Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/050).
Authors: Toth B, Würfel W, Bohlmann M, Zschocke J, Rudnik-Schöneborn S, Nawroth F, Schleußner E, Rogenhofer N, Wischmann T, von Wolff M, Hancke K, von Otte S, Kuon R, Feil K, Tempfer C Abstract Purpose: Official guideline of the German Society of Gynecology and Obstetrics (DGGG), the Austrian Society of Gynecology and Obstetrics (ÖGGG) and the Swiss Society of Gynecology and Obstetrics (SGGG). The aim of this guideline was to standardize the diagnosis and treatment of couples with recurrent miscarriage (RM). Recommendations were based on the current literature and the views of the involved comm...
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Peripartum Haemorrhage, Diagnosis and Therapy. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry No.  015/063, March 2016).
Peripartum Haemorrhage, Diagnosis and Therapy. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry No. 015/063, March 2016). Geburtshilfe Frauenheilkd. 2018 Apr;78(4):382-399 Authors: Schlembach D, Helmer H, Henrich W, von Heymann C, Kainer F, Korte W, Kühnert M, Lier H, Maul H, Rath W, Steppat S, Surbek D, Wacker J Abstract Purpose: This is an official interdisciplinary guideline, published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SG...
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Influence of Maternal Obesity on Pregnancy Complications and Neonatal Outcomes in Diabetic and Nondiabetic Women.
This study aimed to investigate the influence of obesity on pregnancy complications and neonatal outcomes in diabetic and nondiabetic women. Materials and Methods: This retrospective case control study was conducted on 1193 pregnant women and their neonates at a tertiary level maternity hospital between March 2007 and 2011. The pregnant women were classified into 2 groups according to the presence of diabetes mellitus. Six hundred and seven patients with gestational diabetes or pregestational diabetes formed the diabetic group (study group) and 586 patients were in the nondiabetic group (control group). Demographic cha...
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Comparison of Nerve Fiber Density between Patients with Uterine Leiomyoma with and without Pain: a Prospective Clinical Study.
Authors: Giray B, Esim-Buyukbayrak E, Hallac-Keser S, Karageyim-Karsidag AY, Turkgeldi A Abstract Introduction: We aimed to compare the presence and the amount of nerve fibers in endometrial, myometrial and leiomyoma tissues using protein gene product 9.5 (PGP 9.5) and neurofilament (NF) immunohistochemical staining in uterine leiomyoma patients with and without pain complaint. Methods: Patients undergoing hysterectomy for uterine leiomyoma were prospectively enrolled in the study. Twenty-five uterine leiomyoma patients without pelvic pain complaint (visual analog scale (VAS)
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Wnt Signaling Pathway in Uterus of Normal and Seminal Vesicle Excised Mated Mice during Pre-implantation Window.
Conclusions: Significant changes occurred in the expression of several Wnt signaling members and there was a significant association between Wnt signaling and embryo implantation. Seminal vesicle secretion affects Wnt signaling in mice and consequently also affects murine embryo implantation. PMID: 29720747 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - May 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2018 (Part 1) - Primary Breast Cancer and Biomarkers.
Authors: Taran FA, Schneeweiss A, Lux MP, Janni W, Hartkopf AD, Nabieva N, Overkamp F, Kolberg HC, Hadji P, Tesch H, Wöckel A, Ettl J, Lüftner D, Wallwiener M, Müller V, Beckmann MW, Belleville E, Wallwiener D, Brucker SY, Fasching PA, Fehm TN, Schütz F Abstract This summary provides an overview of how new therapies or new aspects of established therapies relate to the latest findings. Neoadjuvant therapy, local therapy, new aspects of systemic therapy, and prognostic and predictive factors are presented. In the neoadjuvant setting, the association between pathological complete response (pCR) an...
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2018 (Part 2) - Advanced Breast Cancer, Quality of Life and Prevention.
Authors: Schneeweiss A, Lux MP, Janni W, Hartkopf AD, Nabieva N, Taran FA, Overkamp F, Kolberg HC, Hadji P, Tesch H, Wöckel A, Ettl J, Lüftner D, Wallwiener M, Müller V, Beckmann MW, Belleville E, Wallwiener D, Brucker SY, Schütz F, Fasching PA, Fehm TN Abstract The treatment of metastatic breast cancer has become more complicated due to increasing numbers of new therapies which need to be tested. Therapies are now being developed to treat special clinical or molecular subgroups. Even though intrinsic molecular subtypes play a major role, more and more new therapies for subgroups and histologica...
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Active Immunisation with Partner Lymphocytes in Female Patients Who Want to Become Pregnant - Current Status.
Authors: Günther V, Alkatout I, Junkers W, Maass N, Ziemann M, Görg S, von Otte S Abstract Around 1 - 3% of all couples who try to have a child are affected by recurrent miscarriage. According to the WHO, recurrent miscarriage is defined as the occurrence of three or more consecutive miscarriages up to the 20th week of pregnancy. There are various causes of recurrent miscarriage; in many cases, the causes remain unclear, with the result that immunological factors are one of the possible causes discussed. For the mother's immune system, the embryo represents a semi-allogeneic transplant, as half of the...
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Maternal Thrombophilia and Recurrent Miscarriage - Is There Evidence That Heparin is Indicated as Prophylaxis against Recurrence?
Conclusion: In contrast to antiphospholipid syndrome, the current data from studies on recurrent spontaneous abortion do not support the prophylactic administration of heparin to treat women with maternal hereditary thrombophilia in subsequent pregnancies. Nevertheless, the maternal risk of thromboembolic events must determine the indication for thrombosis prophylaxis in pregnancy. PMID: 29576632 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

mTor Inhibitors for the Treatment of Endometriosis.
Authors: Barra F, Ferrero S PMID: 29576633 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Pregnancy-associated Death - Clarifying the Cause of Death and Medico-legal Assessments in Accusations of Malpractice.
Conclusion: The death of a pregnant woman should not automatically raise the suspicion of malpractice, although the question does arise in cases of bleeding complications only detected at very late stages. Experts must prove that a real mistake was made during treatment and provide evidence of the causality between malpractice and patient death. Particularly when well-known complications of pregnancy were present, this is only the case if poor monitoring resulted in the complication being detected too late or if treatment was not in accordance with accepted standards of care. The majority of pregnancy-associated deaths are...
Source: Geburtshilfe und Frauenheilkunde - February 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Help-seeking Following Termination of Pregnancy after Diagnosis of Fetal Anomaly: Women's Intentions and Experiences 1 to 7 Years after the Event.
Conclusion: Gynecologists are among the most preferred health professionals for women to discuss psychological problems in the aftermath of an abortion after diagnosis of fetal anomaly. They should be actively involved in screening, diagnostic assessment, and referral of affected women. PMID: 29479112 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - February 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Does an Immigrant Background Affect the Indication, Incidence or Outcome of Emergency Cesarean Section? Results of the Prospective Data Collection of 111 Births.
Authors: David M, Scherer KA, Henrich W, Breckenkamp J Abstract Objectives: Does the incidence and/or indication(s) for emergency cesarean section differ if the pregnant woman has an immigrant background (IB)? Does a lack of language proficiency (communication problems) and a low acculturation level result in a longer decision-to-delivery interval (D-D interval)? Are neonates born to women with IB by emergency cesarean section in a poorer condition post delivery? Patient cohorts and method: Standardized interviews were carried out before or immediately after delivery in three Berlin obstetric hospitals. Questio...
Source: Geburtshilfe und Frauenheilkunde - February 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Use of Bladder Filling to Prevent Urinary System Complications in the Management of Placenta Percreta: a Randomized Prospective Study.
Conclusions: Filling the bladder with saline solution and mobilization of the bladder from the lower uterine segment did not have a statistically significant beneficial effect on preventing complications of the genitourinary system. But although the beneficial effects were not significant, shorter operation times, shorter postoperative hospital stays, and fewer bladder injuries were noted in patients whose bladders were filled. PMID: 29479114 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - February 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Intrauterine Growth Restriction. Guideline of the German Society of Gynecology and Obstetrics (S2k-Level, AWMF Registry No.  015/080, October 2016).
Intrauterine Growth Restriction. Guideline of the German Society of Gynecology and Obstetrics (S2k-Level, AWMF Registry No. 015/080, October 2016). Geburtshilfe Frauenheilkd. 2017 Nov;77(11):1157-1173 Authors: Kehl S, Dötsch J, Hecher K, Schlembach D, Schmitz D, Stepan H, Gembruch U Abstract Aims: The aim of this official guideline published and coordinated by the German Society of Gynecology and Obstetrics (DGGG) was to provide consensus-based recommendations obtained by evaluating the relevant literature for the diagnostic treatment and management of women with fetal growth restriction. ...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Is Breast Surgery Necessary for Breast Carcinoma in Complete Remission Following Neoadjuvant Chemotherapy?
Authors: Richter H, Hennigs A, Schaefgen B, Hahn M, Blohmer JU, Kümmel S, Kühn T, Thill M, Friedrichs K, Sohn C, Golatta M, Heil J Abstract The likelihood of pathological complete remission (pCR) of breast cancer following neoadjuvant chemotherapy (NACT) is increasing; most of all in the triple negative and HER2 positive tumour subgroups. The question thus arises whether or not breast surgery is necessary when there is complete remission after NACT, and whether it provides any improvement of the oncological treatment result when tumour is no longer detectable. Avoiding surgery and possibly even radiothera...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Role of Indocyanine Green in Fluorescence Imaging with Near-Infrared Light to Identify Sentinel Lymph Nodes, Lymphatic Vessels and Pathways Prior to Surgery - A Critical Evaluation of Options.
Authors: Hackethal A, Hirschburger M, Eicker SO, Mücke T, Lindner C, Buchweitz O Abstract Modern surgical strategies aim to reduce trauma by using functional imaging to improve surgical outcomes. This reviews considers and evaluates the importance of the fluorescent dye indocyanine green (ICG) to visualize lymph nodes, lymphatic pathways and vessels and tissue borders in an interdisciplinary setting. The work is based on a selective search of the literature in PubMed, Scopus, and Google Scholar and the authors' own clinical experience. Because of its simple, radiation-free and uncomplicated application, ICG ha...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Letrozole vs. Placebo Pretreatment in the Medical Management of First Trimester Missed Miscarriage: a Randomized Controlled Trial.
Authors: Torky HA, Marie H, ElDesouky E, Gebreel S, Raslan O, Moussa AA, Ahmad AM, Zain E, Mohsen MN Abstract Introduction: Misoprostol is used for the medical management of miscarriage as it is more effective in the early stages of pregnancy. Letrozole has an anti-estrogen effect and is used for the pretreatment of miscarriage with misoprostol. Aim: The aim of this study was compare the efficacy and safety of letrozole with placebo pretreatment in the medical management of first trimester missed miscarriage. Design: This was a prospective randomized case-control study. Patients and Methods: Four hundre...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Comparison of Four Methods of Treating Ectopic Pregnancy: A Retrospective Cohort Study.
Authors: Inal ZO, Inal HA Abstract Objective: To compare the results of expectant management, single and multidose methotrexate (MTX) and surgical management of ectopic pregnancy (EP). Materials and Methods: In this retrospective cohort study, the original files of 233 patients who were treated for EP between May 2009 and December 2016 were analyzed. The patients were assigned to the following groups based on the applied treatment methods: Group 1, expectant management (n = 24), Group 2, single-dose MTX (n = 144), Group 3, multiple-dose MTX (n = 25), and Group 4, surgic...
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Smoking Decreases Endometrial Thickness in IVF/ICSI Patients.
Conclusion: We showed that smoking has a negative effect on endometrial thickness on the day of embryo transfer. This may help to further explain the detrimental influence of tobacco smoke on implantation and pregnancy rates during assisted reproduction therapy. PMID: 29375149 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - January 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Preconception Optimization of Glucose and Insulin Metabolism in Women Wanting to Conceive - High Rate of Spontaneous Conception Prior to Planned Assisted Reproduction.
Conclusion: The high rate of spontaneous conceptions in the cohort of women wishing to conceive emphasizes the importance of optimizing glucose/insulin metabolism prior to conception. The high rate of GDM in a cohort of pregnant women with a history of sterility also emphasizes the importance of expanding diagnostic testing for sterility to include the investigation of glucose metabolism and testing for insulin resistance. It is possible that PCOS patients in particular could benefit from treatment with metformin prior to conception, and this could explain the high rate of live births in this patient cohort. PMID: 2927...
Source: Geburtshilfe und Frauenheilkunde - December 26, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2017 - Implementation of Novel Therapies.
Authors: Lux MP, Janni W, Hartkopf AD, Nabieva N, Taran FA, Overkamp F, Kolberg HC, Hadji P, Tesch H, Ettl J, Huober JB, Lüftner D, Wallwiener M, Müller V, Beckmann MW, Belleville E, Fehm TN, Wallwiener D, Brucker SY, Schneeweiss A, Fasching PA Abstract In recent years, numerous new therapy options for patients with breast cancer have been developed in clinical studies, with some options already approved for routine treatment. As the speed at which innovations are introduced increases, the importance of conferences also increases, as conferences are where the data underpinning new therapies are usually pr...
Source: Geburtshilfe und Frauenheilkunde - December 24, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Circulating Tumour Cells, Circulating Tumour DNA and Circulating MicroRNA in Metastatic Breast Carcinoma - What is the Role of Liquid Biopsy in Breast Cancer?
Authors: Polasik A, Tzschaschel M, Schochter F, de Gregorio A, Friedl TWP, Rack B, Hartkopf A, Fasching PA, Schneeweiss A, Müller V, Huober J, Janni W, Fehm T Abstract Dissemination of tumour cells and the development of solid metastases occurs via blood vessels and lymphatics. Circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) can be detected in venous blood in patients with early and metastatic breast cancer, and their prognostic relevance has been demonstrated on numerous occasions. Repeated testing for CTCs and ctDNA, or regular so-called "liquid biopsy", can be performed easily a...
Source: Geburtshilfe und Frauenheilkunde - December 24, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

A Systematic Review of Mycoplasma and Ureaplasma in Urogynaecology.
Authors: Combaz-Söhnchen N, Kuhn A Abstract Mycoplasma species relevant to the urogenital tract include mycoplasma hominis, mycoplasma genitalia and ureaplasma urealyticum. Their occurrence in the context of urogynaecological disease has been demonstrated in urethritis, cystitis and upper renal tract infections. Their role in hyperactive bladder and interstitial cystitis/painful bladder syndrome is controversial. All the above-mentioned microorganisms can occur as commensals or as potential pathogens. In most cases their role in any particular pathology cannot be proven, only presumed. The aim of this systemat...
Source: Geburtshilfe und Frauenheilkunde - December 24, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Repetitive Maturation of Oocytes From Non-Stimulated Xenografted Ovarian Tissue From a Prepubertal Patient Indicating the Independence of Human Ovarian Tissue.
Conclusion: Xenotransplanted prepubertal ovarian tissue has the potential for repetitive oocyte retrieval cycles without administering exogenous hormones. The results indicate that the human ovarian tissue might be able to synchronize the hypothalamus-hypophysis-axes of the mouse to the physiological human cycle; this should be investigated in future studies. PMID: 29269958 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 24, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Effect of Premature Rupture of Membranes on Induction of Labor: A Historical Cohort Study.
Authors: Kehl S, Weiss C, Dammer U, Baier F, Faschingbauer F, Beckmann MW, Sütterlin M, Pretscher J Abstract Objective: The aim of this study was to assess the influence of premature rupture of membranes (PROM) on the induction of labor. Material and Method: This historical cohort study analyzed 1861 inductions of labor at term using misoprostol which occurred between 2010 and 2015. Exclusion criteria included intrauterine fetal death, previous cesarean section, and fetal structural or chromosomal anomalies. Induction of labor for PROM (PROM group) was compared to induction for other indications (no-PROM g...
Source: Geburtshilfe und Frauenheilkunde - December 5, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Personal Preference of Mode of Delivery. What do Urogynaecologists choose? Preliminary Results of the DECISION Study.
Conclusions: Urogynaecologists prefer vaginal delivery for themselves. There is a great interest to participate in a risk stratification process in order to approach childbirth in an individualized and risk-adapted manner. PMID: 29200474 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 5, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Pregnancy Outcomes in Maternal Neuropsychiatric Illness and Substance Abuse.
Conclusion: The study shows a relationship between maternal neuropsychiatric illness and pregnancy outcomes independent of medication use. Rates of spontaneous abortion were higher. Children were born earlier, yet the neonatal outcomes birth weight, head circumference and Apgar score were not worse than children of mentally healthy women. PMID: 29200475 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 5, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Outcome of Cesarean Myomectomy: Is it a Safe Procedure?
Authors: Senturk MB, Polat M, Doğan O, Pulatoğlu Ç, Yardımcı OD, Karakuş R, Tayyar AT Abstract Objective: Myomectomy performed during cesarean section is still controversial because of the potential for associated complications, especially with large myomas. Many obstetricians avoid performing cesarean myomectomy procedures because of the risk of uncontrollable hemorrhage. However, the prevalence of pregnant women with myomas is increasing, leading to an increase in the likelihood that physicians will encounter this issue. The aim of this study was to compare outcomes and complications of patients who e...
Source: Geburtshilfe und Frauenheilkunde - December 5, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Assessing the Clinical Benefit of Systemic Adjuvant Therapies for Early Breast Cancer.
Authors: Möbus V, Hell S, Schmidt M Abstract Oncologic therapy is currently undergoing significant changes. A number of innovative targeted medications currently in clinical development have raised high expectations. With that in mind, discussions about terms such as "clinical benefit" and "clinical relevance" are highly topical. This also applies to further developments in the field of adjuvant systemic therapies for early-stage breast cancer. As the treatment aim is curative, assessment of the clinical benefit of adjuvant therapies must be largely based on efficacy outcomes. The focus mus...
Source: Geburtshilfe und Frauenheilkunde - November 4, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Fertility Preservation in Female Patients with Breast Cancer - a Current Overview.
Authors: Guenther V, Alkatout I, Junkers W, Bauerschlag D, Maass N, von Otte S Abstract Many premenopausal patients who develop breast cancer have not yet completed their family planning, so measures of fertility protection to preserve their fertile potential would be beneficial. Polychemotherapy causes irreversible damage to the ovarian follicles - irrespective of whether in a neoadjuvant or adjuvant setting - and this can sometimes result in permanent infertility. Depending on which cytostatic agents are used and on the age-related ovarian reserve of the woman, gonadotoxic risk must be classified as low, moderate...
Source: Geburtshilfe und Frauenheilkunde - November 4, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

PI3K/AKT/mTOR Pathway in Ovarian Cancer Treatment: Are We on the Right Track?
Authors: Gasparri ML, Bardhi E, Ruscito I, Papadia A, Farooqi AA, Marchetti C, Bogani G, Ceccacci I, Mueller MD, Benedetti Panici P Abstract The high recurrence rate and the low overall survival in ovarian cancer suggest that a more specific therapeutic approach in addition to conventional treatment is required. Translational and clinical research is investigating new molecular targets in order to find an alternative way to affect tumor growth and to minimize the overlap of toxicity of antiblastic agents. Given its implication in many cellular activities including regulation of cell growth, motility, survival, prol...
Source: Geburtshilfe und Frauenheilkunde - November 4, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Influence of Paclitaxel and Heparin on Vitality, Proliferation and Cytokine Production of Endometrial Cancer Cells.
Conclusion: Further in-depth studies are needed to investigate the functions of cytokines CCL2, CCL5 and IL-6 in endometrial cancer cells treated with paclitaxel. Although no general effect on cytokine secretion was detected following heparin treatment, a selective modulatory impact could exist. PMID: 29093604 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - November 4, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Music in Obstetrics: An Intervention Option to Reduce Tension, Pain and Stress.
Authors: Wulff V, Hepp P, Fehm T, Schaal NK Abstract In recent years, the effect of music interventions and music therapy has experienced increased attention in the literature. It has been shown that music has positive effects on cognitive and physical performance, such as concentration and endurance, as well as on psychological parameters, such as anxiety and relaxation. Studies within the context of medicine in particular are increasingly indicating that music may be used as an intervention for relief against anxiety, stress and pain. Music is therefore seen in actual practice as a supplement to conventional phar...
Source: Geburtshilfe und Frauenheilkunde - September 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Fears and Concerns of Patients with Uterine Fibroids - a Survey of 807 Women.
CONCLUSIONS: Due to the benign nature of uterine fibroids and their good treatability, fibroid-associated fears are generally unfounded. Precise knowledge of patient fears and concerns should be integrated into clinical care with targeted psychological support to help patients better understand their condition. PMID: 28959061 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

How Do Patients Experience Individualized Medicine? A Qualitative Interview-based Study of Gene Expression Analyses in the Treatment of Breast Cancer.
CONCLUSION: The results of the study highlight the challenge of taking psychosocial aspects of medical treatment sufficiently into consideration, given the ever increasing options for molecular genomic individualization. PMID: 28959062 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Quality of Life, Sexuality, Anatomical Results and Side-effects of Implantation of an Alloplastic Mesh for Cystocele Correction at Follow-up after 36 Months.
Authors: Fünfgeld C, Stehle M, Henne B, Kaufhold J, Watermann D, Grebe M, Mengel M Abstract INTRODUCTION: Pelvic organ prolapse can significantly reduce quality of life of affected women, with many cases requiring corrective surgery. The rate of recurrence is relatively high after conventional prolapse surgery. In recent years, alloplastic meshes have increasingly been implanted to stabilize the pelvic floor, which has led to considerable improvement of anatomical results. But the potential for mesh-induced risks has led to a controversial discussion on the use of surgical meshes in urogynecology. The impact o...
Source: Geburtshilfe und Frauenheilkunde - September 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Prevalence and Trends in the Utilization of Gynecological Services by Adolescent Girls in Germany. Results of the German Health Survey for Children and Adolescents (KiGGS).
Authors: Krause L, Seeling S, Prütz F, Rommel A Abstract There is only limited data available on the utilization of gynecological services in Germany. Based on data from the German Health Survey for Children and Adolescents (KiGGS) of the Robert Koch Institute, a survey carried out across all of Germany, this study aimed to examine the utilization of gynecological services by girls in Germany. Data from the KiGGS Wave 1 survey (2009 - 2012) was used to analyze the factors which affect utilization. The KiGGS baseline study (2003 - 2006) was used to analyze trends. The database consisted of a subsample f...
Source: Geburtshilfe und Frauenheilkunde - September 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

"Epidemiological Follow-up 15 Years After Presumably False Diagnoses of Breast Cancer" - A Statement by the German Senology Society.
"Epidemiological Follow-up 15 Years After Presumably False Diagnoses of Breast Cancer" - A Statement by the German Senology Society. Geburtshilfe Frauenheilkd. 2012 Jun;72(6):523-524 Authors: Becker S, Dietel M, Wallwiener D PMID: 28867825 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 6, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Comment on the Article "Epidemiological Follow-up 15 Years After the Breast Cancer Scandal in Essen" (Hauth et al.).
Comment on the Article "Epidemiological Follow-up 15 Years After the Breast Cancer Scandal in Essen" (Hauth et al.). Geburtshilfe Frauenheilkd. 2012 Jun;72(6):525-526 Authors: Schlake W PMID: 28867826 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 6, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Preservation of Fertility or Ovarian Function in Patients with Breast Cancer or Gynecologic and Internal Malignancies.
Authors: Stachs A, Hartmann S, Gerber B Abstract Because of the efficacy of systemic therapies, neoplasias which occur in pediatric and adolescent patients and in young adults have high cure rates. This means that fulfilling their wish to have children has become a more pressing concern, particularly among young women with malignant tumors. Premature ovarian failure is also a not insignificant problem as it has a lasting detrimental effect on quality of life. Every oncology patient who may potentially wish to have children should be informed about their options for preserving fertility prior to starting treatment. ...
Source: Geburtshilfe und Frauenheilkunde - August 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Implementation and Feasibility of Electronic Patient-Reported Outcome (ePRO) Data Entry in the PRAEGNANT Real-Time Advanced and Metastatic Breast Cancer Registry.
CONCLUSIONS: Incorporating ePRO questionnaires into an advanced breast cancer registry is feasible, and no major hurdles were reported. Involving stakeholders from the start, the application is tailored to the capacities and abilities of both patients and clinical staff. The patients' compliance was better with some questionnaires, but others may present difficulties. PMID: 28845051 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Should Breast Cancer Surgery Be Done in an Outpatient Setting?: Health Economics From the Perspective of Service Providers.
CONCLUSION: Carrying out breast cancer surgery as an outpatient procedure would result in a significant shortfall of revenues. Additional services from certified centers, such as the interdisciplinary planning of treatment, psycho-oncological and social-medical care with the involvement of relatives, detailed documentation, etc., which are currently provided without surcharge or adequate remuneration, could no longer be maintained. The quality of processes and excellent results which have been achieved and ultimately the care given by certified facilities would be significantly at risk. PMID: 28845052 [PubMed - in proc...
Source: Geburtshilfe und Frauenheilkunde - August 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Value of Partial HPV Genotyping After Conization of Cervical Dysplasias.
CONCLUSION: At follow-up after conization of CIN the combination of high risk HPV detection and partial genotyping of HPV 16 constitutes excellent diagnostic criteria for recurrence/persistence of CIN. PMID: 28845053 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Duty Rosters and Workloads of Obstetricians in Germany: Results of a Germany-wide Survey.
Authors: Neimann J, Knabl J, Puppe J, Bayer CM, Gass P, Gabriel L, Seelbach-Goebel B, Lermann J, Schott S Abstract BACKGROUND: Compiling a daily hospital roster which complies with existing laws and tariff regulations and meets the requirements for ongoing professional training while also taking the legal regulations on the health of employees into account makes planning the duty roster a challenge. The aim of this study was to obtain a realistic picture of existing duty roster systems and of the current workloads of obstetricians in Germany. METHOD: This online survey was sent to 2770 physicians training to be...
Source: Geburtshilfe und Frauenheilkunde - August 30, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Initial Treatment of Patients with Primary Breast Cancer: Evidence, Controversies, Consensus: Spectrum of Opinion of German Specialists at the 15th International St.  Gallen Breast Cancer Conference (Vienna 2017).
Initial Treatment of Patients with Primary Breast Cancer: Evidence, Controversies, Consensus: Spectrum of Opinion of German Specialists at the 15th International St. Gallen Breast Cancer Conference (Vienna 2017). Geburtshilfe Frauenheilkd. 2017 Jun;77(6):633-644 Authors: Untch M, Huober J, Jackisch C, Schneeweiss A, Brucker SY, Dall P, Denkert C, Fasching PA, Fehm T, Gerber B, Janni W, Kühn T, Lüftner D, Möbus V, Müller V, Rody A, Sinn P, Thill M, Thomssen C, Harbeck N, Liedtke C Abstract The St. Gallen International Consensus Conference on the treatment of patients with p...
Source: Geburtshilfe und Frauenheilkunde - August 6, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Lung Metastasectomy for Pulmonary Metastatic Breast Carcinoma.
Authors: Macherey S, Mallmann P, Malter W, Doerr F, Heldwein M, Wahlers T, Hekmat K Abstract Breast carcinoma with pulmonary metastasis can be treated locally or systemically. Following primary tumour resection patients with isolated, completely resectable pulmonary nodules and definite functional operability can be offered lung metastasis resection. Following metastasectomy a median survival of 32 to 96.6 months can be achieved with corresponding five-year survival rates between 30.8 and 54.4%. The procedure is associated with a mortality rate of 0 to 3%. The most important independent prognostic factor for long-t...
Source: Geburtshilfe und Frauenheilkunde - August 6, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

MR-Guided Focused Ultrasound in Fibroid Treatment - Results of the 3rd Radiological-Gynecological Expert Meeting.
Authors: David M, Matzko M PMID: 28769128 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 6, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Uterine Artery Embolization (UAE) for Fibroid Treatment: Results of the 6th Radiological Gynecological Expert Meeting.
Authors: Kröncke T, David M PMID: 28769129 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 6, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Consensus Meetings Regarding Uterine Artery Embolization and Focused Ultrasound in Fibroid Treatment: an Analysis.
Authors: Kröncke T, David M, Matzko MF PMID: 28769130 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 6, 2017 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research