The prevalence of cognitive impairment in older Indian persons with cancer and brain metastases
CONCLUSION: Older persons with cancer and brain metastases were not found to have a higher occurrence of cognitive impairment than those without brain metastases in this study. The next step is to understand whether older persons with brain metastases are at a higher risk for cognitive decline as a result of therapeutic interventions such as cranial radiotherapy and chemotherapy.PMID:35702404 | PMC:PMC9117002 | DOI:10.3332/ecancer.2022.1372 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 15, 2022 Category: Cancer & Oncology Authors: Aditya Dhanawat Vanita Noronha Anant Ramaswamy Shreya Gattani Renita Castelino Ratan Dhekale Sarika Mahajan Vijay Patil Nandini Menon Anuradha Daptardar Vikram Gota Shripad Banavali Rajendra Badwe Kumar Prabhash Source Type: research

Association of optic nerve sheath lesion and brain or meningeal metastasis caused by lung cancer
ConclusionsThe pathway of choroidal and optic nerve sheath lesions was different. Optic nerve sheath lesions were associated with brain and meningeal metastasis. When lung cancer-induced meningeal metastasis is suspected, orbital MRI is recommended to assist in the diagnosis. (Source: Thoracic Cancer)
Source: Thoracic Cancer - June 15, 2022 Category: Cancer & Oncology Authors: Shuai Song, Dong Chang, Hao Li, Chunquan Liu, Yong Cui, Hongyang Li Tags: ORIGINAL ARTICLE Source Type: research

Predictors of Lung Adenocarcinoma With Leptomeningeal Metastases: A 2022 Targeted-Therapy-Assisted molGPA Model
ConclusionsThe 2022 molGPA model, a substantial update of previous molGPA models with better prediction performance, may be useful in clinical decision making and stratification of future clinical trials. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - June 10, 2022 Category: Cancer & Oncology Source Type: research

Single-cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases
Clin Transl Med. 2022 Jun;12(6):e885. doi: 10.1002/ctm2.885.ABSTRACTLeptomeningeal metastases (LM) occur in patients with breast cancer (BC) and lung cancer (LC) showing exceptionally poor prognosis. The cerebrospinal fluid (CSF) tumour microenvironment (TME) of LM patients is not well defined at a single-cell level. Based on the 10× genomics single-cell RNA sequencing (scRNA-seq) data from GEO database including five patient-derived CSF samples of BC-LM and LC-LM, and four patient-derived CSF samples of idiopathic intracranial hypertension (IIH) as controls, we analysed single-cell transcriptome characteristics of CSF TM...
Source: Clinical Lung Cancer - June 9, 2022 Category: Cancer & Oncology Authors: Haoyu Ruan Zhe Wang Ziwei Sun Jia Wei Lei Zhang Huanyu Ju Ting Wang Chao Zhang Ming Guan Shiyang Pan Source Type: research

Single-cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases
Clin Transl Med. 2022 Jun;12(6):e885. doi: 10.1002/ctm2.885.ABSTRACTLeptomeningeal metastases (LM) occur in patients with breast cancer (BC) and lung cancer (LC) showing exceptionally poor prognosis. The cerebrospinal fluid (CSF) tumour microenvironment (TME) of LM patients is not well defined at a single-cell level. Based on the 10× genomics single-cell RNA sequencing (scRNA-seq) data from GEO database including five patient-derived CSF samples of BC-LM and LC-LM, and four patient-derived CSF samples of idiopathic intracranial hypertension (IIH) as controls, we analysed single-cell transcriptome characteristics of CSF TM...
Source: Clinical Breast Cancer - June 9, 2022 Category: Cancer & Oncology Authors: Haoyu Ruan Zhe Wang Ziwei Sun Jia Wei Lei Zhang Huanyu Ju Ting Wang Chao Zhang Ming Guan Shiyang Pan Source Type: research

Single-cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases
Clin Transl Med. 2022 Jun;12(6):e885. doi: 10.1002/ctm2.885.ABSTRACTLeptomeningeal metastases (LM) occur in patients with breast cancer (BC) and lung cancer (LC) showing exceptionally poor prognosis. The cerebrospinal fluid (CSF) tumour microenvironment (TME) of LM patients is not well defined at a single-cell level. Based on the 10× genomics single-cell RNA sequencing (scRNA-seq) data from GEO database including five patient-derived CSF samples of BC-LM and LC-LM, and four patient-derived CSF samples of idiopathic intracranial hypertension (IIH) as controls, we analysed single-cell transcriptome characteristics of CSF TM...
Source: Clinical Lung Cancer - June 9, 2022 Category: Cancer & Oncology Authors: Haoyu Ruan Zhe Wang Ziwei Sun Jia Wei Lei Zhang Huanyu Ju Ting Wang Chao Zhang Ming Guan Shiyang Pan Source Type: research

Single-cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases
Clin Transl Med. 2022 Jun;12(6):e885. doi: 10.1002/ctm2.885.ABSTRACTLeptomeningeal metastases (LM) occur in patients with breast cancer (BC) and lung cancer (LC) showing exceptionally poor prognosis. The cerebrospinal fluid (CSF) tumour microenvironment (TME) of LM patients is not well defined at a single-cell level. Based on the 10× genomics single-cell RNA sequencing (scRNA-seq) data from GEO database including five patient-derived CSF samples of BC-LM and LC-LM, and four patient-derived CSF samples of idiopathic intracranial hypertension (IIH) as controls, we analysed single-cell transcriptome characteristics of CSF TM...
Source: Clinical Breast Cancer - June 9, 2022 Category: Cancer & Oncology Authors: Haoyu Ruan Zhe Wang Ziwei Sun Jia Wei Lei Zhang Huanyu Ju Ting Wang Chao Zhang Ming Guan Shiyang Pan Source Type: research

Single-cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases
Clin Transl Med. 2022 Jun;12(6):e885. doi: 10.1002/ctm2.885.ABSTRACTLeptomeningeal metastases (LM) occur in patients with breast cancer (BC) and lung cancer (LC) showing exceptionally poor prognosis. The cerebrospinal fluid (CSF) tumour microenvironment (TME) of LM patients is not well defined at a single-cell level. Based on the 10× genomics single-cell RNA sequencing (scRNA-seq) data from GEO database including five patient-derived CSF samples of BC-LM and LC-LM, and four patient-derived CSF samples of idiopathic intracranial hypertension (IIH) as controls, we analysed single-cell transcriptome characteristics of CSF TM...
Source: Clinical Genitourinary Cancer - June 9, 2022 Category: Cancer & Oncology Authors: Haoyu Ruan Zhe Wang Ziwei Sun Jia Wei Lei Zhang Huanyu Ju Ting Wang Chao Zhang Ming Guan Shiyang Pan Source Type: research