Role of Routine Peritoneal Biopsies During Risk Reducing Salpingo-Oophorectomy (RRSO)
Conclusions The routine use of peritoneal biopsies during RRSO does not improve detection of occult ovarian cancer or STIC but prolongs the operation time significantly. By omitting peritoneal biopsies in RRSO not only perioperative risks are diminished but also costs could be reduced by shortening of surgery time as well as decreased number of pathological samples.PMID:34531609 | PMC:PMC8437580 | DOI:10.1055/a-1395-7715 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 17, 2021 Category: OBGYN Authors: Therese Pross Maria Margarete Karsten Jens-Uwe Blohmer Dorothee Speiser Source Type: research

Sexual Disorders in Women with Overactive Bladder and Urinary Stress Incontinence Compared to Controls: A Prospective Study
Conclusions There is a high prevalence of SD in women with urinary incontinence. Patients with OAB reported a greater negative impact on sexual function and had significantly lower scores for the FSFI questionnaire than patients with stress incontinence or controls.PMID:34531610 | PMC:PMC8437582 | DOI:10.1055/a-1499-8392 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 17, 2021 Category: OBGYN Authors: Gert Naumann Thomas Hitschold Dominique Frohnmeyer Peter Majinge Rainer Lange Source Type: research

Influence of Pregnancy-Related Conditions on Human Epididymis Protein 4 Serum Levels in Comparison to CA  125 - a Prospective Cohort Trial
Geburtshilfe Frauenheilkd. 2021 Sep;81(9):1047-1054. doi: 10.1055/a-1475-4296. Epub 2021 Sep 13.ABSTRACTIntroduction HE4 and CA 125, two established biomarkers for assessing adnexal masses in non-pregnant women, are hardly investigated in pregnancy, especially in pregnancy-associated conditions. The aim was to evaluate HE4 and CA 125 levels in the course of pregnancy and to assess the impact of pregnancy disorders, contractions and rupture of membranes on HE4 and CA 125 serum levels in order to use these parameters for evaluation of adnexal masses in pregnancy. Patients and Methods Blood samples (n = 238) of 201 women seen...
Source: Geburtshilfe und Frauenheilkunde - September 17, 2021 Category: OBGYN Authors: Samira Abdel Azim Irene Mutz-Dehbalaie Verena Wieser Astrid Berger Bettina B öttcher Heidi Fiegl Christian Marth Andreas Widschwendter Source Type: research

Prediction of Spontaneous Preterm Birth in At-risk Women Using Thrombospondin 1 from Cervicovaginal Fluid: A Prospective Observational Study
This study aimed to validate the predictive capability of these biomarkers in patients at risk of preterm birth. Materials and Methods We included 109 women with symptoms of threatened spontaneous preterm birth between weeks 20 0/7 and 31 6/7 of gestation. Inclusion criteria were uterine contractions, cervical length of less than 25 mm, or a personal history of spontaneous preterm birth. Multiple gestations were also included. Samples of cervicovaginal fluid were taken before performing a digital examination and transvaginal ultrasound. Levels of cervicovaginal thrombospondin 1, desmoplakin and stratifin were quantified by...
Source: Geburtshilfe und Frauenheilkunde - September 17, 2021 Category: OBGYN Authors: Johannes Stubert Kathleen Gr ündler Bernd Gerber Dagmar-Ulrike Richter Max Dieterich Source Type: research

Induction of Labour. Guideline of the DGGG, OEGGG and SGGG (S2k, AWMF Registry No.  015-088, December 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):870-895. doi: 10.1055/a-1519-7713. Epub 2021 Aug 9.ABSTRACTAim The aim of this official guideline published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG) in cooperation with the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG) is to provide a consensus-based overview of the indications, methods and general management of induction of labour by evaluating the relevant literature. Methods This S2k guideline was developed using a structured consensus process which included representative membe...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Irene H ösli Ulrich Pecks Philipp Reif Ralf L Schild Markus Schmidt Dagmar Schmitz Christiane Schwarz Daniel Surbek Michael Abou-Dakn Source Type: research

Caesarean Section. Guideline of the DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No.  015/084, June 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):896-921. doi: 10.1055/a-1529-6141. Epub 2021 Aug 9.ABSTRACTPurpose This is an official S3-guideline of the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (ÖGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG). The guideline contains evidence-based information and recommendations on indications, complications, methods and care associated with delivery by caesarean section for all medical specialties involved as well as for pregnant women. Methods This guideline has adapted information and recommendations issued...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Frank Louwen Uwe Wagner Michael Abou-Dakn J örg Dötsch Burkhard Lawrenz David Ehm Daniel Surbek Andreas Essig Monika Greening Rainhild Sch äfers Elke Mattern Ina C Waterstradt Ralph K ästner Wolf L ütje Peter Kranke Leila Messroghli Manuel Wenk Sven Source Type: research

Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):922-939. doi: 10.1055/a-1386-3912. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on the bile acid level. ICP is associated with increased risks for adverse perinatal outcomes, including preterm delivery, meconium-stained amniotic fluid, and stillbirth. Acute fetal asphyxia and ...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Carsten Hagenbeck Amr Hamza Sven Kehl Holger Maul Frank Lammert Verena Keitel Matthias C H ütten Ulrich Pecks Source Type: research

Intrahepatic Cholestasis of Pregnancy
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):940-947. doi: 10.1055/a-1522-5178. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intr...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Stanis ław M Jurk Andreas E Kremer Ekkehard Schleussner Source Type: research

Prediction of Adverse Pregnancy Outcome Related to Placental Dysfunction Using the sFlt-1/PlGF Ratio: A Narrative Review
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):948-954. doi: 10.1055/a-1403-2576. Epub 2021 Aug 9.ABSTRACTThe sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio is a helpful tool for the prediction and diagnosis of preeclampsia (PE). Current data even show that the ratio has the potential to predict adverse pregnancy outcomes (APO) caused by placental pathologies. The aim of this article is to give a brief overview of recent findings on APO predictions based on the sFlt-1/PlGF ratio. The focus is on obstetric pathologies related to placental dysfunction (PD) such as PE and/or fetal growth restricti...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Oliver Graupner Christian Enzensberger Source Type: research

Labour Induction with Misoprostol in German Obstetric Clinics: What Are the Facts on Such Use?
Conclusion Misoprostol is an established agent for labour induction in German clinics. The dosing schemes used vary. Improvements of currently common management practices are required, especially in the area of labour induction (CTG checks before and after administration of labour-inducing medication, no administration of prostaglandin if contractions are ongoing). The discussion of use of misoprostol in the media resulted in stoppage of its use mainly in smaller clinics.PMID:34393259 | PMC:PMC8354357 | DOI:10.1055/a-1538-2200 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Christel Weiss Werner Rath Michael Schneider Florian Stumpfe Florian Faschingbauer Matthias W Beckmann Patrick Stelzl Source Type: research

Cardiovascular Risk Reduction in Women Following Hypertensive Disorders of Pregnancy - a Prospective, Randomised, Controlled Interventional Study
Conclusion The study documents the feasibility of lifestyle intervention with physical exercise after delivery (starting 6 weeks postpartum). The intervention showed a significant clinical effect by reducing arterial stiffness to the level of the reference group. Before this intervention can be included in the standard of care and prevention, follow-up studies must confirm these results and the medium-term effects on cardiovascular risk.PMID:34393260 | PMC:PMC8354345 | DOI:10.1055/a-1345-8733 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Marcus Riemer Stephan Schulze Lisa Wagner Manon Richter Gertrud Ayerle Andreas Simm Sven Seeger Ren é Schwesig Michael Tchirikov Gregor Seliger Source Type: research

Induction of Labour. Guideline of the DGGG, OEGGG and SGGG (S2k, AWMF Registry No.  015-088, December 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):870-895. doi: 10.1055/a-1519-7713. Epub 2021 Aug 9.ABSTRACTAim The aim of this official guideline published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG) in cooperation with the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG) is to provide a consensus-based overview of the indications, methods and general management of induction of labour by evaluating the relevant literature. Methods This S2k guideline was developed using a structured consensus process which included representative membe...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Irene H ösli Ulrich Pecks Philipp Reif Ralf L Schild Markus Schmidt Dagmar Schmitz Christiane Schwarz Daniel Surbek Michael Abou-Dakn Source Type: research

Caesarean Section. Guideline of the DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No.  015/084, June 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):896-921. doi: 10.1055/a-1529-6141. Epub 2021 Aug 9.ABSTRACTPurpose This is an official S3-guideline of the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (ÖGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG). The guideline contains evidence-based information and recommendations on indications, complications, methods and care associated with delivery by caesarean section for all medical specialties involved as well as for pregnant women. Methods This guideline has adapted information and recommendations issued...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Frank Louwen Uwe Wagner Michael Abou-Dakn J örg Dötsch Burkhard Lawrenz David Ehm Daniel Surbek Andreas Essig Monika Greening Rainhild Sch äfers Elke Mattern Ina C Waterstradt Ralph K ästner Wolf L ütje Peter Kranke Leila Messroghli Manuel Wenk Sven Source Type: research

Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):922-939. doi: 10.1055/a-1386-3912. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on the bile acid level. ICP is associated with increased risks for adverse perinatal outcomes, including preterm delivery, meconium-stained amniotic fluid, and stillbirth. Acute fetal asphyxia and ...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Carsten Hagenbeck Amr Hamza Sven Kehl Holger Maul Frank Lammert Verena Keitel Matthias C H ütten Ulrich Pecks Source Type: research

Intrahepatic Cholestasis of Pregnancy
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):940-947. doi: 10.1055/a-1522-5178. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intr...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Stanis ław M Jurk Andreas E Kremer Ekkehard Schleussner Source Type: research

Prediction of Adverse Pregnancy Outcome Related to Placental Dysfunction Using the sFlt-1/PlGF Ratio: A Narrative Review
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):948-954. doi: 10.1055/a-1403-2576. Epub 2021 Aug 9.ABSTRACTThe sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio is a helpful tool for the prediction and diagnosis of preeclampsia (PE). Current data even show that the ratio has the potential to predict adverse pregnancy outcomes (APO) caused by placental pathologies. The aim of this article is to give a brief overview of recent findings on APO predictions based on the sFlt-1/PlGF ratio. The focus is on obstetric pathologies related to placental dysfunction (PD) such as PE and/or fetal growth restricti...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Oliver Graupner Christian Enzensberger Source Type: research

Labour Induction with Misoprostol in German Obstetric Clinics: What Are the Facts on Such Use?
Conclusion Misoprostol is an established agent for labour induction in German clinics. The dosing schemes used vary. Improvements of currently common management practices are required, especially in the area of labour induction (CTG checks before and after administration of labour-inducing medication, no administration of prostaglandin if contractions are ongoing). The discussion of use of misoprostol in the media resulted in stoppage of its use mainly in smaller clinics.PMID:34393259 | PMC:PMC8354357 | DOI:10.1055/a-1538-2200 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Christel Weiss Werner Rath Michael Schneider Florian Stumpfe Florian Faschingbauer Matthias W Beckmann Patrick Stelzl Source Type: research

Cardiovascular Risk Reduction in Women Following Hypertensive Disorders of Pregnancy - a Prospective, Randomised, Controlled Interventional Study
Conclusion The study documents the feasibility of lifestyle intervention with physical exercise after delivery (starting 6 weeks postpartum). The intervention showed a significant clinical effect by reducing arterial stiffness to the level of the reference group. Before this intervention can be included in the standard of care and prevention, follow-up studies must confirm these results and the medium-term effects on cardiovascular risk.PMID:34393260 | PMC:PMC8354345 | DOI:10.1055/a-1345-8733 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Marcus Riemer Stephan Schulze Lisa Wagner Manon Richter Gertrud Ayerle Andreas Simm Sven Seeger Ren é Schwesig Michael Tchirikov Gregor Seliger Source Type: research

Induction of Labour. Guideline of the DGGG, OEGGG and SGGG (S2k, AWMF Registry No.  015-088, December 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):870-895. doi: 10.1055/a-1519-7713. Epub 2021 Aug 9.ABSTRACTAim The aim of this official guideline published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG) in cooperation with the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG) is to provide a consensus-based overview of the indications, methods and general management of induction of labour by evaluating the relevant literature. Methods This S2k guideline was developed using a structured consensus process which included representative membe...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Irene H ösli Ulrich Pecks Philipp Reif Ralf L Schild Markus Schmidt Dagmar Schmitz Christiane Schwarz Daniel Surbek Michael Abou-Dakn Source Type: research

Caesarean Section. Guideline of the DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No.  015/084, June 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):896-921. doi: 10.1055/a-1529-6141. Epub 2021 Aug 9.ABSTRACTPurpose This is an official S3-guideline of the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (ÖGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG). The guideline contains evidence-based information and recommendations on indications, complications, methods and care associated with delivery by caesarean section for all medical specialties involved as well as for pregnant women. Methods This guideline has adapted information and recommendations issued...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Frank Louwen Uwe Wagner Michael Abou-Dakn J örg Dötsch Burkhard Lawrenz David Ehm Daniel Surbek Andreas Essig Monika Greening Rainhild Sch äfers Elke Mattern Ina C Waterstradt Ralph K ästner Wolf L ütje Peter Kranke Leila Messroghli Manuel Wenk Sven Source Type: research

Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):922-939. doi: 10.1055/a-1386-3912. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on the bile acid level. ICP is associated with increased risks for adverse perinatal outcomes, including preterm delivery, meconium-stained amniotic fluid, and stillbirth. Acute fetal asphyxia and ...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Carsten Hagenbeck Amr Hamza Sven Kehl Holger Maul Frank Lammert Verena Keitel Matthias C H ütten Ulrich Pecks Source Type: research

Intrahepatic Cholestasis of Pregnancy
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):940-947. doi: 10.1055/a-1522-5178. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intr...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Stanis ław M Jurk Andreas E Kremer Ekkehard Schleussner Source Type: research

Prediction of Adverse Pregnancy Outcome Related to Placental Dysfunction Using the sFlt-1/PlGF Ratio: A Narrative Review
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):948-954. doi: 10.1055/a-1403-2576. Epub 2021 Aug 9.ABSTRACTThe sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio is a helpful tool for the prediction and diagnosis of preeclampsia (PE). Current data even show that the ratio has the potential to predict adverse pregnancy outcomes (APO) caused by placental pathologies. The aim of this article is to give a brief overview of recent findings on APO predictions based on the sFlt-1/PlGF ratio. The focus is on obstetric pathologies related to placental dysfunction (PD) such as PE and/or fetal growth restricti...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Oliver Graupner Christian Enzensberger Source Type: research

Labour Induction with Misoprostol in German Obstetric Clinics: What Are the Facts on Such Use?
Conclusion Misoprostol is an established agent for labour induction in German clinics. The dosing schemes used vary. Improvements of currently common management practices are required, especially in the area of labour induction (CTG checks before and after administration of labour-inducing medication, no administration of prostaglandin if contractions are ongoing). The discussion of use of misoprostol in the media resulted in stoppage of its use mainly in smaller clinics.PMID:34393259 | PMC:PMC8354357 | DOI:10.1055/a-1538-2200 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Christel Weiss Werner Rath Michael Schneider Florian Stumpfe Florian Faschingbauer Matthias W Beckmann Patrick Stelzl Source Type: research

Cardiovascular Risk Reduction in Women Following Hypertensive Disorders of Pregnancy - a Prospective, Randomised, Controlled Interventional Study
Conclusion The study documents the feasibility of lifestyle intervention with physical exercise after delivery (starting 6 weeks postpartum). The intervention showed a significant clinical effect by reducing arterial stiffness to the level of the reference group. Before this intervention can be included in the standard of care and prevention, follow-up studies must confirm these results and the medium-term effects on cardiovascular risk.PMID:34393260 | PMC:PMC8354345 | DOI:10.1055/a-1345-8733 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Marcus Riemer Stephan Schulze Lisa Wagner Manon Richter Gertrud Ayerle Andreas Simm Sven Seeger Ren é Schwesig Michael Tchirikov Gregor Seliger Source Type: research

Induction of Labour. Guideline of the DGGG, OEGGG and SGGG (S2k, AWMF Registry No.  015-088, December 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):870-895. doi: 10.1055/a-1519-7713. Epub 2021 Aug 9.ABSTRACTAim The aim of this official guideline published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG) in cooperation with the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG) is to provide a consensus-based overview of the indications, methods and general management of induction of labour by evaluating the relevant literature. Methods This S2k guideline was developed using a structured consensus process which included representative membe...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Irene H ösli Ulrich Pecks Philipp Reif Ralf L Schild Markus Schmidt Dagmar Schmitz Christiane Schwarz Daniel Surbek Michael Abou-Dakn Source Type: research

Caesarean Section. Guideline of the DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No.  015/084, June 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):896-921. doi: 10.1055/a-1529-6141. Epub 2021 Aug 9.ABSTRACTPurpose This is an official S3-guideline of the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (ÖGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG). The guideline contains evidence-based information and recommendations on indications, complications, methods and care associated with delivery by caesarean section for all medical specialties involved as well as for pregnant women. Methods This guideline has adapted information and recommendations issued...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Frank Louwen Uwe Wagner Michael Abou-Dakn J örg Dötsch Burkhard Lawrenz David Ehm Daniel Surbek Andreas Essig Monika Greening Rainhild Sch äfers Elke Mattern Ina C Waterstradt Ralph K ästner Wolf L ütje Peter Kranke Leila Messroghli Manuel Wenk Sven Source Type: research

Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):922-939. doi: 10.1055/a-1386-3912. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on the bile acid level. ICP is associated with increased risks for adverse perinatal outcomes, including preterm delivery, meconium-stained amniotic fluid, and stillbirth. Acute fetal asphyxia and ...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Carsten Hagenbeck Amr Hamza Sven Kehl Holger Maul Frank Lammert Verena Keitel Matthias C H ütten Ulrich Pecks Source Type: research

Intrahepatic Cholestasis of Pregnancy
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):940-947. doi: 10.1055/a-1522-5178. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intr...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Stanis ław M Jurk Andreas E Kremer Ekkehard Schleussner Source Type: research

Prediction of Adverse Pregnancy Outcome Related to Placental Dysfunction Using the sFlt-1/PlGF Ratio: A Narrative Review
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):948-954. doi: 10.1055/a-1403-2576. Epub 2021 Aug 9.ABSTRACTThe sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio is a helpful tool for the prediction and diagnosis of preeclampsia (PE). Current data even show that the ratio has the potential to predict adverse pregnancy outcomes (APO) caused by placental pathologies. The aim of this article is to give a brief overview of recent findings on APO predictions based on the sFlt-1/PlGF ratio. The focus is on obstetric pathologies related to placental dysfunction (PD) such as PE and/or fetal growth restricti...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Oliver Graupner Christian Enzensberger Source Type: research

Labour Induction with Misoprostol in German Obstetric Clinics: What Are the Facts on Such Use?
Conclusion Misoprostol is an established agent for labour induction in German clinics. The dosing schemes used vary. Improvements of currently common management practices are required, especially in the area of labour induction (CTG checks before and after administration of labour-inducing medication, no administration of prostaglandin if contractions are ongoing). The discussion of use of misoprostol in the media resulted in stoppage of its use mainly in smaller clinics.PMID:34393259 | PMC:PMC8354357 | DOI:10.1055/a-1538-2200 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Christel Weiss Werner Rath Michael Schneider Florian Stumpfe Florian Faschingbauer Matthias W Beckmann Patrick Stelzl Source Type: research

Cardiovascular Risk Reduction in Women Following Hypertensive Disorders of Pregnancy - a Prospective, Randomised, Controlled Interventional Study
Conclusion The study documents the feasibility of lifestyle intervention with physical exercise after delivery (starting 6 weeks postpartum). The intervention showed a significant clinical effect by reducing arterial stiffness to the level of the reference group. Before this intervention can be included in the standard of care and prevention, follow-up studies must confirm these results and the medium-term effects on cardiovascular risk.PMID:34393260 | PMC:PMC8354345 | DOI:10.1055/a-1345-8733 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Marcus Riemer Stephan Schulze Lisa Wagner Manon Richter Gertrud Ayerle Andreas Simm Sven Seeger Ren é Schwesig Michael Tchirikov Gregor Seliger Source Type: research

Induction of Labour. Guideline of the DGGG, OEGGG and SGGG (S2k, AWMF Registry No.  015-088, December 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):870-895. doi: 10.1055/a-1519-7713. Epub 2021 Aug 9.ABSTRACTAim The aim of this official guideline published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG) in cooperation with the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG) is to provide a consensus-based overview of the indications, methods and general management of induction of labour by evaluating the relevant literature. Methods This S2k guideline was developed using a structured consensus process which included representative membe...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Irene H ösli Ulrich Pecks Philipp Reif Ralf L Schild Markus Schmidt Dagmar Schmitz Christiane Schwarz Daniel Surbek Michael Abou-Dakn Source Type: research

Caesarean Section. Guideline of the DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No.  015/084, June 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):896-921. doi: 10.1055/a-1529-6141. Epub 2021 Aug 9.ABSTRACTPurpose This is an official S3-guideline of the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (ÖGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG). The guideline contains evidence-based information and recommendations on indications, complications, methods and care associated with delivery by caesarean section for all medical specialties involved as well as for pregnant women. Methods This guideline has adapted information and recommendations issued...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Frank Louwen Uwe Wagner Michael Abou-Dakn J örg Dötsch Burkhard Lawrenz David Ehm Daniel Surbek Andreas Essig Monika Greening Rainhild Sch äfers Elke Mattern Ina C Waterstradt Ralph K ästner Wolf L ütje Peter Kranke Leila Messroghli Manuel Wenk Sven Source Type: research

Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):922-939. doi: 10.1055/a-1386-3912. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on the bile acid level. ICP is associated with increased risks for adverse perinatal outcomes, including preterm delivery, meconium-stained amniotic fluid, and stillbirth. Acute fetal asphyxia and ...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Carsten Hagenbeck Amr Hamza Sven Kehl Holger Maul Frank Lammert Verena Keitel Matthias C H ütten Ulrich Pecks Source Type: research

Intrahepatic Cholestasis of Pregnancy
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):940-947. doi: 10.1055/a-1522-5178. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intr...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Stanis ław M Jurk Andreas E Kremer Ekkehard Schleussner Source Type: research

Prediction of Adverse Pregnancy Outcome Related to Placental Dysfunction Using the sFlt-1/PlGF Ratio: A Narrative Review
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):948-954. doi: 10.1055/a-1403-2576. Epub 2021 Aug 9.ABSTRACTThe sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio is a helpful tool for the prediction and diagnosis of preeclampsia (PE). Current data even show that the ratio has the potential to predict adverse pregnancy outcomes (APO) caused by placental pathologies. The aim of this article is to give a brief overview of recent findings on APO predictions based on the sFlt-1/PlGF ratio. The focus is on obstetric pathologies related to placental dysfunction (PD) such as PE and/or fetal growth restricti...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Oliver Graupner Christian Enzensberger Source Type: research

Labour Induction with Misoprostol in German Obstetric Clinics: What Are the Facts on Such Use?
Conclusion Misoprostol is an established agent for labour induction in German clinics. The dosing schemes used vary. Improvements of currently common management practices are required, especially in the area of labour induction (CTG checks before and after administration of labour-inducing medication, no administration of prostaglandin if contractions are ongoing). The discussion of use of misoprostol in the media resulted in stoppage of its use mainly in smaller clinics.PMID:34393259 | PMC:PMC8354357 | DOI:10.1055/a-1538-2200 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Christel Weiss Werner Rath Michael Schneider Florian Stumpfe Florian Faschingbauer Matthias W Beckmann Patrick Stelzl Source Type: research

Cardiovascular Risk Reduction in Women Following Hypertensive Disorders of Pregnancy - a Prospective, Randomised, Controlled Interventional Study
Conclusion The study documents the feasibility of lifestyle intervention with physical exercise after delivery (starting 6 weeks postpartum). The intervention showed a significant clinical effect by reducing arterial stiffness to the level of the reference group. Before this intervention can be included in the standard of care and prevention, follow-up studies must confirm these results and the medium-term effects on cardiovascular risk.PMID:34393260 | PMC:PMC8354345 | DOI:10.1055/a-1345-8733 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Marcus Riemer Stephan Schulze Lisa Wagner Manon Richter Gertrud Ayerle Andreas Simm Sven Seeger Ren é Schwesig Michael Tchirikov Gregor Seliger Source Type: research

Induction of Labour. Guideline of the DGGG, OEGGG and SGGG (S2k, AWMF Registry No.  015-088, December 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):870-895. doi: 10.1055/a-1519-7713. Epub 2021 Aug 9.ABSTRACTAim The aim of this official guideline published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG) in cooperation with the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG) is to provide a consensus-based overview of the indications, methods and general management of induction of labour by evaluating the relevant literature. Methods This S2k guideline was developed using a structured consensus process which included representative membe...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Irene H ösli Ulrich Pecks Philipp Reif Ralf L Schild Markus Schmidt Dagmar Schmitz Christiane Schwarz Daniel Surbek Michael Abou-Dakn Source Type: research

Caesarean Section. Guideline of the DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No.  015/084, June 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):896-921. doi: 10.1055/a-1529-6141. Epub 2021 Aug 9.ABSTRACTPurpose This is an official S3-guideline of the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (ÖGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG). The guideline contains evidence-based information and recommendations on indications, complications, methods and care associated with delivery by caesarean section for all medical specialties involved as well as for pregnant women. Methods This guideline has adapted information and recommendations issued...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Frank Louwen Uwe Wagner Michael Abou-Dakn J örg Dötsch Burkhard Lawrenz David Ehm Daniel Surbek Andreas Essig Monika Greening Rainhild Sch äfers Elke Mattern Ina C Waterstradt Ralph K ästner Wolf L ütje Peter Kranke Leila Messroghli Manuel Wenk Sven Source Type: research

Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):922-939. doi: 10.1055/a-1386-3912. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on the bile acid level. ICP is associated with increased risks for adverse perinatal outcomes, including preterm delivery, meconium-stained amniotic fluid, and stillbirth. Acute fetal asphyxia and ...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Carsten Hagenbeck Amr Hamza Sven Kehl Holger Maul Frank Lammert Verena Keitel Matthias C H ütten Ulrich Pecks Source Type: research

Intrahepatic Cholestasis of Pregnancy
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):940-947. doi: 10.1055/a-1522-5178. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intr...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Stanis ław M Jurk Andreas E Kremer Ekkehard Schleussner Source Type: research

Prediction of Adverse Pregnancy Outcome Related to Placental Dysfunction Using the sFlt-1/PlGF Ratio: A Narrative Review
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):948-954. doi: 10.1055/a-1403-2576. Epub 2021 Aug 9.ABSTRACTThe sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio is a helpful tool for the prediction and diagnosis of preeclampsia (PE). Current data even show that the ratio has the potential to predict adverse pregnancy outcomes (APO) caused by placental pathologies. The aim of this article is to give a brief overview of recent findings on APO predictions based on the sFlt-1/PlGF ratio. The focus is on obstetric pathologies related to placental dysfunction (PD) such as PE and/or fetal growth restricti...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Oliver Graupner Christian Enzensberger Source Type: research

Labour Induction with Misoprostol in German Obstetric Clinics: What Are the Facts on Such Use?
Conclusion Misoprostol is an established agent for labour induction in German clinics. The dosing schemes used vary. Improvements of currently common management practices are required, especially in the area of labour induction (CTG checks before and after administration of labour-inducing medication, no administration of prostaglandin if contractions are ongoing). The discussion of use of misoprostol in the media resulted in stoppage of its use mainly in smaller clinics.PMID:34393259 | PMC:PMC8354357 | DOI:10.1055/a-1538-2200 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Christel Weiss Werner Rath Michael Schneider Florian Stumpfe Florian Faschingbauer Matthias W Beckmann Patrick Stelzl Source Type: research

Cardiovascular Risk Reduction in Women Following Hypertensive Disorders of Pregnancy - a Prospective, Randomised, Controlled Interventional Study
Conclusion The study documents the feasibility of lifestyle intervention with physical exercise after delivery (starting 6 weeks postpartum). The intervention showed a significant clinical effect by reducing arterial stiffness to the level of the reference group. Before this intervention can be included in the standard of care and prevention, follow-up studies must confirm these results and the medium-term effects on cardiovascular risk.PMID:34393260 | PMC:PMC8354345 | DOI:10.1055/a-1345-8733 (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Marcus Riemer Stephan Schulze Lisa Wagner Manon Richter Gertrud Ayerle Andreas Simm Sven Seeger Ren é Schwesig Michael Tchirikov Gregor Seliger Source Type: research

Induction of Labour. Guideline of the DGGG, OEGGG and SGGG (S2k, AWMF Registry No.  015-088, December 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):870-895. doi: 10.1055/a-1519-7713. Epub 2021 Aug 9.ABSTRACTAim The aim of this official guideline published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG) in cooperation with the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG) is to provide a consensus-based overview of the indications, methods and general management of induction of labour by evaluating the relevant literature. Methods This S2k guideline was developed using a structured consensus process which included representative membe...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Sven Kehl Irene H ösli Ulrich Pecks Philipp Reif Ralf L Schild Markus Schmidt Dagmar Schmitz Christiane Schwarz Daniel Surbek Michael Abou-Dakn Source Type: research

Caesarean Section. Guideline of the DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No.  015/084, June 2020)
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):896-921. doi: 10.1055/a-1529-6141. Epub 2021 Aug 9.ABSTRACTPurpose This is an official S3-guideline of the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (ÖGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG). The guideline contains evidence-based information and recommendations on indications, complications, methods and care associated with delivery by caesarean section for all medical specialties involved as well as for pregnant women. Methods This guideline has adapted information and recommendations issued...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Frank Louwen Uwe Wagner Michael Abou-Dakn J örg Dötsch Burkhard Lawrenz David Ehm Daniel Surbek Andreas Essig Monika Greening Rainhild Sch äfers Elke Mattern Ina C Waterstradt Ralph K ästner Wolf L ütje Peter Kranke Leila Messroghli Manuel Wenk Sven Source Type: research

Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):922-939. doi: 10.1055/a-1386-3912. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on the bile acid level. ICP is associated with increased risks for adverse perinatal outcomes, including preterm delivery, meconium-stained amniotic fluid, and stillbirth. Acute fetal asphyxia and ...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Carsten Hagenbeck Amr Hamza Sven Kehl Holger Maul Frank Lammert Verena Keitel Matthias C H ütten Ulrich Pecks Source Type: research

Intrahepatic Cholestasis of Pregnancy
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):940-947. doi: 10.1055/a-1522-5178. Epub 2021 Aug 9.ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intr...
Source: Geburtshilfe und Frauenheilkunde - August 16, 2021 Category: OBGYN Authors: Stanis ław M Jurk Andreas E Kremer Ekkehard Schleussner Source Type: research