Comment on the LACC Trial Investigating Early-stage Cervical Cancer by the Uterus Commission of the Study Group for Gynecologic Oncology (AGO) and the Study Group for Gynecologic Endoscopy (AGE) of the German Society for Gynecology and Obstetrics (DGGG).
Authors: Hillemanns P, Brucker S, Holthaus B, Lampe B, Runnebaum I, Ulrich U, Wallwiener M, Solomayer E, Fehm T, Tempfer C PMID: 30158715 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 1, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Neoadjuvant Therapy of Cervical Carcinoma with the Angiogenesis Inhibitor Bevacizumab: a Single-Centre Analysis.
Discussion Overall, combined therapy with bevacizumab led to a better clinical response. Operability was therefore improved more often. Because of the small patient cohort, larger prospective studies are necessary to validate the effect of neoadjuvant combined therapy with bevacizumab. PMID: 30158716 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 1, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Foetal Morbidity Depending on the Day and Time of Delivery.
Authors: von Ehr J, Wiebking N, Kundu S, von Kaisenberg C, Hillemanns P, Soergel P Abstract Introduction It is known that perinatal mortality is increased with births at night and at the weekend. The aim of the study was to investigate whether there is also an association between the time of delivery (weekday, night, weekend) and perinatal morbidity. Material and Methods All births at Hannover Medical College between 2000 and 2014 were included in a retrospective data analysis. Multiple births, primary sections, severe foetal malformations and intrauterine deaths were not included. A 5-minute Apgar score ≤&thins...
Source: Geburtshilfe und Frauenheilkunde - September 1, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

A Novel Technique for Mapping the Vascularity of Labia Minora Prior to Labiaplasty: Cold Light Illumination.
Discussion This novel technique to assess labial vascularity using a cold light source could be very useful to reduce dehiscence by avoiding excessive resection of highly vascularized tissue. Most units can easily access a cold light source, which can be used to assess labial vascularity prior to labiaplasty. PMID: 30140106 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 26, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Rescue Adjuvant Vaginal Progesterone May Improve Outcomes in Cervical Cerclage Failure.
Conclusion Women with cervical shortening despite the presence of cervical cerclage may benefit from further TVUS cervical length surveillance and the administration of vaginal progesterone if further cervical shortening occurs. Despite both groups having clinically significant shortened cervical lengths and cervical cerclage in situ, adjunct vaginal progesterone treatment resulted in older gestational age at birth and higher birth weight. Further investigation and confirmation of this finding in a larger prospective trial is warranted to explore this potential benefit for the management of preterm birth in future. PMI...
Source: Geburtshilfe und Frauenheilkunde - August 26, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Ramadan Observance during Pregnancy in Germany: a Challenge for Prenatal Care.
Conclusion: To ensure that pregnant Muslim women living in Germany can make their fasting decision based on objective information, it is necessary to raise awareness about Ramadan fasting during pregnancy among medical professionals in Germany. PMID: 30057424 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Endometriosis and Beta-hCG >  775 IU/l Increase the Risk of Non-tube-preserving Surgery for Tubal Pregnancy.
Conclusion: Endometriosis and a beta-hCG value of more than 775 IU/l significantly increased the risk for non-tube-preserving surgery in women with tubal pregnancy. PMID: 30057425 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Perinatal Outcome in Women with a Vietnamese Migration Background - Retrospective Comparative Data Analysis of 3000 Deliveries.
Authors: Boxall N, David M, Schalinski E, Breckenkamp J, Razum O, Hellmeyer L Abstract Introduction: Perinatal data of women with a Vietnamese migration background have not been systematically studied in Germany to date. Numerous details of important maternal and child outcomes were compared and analysed. The study's primary parameters were the frequency of and indication for c-section. Methodology: The perinatal data from a Berlin hospital were analysed retrospectively. The women (Vietnamese migration background vs. autochthonous) were grouped using name analysis. Datasets of 3002 women giving birth, including...
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Using Probability for Pathological Complete Response (pCR) as a Decision Support Marker for Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer Patients - a Survey Among Physicians.
Conclusions: The vast majority of the long-term experienced physicians would embrace the implementation of a further method such as the prediction of pCR probability in clinical routine to support decision making regarding the necessity of neoadjuvant chemotherapy. The cut-off of around 30% pCR probability seems to be a realizable rate to distinguish patient groups. PMID: 30057427 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

"Filling the bladder" at Cesarean Hysterectomy for Placenta Percreta.
"Filling the bladder" at Cesarean Hysterectomy for Placenta Percreta. Geburtshilfe Frauenheilkd. 2018 Jul;78(7):715-716 Authors: Matsubara S PMID: 30057428 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

In reply.
Authors: Özcan HÇ PMID: 30057429 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM (S2k-Level, AWMF Registry No.  015/082, November 2017) - Recommendations and Statements for Girls and Women.
Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM (S2k-Level, AWMF Registry No. 015/082, November 2017) - Recommendations and Statements for Girls and Women. Geburtshilfe Frauenheilkd. 2018 Jun;78(6):567-584 Authors: Dittrich R, Kliesch S, Schüring A, Balcerek M, Baston-Büst DM, Beck R, Beckmann MW, Behringer K, Borgmann-Staudt A, Cremer W, Denzer C, Diemer T, Dorn A, Fehm T, Gaase R, Germeyer A, Geue K, Ghadjar P, Goeckenjan M, Götte M, Guth D, Hauffa BP, Hehr U, Hetzer F, Hirchenhain J, Hoffmann W, Hornemann B, Jantke A, Kentenich H, Kiesel ...
Source: Geburtshilfe und Frauenheilkunde - July 4, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Controversies about the Secondary Prevention of Spontaneous Preterm Birth.
Authors: Kyvernitakis I, Maul H, Bahlmann F Abstract Preterm birth is one of the major global health problems and part of the Millennium Development goals because of the associated high number of perinatal or neonatal mortality and long-term risks of neurodevelopmental and metabolic diseases. Transvaginal sonography has meanwhile been established as a screening tool for spontaneous preterm birth despite its relatively low sensitivity when considering only the cervical length. Vaginal progesterone has been shown to reduce prematurity rates below 34 weeks in a screening population of singleton pregnancies. Up to now,...
Source: Geburtshilfe und Frauenheilkunde - July 4, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Does the Degree of Acculturation Influence Breastfeeding Intention and Start or the Frequency of Early Weaning? Results of a Prospective Observational Study.
Conclusion: The degree of acculturation has relevant significance for some aspects of breastfeeding behaviour in women with a migration background. This should be considered both in breastfeeding promotion programmes and in further national breastfeeding studies. PMID: 29962518 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - July 4, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Opportunistic Salpingectomy at the Time of Benign Laparoscopic Hysterectomy: Assessment of Possible Complications and Histopathological p53-Signatures.
Conclusions: Laparoscopic salpingectomy is both feasible and innocuous during benign hysterectomy. Meticulous histopathologic examination of the tubes may reveal specific abnormalities. PMID: 29962519 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - July 4, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

4th International Consensus Conference on Advanced Breast Cancer (ABC4), Lisbon, November 4, 2017 : ABC4 Consensus: Assessment by a Panel of German Experts.
Authors: Untch M, Würstlein R, Marschner N, Lüftner D, Augustin D, Briest S, Ettl J, Haidinger R, Müller L, Müller V, Ruckhäberle E, Harbeck N, Thomssen C Abstract The fourth international advanced breast cancer consensus conference (ABC4) on the diagnosis and treatment of advanced breast cancer (ABC) headed by Professor Fatima Cardoso was once again held in Lisbon on November 2 - 4, 2017. To simplify matters, the abbreviation ABC will be used hereinafter in the text. In clinical practice, the abbreviation corresponds to metastatic breast cancer or locally far-advanced disease. This yea...
Source: Geburtshilfe und Frauenheilkunde - June 10, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Risk, Prediction and Prevention of Hereditary Breast Cancer - Large-Scale Genomic Studies in Times of Big and Smart Data.
Authors: Wunderle M, Olmes G, Nabieva N, Häberle L, Jud SM, Hein A, Rauh C, Hack CC, Erber R, Ekici AB, Hoyer J, Vasileiou G, Kraus C, Reis A, Hartmann A, Schulz-Wendtland R, Lux MP, Beckmann MW, Fasching PA Abstract Over the last two decades genetic testing for mutations in BRCA1 and BRCA2 has become standard of care for women and men who are at familial risk for breast or ovarian cancer. Currently, genetic testing more often also includes so-called panel genes, which are assumed to be moderate-risk genes for breast cancer. Recently, new large-scale studies provided more information about the risk estimation ...
Source: Geburtshilfe und Frauenheilkunde - June 10, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Galactography with Tomosynthesis Technique (Galactomosynthesis) - Renaissance of a Method?
Conclusion: This is the first time breast tomosynthesis was used in galactography (galactomosynthesis) to create digital 3-dimensional images of suspicious findings. When used together with the generated synthetic digital 2D full-field mammograms, it could be a useful complementary procedure for the diagnosis of breast anomalies and could herald a renaissance of this method. Compared with high-resolution ductal ultrasound, the investigators achieved better results with contrast-enhanced galactography using tomosynthesis and the generated synthetic digital 2D full-field mammograms, as confirmed by histopathological findings...
Source: Geburtshilfe und Frauenheilkunde - June 10, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

SOFIA: A Novel Automated Breast Ultrasound System Used on Patients in the Prone Position: A Pilot Study on Lesion Detection in Comparison to Handheld Grayscale Ultrasound.
Conclusion: No cancer was missed when SOFIA was used in this preselected study population. The scanning time was approximately half of that required for B-mode ultrasound. The additional unnecessary recall rate was 16.67%. Larger D cup-size breasts were difficult to position and resulted in an incomplete image in four cases. PMID: 29880985 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 10, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Mammography Screening 2.0 - How Can Risk-Adapted Screening be Implemented in Clinical Practice?: Results of a Focus Group Discussion with Experts in the RISIKOLOTSE.DE Project.
Discussion with Experts in the RISIKOLOTSE.DE Project. Geburtshilfe Frauenheilkd. 2018 May;78(5):506-511 Authors: Fürst N, Kiechle M, Strahwald B, Quante AS Abstract Introduction: The mammography screening programme has been the subject of criticism for some time. Invitation to take part is currently based only on the risk factors of age and female sex, whereby women with an above-average risk are screened too seldom and women with a low risk are possibly screened too often. In future, an individualised risk assessment could make a risk-adapted procedure possible in breast cancer screening. In the...
Source: Geburtshilfe und Frauenheilkunde - June 10, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/050).
Authors: Toth B, Würfel W, Bohlmann M, Zschocke J, Rudnik-Schöneborn S, Nawroth F, Schleußner E, Rogenhofer N, Wischmann T, von Wolff M, Hancke K, von Otte S, Kuon R, Feil K, Tempfer C Abstract Purpose: Official guideline of the German Society of Gynecology and Obstetrics (DGGG), the Austrian Society of Gynecology and Obstetrics (ÖGGG) and the Swiss Society of Gynecology and Obstetrics (SGGG). The aim of this guideline was to standardize the diagnosis and treatment of couples with recurrent miscarriage (RM). Recommendations were based on the current literature and the views of the involved comm...
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Peripartum Haemorrhage, Diagnosis and Therapy. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry No.  015/063, March 2016).
Peripartum Haemorrhage, Diagnosis and Therapy. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry No. 015/063, March 2016). Geburtshilfe Frauenheilkd. 2018 Apr;78(4):382-399 Authors: Schlembach D, Helmer H, Henrich W, von Heymann C, Kainer F, Korte W, Kühnert M, Lier H, Maul H, Rath W, Steppat S, Surbek D, Wacker J Abstract Purpose: This is an official interdisciplinary guideline, published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SG...
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Influence of Maternal Obesity on Pregnancy Complications and Neonatal Outcomes in Diabetic and Nondiabetic Women.
This study aimed to investigate the influence of obesity on pregnancy complications and neonatal outcomes in diabetic and nondiabetic women. Materials and Methods: This retrospective case control study was conducted on 1193 pregnant women and their neonates at a tertiary level maternity hospital between March 2007 and 2011. The pregnant women were classified into 2 groups according to the presence of diabetes mellitus. Six hundred and seven patients with gestational diabetes or pregestational diabetes formed the diabetic group (study group) and 586 patients were in the nondiabetic group (control group). Demographic cha...
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Comparison of Nerve Fiber Density between Patients with Uterine Leiomyoma with and without Pain: a Prospective Clinical Study.
Authors: Giray B, Esim-Buyukbayrak E, Hallac-Keser S, Karageyim-Karsidag AY, Turkgeldi A Abstract Introduction: We aimed to compare the presence and the amount of nerve fibers in endometrial, myometrial and leiomyoma tissues using protein gene product 9.5 (PGP 9.5) and neurofilament (NF) immunohistochemical staining in uterine leiomyoma patients with and without pain complaint. Methods: Patients undergoing hysterectomy for uterine leiomyoma were prospectively enrolled in the study. Twenty-five uterine leiomyoma patients without pelvic pain complaint (visual analog scale (VAS)
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Wnt Signaling Pathway in Uterus of Normal and Seminal Vesicle Excised Mated Mice during Pre-implantation Window.
Conclusions: Significant changes occurred in the expression of several Wnt signaling members and there was a significant association between Wnt signaling and embryo implantation. Seminal vesicle secretion affects Wnt signaling in mice and consequently also affects murine embryo implantation. PMID: 29720747 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2018 (Part 1) - Primary Breast Cancer and Biomarkers.
Authors: Taran FA, Schneeweiss A, Lux MP, Janni W, Hartkopf AD, Nabieva N, Overkamp F, Kolberg HC, Hadji P, Tesch H, Wöckel A, Ettl J, Lüftner D, Wallwiener M, Müller V, Beckmann MW, Belleville E, Wallwiener D, Brucker SY, Fasching PA, Fehm TN, Schütz F Abstract This summary provides an overview of how new therapies or new aspects of established therapies relate to the latest findings. Neoadjuvant therapy, local therapy, new aspects of systemic therapy, and prognostic and predictive factors are presented. In the neoadjuvant setting, the association between pathological complete response (pCR) an...
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2018 (Part 2) - Advanced Breast Cancer, Quality of Life and Prevention.
Authors: Schneeweiss A, Lux MP, Janni W, Hartkopf AD, Nabieva N, Taran FA, Overkamp F, Kolberg HC, Hadji P, Tesch H, Wöckel A, Ettl J, Lüftner D, Wallwiener M, Müller V, Beckmann MW, Belleville E, Wallwiener D, Brucker SY, Schütz F, Fasching PA, Fehm TN Abstract The treatment of metastatic breast cancer has become more complicated due to increasing numbers of new therapies which need to be tested. Therapies are now being developed to treat special clinical or molecular subgroups. Even though intrinsic molecular subtypes play a major role, more and more new therapies for subgroups and histologica...
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Active Immunisation with Partner Lymphocytes in Female Patients Who Want to Become Pregnant - Current Status.
Authors: Günther V, Alkatout I, Junkers W, Maass N, Ziemann M, Görg S, von Otte S Abstract Around 1 - 3% of all couples who try to have a child are affected by recurrent miscarriage. According to the WHO, recurrent miscarriage is defined as the occurrence of three or more consecutive miscarriages up to the 20th week of pregnancy. There are various causes of recurrent miscarriage; in many cases, the causes remain unclear, with the result that immunological factors are one of the possible causes discussed. For the mother's immune system, the embryo represents a semi-allogeneic transplant, as half of the...
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Maternal Thrombophilia and Recurrent Miscarriage - Is There Evidence That Heparin is Indicated as Prophylaxis against Recurrence?
Conclusion: In contrast to antiphospholipid syndrome, the current data from studies on recurrent spontaneous abortion do not support the prophylactic administration of heparin to treat women with maternal hereditary thrombophilia in subsequent pregnancies. Nevertheless, the maternal risk of thromboembolic events must determine the indication for thrombosis prophylaxis in pregnancy. PMID: 29576632 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

mTor Inhibitors for the Treatment of Endometriosis.
Authors: Barra F, Ferrero S PMID: 29576633 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Pregnancy-associated Death - Clarifying the Cause of Death and Medico-legal Assessments in Accusations of Malpractice.
Conclusion: The death of a pregnant woman should not automatically raise the suspicion of malpractice, although the question does arise in cases of bleeding complications only detected at very late stages. Experts must prove that a real mistake was made during treatment and provide evidence of the causality between malpractice and patient death. Particularly when well-known complications of pregnancy were present, this is only the case if poor monitoring resulted in the complication being detected too late or if treatment was not in accordance with accepted standards of care. The majority of pregnancy-associated deaths are...
Source: Geburtshilfe und Frauenheilkunde - February 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Help-seeking Following Termination of Pregnancy after Diagnosis of Fetal Anomaly: Women's Intentions and Experiences 1 to 7 Years after the Event.
Conclusion: Gynecologists are among the most preferred health professionals for women to discuss psychological problems in the aftermath of an abortion after diagnosis of fetal anomaly. They should be actively involved in screening, diagnostic assessment, and referral of affected women. PMID: 29479112 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - February 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Does an Immigrant Background Affect the Indication, Incidence or Outcome of Emergency Cesarean Section? Results of the Prospective Data Collection of 111 Births.
Authors: David M, Scherer KA, Henrich W, Breckenkamp J Abstract Objectives: Does the incidence and/or indication(s) for emergency cesarean section differ if the pregnant woman has an immigrant background (IB)? Does a lack of language proficiency (communication problems) and a low acculturation level result in a longer decision-to-delivery interval (D-D interval)? Are neonates born to women with IB by emergency cesarean section in a poorer condition post delivery? Patient cohorts and method: Standardized interviews were carried out before or immediately after delivery in three Berlin obstetric hospitals. Questio...
Source: Geburtshilfe und Frauenheilkunde - February 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Use of Bladder Filling to Prevent Urinary System Complications in the Management of Placenta Percreta: a Randomized Prospective Study.
Conclusions: Filling the bladder with saline solution and mobilization of the bladder from the lower uterine segment did not have a statistically significant beneficial effect on preventing complications of the genitourinary system. But although the beneficial effects were not significant, shorter operation times, shorter postoperative hospital stays, and fewer bladder injuries were noted in patients whose bladders were filled. PMID: 29479114 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - February 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Intrauterine Growth Restriction. Guideline of the German Society of Gynecology and Obstetrics (S2k-Level, AWMF Registry No.  015/080, October 2016).
Intrauterine Growth Restriction. Guideline of the German Society of Gynecology and Obstetrics (S2k-Level, AWMF Registry No. 015/080, October 2016). Geburtshilfe Frauenheilkd. 2017 Nov;77(11):1157-1173 Authors: Kehl S, Dötsch J, Hecher K, Schlembach D, Schmitz D, Stepan H, Gembruch U Abstract Aims: The aim of this official guideline published and coordinated by the German Society of Gynecology and Obstetrics (DGGG) was to provide consensus-based recommendations obtained by evaluating the relevant literature for the diagnostic treatment and management of women with fetal growth restriction. ...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Is Breast Surgery Necessary for Breast Carcinoma in Complete Remission Following Neoadjuvant Chemotherapy?
Authors: Richter H, Hennigs A, Schaefgen B, Hahn M, Blohmer JU, Kümmel S, Kühn T, Thill M, Friedrichs K, Sohn C, Golatta M, Heil J Abstract The likelihood of pathological complete remission (pCR) of breast cancer following neoadjuvant chemotherapy (NACT) is increasing; most of all in the triple negative and HER2 positive tumour subgroups. The question thus arises whether or not breast surgery is necessary when there is complete remission after NACT, and whether it provides any improvement of the oncological treatment result when tumour is no longer detectable. Avoiding surgery and possibly even radiothera...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Role of Indocyanine Green in Fluorescence Imaging with Near-Infrared Light to Identify Sentinel Lymph Nodes, Lymphatic Vessels and Pathways Prior to Surgery - A Critical Evaluation of Options.
Authors: Hackethal A, Hirschburger M, Eicker SO, Mücke T, Lindner C, Buchweitz O Abstract Modern surgical strategies aim to reduce trauma by using functional imaging to improve surgical outcomes. This reviews considers and evaluates the importance of the fluorescent dye indocyanine green (ICG) to visualize lymph nodes, lymphatic pathways and vessels and tissue borders in an interdisciplinary setting. The work is based on a selective search of the literature in PubMed, Scopus, and Google Scholar and the authors' own clinical experience. Because of its simple, radiation-free and uncomplicated application, ICG ha...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Letrozole vs. Placebo Pretreatment in the Medical Management of First Trimester Missed Miscarriage: a Randomized Controlled Trial.
Authors: Torky HA, Marie H, ElDesouky E, Gebreel S, Raslan O, Moussa AA, Ahmad AM, Zain E, Mohsen MN Abstract Introduction: Misoprostol is used for the medical management of miscarriage as it is more effective in the early stages of pregnancy. Letrozole has an anti-estrogen effect and is used for the pretreatment of miscarriage with misoprostol. Aim: The aim of this study was compare the efficacy and safety of letrozole with placebo pretreatment in the medical management of first trimester missed miscarriage. Design: This was a prospective randomized case-control study. Patients and Methods: Four hundre...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Comparison of Four Methods of Treating Ectopic Pregnancy: A Retrospective Cohort Study.
Authors: Inal ZO, Inal HA Abstract Objective: To compare the results of expectant management, single and multidose methotrexate (MTX) and surgical management of ectopic pregnancy (EP). Materials and Methods: In this retrospective cohort study, the original files of 233 patients who were treated for EP between May 2009 and December 2016 were analyzed. The patients were assigned to the following groups based on the applied treatment methods: Group 1, expectant management (n = 24), Group 2, single-dose MTX (n = 144), Group 3, multiple-dose MTX (n = 25), and Group 4, surgic...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Smoking Decreases Endometrial Thickness in IVF/ICSI Patients.
Conclusion: We showed that smoking has a negative effect on endometrial thickness on the day of embryo transfer. This may help to further explain the detrimental influence of tobacco smoke on implantation and pregnancy rates during assisted reproduction therapy. PMID: 29375149 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Preconception Optimization of Glucose and Insulin Metabolism in Women Wanting to Conceive - High Rate of Spontaneous Conception Prior to Planned Assisted Reproduction.
Conclusion: The high rate of spontaneous conceptions in the cohort of women wishing to conceive emphasizes the importance of optimizing glucose/insulin metabolism prior to conception. The high rate of GDM in a cohort of pregnant women with a history of sterility also emphasizes the importance of expanding diagnostic testing for sterility to include the investigation of glucose metabolism and testing for insulin resistance. It is possible that PCOS patients in particular could benefit from treatment with metformin prior to conception, and this could explain the high rate of live births in this patient cohort. PMID: 2927...
Source: Geburtshilfe und Frauenheilkunde - December 26, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2017 - Implementation of Novel Therapies.
Authors: Lux MP, Janni W, Hartkopf AD, Nabieva N, Taran FA, Overkamp F, Kolberg HC, Hadji P, Tesch H, Ettl J, Huober JB, Lüftner D, Wallwiener M, Müller V, Beckmann MW, Belleville E, Fehm TN, Wallwiener D, Brucker SY, Schneeweiss A, Fasching PA Abstract In recent years, numerous new therapy options for patients with breast cancer have been developed in clinical studies, with some options already approved for routine treatment. As the speed at which innovations are introduced increases, the importance of conferences also increases, as conferences are where the data underpinning new therapies are usually pr...
Source: Geburtshilfe und Frauenheilkunde - December 24, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer?
Authors: Polasik A, Tzschaschel M, Schochter F, de Gregorio A, Friedl TWP, Rack B, Hartkopf A, Fasching PA, Schneeweiss A, Müller V, Huober J, Janni W, Fehm T Abstract Dissemination of tumour cells and the development of solid metastases occurs via blood vessels and lymphatics. Circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) can be detected in venous blood in patients with early and metastatic breast cancer, and their prognostic relevance has been demonstrated on numerous occasions. Repeated testing for CTCs and ctDNA, or regular so-called "liquid biopsy", can be performed easily a...
Source: Geburtshilfe und Frauenheilkunde - December 24, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

A Systematic Review of Mycoplasma and Ureaplasma in Urogynaecology.
Authors: Combaz-Söhnchen N, Kuhn A Abstract Mycoplasma species relevant to the urogenital tract include mycoplasma hominis, mycoplasma genitalia and ureaplasma urealyticum. Their occurrence in the context of urogynaecological disease has been demonstrated in urethritis, cystitis and upper renal tract infections. Their role in hyperactive bladder and interstitial cystitis/painful bladder syndrome is controversial. All the above-mentioned microorganisms can occur as commensals or as potential pathogens. In most cases their role in any particular pathology cannot be proven, only presumed. The aim of this systemat...
Source: Geburtshilfe und Frauenheilkunde - December 24, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Repetitive Maturation of Oocytes From Non-Stimulated Xenografted Ovarian Tissue From a Prepubertal Patient Indicating the Independence of Human Ovarian Tissue.
Conclusion: Xenotransplanted prepubertal ovarian tissue has the potential for repetitive oocyte retrieval cycles without administering exogenous hormones. The results indicate that the human ovarian tissue might be able to synchronize the hypothalamus-hypophysis-axes of the mouse to the physiological human cycle; this should be investigated in future studies. PMID: 29269958 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 24, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Effect of Premature Rupture of Membranes on Induction of Labor: A Historical Cohort Study.
Authors: Kehl S, Weiss C, Dammer U, Baier F, Faschingbauer F, Beckmann MW, Sütterlin M, Pretscher J Abstract Objective: The aim of this study was to assess the influence of premature rupture of membranes (PROM) on the induction of labor. Material and Method: This historical cohort study analyzed 1861 inductions of labor at term using misoprostol which occurred between 2010 and 2015. Exclusion criteria included intrauterine fetal death, previous cesarean section, and fetal structural or chromosomal anomalies. Induction of labor for PROM (PROM group) was compared to induction for other indications (no-PROM g...
Source: Geburtshilfe und Frauenheilkunde - December 5, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Personal Preference of Mode of Delivery. What do Urogynaecologists choose? Preliminary Results of the DECISION Study.
Conclusions: Urogynaecologists prefer vaginal delivery for themselves. There is a great interest to participate in a risk stratification process in order to approach childbirth in an individualized and risk-adapted manner. PMID: 29200474 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 5, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Pregnancy Outcomes in Maternal Neuropsychiatric Illness and Substance Abuse.
Conclusion: The study shows a relationship between maternal neuropsychiatric illness and pregnancy outcomes independent of medication use. Rates of spontaneous abortion were higher. Children were born earlier, yet the neonatal outcomes birth weight, head circumference and Apgar score were not worse than children of mentally healthy women. PMID: 29200475 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 5, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Outcome of Cesarean Myomectomy: Is it a Safe Procedure?
Authors: Senturk MB, Polat M, Doğan O, Pulatoğlu Ç, Yardımcı OD, Karakuş R, Tayyar AT Abstract Objective: Myomectomy performed during cesarean section is still controversial because of the potential for associated complications, especially with large myomas. Many obstetricians avoid performing cesarean myomectomy procedures because of the risk of uncontrollable hemorrhage. However, the prevalence of pregnant women with myomas is increasing, leading to an increase in the likelihood that physicians will encounter this issue. The aim of this study was to compare outcomes and complications of patients who e...
Source: Geburtshilfe und Frauenheilkunde - December 5, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Assessing the Clinical Benefit of Systemic Adjuvant Therapies for Early Breast Cancer.
Authors: Möbus V, Hell S, Schmidt M Abstract Oncologic therapy is currently undergoing significant changes. A number of innovative targeted medications currently in clinical development have raised high expectations. With that in mind, discussions about terms such as "clinical benefit" and "clinical relevance" are highly topical. This also applies to further developments in the field of adjuvant systemic therapies for early-stage breast cancer. As the treatment aim is curative, assessment of the clinical benefit of adjuvant therapies must be largely based on efficacy outcomes. The focus mus...
Source: Geburtshilfe und Frauenheilkunde - November 4, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research