Academisation of the Midwifery Profession and the Implementation of Higher Education in the Context of the New Requirements for Licensure.
Authors: Graf J, Simoes E, Blaschke S, Plappert CF, Hill J, Riefert MJ, Abele H Abstract The academization of the midwifery profession poses great challenges for Germany, especially due to the tight timelines: Corresponding courses of study can in principle be offered at both universities and technical colleges - although contrary to the recommendations of the Science Council. This means that there is a heterogeneity in midwifery qualifications and promotes a discussion regarding coherent study concepts. This process must be accompanied with great care so that midwifery courses of study are not designed to be of po...
Source: Geburtshilfe und Frauenheilkunde - October 7, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Fetal Growth Restriction - Diagnostic Work-up, Management and Delivery.
Authors: Schlembach D Abstract Fetal or intrauterine growth restriction (FGR/IUGR) affects approximately 5 - 8% of all pregnancies and refers to a fetus not exploiting its genetically determined growth potential. Not only a major cause of perinatal morbidity and mortality, it also predisposes these fetuses to the development of chronic disorders in later life. Apart from the timely diagnosis and identification of the causes of FGR, the obstetric challenge primarily entails continued antenatal management with optimum timing of delivery. In order to minimise premature birth morbidity, intensive fetal monitoring a...
Source: Geburtshilfe und Frauenheilkunde - October 7, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Lung Sonography in Obstetrics during COVID-19.
Authors: Recker F, Weber E, Strizek B, Gembruch U, Seibel A Abstract In the current coronavirus SARS-CoV-2 pandemic, certain patients are becoming seriously ill. Lung pathologies are common, and some patients even go on to develop acute respiratory distress syndrome (ARDS), which requires intubation and artificial respiration of the critically ill patient. Imaging of the lung is absolutely necessary to obtain a diagnosis, assess the course of disease and for treatment. Particularly in gynecology and obstetrics (OBGYN), ultrasound scans of the lung can be a useful additional tool when caring for pregnant patients in...
Source: Geburtshilfe und Frauenheilkunde - October 7, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Delivery of Twin Gestation ( ≥ 32.0 Weeks): The Vaginal Route as a Practicable and Safe Alternative to Cesarean Section.
Conclusion Vaginal delivery in twin pregnancies is a practicable and safe option in specific defined conditions and when the appropriate infrastructure and clinical experience is available. PMID: 33012835 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - October 7, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Current Approach for External Cephalic Version in Germany.
Conclusion The approach used in Germany to carry out external cephalic version is based on the (expired) German guideline on breech presentation. Based on the evidence obtained, a number of individual recommendations should be re-evaluated. More recent international guidelines could be useful to update the standard procedure. PMID: 33012836 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - October 7, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Significance of Preoperative Computed Tomography for Predicting Optimal Cytoreduction in Advanced Ovarian Cancer.
Conclusion Although risk parameters for suboptimal tumour reduction can be identified by CT of the abdomen, surgical exploration with histological confirmation of the diagnosis is essential because of the poor diagnostic accuracy. PMID: 32905205 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 11, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Expansile Endocervical Crypt Involvement by CIN2  - 3 as a Risk Factor for High Grade Cytology Recurrence After Cold Coagulation Cervical Treatment.
Conclusions Expansile ECI is a risk factor that increases the likelihood of high grade cytology recurrence following cold coagulation. Deeper pretreatment cervical punch biopsies need to be taken so as not to miss expansile ECI prior to ablative treatment. PMID: 32905285 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 11, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Prevalence of BRCA1 and BRCA2 Mutations in Patients with Primary Ovarian Cancer - Does the German Checklist for Detecting the Risk of Hereditary Breast and Ovarian Cancer Adequately Depict the Need for Consultation?
Conclusions The BRCA1/2 mutation prevalence in EOC patients positively correlates with a rising checklist score. Already with singular EOC, the prevalence of a BRCA1/2 mutation exceeds the required 10% threshold. Our data support the recommendation of the S3 guidelines Ovarian Cancer of offering genetic testing to all patients with EOC. Optimisation of the checklist with clear identification of the testing indication in this population should therefore be aimed for. PMID: 32905297 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 11, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Trastuzumab Biosimilars in the Therapy of Breast Cancer - "Real World" Experiences from four Bavarian University Breast Centres.
Trastuzumab Biosimilars in the Therapy of Breast Cancer - "Real World" Experiences from four Bavarian University Breast Centres. Geburtshilfe Frauenheilkd. 2020 Sep;80(9):924-931 Authors: Hester A, Gaß P, Fasching PA, Krämer AK, Ettl J, Diessner J, Wöckel A, Egger T, Stock K, Redlin J, Andraschko M, Harbeck N, Würstlein R Abstract Introduction With the introduction of the first trastuzumab biosimilar in the summer of 2018, biosimilar antibodies for breast cancer have found their way into the area of gynaecological oncology. The switch of anti-human epidermal growth factor...
Source: Geburtshilfe und Frauenheilkunde - September 11, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Statement of the AGO and AG-CPC on the Aftercare/Follow-up for Surgical Procedures of the Lower Genital Tract after the Introduction of a New Cancer Screening Guideline.
Authors: Hillemanns P, Tempfer C, Beckmann MW, Küppers V, Quaas J Abstract The new guideline on organized cancer screening programs has been in force in Germany since January 1st, 2020. The guideline has amended earlier recommendations on cytological examinations, which were previously carried out annually during screening. The guidelines-based recommendations on the appropriate follow-up for preinvasive and invasive lesions of the uterine cervix and endometrium are briefly outlined and differentiated from screening cytology and Pap/HPV co-testing as described in the guideline on organized cancer screening pro...
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

COVID-19 During Pregnancy and Puerperium - A Review by the Austrian Society of Gynaecology and Obstetrics (OEGGG).
Authors: Klaritsch P, Ciresa-König A, Pristauz-Telsnigg G, board of the OEGGG Abstract After the first case of COVID-19 pneumonia was reported in Wuhan, Hubei Province, China, in December 2019, the infection quickly spread to the rest of China and then to the wider world. The available information on pregnant women infected with COVID-19 is now significantly greater. There are now several case series and systematic reviews of cohorts, some of which include more than 100 cases. This review evaluates the scientific literature available until May 1, 2020 and discusses common questions about COVID-19 in the conte...
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Pregnancy Outcomes Following Letrozole Use in Frozen-thawed Embryo Transfer Cycles: A Systematic Review and Meta-analysis.
Authors: Chen D, Shen X, Fu Y, Ding C, Zhong Y, Zhou C Abstract While widely used for ovulation induction in assisted reproductive technology, the clinical efficacy of letrozole for endometrial preparation prior to frozen-thawed embryo transfer (FET) cycles remains yet to be elucidated. We performed a meta-analysis to compare pregnancy outcomes after letrozole use with those of other endometrial preparation protocols in patients undergoing FET. PubMed, Scopus, Embase and the Cochrane Library were searched for eligible studies. Clinical pregnancy rate (CPR), live birth rate (LBR) and birth defect rate (BDR) were ana...
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Sociodemographic Differences in Health Awareness and Oral Health in Pregnant Women.
Conclusion The rate of awareness of the risks and consequences of pregnancy for oral health must be increased. The main aim for primary prophylaxis should be a reduction in the periodontal bacteria and caries of the mother and father. PMID: 32817990 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Impact of Transferring a Poor Quality Embryo Along with a Good Quality Embryo on Pregnancy Outcomes in IVF/ICSI Cycles: a Retrospective Study.
Conclusion DET with mixed quality embryos results with lower clinical pregnancy and live birth rates compared with DET with two good quality embryos at the blastocyst stage. At cleavage stage transfer, there is no difference in live birth rates between the two groups. PMID: 32817991 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Tacrolimus Improves the Implantation Rate in Patients with Elevated Th1/2 Helper Cell Ratio and Repeated Implantation Failure (RIF).
Conclusions Our findings suggest that RIF patients with a higher Th1/Th2 ratio could be candidates for tacrolimus therapy and that this immunosuppressive drug could be acting through upregulation of LIF, IL-10, and IL-17. PMID: 32817992 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Correction: Hydroxychloroquine as a Preventive and Therapeutic Option in Preeclampsia - a Literature Review.
Authors: Deharde D, Klockenbusch W, Schmitz R, Brand M, Köster HA, Oelmeier de Murcia K PMID: 32792706 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Hydroxychloroquine as a Preventive and Therapeutic Option in Preeclampsia - a Literature Review.
Authors: Deharde D, Klockenbusch W, Schmitz R, Brand M, Köster HA, de KO Abstract Preeclampsia is one of the most feared complications of pregnancy and puerperium and represents a serious threat to mother and child. In addition, a history of preeclampsia increases the risk of future cardiovascular events. New diagnostic and therapeutic approaches are needed. New therapeutic options are currently being discussed, one of which is the administration of hydroxychloroquine. It is an antimalarial drug which is also used to treat rheumatological disease and its use in pregnancy is considered safe. A reduced incidence...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Rare Ectopic Pregnancies - A Literature Review for the Period 2007  - 2019 on Locations Outside the Uterus and Fallopian Tubes.
We present an overview of potential very rare locations of ectopic pregnancies, their symptoms, diagnosis and treatment, based on a systematic analysis of case reports. A literature review of the databases PubMed, Livivo and Google Scholar for the period 2007 to 2019 was carried out. A total of 113 publications were included in our review. These studies describe EP implantations in the posterior cul-de-sac, on the uterine serosa and uterine ligaments, in the vicinity of almost all intraperitoneal organs, on the abdominal wall as well as in retroperitoneal sites. The most common presenting symptom was abdominal pain occurri...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Continuous Body Temperature Monitoring to Improve the Diagnosis of Female Infertility.
Conclusions Continuous body temperature monitoring with a vaginal biosensor can improve the standard diagnostic procedures used to determine ovulatory dysfunction, especially if dysfunction is due to luteal phase deficiency and polycystic ovary syndrome. Analysis of the lowest daily body temperature combined with the basal body temperature measurements used in fertility awareness methods may be equieffective to continuous body temperature measurements with OvulaRing. The results of this study show that a revised diagnostic approach using fewer hormonal assessments combined with continuous body temperature monitoring can re...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients.
Authors: Rehnitz J, Rösner S, Harsch J, Dietrich J, Bruckner T, Capp E, Strowitzki T, Germeyer A Abstract Introduction Azoospermia affects about 1% of men, of whom up to 15% inquire about infertility treatment. Information about predictive factors for these couples is very limited. Patients, Materials and Methods We performed a retrospective analysis of the clinical records of 118 cycles of intracytoplasmic sperm injection treatment after testicular sperm extraction for male azoospermia carried out between January 2008 and October 2015. Of those, 66 were first, 35 second, and 17 third cycles. Statistical signi...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Factors Influencing Postoperative Recovery and Time Off Work of Patients with Benign Indications for Surgery - Results of a Prospective Study.
Authors: Strozyk S, Wernecke KD, Sehouli J, David M Abstract Objectives The study aimed to answer a number of questions: Which medical, psychological and sociodemographic factors affect the recovery of women after gynecological surgery for benign indications? Does patients' health-related quality of life improve after surgical intervention? How long are patients signed off work postoperatively? How do patients assess their own capacity to work? Method Study population: All women between the ages of 18 and 67 years who underwent gynecological surgery for benign indications at the Charité Campus Virchow Clinic...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

ABC5 International Consensus Conference on Advanced Breast Cancer, Lisbon, 16 November 2019: Commentary by the German panel of experts on the ABC5 voting results.
We present a commentary on the voting results of the ABC5 panelists in Lisbon by a working group of German breast cancer specialists together with the implications for routine clinical care in Germany. The commentary is based on the recommendations of the Breast Commission of the German Gynecological Oncology Working Group (AGO). This commentary is useful, it includes country-specific features for the ABC consensus. PMID: 32565549 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Association between Obesity and Premenopausal Breast Cancer According to Intrinsic Subtypes - a Systematic Review.
Conclusion Higher BMI might influence aggressive tumor characteristics among premenopausal women and has divergent impacts on the risk of different breast cancer subtypes. Further research is needed to confirm these results and to evaluate potential pathophysiologic mechanisms for the relationship between obesity and aggressive premenopausal breast cancer subtypes. PMID: 32565550 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Long-term Incidence and Mortality Trends for Breast Cancer in Germany.
Conclusion The analysis suggests that the introduction of mammography screening contributed to a decrease in the incidence of advanced-stage breast cancers and in breast cancer-related mortality rates but also resulted in a substantial number of overdiagnoses. The relatively unfavourable incidence trend in the group of younger women, particularly in East Germany, should be interpreted in the context of lifestyle changes. The slight increase in mortality observed in the group of older women after 2008 requires further analysis. PMID: 32565551 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Distribution of the 21-Gene Breast Recurrence Score in Patients with Primary Breast Cancer in Germany.
Conclusions The distribution of the 21-gene RS in German patients that were tested in routine clinical practice indicates that, according to the results of the TAILORx trial, chemotherapy may not be beneficial in most of these. PMID: 32565552 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate - Retrospective Single-centre 10-Year Experience.
Conclusion DIEP flap surgery is an excellent option for autologous breast reconstruction, with a low rate of donor site morbidity and low complication rates. DIEP flap surgery carried out in a specialised interdisciplinary breast centre in a standardised clinical setting after prior careful patient selection to take account of risk factors such as high BMI and smoking is a reliable method with a low complication rate and satisfactory long-term reconstruction results. PMID: 32565553 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

SARS-CoV-2/COVID-19: Evidence-Based Recommendations on Diagnosis and Therapy.
Authors: Bein B, Bachmann M, Huggett S, Wegermann P Abstract COVID-19, a new viral disease affecting primarily the respiratory system and the lung, has caused a pandemic posing serious challenges to healthcare systems around the world. In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. Mortality is about 1 - 2%. Protecting healthcare workers is of paramount importance in order to prevent hospital-acquired infections. Therefore, during all procedures associated with aerosol production, personal protective equipment consist...
Source: Geburtshilfe und Frauenheilkunde - May 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

HELLP Syndrome or Acute Fatty Liver of Pregnancy: A Differential Diagnostic Challenge: Common Features and Differences.
Authors: Rath W, Tsikouras P, Stelzl P Abstract HELLP syndrome and the less common acute fatty liver of pregnancy (AFL) are unpredictable, life-threatening complications of pregnancy. The similarities in their clinical and laboratory presentations are often challenging for the obstetrician when making a differential diagnosis. Both diseases are characterised by microvesicular steatosis of varying degrees of severity. A specific risk profile does not exist for either of the entities. Genetic defects in mitochondrial fatty acid oxidation and multiple pregnancy are considered to be common predisposing factors. The dia...
Source: Geburtshilfe und Frauenheilkunde - May 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Changes in Maternal Body Mass Index, Weight Gain and Outcome of Singleton Pregnancies from 2000 to 2015: A Population-based Retrospective Cohort Study in Hesse/Germany.
Authors: Noever K, Schubert J, Reuschel E, Timmesfeld N, Arabin B Abstract Introduction Maternal obesity and excessive gestational weight gain (GWG) affect the outcomes of women and their offspring. Our aim was to evaluate population-based data from Germany. Material and Methods Data from 583 633/791 514 mother-child pairs obtained from the perinatal database in Hesse for the period from 2000 to 2015 were used after excluding incomplete or non-plausible datasets. Early-stage pregnancy maternal body mass index (BMI) and GWG were evaluated. Significant outcome changes were calculated using linear or logistic regr...
Source: Geburtshilfe und Frauenheilkunde - May 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

CT Scan in the Prediction of Lymph Node Involvement in Ovarian Cancer - a Retrospective Analysis of a Tertiary Gyneco-Oncological Unit.
Conclusion The preoperative prediction of lymph node status by computer tomography is limited. A decision for or against lymphadenectomy should not be made solely on the basis of this approach. PMID: 32435068 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - May 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Re-augmentation of the Axilla Using a Turn-Over Flap - a New Approach for the Surgical Treatment of Secondary Lymphedema After Breast Cancer.
Conclusion Complete removal of the axillary scar tissue after breast cancer treatment and re-augmentation of the axilla with a turnover flap results in a reduction in ipsilateral lymphedema and an improvement in pain and quality of life. We interpret these findings as a result of the physiological re-alignment of the lymphatic vessels combined with a lymph node-containing local transposition flap. Therefore, re-augmentation with a turnover flap could be an effective non-microsurgical alternative to lymph node transplantation. PMID: 32435069 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - May 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

SARS-CoV-2 Infection in Pregnancy - a Review of the Current Literature and Possible Impact on Maternal and Neonatal Outcome.
Authors: Stumpfe FM, Titzmann A, Schneider MO, Stelzl P, Kehl S, Fasching PA, Beckmann MW, Ensser A Abstract In December 2019, cases of pneumonia of unknown cause first started to appear in Wuhan in China; subsequently, a new coronavirus was soon identified as the cause of the illness, now known as Coronavirus Disease 2019 (COVID-19). Since then, infections have been confirmed worldwide in numerous countries, with the number of cases steadily rising. The aim of the present review is to provide an overview of the new severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) and, in particular, to deduce fr...
Source: Geburtshilfe und Frauenheilkunde - April 24, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2020 Part 2 - Advanced Breast Cancer: New Treatments and Implementation of Therapies with Companion Diagnostics.
Authors: Lüftner D, Schneeweiss A, Hartkopf AD, Müller V, Wöckel A, Janni W, Ettl J, Belleville E, Schütz F, Thill M, Huober J, Fasching PA, Kolberg HC, Pöschke P, Welslau M, Overkamp F, Tesch H, Fehm TN, Lux MP Abstract For patients with locally advanced or metastatic breast cancer, new and effective therapies such as CDK4/6 inhibitors, PARP inhibitors and a PD-L1 inhibitor have been introduced in recent years. This review presents an update on the available studies with their data. In addition, two innovative anti-HER2 therapies are presented (trastuzumab-deruxtecan and tucatinib) for whi...
Source: Geburtshilfe und Frauenheilkunde - April 24, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Use of Taxanes in Metastatic HER2-negative Breast Cancer - a Status Report.
Authors: Gluz O, Kolberg-Liedtke C, Marmé F, Thill M Abstract The most important goal of treatment of patients with metastatic breast cancer is maintenance or even improvement of quality of life. In this setting, chemotherapy should be used with as much restraint as possible. If palliative chemotherapy is indicated, the taxane drug class is an established treatment option. The updated guidelines of the Gynaecological Oncology Working Group (AGO), Breast Committee, of the German Society for Gynaecology and Obstetrics (DGGG) and the German Cancer Society e. V. (DKG) provide recommendations with the greatest ...
Source: Geburtshilfe und Frauenheilkunde - April 24, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for the Classification of Germline Sequence Variants in Risk Genes for Hereditary Breast and Ovarian Cancer.
Authors: Wappenschmidt B, Hauke J, Faust U, Niederacher D, Wiesmüller L, Schmidt G, Groß E, Gehrig A, Sutter C, Ramser J, Rump A, Arnold N, Meindl A Abstract More than ten years ago, the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) set up a panel of experts (VUS Task Force) which was tasked with reviewing the classifications of genetic variants reported by individual centres of the GC-HBOC to the central database in Leipzig and reclassifying them, where necessary, based on the most recent data. When it evaluates variants, the VUS Task Force must arrive at a consensus. The resultin...
Source: Geburtshilfe und Frauenheilkunde - April 24, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2020 Part 1 - Early Breast Cancer: Consolidation of Knowledge About Known Therapies.
Authors: Schneeweiss A, Hartkopf AD, Müller V, Wöckel A, Lux MP, Janni W, Ettl J, Belleville E, Huober J, Thill M, Fasching PA, Kolberg HC, Pöschke P, Welslau M, Overkamp F, Tesch H, Fehm TN, Lüftner D, Schütz F Abstract This review is intended to present the latest developments in the prevention and treatment of early breast cancer. The risk of breast cancer can be increasingly better characterised with large epidemiological studies on genetic and non-genetic risk factors. Through new analyses, the evidence for high-penetrance genes as well as for low-penetrance genes was able to be improv...
Source: Geburtshilfe und Frauenheilkunde - March 8, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Risk Factors for Impaired Patient-Reported Satisfaction and Increased Length of Hospital Stay Following Hysterectomy on Benign Indications in Premenopausal Women: a Study From the Swedish National Register for Gynecological Surgery.
Conclusions Complications were strongly associated with lower patient satisfaction. Preoperative expectations of surgery, indication, mode of surgery and life-style factors had impact on the satisfaction. Patient-centered information to ensure realistic expectations and prevention of complications seem to be essential to gain optimal patient satisfaction with surgery. PMID: 32139918 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 8, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Clinical Efficacy and Safety of Major Uterine Wall Resection and Reconstruction of the Uterus Combined with LNG-IUS for the Treatment of Severe Adenomyosis.
Conclusion MURU combined with LNG-IUS is an efficacious and safe treatment for severe adenomyosis. This combined technique is not only effective to manage severe adenomyosis but also preserves as much of the uterus as possible. PMID: 32139919 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 8, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Cycle-related Diarrhea and Dysmenorrhea are Independent Predictors of Peritoneal Endometriosis, Cycle-related Dyschezia is an Independent Predictor of Rectal Involvement.
Conclusion Cycle-related diarrhea and dysmenorrhea increase the risk probability of peritoneal endometriosis. Dyschezia increases the risk probability of rectal endometriosis. PMID: 32139920 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 8, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Comparison of Clinical Symptoms of Assumed vs. Actual Uterine Fibroids - Symptoms Described by Patients and Ultrasound Findings.
Conclusions The presence of manifest symptoms (dysmenorrhea, dyspareunia, premenstrual pain, bleeding disorders) does not allow conclusions to be made about the number or size of fibroids or about which therapy is indicated. Even an erroneous assumption about the presence of fibroids may result in patients experiencing symptoms. PMID: 32139921 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 8, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Exploration of the Relationship Between Gut Microbiota and Polycystic Ovary Syndrome (PCOS): a Review.
This article reviews possible mechanisms and treatment options for PCOS, based on methods which target the GM, and offers new ideas for the treatment of PCOS. PMID: 32109968 [PubMed - as supplied by publisher] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 1, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

An Economic Analysis of Aneuploidy Screening of Oocytes in Assisted Reproduction in Germany.
Conclusion The use of PGT-A with aCGH in assisted reproduction cannot be recommended from a cost-effectiveness perspective. PMID: 32109969 [PubMed - as supplied by publisher] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 1, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

QS ENDO Real - A Study by the German Endometriosis Research Foundation (SEF) on the Reality of Care for Patients with Endometriosis in Germany, Austria and Switzerland.
Authors: Zeppernick F, Zeppernick M, Janschek E, Wölfler M, Bornemann S, Holtmann L, Oehmke F, Brandes I, Scheible CM, Salehin D, Pethick SV, Boosz AS, Krämer B, Sillem M, Bühler K, Keckstein J, Schweppe KW, Meinhold-Heerlein I, QS Endo Working Group of the Endometriosis Research Foundation (SEF) Abstract Endometriosis affects a significant number of young premenopausal women. Quite apart from the medical challenges, endometriosis is a relevant burden for healthcare and social security systems. Standardized quality indicators for the treatment of endometriosis have not previously been systematically...
Source: Geburtshilfe und Frauenheilkunde - March 1, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Predictors for the Early Termination of a Psychological Intervention During Treatment with Assisted Reproductive Technologies.
Conclusions The statistically significant effects found in this study with regard to the stress indicators in connection with drop-outs from psychosocial intervention studies indicate that it is advisable to continue to seek measures for people undergoing stressful medical treatments in order to motivate and support them and thus optimally utilise the opportunities of a medical treatment. The number of patients who endure their ART treatment may also increase as a result, which could lead in turn to increased patient satisfaction over the long term (and thus possibly to higher pregnancy rates). PMID: 32109971 [PubMed -...
Source: Geburtshilfe und Frauenheilkunde - March 1, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Association between Emotional State Changes in Infertile Couples and Outcome of Fertility Treatment.
Conclusion Our study suggests the importance of couples' emotional dynamics for having a child and an association between couples' emotional reactions during IVF cycles and treatment success. PMID: 32109972 [PubMed - as supplied by publisher] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 1, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Prophylaxis and Therapy of Venous Thrombotic Events (VTE) in Pregnancy and the Postpartum Period.
Authors: Sucker C Abstract Venous thromboembolisms and pulmonary embolisms are one of the main causes of morbidity and mortality in pregnancy. The increased risk of thrombotic events caused by the physiological changes during pregnancy alone does not justify any medical antithrombotic prophylaxis. However, if there are also other risk factors such as a history of thromboses, hormonal stimulation as part of fertility treatment, thrombophilia, increased age of the pregnant woman, severe obesity or predisposing concomitant illnesses, the risk of thrombosis should be re-evaluated - if possible by a coagulation speciali...
Source: Geburtshilfe und Frauenheilkunde - January 18, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Zika Virus and Pregnancy: Association between Acute Infection and Microcephaly in Newborns in the State of Rio de Janeiro, Brazil.
Authors: Pereira AM, Araujo Júnior E, Werner H, Monteiro DLM Abstract Introduction Aim of the study was to evaluate the association between microcephaly and acute infection with Zika virus (ZIKV) in pregnant women in the state of Rio de Janeiro, Brazil. Infection was confirmed by laboratory testing. Materials and Methods A cross-sectional retrospective study of pregnant women with symptoms occurring between 2015 and 2016 suggestive of acute ZIKV infection was carried out, with confirmation of infection done by blood or urine RT-PCR. The relative proportions of categorical variables were calculated for two di...
Source: Geburtshilfe und Frauenheilkunde - January 18, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

STudy on E-Cigarettes and Pregnancy (STEP) - Study Protocol of a Mixed Methods Study on Risk Perception of E-Cigarette Use During Pregnancy and Sample Description.
Conclusion Data collection was successful for both the qualitative and quantitative parts of the study. When interpreting the results of STEP, different limitations should be taken into account. The results of STEP provide starting points for the development of tailored preventive measures for pregnant women. PMID: 31949321 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - January 18, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

5 Years' Experience of a Tertiary Center with Thrombocytopenic Pregnancies: Gestational Thrombocytopenia, Idiopathic Thrombocytopenic Purpura and Hypertensive Disorders of Pregnancy.
Authors: Fadiloglu E, Unal C, Tanacan A, Portakal O, Beksac MS Abstract Aim To evaluate thrombocytopenic pregnancies including gestational thrombocytopenia (GT), idiopathic thrombocytopenic purpura (ITP), and hypertensive disorders of pregnancy (HDP). Materials and Methods We evaluated the pregnancy outcomes and laboratory findings of 385 patients diagnosed with GT, ITP, or HDP whose thrombocyte levels were
Source: Geburtshilfe und Frauenheilkunde - January 18, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Change in Attitudes Towards Abortion in Former West and East Germany After Reunification: A Latent Class Analysis and Implications for Abortion Access.
Conclusion Negative attitudes towards abortion have increased in Western and Eastern Germany during the two decades following reunification and may harm women by limiting acceptability and accessibility of abortion care. Abortion policies, public discourse and provision of abortion care should be informed by international guidelines protecting women's health and rights. PMID: 31949323 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - January 18, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research