Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Breast Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Genitourinary Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Breast Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Genitourinary Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
Successful treatment of pediatric patients with high-grade gliomas featuring leptomeningeal metastases by targeting BRAF V600E mutations with dabrafenib plus trametinib: two illustrative cases
This report shows that dabrafenib and trametinib are effective not only for recurrent lesions but also for LMM in pediatric patients. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - April 10, 2024 Category: Cancer & Oncology Source Type: research
TIP24-199: Rhenium (Re-186) Obisbemeda {Re-186-Nanoliposome (186RNL)} in Leptomeningeal Metastases [LM] Phase 1/2A Dose Escalation Trial: Update of Initial Safety and Feasibility Through Cohorts 1-4
J Natl Compr Canc Netw. 2024 Apr 5;22(2.5):TIP24-199. doi: 10.6004/jnccn.2023.7222.NO ABSTRACTPMID:38580269 | DOI:10.6004/jnccn.2023.7222 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 5, 2024 Category: Cancer & Oncology Authors: Norman LaFrance Andrew Brenner Priya Kumthekar Michael Youssef Ande Bao Melissa Moore Joel Michalek Marc Hedrick William Phillips Toral Patel Jeffrey Weinberg John Floyd Source Type: research
Disseminating Necrotizing Leukoencephalopathy Associated With Intra-CSF Methotrexate Chemotherapy: A Retrospective Observational Study
This study aims to determine the incidence, characteristics, risk factors, and outcomes of DNL following intra-CSF MTX chemotherapy for LM.METHODS: We retrospectively reviewed patients with LM who received intra-CSF MTX between 2001 and 2021 at the National Cancer Center of Korea. Patients with a follow-up duration of <3 months and those without follow-up MRI after MTX administration were excluded. The primary outcome was the development of DNL, evaluated based on the clinical and radiologic definitions of DNL. Logistic and Cox proportional regression models were used to assess the risk of DNL in patients with LM receiv...
Source: Cancer Control - February 16, 2024 Category: Cancer & Oncology Authors: Ki Hoon Kim Moowan Park Eun Young Park Ho-Shin Gwak Su-Hyun Kim Ji Won Seo Jae-Won Hyun Ho Jin Kim Yun-Sik Dho Sang-Hoon Shin Heon Yoo Kyu Chang Wang Source Type: research
EGFR amplification indicated poor prognosis in EGFR ‐mutated lung cancer with leptomeningeal metastases
ConclusionEGFR amplification indicated poor prognosis in EGFR-mutated lung cancer with leptomeningeal metastases, providing a novel pathogenesis and treatment direction of these patients. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 2, 2024 Category: Respiratory Medicine Authors: Di Geng,
Ruina Niu,
Jinghong Li,
Sanxing Guo,
Qianqian Guo,
Siyuan Huang,
Yurong Wang Tags: ORIGINAL ARTICLE Source Type: research
Mechanistic Modeling of Intrathecal Chemotherapy Pharmacokinetics in the Human Central Nervous System
CONCLUSIONS: CNS PBPK modeling, in line with available clinical efficacy data, confirms the therapeutic value of intrathecal chemotherapy with antibody or small molecule drugs for treating neoplastic meningitis and warrants further clinical investigation of intrathecal antibody drugs to treat brain parenchyma tumors. Compared to intraventricular injection, intraventricular 24-h infusion may mitigate neurotoxicity while retaining potential efficacy.PMID:38289997 | DOI:10.1158/1078-0432.CCR-23-3062 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - January 30, 2024 Category: Cancer & Oncology Authors: Jing Li Andrew Wu Seongho Kim Source Type: research
Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors
Transl Oncol. 2024 Mar;41:101881. doi: 10.1016/j.tranon.2024.101881. Epub 2024 Jan 12.ABSTRACTFor patients with central nervous system (CNS) malignancies, liquid biopsies of the cerebrospinal fluid (CSF) may offer an unparalleled source of information about the tumor, with much less risk than traditional biopsies. Two techniques have been adapted to CSF in clinical settings: circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). CTCs have been employed mostly as a diagnostic tool for leptomeningeal metastases in epithelial tumors, although they may also have value in the prognostication and monitoring of this di...
Source: Translational Oncology - January 13, 2024 Category: Cancer & Oncology Authors: Maria Diaz Sofia Chudsky Elena Pentsova Alexandra M Miller Source Type: research
Intrathecal Therapy Options for Meningeal Carcinomatosis
Geburtshilfe Frauenheilkd. 2023 Nov 8;84(1):59-67. doi: 10.1055/a-2185-0457. eCollection 2024 Jan.ABSTRACTAround 5 percent of all patients with metastatic breast cancer go on to develop distant metastases in the meninges, also known as meningeal carcinomatosis. The median survival of these patients is between 3.5 and 4.5 months. Current treatment approaches are based on radiotherapy, systemic and intrathecal therapy. Methotrexate, liposomal cytarabine and trastuzumab are the most common substances used for intrathecal therapy. The aim of this review was to provide an overview of these intrathecal therapy options for mening...
Source: Geburtshilfe und Frauenheilkunde - January 11, 2024 Category: OBGYN Authors: Madeleine Marowsky Volkmar M üller Barbara Schmalfeldt Kerstin Riecke Isabell Witzel Elena Laakmann Source Type: research
Diagnostic challenges of neurosarcoidosis in non-endemic areas
ConclusionNS with unusual features, especially in non-endemic areas, continues to yield diagnostic challenges for neurologists, neuroradiologists, and pathologists. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 11, 2024 Category: Neurology Source Type: research
Long-term response to sequential anti-HER2 therapies including trastuzumab-deruxtecan in a patient with HER2-positive metastatic breast cancer with leptomeningeal metastases: a case report and review of the literature
The incidence of leptomeningeal metastases (LM) is increasing among breast cancer patients, but their prognosis remains dismal. Many therapeutic options are now available to treat HER2-positive (HER2+) metastatic breast cancer (MBC) involving the central nervous system (CNS). This case report illustrates a long-lasting response of more than 2 years in a patient with HER2+ MBC with LM after sequential administration of systemic and intrathecal (IT) anti-HER2 therapies and highlights that an appropriate treatment of HER2+ LM can result in durable survival. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 10, 2024 Category: Cancer & Oncology Source Type: research
Cerebrospinal fluid ctDNA testing shows an advantage over plasma ctDNA testing in advanced non-small cell lung cancer patients with brain metastases
ConclusionOur study indicated that the CSF ctDNA detected by NGS may reflect the molecular characteristics and heterogeneity of NSCLC-LM. Timely screening of patients with NSCLC for CSF ctDNA, especially for patients with positive plasma ctDNA, may facilitate the early detection of LM. Furthermore, patients with the EGFR 19del may have a higher risk of developing BPM. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 10, 2024 Category: Cancer & Oncology Source Type: research
