Diffuse cortical hypermetabolism of the cerebellum in meningeal carcinomatosis: Assessment with 18F-FDG-PET/CT and MRI
Publication date: Available online 29 April 2019Source: Diagnostic and Interventional ImagingAuthor(s): A. Crombé, A.-L. Cazeau, S. Cousin, F. Chomy, J. Bacci, M. Kind (Source: Diagnostic and Interventional Imaging)
Source: Diagnostic and Interventional Imaging - May 1, 2019 Category: Radiology Source Type: research

Meningeal carcinomatosis from bladder cancer: A case report and review of the literature.
Abstract A 66-year-old Japanese male patient was referred to Saitama Medical University International Medical Center for treatment of bladder cancer (clinical stage T2 or higher without metastasis), and underwent radical cystectomy with pelvic lymphadenectomy. The histopathological diagnosis was high-grade urothelial carcinoma (pathological stage T2bN2, ly1, v0) and 2 cycles of adjuvant systemic chemotherapy (gemcitabine plus cisplatin) were administered. At 15 months after the operation, mediastinal and lung hilar lymph nodes and multiple bone metastases were identified on computed tomography imaging. Aft...
Source: Clinical Lung Cancer - April 23, 2019 Category: Cancer & Oncology Authors: Umezawa Y, Shirotake S, Kaneko G, Nishimoto K, Okada Y, Uchino A, Yasuda M, Oyama M Tags: Mol Clin Oncol Source Type: research

Meningeal enhancement depicted by magnetic resonance imaging in tumor patients: neoplastic meningitis or therapy-related enhancement?
ConclusionsThe overall prevalence of the presence of false-positive meningeal contrast enhancement is low (<  1%) and not associated with specific imaging patterns. We hypothesize that there is a possible relationship between immunotherapy and ‘pseudomeningeosis’. Therefore, in all cases with suspected neoplastic meningitis, the cerebrospinal fluid should be analyzed to confirm the diagnosis, especia lly in patients undergoing immunotherapy. (Source: Neuroradiology)
Source: Neuroradiology - April 17, 2019 Category: Radiology Source Type: research

Central Nervous System Failure in Korean Breast Cancer Patients with HER2-Enriched Subtype: Korean Radiation Oncology Group 16-15 Multicenter Retrospective Study.
Conclusion: Adjuvant trastuzumab was associated with higher CNS failure rate in Korean patients with HER2-enriched breast cancer. Close monitoring and reasonable approaches such as CNS penetrating HER2 blockades combined with the current standard therapy could contribute to improving intracranial tumor control and quality of life in patients with CNS metastasis from HER2-enriched breast cancer. PMID: 30941239 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

A molecular graded prognostic assessment (molGPA) model specific for estimating survival in lung cancer patients with leptomeningeal metastases
Leptomeningeal metastases (LM) are a severe complication of systemic cancer usually occurring in advanced stages which affect approximately 1 –10% of patients with solid tumors. [1–6] The incidence of LM (3–5%) in advanced NSCLC has increased over the last 10 years, especially in subgroups of patients with targetable mutations [6–8]. Although therapies such as molecular targeted treatments and immunotherapies have been described, standard treatment for LM is yet to be established [6,8–13].The median OS of lung cancer patients with LM is poor though with improvement from a historical 1–3 months to 3–11 months ...
Source: Lung Cancer - March 17, 2019 Category: Cancer & Oncology Authors: Kai Yin, Yang-Si Li, Mei-Mei Zheng, Ben-Yuan Jiang, Wen-Feng Li, Jin-Ji Yang, Hai-Yan Tu, Qing Zhou, Wen-Zhao Zhong, Xue-Ning Yang, Hua-Jun Chen, Hong-Hong Yan, Lin-Lin Li, Yi-Long Wu, Xu-Chao Zhang Source Type: research

The therapeutic value of cerebrospinal fluid ctDNA detection by next-generation sequencing for meningeal carcinomatosis: a case report
It is usually very complicated to treat meningeal carcinomatosis, and it is important to treat it as soon as possible. (Source: BMC Neurology)
Source: BMC Neurology - March 9, 2019 Category: Neurology Authors: Xiaosu Guo, Junzhao Cui, Yue Zhao, Weixin Han, Yueli Zou, Ruiping Gao, Qing Li, Xiaoqing Li, Junying He and Hui Bu Tags: Case report Source Type: research

Next-generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Leptomeningeal Carcinomatosis: Review of 2 Cases
Conclusions: The next-generation EGFR-TKIs may have improved success in treatment of leptomeningeal metastases in non–small cell lung adenocarcinoma when compared with the first-generation and second-generation EGFR-TKIs. Next-generation EGFR-TKI monotherapy should be considered in select patients with leptomeningeal metastases from lung adenocarcinoma. More research is needed to review this potential therapeutic option, especially for use as first-line therapy. (Source: The Neurologist)
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Management of choroid plexus tumors —an institutional experience
ConclusionsWe could confirm that GTR is crucial for treatment of choroid plexus tumors. Parenchymal tumor infiltration as detected intraoperatively was associated with the extent of resection and not limited to CPC. CSF disturbances mandating treatment may persist after resection. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - February 19, 2019 Category: Neurosurgery Source Type: research

Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases
The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different ... (Source: BMC Cancer)
Source: BMC Cancer - February 12, 2019 Category: Cancer & Oncology Authors: Mengxi Ge, Qiong Zhan, Zhenzhen Zhang, Xiaoyu Ji, Xinli Zhou, Ruofan Huang and Xiaohua Liang Tags: Research article Source Type: research

Helical tomotherapy in patients with leptomeningeal metastases
(Source: Cancer Management and Research)
Source: Cancer Management and Research - December 30, 2018 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

Sudden blindness and deafness disclosing meningeal carcinomatosis in non-small cell lung cancer
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - December 6, 2018 Category: Neurology Source Type: research

Seminoma with Neoplastic Meningitis Treated with Craniospinal Irradiation
This article highlights a unique case of pure seminoma with neoplastic meningitis and illustrates the effectiveness of craniospinal irradiation as a treatment modality. (Source: The Oncologist)
Source: The Oncologist - November 12, 2018 Category: Cancer & Oncology Authors: Kaylyn D. Sinicrope, Alexander B. Kaplan, Priscilla K. Brastianos Tags: Neuro-Oncology, Genitourinary Cancer Brief Communications Source Type: research

Clinicopathological and Treatment‐Associated Prognostic Factors in Patients with Breast Cancer Leptomeningeal Metastases in Relation to Tumor Biology
Conclusion.Despite being limited by their retrospective nature, these results highlight the need for clinical trials in BC LMD, stratified on tumor biology.Implications for Practice.Leptomeningeal disease (LMD) is a devastating complication of breast cancer (BC), and its optimal therapy is still not defined. Here, patient characteristics, treatment patterns, and prognostic factors from a contemporary cohort of 153 BC‐related LMD patients are reported. In multivariate analysis, Eastern Cooperative Oncology Group performance status, cerebrospinal fluid glucose levels, and having received systemic treatment were confirmed a...
Source: The Oncologist - November 12, 2018 Category: Cancer & Oncology Authors: Gaia Griguolo, Stephane Pouderoux, Maria Vittoria Dieci, William Jacot, Celine Bourgier, Federica Miglietta, Nelly Firmin, Pierfranco Conte, Marie Viala, Valentina Guarneri, Amelie Darlix Tags: Breast Cancer Source Type: research

Unique genomic profiles obtained from cerebrospinal fluid cell-free DNA of non-small cell lung cancer patients with leptomeningeal metastases.
CONCLUSIONS: Collectively, we demonstrated that CSF provides a more comprehensive profile of LM than plasma in a large cohort, thus can be used as an alternative source of liquid biopsy for LM patients. PMID: 30395779 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - November 5, 2018 Category: Cancer & Oncology Authors: Ying S, Ke H, Ding Y, Liu Y, Tang X, Yang D, Li M, Liu J, Yu B, Xiang J, Mao X, Han-Zhang H, Hu W, Chen L Tags: Cancer Biol Ther Source Type: research

Baseline serum/cerebrospinal fluid ratio of carcinoembryonic antigen and carbohydrate antigen series biomarkers in non-neoplastic diseases: a cross-sectional study on 224 patients.
CONCLUSIONS: Here, serum/CSF ratios of six tumor markers were determined in non-neoplastic diseases. The usefulness of this index for diagnosis, management, and prognostic utility of leptomeningeal metastases must be validated in larger cohort studies over the long term. PMID: 30403967 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 4, 2018 Category: Biochemistry Authors: Zhang Y, Ban R, Shi Q, Tian C Tags: Clin Biochem Source Type: research