabetic patient. Despite the swift diagnosis and management; the fungal invasion of the right internal carotid artery lead to massive ischemic stroke.Timely diagnosis and management is crucial f...
Source: Medical Mycology Case Reports - September 22, 2018 Category: Biology Source Type: research

Utilization of Voriconazole Drug Monitoring in the Treatment of Cutaneous Scedosporium apiospermum Infection
We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 14, 2018 Category: Biology Source Type: research

Isolation of Cryptococcus gattii VGIII from feline nasal injury
Publication date: Available online 12 September 2018Source: Medical Mycology Case ReportsAuthor(s): Peggy Vieille, Rodrigo Cruz, Paula León, Nicolás Cáceres, Gustavo GiusianoAbstractHereby we communicate the first autochthon isolation of Cryptococcus gattii VGIII in Chile, which was obtained from a nasal injury in a domestic cat in the Valparaíso region in Chile. The strain was identified using morphophysiological tests, MALDI-TOF, and URA5 gene PCR-RFLP analysis. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 13, 2018 Category: Biology Source Type: research

Intracatheter Antifungal Lock Leading to Detrimental Complications
We report two cases where antifungal lock were performed in PD patients presented with PD-related fungal infection that not only had no effect on abating the infection but also causing paradoxical outcomes. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 13, 2018 Category: Biology Source Type: research

Post-traumatic fatal disseminated Apophysomyces elegans infection
We describe a case of disseminated post-traumatic Apophysomyces elegans in an immunocompetent patient status-post soil inoculation. Fungi introduced at a deep arm laceration leads to neurovascular invasion and dissemination prior to amputation and systemic treatment. We specify strict post-traumatic wound surveillance protocol and roles of novel tissue tests to improve time to diagnosis and prognosis of frequently fatal post-traumatic Mucorales infections (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 7, 2018 Category: Biology Source Type: research

Fatal fulminant cryptococcemia complicating sarcoidosis: is it to be expected?
We describe a case of cryptococcemia that rapidly progressed toward fatality without apparent other sites of infection. We discuss on the importance of serum cryptococcal polysaccharide antigen testing for identifying at-risk patients who might benefit from timely diagnosis and treatment of cryptococcosis (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - August 17, 2018 Category: Biology Source Type: research

Successful treatment of C. auris shunt infection with intraventricular caspofungin
We describe here an adult with nosocomial CSF shunt infection due to multi drug resistant C. auris. Systemic therapy with echinocandin and flucytosine failed. Fortunately, administration of daily intraventricular caspofungin 10 mg for 10 days in conjunction with systemic voriconazole resulted in both clinical and microbiological cure. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - August 12, 2018 Category: Biology Source Type: research

Canine rhinitis caused by an uncommonly-diagnosed fungus, Scedosporium apiospermum
Publication date: Available online 8 August 2018Source: Medical Mycology Case ReportsAuthor(s): Christopher Smith, Lucy Woolford, Jessica Talbot, Ken C Lee, Paul CrockerAbstractA Golden Retriever cross was presented with a four week history of violent sneezing and licking at the nasal planum. Nasal mycosis was diagnosed and Aspergillus sp. presumed the causative agent, until culture, PCR and DNA sequencing showed that Scedosporium apiospermum, an uncommonly diagnosed, yet emerging, fungal pathogen, was the agent responsible. Debridement of the fungal plaques and systemic itraconazole therapy resulted in complete resolution...
Source: Medical Mycology Case Reports - August 8, 2018 Category: Biology Source Type: research