Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
Colonial-driven extinction of the blue antelope despite genomic adaptation to low population size
Curr Biol. 2024 Apr 9:S0960-9822(24)00391-9. doi: 10.1016/j.cub.2024.03.051. Online ahead of print.ABSTRACTLow genomic diversity is generally indicative of small population size and is considered detrimental by decreasing long-term adaptability.1,2,3,4,5,6 Moreover, small population size may promote gene flow with congeners and outbreeding depression.7,8,9,10,11,12,13 Here, we examine the connection between habitat availability, effective population size (Ne), and extinction by generating a 40× nuclear genome from the extinct blue antelope (Hippotragus leucophaeus). Historically endemic to the relatively small Cape Floris...
Source: Current Biology - April 13, 2024 Category: Biology Authors: Elisabeth Hempel J Tyler Faith Michaela Preick Deon de Jager Scott Barish Stefanie Hartmann Jos é H Grau Yoshan Moodley Gregory Gedman Kathleen Morrill Pirovich Faysal Bibi Daniela C Kalthoff Sven Bocklandt Ben Lamm Love Dal én Michael V Westbury Michae Source Type: research
Colonial-driven extinction of the blue antelope despite genomic adaptation to low population size
Curr Biol. 2024 Apr 9:S0960-9822(24)00391-9. doi: 10.1016/j.cub.2024.03.051. Online ahead of print.ABSTRACTLow genomic diversity is generally indicative of small population size and is considered detrimental by decreasing long-term adaptability.1,2,3,4,5,6 Moreover, small population size may promote gene flow with congeners and outbreeding depression.7,8,9,10,11,12,13 Here, we examine the connection between habitat availability, effective population size (Ne), and extinction by generating a 40× nuclear genome from the extinct blue antelope (Hippotragus leucophaeus). Historically endemic to the relatively small Cape Floris...
Source: Current Biology - April 13, 2024 Category: Biology Authors: Elisabeth Hempel J Tyler Faith Michaela Preick Deon de Jager Scott Barish Stefanie Hartmann Jos é H Grau Yoshan Moodley Gregory Gedman Kathleen Morrill Pirovich Faysal Bibi Daniela C Kalthoff Sven Bocklandt Ben Lamm Love Dal én Michael V Westbury Michae Source Type: research
Colonial-driven extinction of the blue antelope despite genomic adaptation to low population size
Curr Biol. 2024 Apr 9:S0960-9822(24)00391-9. doi: 10.1016/j.cub.2024.03.051. Online ahead of print.ABSTRACTLow genomic diversity is generally indicative of small population size and is considered detrimental by decreasing long-term adaptability.1,2,3,4,5,6 Moreover, small population size may promote gene flow with congeners and outbreeding depression.7,8,9,10,11,12,13 Here, we examine the connection between habitat availability, effective population size (Ne), and extinction by generating a 40× nuclear genome from the extinct blue antelope (Hippotragus leucophaeus). Historically endemic to the relatively small Cape Floris...
Source: Current Biology - April 13, 2024 Category: Biology Authors: Elisabeth Hempel J Tyler Faith Michaela Preick Deon de Jager Scott Barish Stefanie Hartmann Jos é H Grau Yoshan Moodley Gregory Gedman Kathleen Morrill Pirovich Faysal Bibi Daniela C Kalthoff Sven Bocklandt Ben Lamm Love Dal én Michael V Westbury Michae Source Type: research
News at a glance: Jailed conservationists freed, physics titan dies, and diversity in anatomical illustrations
ASTRONOMY
Scientists flock to the eclipse
Tens of millions in North America turned their specially protected eyes to the skies on 8 April for several minutes of darkness when the Moon blocked the disk of the Sun, casting a shadow across Mexico, 15 U.S. states, and Canada. Researchers and citizen scientists seized the opportunity to study the corona—the wispy, outer layer of the Sun’s atmosphere—from the ground and in eclipse-chasing aircraft. They expected to see loops of plasma and other solar flares because the eclipse coincided with solar maximum, a period of high magnetic activity. Research...
Source: Science of Aging Knowledge Environment - April 11, 2024 Category: Geriatrics Source Type: research
Molecules, Vol. 29, Pages 1689: Phytochemical Profile and Bioactivity of Bound Polyphenols Released from Rosa roxburghii Fruit Pomace Dietary Fiber by Solid-State Fermentation with Aspergillus niger
This study aimed to investigate the phytochemical profile, bioactivity, and release mechanism of bound polyphenols (BPs) released from Rosa roxburghii fruit pomace insoluble dietary fiber (RPDF) through solid-state fermentation (SSF) with Aspergillus niger. The results indicated that the amount of BPs released from RPDF through SSF was 17.22 mg GAE/g DW, which was significantly higher than that achieved through alkaline hydrolysis extraction (5.33 mg GAE/g DW). The BPs released through SSF exhibited superior antioxidant and &alpha;-glucosidase inhibitory activities compared to that released through alkaline hydroly...
Source: Molecules - April 9, 2024 Category: Chemistry Authors: Qing Chen Juan Su Yue Zhang Chao Li Siming Zhu Tags: Article Source Type: research
Novel chitosan-based smart bio-nanocomposite films incorporating TiO < sub > 2 < /sub > nanoparticles for white bread preservation
Int J Biol Macromol. 2024 Apr 5:131367. doi: 10.1016/j.ijbiomac.2024.131367. Online ahead of print.ABSTRACTChitosan (CS)-based bio-nanocomposite food packaging films were prepared via solvent-casting method by incorporating a unique combination of additives and fillers, including polyvinyl alcohol (PVA), glycerol, Tween 80, castor oil (CO), and nano titanium dioxide (TiO2) in various proportions to enhance film properties. For a comprehensive analysis of the synthesized films, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), tensile testing, field emission scanning ...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: None Geeta None Shivani Neeru Devi None Shayoraj Neha Bansal Sanjay Sharma Santosh Kumar Dubey Satish Kumar Source Type: research
Novel chitosan-based smart bio-nanocomposite films incorporating TiO < sub > 2 < /sub > nanoparticles for white bread preservation
Int J Biol Macromol. 2024 Apr 5:131367. doi: 10.1016/j.ijbiomac.2024.131367. Online ahead of print.ABSTRACTChitosan (CS)-based bio-nanocomposite food packaging films were prepared via solvent-casting method by incorporating a unique combination of additives and fillers, including polyvinyl alcohol (PVA), glycerol, Tween 80, castor oil (CO), and nano titanium dioxide (TiO2) in various proportions to enhance film properties. For a comprehensive analysis of the synthesized films, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), tensile testing, field emission scanning ...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: None Geeta None Shivani Neeru Devi None Shayoraj Neha Bansal Sanjay Sharma Santosh Kumar Dubey Satish Kumar Source Type: research
Activity-based protein profiling technology reveals malate dehydrogenase as the target protein of cinnamaldehyde against Aspergillus niger
This study endeavors to unveil the molecular-level antifungal mechanism of cinnamaldehyde via a chemoproteomics approach, thereby offering valuable insights for further development and utilization of cinnamaldehyde in preventing and mitigating food spoilage.PMID:38579546 | DOI:10.1016/j.ijfoodmicro.2024.110685 (Source: International Journal of Food Microbiology)
Source: International Journal of Food Microbiology - April 5, 2024 Category: Food Science Authors: Xin Wang Bowen Wang Yulan Hu Zhao Zhang Bingjian Zhang Source Type: research
Activity-based protein profiling technology reveals malate dehydrogenase as the target protein of cinnamaldehyde against Aspergillus niger
This study endeavors to unveil the molecular-level antifungal mechanism of cinnamaldehyde via a chemoproteomics approach, thereby offering valuable insights for further development and utilization of cinnamaldehyde in preventing and mitigating food spoilage.PMID:38579546 | DOI:10.1016/j.ijfoodmicro.2024.110685 (Source: International Journal of Food Microbiology)
Source: International Journal of Food Microbiology - April 5, 2024 Category: Food Science Authors: Xin Wang Bowen Wang Yulan Hu Zhao Zhang Bingjian Zhang Source Type: research
Antimicrobial Spiroketal macrolides and Dichloro-Diketopiperazine from Micromonospora sp. FIMYZ51
Fitoterapia. 2024 Apr 2:105946. doi: 10.1016/j.fitote.2024.105946. Online ahead of print.ABSTRACTFour compounds (1-4) featuring with an L-rhodinose and spiroketal, possess uncommon continuous hydroxy groups in the macrolide skeleton, and a dichloro-diketopiperazine (5) were isolated from a marine derived Micromonospora sp. FIMYZ51. The determination of the relative and absolute configurations of all isolates was achieved by extensive spectroscopic analyses, single-crystal X-ray diffraction analysis, and ECD calculations. According to structural characteristic and genomic sequences, a plausible biosynthetic pathway for comp...
Source: Fitoterapia - April 4, 2024 Category: Biochemistry Authors: Wei Zhao Hong Jiang Yichao Ge Chengzeng Zhou Yihan Ma Jian Zhou Yang Xie Yinuo Wang Bin Wu Source Type: research
Enhancing the bioavailability and antioxidant activity of natamycin E235-ferulic acid loaded polyethylene glycol/carboxy methyl cellulose films as anti-microbial packaging for food application
This study investigated the development of biodegradable films made from a combination of polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and mixtures from natamycin and ferulic acid. The films were characterized for their surface microstructure, antioxidant activity, thermal stability, mechanical properties, permeability and antifungal/bacterial activity. The addition of natamycin and ferulic acid to the film matrix enhanced antioxidant activity, thermal stability, antimicrobial activity, reduced the water vapor permeability (WVP) to 1.083 × 10-10 g × m-1s-1Pa-1, imparted opaque color and increased opacity up t...
Source: International Journal of Biological Macromolecules - April 3, 2024 Category: Biochemistry Authors: Mohamed Abdin Mohamed Ahmed Naeem Mohamed M Aly-Aldin Source Type: research
Biological control effect of Trichoderma harzianum (Hypocreales: Hypocreaceae) against phytopathogens
AbstractChemical pesticides are synthetic substances created to manage plant pests. Frequent chemical usage causes extensive damage to crops and contributes to pest resistance, leading to environmental contamination, harm to non-target organisms, the emergence of pesticide-resistant species, and potential health hazards for humans. The aim of this study is to isolate, identify, and characterize biocontrol agentsTrichoderma harzianum and evaluate their effects on various plant phytopathogens.T. harzianum biocontrol effects were tested against various fungal phytopathogens, includingSclerotium rolfsii,Alternaria sp.,Pythium ...
Source: Environmental Quality Management - April 3, 2024 Category: Environmental Health Authors: Kannan Swathy,
Vadesha Nisha,
Perumal Vivekanandhan Tags: RESEARCH ARTICLE Source Type: research
Clinicopathological study of otomycosis in a tertiary hospital in South-west Nigeria
Conclusions: Otomycosis commonly present with itchy ears, the pathogenic fungi commonly being Aspergillus species. Thefactors associated with positive fungal culture were age, non-usage of ototopic agents and presence of co-morbidity. Treatmentmodality used was local debridement and topical antifungal agents, which produced favourable response in most patients.Keywords: Otomycosis; mycology; presentations; treatment; complications; associations. (Source: African Health Sciences)
Source: African Health Sciences - April 1, 2024 Category: African Health Authors: Olusola A Sogebi, Emmanuel A Oyewole, Olubunmi A Osinupebi Source Type: research
