Acute Severe Anaphylaxis in Nepali Patients with Neurotoxic Snakebite Envenoming Treated with the VINS Polyvalent Antivenom.
Authors: Sharma SK, Alirol E, Ghimire A, Shrestha S, Jha R, Parajuli SB, Shrestha D, Shrestha SJ, Bista A, Warrell D, Kuch U, Chappuis F, Taylor WRJ Abstract Diagnosing and treating acute severe and recurrent antivenom-related anaphylaxis (ARA) is challenging and reported experience is limited. Herein, we describe our experience of severe ARA in patients with neurotoxic snakebite envenoming in Nepal. Patients were enrolled in a randomised, double-blind trial of high vs. low dose antivenom, given by intravenous (IV) push, followed by infusion. Training in ARA management emphasised stopping antivenom and giving intra...
Source: Journal of Tropical Medicine - June 18, 2019 Category: Tropical Medicine Tags: J Trop Med Source Type: research

IJERPH, Vol. 16, Pages 2145: Socio-Demographic and Diet-Related Factors Associated with Insufficient Fruit and Vegetable Consumption among Adolescent Girls in Rural Communities of Southern Nepal
This study was undertaken to identify associations between socio-demographic and diet-related factors with insufficient fruit and vegetable consumption among adolescent girls living in rural communities. This community-based, cross-sectional study was conducted on 407 adolescent girls from rural communities in the Bateshwar rural municipality of Dhanusha district, Southern Nepal between 12 October, 2018 and 14 December, 2018. The study subjects responded to FV consumption and dietary factor-related questionnaires, and anthropometric measurements were taken. Data were analyzed using the univariate logistic regression follow...
Source: International Journal of Environmental Research and Public Health - June 17, 2019 Category: Environmental Health Authors: Jitendra Kumar Singh Dilaram Acharya Salila Gautam Mandira Adhikari Ji-Hyuk Park Seok-Ju Yoo Kwan Lee Tags: Article Source Type: research

Chemical Composition, Enantiomeric Distribution, and Biological Activities of Rhododendron anthopogon Leaf Essential Oil from Nepal.
Authors: Dosoky NS, Satyal P, Pokharel S, Setzer WN Abstract Rhododendron anthopogon D. Don., A small compact Himalayan shrub growing in Nepal, is a known medicinal plant used to treat sore throat, colds, blood disorders, bone disease, potato allergies, and vomiting, and to relieve liver disorders, headaches and back pain. The present study investigated the chemical composition and bioactivities of the leaf essential oil from R. anthopogon from Dhankuta, Nepal. The essential oil from leaves was obtained by hydrodistillation and a detailed chemical analysis was conducted by gas chromatography - mass spectrometry.(GC...
Source: Natural Product Communications - June 15, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research

Detection of antibodies against bluetongue virus among goats of different eco-climatic zones of Nepal
AbstractA cross-sectional study was conducted to determine sero-prevalence of bluetongue virus (BTV) among of different ecological zones of Nepal. A total of 342 goat serum samples were tested by using c-ELISA for the presence of antibodies against BTV. Out of the total 342 serum samples tested, 130 were positive giving an overall sero-prevalence of 38.01%. Significantly higher sero-prevalence was found (p 
Source: Comparative Clinical Pathology - June 15, 2019 Category: Pathology Source Type: research

Prominent Spasticity and Hyperreflexia of the Legs in a Nepalese Patient with Friedreich Ataxia.
Authors: Naruse H, Takahashi Y, Ishiura H, Matsukawa T, Mitsui J, Ichikawa Y, Hamada M, Shimizu J, Goto J, Toda T, Tsuji S Abstract Friedreich ataxia (FRDA) is an autosomal recessive spinocerebellar ataxia caused by mutations of FXN. Hypotonus and hyporeflexia of the lower extremities are observed in most FRDA patients. Patients with hyperreflexia, called Friedreich ataxia with retained reflexes (FARR), have also been identified. We herein report the case of a 16-year-old Nepalese boy presenting with early-onset ataxia with prominent spasticity and hyperreflexia of the legs. Mutational analyses established the diag...
Source: Internal Medicine - June 12, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

What Physicians Should Advise their Mature Patients Concerning Gender Transition
Clearly, the issue of gender being a binary characteristic of humans is a societal norm of western culture [1]. Many cultures such as the Hijra of Nepal, Bangladesh, Pakistan and India, the Muxes of Mexico and the Bugis Tribe of Indonesia recognize more than two genders. However, over the past five years, western society is breaking down gender silos and with this the number of individuals describing themselves as transgender has increased. As transgender individuals work their way into healthcare systems, clinicians in many different specialties are being called on to help facilitate both affirmation of gender and mainten...
Source: Maturitas - June 12, 2019 Category: Primary Care Authors: Anne Koch Source Type: research

Physical restraining: Nurses knowledge and practice in Tertiary Care Hospital of Eastern Nepal
AbstractAimThe aim was to assess the level of knowledge and practice on physical restraints.DesignA descriptive cross ‐sectional study design was adopted.MethodsA total enumerative sampling technique was used to select 117 nurses working in ICU, medical wards, psychiatric ward and emergency unit of Tertiary Care Hospital, Nepal. After obtaining written consent from each participant, self ‐administered questionnaires on socio‐demographic profile, knowledge and practice about physical restraints were distributed.ResultsMost nurses (55.6%) were from age group of 18 –25 years. Most of the participants (82.1%) ...
Source: Nursing Open - June 12, 2019 Category: Nursing Authors: Nirmala Pradhan, Sami Lama, Gayananda Mandal, Erina Shrestha Tags: RESEARCH ARTICLE Source Type: research

History of abuse and neglect and their associations with mental health in rescued child labourers in Nepal.
CONCLUSIONS: Our estimates of physical abuse in this at-risk juvenile sample were commensurate to those reported in general-population youth samples in Nepal, but sexual and emotional abuse rates were somewhat lower. The potential presence of anxiety and trauma in this sample that may result from maltreatment requires replication, but underscores an urgent need for routine mental health screening in rescued child labourers during rehabilitation efforts. PMID: 31185738 [PubMed - as supplied by publisher] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - June 12, 2019 Category: Psychiatry Authors: Dhakal S, Niraula S, Sharma NP, Sthapit S, Bennett E, Vaswani A, Pandey R, Kumari V, Lau JY Tags: Aust N Z J Psychiatry Source Type: research

Adherence to antiretroviral treatment and associated factors among people living with HIV and AIDS in CHITWAN, Nepal
This study aimed at de... (Source: BMC Public Health)
Source: BMC Public Health - June 10, 2019 Category: Consumer Health News Authors: Sujan Neupane, Govinda Prasad Dhungana and Harish Chandra Ghimire Tags: Research article Source Type: research

Inter-rater reliability of Timed Up and Go test in older adults measured by physiotherapist and caregivers
. (Source: European Journal of Physiotherapy)
Source: European Journal of Physiotherapy - June 8, 2019 Category: Rehabilitation Authors: Govinda M. Nepal Manoj Basaula Saurab Sharma Source Type: research

Sexual violence as a predictor of unintended pregnancy among married young women: evidence from the 2016 Nepal demographic and health survey
Sexual violence in marital relationship is higher among women married at young age. Although sexual violence has been found to increase risk for unintended pregnancy, there is a limited published data from Nep... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - June 7, 2019 Category: OBGYN Authors: Kiran Acharya, Yuba Raj Paudel and Pramita Silwal Tags: Research article Source Type: research

Factors Associated With Stillbirth Among Pregnant Women in Nepal.
CONCLUSIONS: Stillbirth continues to be a major problem among women, especially those with higher maternal age, those who are illiterate, and residents of certain geographical regions. To minimize stillbirth in Nepal, plans and policies should be focused on women with low education levels and residents of rural areas, especially in the western mountain and far-western hill regions. PMID: 31163950 [PubMed - in process] (Source: Journal of Preventive Medicine and Public Health)
Source: Journal of Preventive Medicine and Public Health - June 6, 2019 Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research

Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
Publication date: 4 June 2019Source: Cell Reports, Volume 27, Issue 10Author(s): Maheshwor Timilshina, Zhiwei You, Sonja M. Lacher, Suman Acharya, Liyuan Jiang, Youra Kang, Jung-Ae Kim, Hyeun Wook Chang, Keuk-Jun Kim, Byoungduck Park, Jae-Hyoung Song, Hyun-Jeong Ko, Yun-Yong Park, Min-Jung Ma, Mahesh Raj Nepal, Tae Cheon Jeong, Yeonseok Chung, Ari Waisman, Jae-Hoon ChangSummaryThe function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator by linking cellular me...
Source: Cell Reports - June 5, 2019 Category: Cytology Source Type: research

Access to and use of medicines in the Annapurna region of Western Nepal and possible impacting factors
This study investigates access to and use of medicines through health facility and household-based studies using standardised tools and through a series of structured key informant interviews with various stakeholders in health.Overall, access to essential medicines at public health facilities was good, but this was not benefitting households as much as it should. People were using the private sector for medicines because of their perception about the quality and limited numbers  of government-supplied free medicines. They utilised money from remittances and tourism, and subsidised healthcare from non-government organ...
Source: Journal of Pharmaceutical Policy and Practice - June 4, 2019 Category: Pharmaceuticals Source Type: research

Association between K469E polymorphism of ICAM ‐1 gene and susceptibility of ischemic stroke: An updated meta‐analysis
ConclusionK469E polymorphism of ICAM ‐1 gene might be a risk factor for ischemic stroke in Caucasians, which suggested that K469E polymorphism might help in early identification of those at risk and help in primary prevention of ischemic stroke. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - June 3, 2019 Category: Genetics & Stem Cells Authors: Gaurav Nepal, Jayant Kumar Yadav, YuHui Kong Tags: ORIGINAL ARTICLE Source Type: research

Etiology of Central Nervous System Infections in a Rural Area of Nepal Using Molecular Approaches.
In conclusion, the etiology could not be found in 77% of the samples, indicating that the commercial PCR panels used are not suitable in this setting. Future studies on the etiology of CNS infections in Nepal could include metagenomic techniques. PMID: 31162021 [PubMed - as supplied by publisher] (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - June 3, 2019 Category: Tropical Medicine Authors: Säll O, Thulin Hedberg S, Neander M, Tiwari S, Dornon L, Bom R, Lagerqvist N, Sundqvist M, Mölling P Tags: Am J Trop Med Hyg Source Type: research

A Study on Pattern of Retinal Detachment in Patients with Choroidal Coloboma and Its Outcome after Surgery at a Tertiary Eye Hospital in Nepal.
Conclusion: The overall anatomic success rate of retina reattachment surgery in colobomatous eye is good, and the visual outcome following surgery can improve in majority of the cases or may remain same in few cases. Hence, timely surgery is advocated. But careful follow-up is required as the risk of postoperative complications is also high. PMID: 31143474 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2019 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Domestic violence and perinatal outcomes – a prospective cohort study from Nepal
Domestic violence is one of the most common forms of violence against women. Domestic violence during pregnancy is associated with adverse perinatal and maternal outcomes. We aimed to assess whether domestic v... (Source: Cell Division)
Source: Cell Division - May 31, 2019 Category: Cytology Authors: Kunta Devi Pun, Poonam Rishal, Elisabeth Darj, Jennifer Jean Infanti, Shrinkhala Shrestha, Mirjam Lukasse and Berit Schei Tags: Research article Source Type: research

Total Endoscopic Transcanal Cartilage Myringoplasty: A Prospective Study
The objective of the present study was to evaluate the graft uptake rate and to evaluate the hearing results. Methods This is a prospective study. We have analyzed 139 patients who underwent surgery for chronic otitis media (COM) of the mucosal type. All of the surgeries were performed exclusively under total endoscopic transcanal approach using tragal cartilage as graft, underlay technique. We have evaluated the postoperative graft uptake and performed a hearing evaluation at 6 weeks, at 12 weeks, and at 6 months. Results During the study period, 139 patients were included, out of which 13 were lost to fol...
Source: International Archives of Otorhinolaryngology - May 31, 2019 Category: ENT & OMF Authors: Shakya, Dipesh KC, Arun Nepal, Ajit Tamang, Nirmala Tags: Original Research Source Type: research

Lacrimal Sac Rhinosporidiosis; Case report and review of literature with a new grading system to optimize treatment
We present a grading system based on our own experience in a case of extensive rhinospodiosis of lacrimal sac and review of 31 studies published in the literature.A 24-year-old male from Nepal presented with the complaints of watering from his right eye of 13 years duration, swelling in the right medial canthal area with an extension to the inferior part of the orbit for 12 years and nasal blockage for 1.5 years. The patient had a history of previous intervention in which biopsy was taken from the nose and sent for histopathology that confirmed rhinosporidiosis. An extended intranasal endoscopic dacryocystectomy was done a...
Source: Saudi Journal of Ophthalmology - May 29, 2019 Category: Opthalmology Source Type: research

Integrating postpartum contraceptive counseling and IUD insertion services into maternity care in Nepal: results from stepped-wedge randomized controlled trial
In Nepal, 54% of women have an unmet need for family planning within the 2 years following a birth. Provision of a long-acting and reversible contraceptive method at the time of birth in health facilities coul... (Source: Reproductive Health)
Source: Reproductive Health - May 29, 2019 Category: OBGYN Authors: Elina Pradhan, David Canning, Iqbal H. Shah, Mahesh Puri, Erin Pearson, Kusum Thapa, Lata Bajracharya, Manju Maharjan, Dev C. Maharjan, Lata Bajracharya, Ganga Shakya and Pushpa Chaudhary Tags: Research Source Type: research

The impact of unconditional child cash grant on child malnutrition and its immediate and underlying causes in five districts of the Karnali Zone, Nepal – A trend analysis
AbstractBackgroundThe impact of unconditional cash transfers on child malnutrition and its determinants remains poorly understood. The aim of this study was evaluate the impact of an unconditional child cash grant on children ’s nutritional status and its immediate (infant and young child feeding, dietary diversity, food consumption, and child infection and care) and underlying (household food security; Water, Hygiene and Sanitation (WASH) determinants among children younger than five years in the Karnali Zone, Nepal.MethodsThe five districts of the Karnali Zone received standard social welfare services in the f...
Source: Archives of Public Health - May 29, 2019 Category: International Medicine & Public Health Source Type: research

Factors associated with induced abortion in Nepal: data from a nationally representative population-based cross-sectional survey
Despite the legalization of abortion services in 2002, unsafe abortion (abortion services conducted by persons lacking necessary skill or in substandard settings or both) continues to be a public health concer... (Source: Reproductive Health)
Source: Reproductive Health - May 28, 2019 Category: OBGYN Authors: Suresh Mehata, Jamie Menzel, Navaraj Bhattarai, Sharad Kumar Sharma, Mukta Shah, Erin Pearson and Kathryn Andersen Tags: Research Source Type: research

IJERPH, Vol. 16, Pages 1887: Maternal Factors and the Utilization of Maternal Care Services Associated with Infant Feeding Practices among Mothers in Rural Southern Nepal
This study aimed to investigate the maternal factors and utilization of maternal care services associated with infant feeding practices in rural areas of Southern Nepal. Data from a cluster randomized controlled trial ‘MATRI-SUMAN’(Maternal Alliance for Technological Research Initiative on Service Utilization and Maternal Nutrition) conducted between 2015–2016 were analyzed. A total of 426 pregnant women in their second trimester were recruited from the MATRI-SUMAN trial, which was conducted on six villages in rural areas of the Dhanusha district, Nepal. A total of 379 mothers that...
Source: International Journal of Environmental Research and Public Health - May 28, 2019 Category: Environmental Health Authors: Acharya Singh Kandel Park Yoo Lee Tags: Article Source Type: research

Toward cleaner air for a billion Indians [Environmental Sciences]
Exposure to fine particulate matter (PM2.5) is a major risk factor for premature death (1). Few regions of the world experience ambient PM2.5 concentrations as high as the Indo-Gangetic Plains (IGP), home to more than a billion people in India, Pakistan, Nepal, and Bangladesh. Ground-based monitoring data are incomplete in... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - May 28, 2019 Category: Science Authors: Joshua S. Apte, Pallavi Pant Tags: Commentaries Source Type: research

Excess urinary iodine concentration and thyroid dysfunction among school age children of eastern Nepal: a matter of concern
Deficiency as well as excess dietary iodine is associated with several thyroid disorders including Grave ’s disease and goitre. Previously, cross sectional studies conducted among school children in Nepal showe... (Source: BMC Research Notes)
Source: BMC Research Notes - May 27, 2019 Category: Research Authors: Man Kumar Tamang, Basanta Gelal, Binaya Tamang, Madhab Lamsal, David Brodie and Nirmal Baral Tags: Research note Source Type: research

Enteric dysfunction and other factors associated with attained size at 5  years: MAL-ED birth cohort study findings.
CONCLUSIONS: EED markers, bacterial density, and iron markers are associated with growth at 5 y of age. Interventions to reduce bacterial burden and EED may improve long-term growth in low-income settings. PMID: 31127812 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - May 25, 2019 Category: Nutrition Authors: Richard SA, McCormick BJJ, Murray-Kolb LE, Lee GO, Seidman JC, Mahfuz M, Ahmed T, Guerrant RL, Petri WA, Rogawski ET, Houpt E, Kang G, Mduma E, Kosek MN, Lima AAM, Shrestha SK, Chandyo RK, Bhutta Z, Bessong P, Caulfield LE, MAL-ED Network Investigators Tags: Am J Clin Nutr Source Type: research

Effect of a participatory intervention in women ’s self-help groups for the prevention of chronic suppurative otitis media in their children in Jumla Nepal: a cluster-randomised trial
Chronic suppurative otitis media (CSOM) causes preventable deafness and disproportionately affects children living in poverty. Our hypothesis was that health promotion in women ’s groups would increase their kn... (Source: BMC Pediatrics)
Source: BMC Pediatrics - May 23, 2019 Category: Pediatrics Authors: Susan Clarke, Robyn Richmond, Heather Worth, Rajendra Wagle and Andrew Hayen Tags: Research article Source Type: research

The Professional Role of Skilled Birth Attendants’ in Nepal-A Phenomenographic Study
ConclusionThe nurse midwives’ vulnerability emerged especially in rural areas while preventing complications and minimised new-born and maternal death. Often working alone with lack of proper equipment and access to other medical professionals. The nurse midwives perceived that their professional roles required knowledge and experiences, where safety was closely linked to health education. Ethical dilemma could arise when they had to relate to the families' cultural decisions. Education was a key factor close to life-saving procedures, to retain good quality and safety in new-born and maternal healthcare. The nurse m...
Source: Sexual and Reproductive Healthcare - May 22, 2019 Category: Reproduction Medicine Source Type: research

Scrub Typhus Complicated by ARDS, Myocarditis, and Encephalitis Imported to Oman from Nepal.
Authors: Mahdi AS, Al-Khalili SM, Chung CC, Molai M, Ibrahim H, Eskild P, Khamis F, Nenad P Abstract Scrub typhus is a potentially fatal rickettsial infection caused by Orientia tsutsugamushi. It is an obligate intracellular Gram-negative bacterium transmitted by the bite of infected chigger larva. The disease is distributed from Asia to the Pacific islands, and this region is known as the Tsutsugamushi Triangle. A 28-year-old man was admitted to the Royal Hospital with a four-day history of fever, headache, rigors, anorexia, and a nonspecific macular rash. Clinical presentation, laboratory results as well as epide...
Source: Oman Medical Journal - May 22, 2019 Category: Middle East Health Tags: Oman Med J Source Type: research

Acute gastroenteritis associated with Rotavirus A among children less than 5 years of age in Nepal
This study was conducted to obtain information associated with Rotavirus gastroenteritis and to perform genotyping of Rotavirus A. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - May 22, 2019 Category: Infectious Diseases Authors: Sony Shrestha, Ocean Thakali, Sunayana Raya, Laxman Shrestha, Keshab Parajuli and Jeevan Bahadhur Sherchand Tags: Research article Source Type: research

Correction to: The impact of clinical pharmacy services in Nepal in the context of current health policy: a systematic review
The Fig.  1 was incompletely filled. The correction and corresponding data are shown below. Addition to Fig. 1 “Records identified through database searching”:Cochrane library (n =  6). The original article has been corrected. (Source: Journal of Public Health)
Source: Journal of Public Health - May 22, 2019 Category: Health Management Source Type: research

Wisconsin Rheumatologist Visits Rheumatology Training Program in Nepal
A Milwaukee rheumatologist delivered lectures, participated in Grand Rounds and consulted on rheumatology treatment strategies during his visit this winter to the Patan Academy of Health Sciences (PAHS), Nepal. Paul Halverson, MD, affiliated with Froedtert Hospital and the Medical College of Wisconsin, says the several days he spent in Patan, Nepal, adjacent to Kathmandu and... [Read More] (Source: The Rheumatologist)
Source: The Rheumatologist - May 18, 2019 Category: Rheumatology Authors: Kathy Holliman Tags: Professional Topics Dr. Paul Halverson Nepal Source Type: research

Association Between Earthquake Exposures and Mental Health Outcomes in Phulpingdanda Village After the 2015 Nepal Earthquakes.
Abstract In 2015, two strong earthquakes, as well as continuous, high magnitude aftershocks, struck Nepal. Phulpingdanda village was greatly impacted due to its lack of infrastructure and environmental remoteness. Adults from sampled households were surveyed 1-year later to examine the association between earthquake exposures and indicators of depression, post-traumatic stress disorder (PTSD), and resilience. Results showed 33% of surveyed residents screened positive for depression, 9% screened positive for severe PTSD, and 46% displayed moderate to high resilience. Additionally, participants experienced resource ...
Source: Community Mental Health Journal - May 17, 2019 Category: Psychiatry Authors: Schwind JS, Norman SA, Brown R, Frances RH, Koss E, Karmacharya D, Santangelo SL Tags: Community Ment Health J Source Type: research

A novel multilocus sequence typing scheme identifying genetic diversity amongst Leishmania donovani isolates from a genetically homogeneous population in the Indian subcontinent.
e R Abstract In the Indian subcontinent, infection with Leishmania donovani can cause fatal visceral leishmaniasis (VL). Genetic variation in L. donovani is believed to occur rapidly from environmental changes and through selective drug pressures, thereby allowing continued disease occurrence in this region. All previous molecular markers that are commonly in use Multilocus microsatellite typing (MLMT) and Multilocus Sequence Typing (MLST)), were monomorphic in L. donovani originating from the Indian subcontinent (with only a few exceptions) and hence are not suitable for this region. An MLST scheme consisting of ...
Source: International Journal for Parasitology - May 17, 2019 Category: Parasitology Authors: Banu SS, Meyer W, Ferreira-Paim K, Wang Q, Kuhls K, Cupolillo E, Schönian G, Lee R Tags: Int J Parasitol Source Type: research

Women ’s and girls’ experiences of menstruation in low- and middle-income countries: A systematic review and qualitative metasynthesis
ConclusionsThrough synthesis of extant qualitative studies of menstrual experience, we highlight consistent challenges and developed an integrated model of menstrual experience. This model hypothesises directional pathways that could be tested by future studies and may serve as a framework for program and policy development by highlighting critical antecedents and pathways through which interventions could improve women ’s and girls’ health and well-being. Review protocol registrationThe review protocol registration is PROSPERO: CRD42018089581. (Source: PLoS Medicine)
Source: PLoS Medicine - May 16, 2019 Category: Internal Medicine Authors: Julie Hennegan Source Type: research

Prevalence and correlates of postabortion long-acting reversible contraceptive (LARC) use among young women (24 and below) in Nepal: Strategy in the search for improvements
This study aimed to identify the prevalence a... (Source: Reproductive Health)
Source: Reproductive Health - May 14, 2019 Category: OBGYN Authors: Suresh Mehata, Navaraj Bhattarai, Jamie Menzel, Mukta Shah, Pratik Khanal, Shadie Tofigh, Mukti Nath Khanal, Shibesh Chandra Regmi and Kathryn Andersen Tags: Research Source Type: research

Performance Evaluation of Human-Specific Viral Markers and Application of Pepper Mild Mottle Virus and CrAssphage to Environmental Water Samples as Fecal Pollution Markers in the Kathmandu Valley, Nepal
AbstractMonitoring of environmental water is crucial to protecting humans and animals from possible health risks. Although numerous human-specific viral markers have been designed to track the presence of human fecal contamination in water, they lack adequate sensitivity and specificity in different geographical regions. We evaluated the performances of six human-specific viral markers [Aichi virus 1 (AiV-1), human adenoviruses (HAdVs), BK and JC polyomaviruses (BKPyVs and JCPyVs), pepper mild mottle virus (PMMoV), and crAssphage] using 122 fecal-source samples collected from humans and five animal hosts in the Kathmandu V...
Source: Food and Environmental Virology - May 13, 2019 Category: Virology Source Type: research

Cardiometabolic-Renal Disease in South Asians: Consensus Recommendations from the Cardio Renal Society of America
Background: Rates of cardiometabolic-renal disease are extremely high among South Asians (India, Pakistan, Bangladesh, Sri Lanka, Bhutan, the Maldives, and Nepal) residing in their home countries and worldwide. The Cardio Renal Society of America, National Kidney Foundation of Arizona, and Twinepidemic Inc. convened a task force to examine evidence and reach consensus regarding cardiometabolic-renal disease prevention in South Asians. The task force distilled the findings from 5 years of face-to-face and virtual meetings addressing questions derived from expert reviews of published data using the Delphi technique to create...
Source: Cardiorenal Medicine - May 10, 2019 Category: Urology & Nephrology Source Type: research

Ethnoherpetological notes regarding the paha frogs and conservation implication in Manaslu Conservation Area, Gorkha District, Nepal
Paha hunting is a commonplace recreational activity in the mountainous regions of Nepal. The collection is primarily for food use and secondarily preferred as medicinal forms, and utilized by many ethnic group... (Source: Journal of Ethnobiology and Ethnomedicine)
Source: Journal of Ethnobiology and Ethnomedicine - May 10, 2019 Category: Complementary Medicine Authors: Biraj Shrestha and Min Bahadur Gurung Tags: Research Source Type: research

Tool of economic development, metric of global health: Promoting planned families and economized life in Nepal
Publication date: Available online 8 May 2019Source: Social Science & MedicineAuthor(s): Jan BrunsonAbstractIn contemporary global health and development discourses, contraception is cast in multiple roles: an antipoverty tool at the household level, a tool of economic development at the national level, a smart investment with net gains, a means of empowering women, a way of lowering maternal mortality ratios. In order to examine such discursive uses of contraception – and their implications for women – in a concrete way, I use a compelling case of the history of the promotion of planned families in Nepal a...
Source: Social Science and Medicine - May 10, 2019 Category: Psychiatry & Psychology Source Type: research

Molecules, Vol. 24, Pages 1805: Geographical Discrimination in Curcuminoids Content of Turmeric Assessed by Rapid UPLC-DAD Validated Analytical Method
u Lee A fast and reliable ultra-performance liquid chromatography-diode array detection method was developed and validated for the quantitative assessment of turmeric extracts from different geographical locations. Acclaim RSLC PolarAdvantage II column (2.2 μm, 2.1 × 100 mm) was used to analyze individual curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) from turmeric samples. The detection was done on ultraviolet absorbance at 425 nm and the column temperature was maintained at 45 °C. A mobile phase consisting of acetonitrile and water was found to be suitable for...
Source: Molecules - May 10, 2019 Category: Chemistry Authors: Amrit Poudel Jitendra Pandey Hyeong-Kyu Lee Tags: Article Source Type: research

Simultaneous Adalimumab and Antitubercular Treatment for Latent Tubercular Infection: An Experience from Nepal.
Conclusions: Our findings indicate that screening for LTBI should be more frequent in patients from high tuberculosis burden countries; treatment of LTBI with rifampicin/isoniazid combination for 3 months is effective in preventing reactivation even when adalimumab is started simultaneously. PMID: 31057626 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - May 8, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Perceived stigma among people living with HIV AIDS in Pokhara, Nepal
(Source: HIV/AIDS - Research and Palliative Care)
Source: HIV/AIDS - Research and Palliative Care - May 7, 2019 Category: Infectious Diseases Tags: HIV/AIDS - Research and Palliative Care Source Type: research

Reproductive and Hormonal Factors in Relation to Lung Cancer Among Nepali Women
Background: Of the 1.8 million global incident lung cancer cases estimated in 2012, approximately 60% occurred in less developed regions. Prior studies suggest sex differences in lung cancer risk and a potential role for reproductive and hormonal factors in lung cancer among women. However, the majority of these studies were conducted in developed regions. No prior study has assessed these relationships among Nepali women. Methods: Using data from a hospital-based case-control study conducted in B. P. Koirala Memorial Cancer Hospital (Nepal, 2009-2012), relationships between reproductive and hormonal factors and lung cance...
Source: Frontiers in Oncology - May 7, 2019 Category: Cancer & Oncology Source Type: research

IJERPH, Vol. 16, Pages 1578: Socio-Economic Impact of and Adaptation to Extreme Heat and Cold of Farmers in the Food Bowl of Nepal
This study identified some limitations. The cross sectional and self-reported data, as a common source of information to estimate health impact, level of heat/cold stress and labour productivity loss. Community-based education/community engagement programs could be developed to facilitate proactive adaptation. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - May 6, 2019 Category: Environmental Health Authors: Nanda Kaji Budhathoki Kerstin K. Zander Tags: Article Source Type: research

Determination of azithromycin heteroresistant Campylobacter jejuni in traveler ’s diarrhea
AbstractCampylobacter is the most common cause of traveler ’s diarrhea (TD) and human bacterial gastroenteritis. A heteroresistantCampylobacter jejuni (C. jejuni) isolate, identified by microbiological methods and characterized with molecular techniques, was obtained from a traveler in Nepal suffering TD. The presence of atypical colonies within the clear zone of inhibition was the first evidence of an atypical phenotype, leading to additional characterization of this heteroresistant strain. Antimicrobial susceptibility testing (AST) and population analysis profiling (PAP) demonstrated heteroresistance to azithromyci...
Source: Gut Pathogens - May 6, 2019 Category: Microbiology Source Type: research

Effects of ecotourism on forest loss in the Himalayan biodiversity hotspot based on counterfactual analyses.
This article is protected by copyright. All rights reserved. PMID: 31059151 [PubMed - as supplied by publisher] (Source: Conservation Biology)
Source: Conservation Biology - May 6, 2019 Category: Biology Authors: Brandt JS, Radeloff V, Allendorf T, Butsic V, Roopsind A Tags: Conserv Biol Source Type: research

Designing malaria surveillance strategies for mobile and migrant populations in Nepal: a mixed-methods study
As malaria cases have declined throughout Nepal, imported cases comprise an increasing share of the remaining malaria caseload, yet how to effectively target mobile and migrant populations (MMPs) at greatest r... (Source: Malaria Journal)
Source: Malaria Journal - May 3, 2019 Category: Infectious Diseases Authors: Jennifer L. Smith, Prakash Ghimire, Komal Raj Rijal, Alysse Maglior, Sara Hollis, Ricardo Andrade-Pacheco, Garib Das Thakur, Nabaraj Adhikari, Upendra Thapa Shrestha, Megha Raj Banjara, Bibek Kumar Lal, Jerry O. Jacobson and Adam Bennett Tags: Research Source Type: research