Correction: Osteopontin and Integrin αvβ3 Expression during the Implantation Window in IVF Patients with Elevated Serum Progesterone and Oestradiol Level.
Correction: Osteopontin and Integrin αvβ3 Expression during the Implantation Window in IVF Patients with Elevated Serum Progesterone and Oestradiol Level. Geburtshilfe Frauenheilkd. 2016 Jun;76(6):e1 Authors: He Z, Ma Y, Li L, Liu J, Yang H, Chen C, Lin N, Bai Y, Ma R, Li R, Wu Z, Qiao J Abstract [This corrects the article DOI: 10.1055/s-0041-111697.]. PMID: 31265509 [PubMed - in process] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - July 5, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Surgical Studies of Reconstructive Breast Surgery - An Overview of the Topics at the 2019 Annual Meeting of the Working Group for Reconstructive Surgery in Oncology-Gynecology.
Authors: Paepke S, Kiechle M, Ankel C, Weyrich J, Klein E, Schneider A, Johannigmann-Malek N, Dietrich AS, Ohlinger R, Thill M Abstract This year's annual AWOgyn meeting focused on studies of reconstructive breast surgery. As the majority of breast reconstructions are implant-based, most studies also focused on implant-based reconstruction. Since 2011, the guidelines have recommended using interposed mesh materials as support. The basic idea behind every type of material is to provide coverage and stabilization for the implant by constructing an "internal bra" which will create the appropriate implant sha...
Source: Geburtshilfe und Frauenheilkunde - June 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Primary Therapy of Early Breast Cancer: Evidence, Controversies, Consensus: Spectrum of Opinion of German Specialists on the 16th St.  Gallen International Breast Cancer Conference (Vienna 2019).
Primary Therapy of Early Breast Cancer: Evidence, Controversies, Consensus: Spectrum of Opinion of German Specialists on the 16th St. Gallen International Breast Cancer Conference (Vienna 2019). Geburtshilfe Frauenheilkd. 2019 Jun;79(6):591-604 Authors: Untch M, Thomssen C, Bauerfeind I, Braun M, Brucker SY, Felberbaum R, Hagemann F, Haidinger R, Hönig A, Huober J, Jackisch C, Kolberg HC, Kolberg-Liedtke C, Kühn T, Lüftner D, Maass N, Reimer T, Schneeweiss A, Schumacher-Wulf E, Schütz F, Thill M, Wuerstlein R, Fasching PA, Harbeck N Abstract The results of the international St....
Source: Geburtshilfe und Frauenheilkunde - June 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Diagnosis and Therapy of Triple-Negative Breast Cancer (TNBC) - Recommendations for Daily Routine Practice.
Authors: Schneeweiss A, Denkert C, Fasching PA, Fremd C, Gluz O, Kolberg-Liedtke C, Loibl S, Lück HJ Abstract The rapid increase in knowledge in tumour biology and tumour pathogenesis of triple-negative breast cancer (TNBC) has resulted in new therapeutic approaches and new therapeutic concepts for treatment. For years, TNBC has been considered to be a difficult-to-treat tumour due to its generally aggressive tumour biology and in view of limited therapeutic options. The risk of recurrence and metastasis is higher than in the case of other breast cancer subtypes of the same stage. In addition to surgery and ra...
Source: Geburtshilfe und Frauenheilkunde - June 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Trastuzumab in the Treatment of Pregnant Breast Cancer Patients - an Overview of the Literature.
Authors: Goller SS, Markert UR, Fröhlich K Abstract Breast cancer is one of the most common malignancies which appear during pregnancy. Since women are increasingly not giving birth until they are at a more advanced age, it can be assumed that the incidence of pregnancy-related breast cancers will continue to increase in the future. Because of pregnancy-induced changes and conservative diagnosis, these carcinomas are frequently not detected until they are at an advanced stage and thus generally require systemic adjuvant therapy. The available data on optimal chemotherapeutic management are limited. Particularl...
Source: Geburtshilfe und Frauenheilkunde - June 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Role of Renin-Angiotensin-System in Human Breast Cancer Cells: Is There a Difference in Regulation of Angiogenesis between Hormone-Receptor Positive and Negative Breast Cancer Cells?
Conclusion The RAS-dependent regulation of VEGF between HR-positive and HR-negative breast cancer cells seems do be different. These findings provide evidence for a possible future therapeutic strategy. PMID: 31217631 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2019 Part 3 - Current Developments in Early Breast Cancer: Review and Critical Assessment by an International Expert Panel.
Authors: Kolberg HC, Schneeweiss A, Fehm TN, Wöckel A, Huober J, Pontones C, Titzmann A, Belleville E, Lux MP, Janni W, Hartkopf AD, Taran FA, Wallwiener M, Overkamp F, Tesch H, Ettl J, Lüftner D, Müller V, Schütz F, Fasching PA, Brucker SY Abstract The treatment of breast cancer patients in a curative situation is special in many ways. The local therapy with surgery and radiation therapy is a central aspect of the treatment. The complete elimination of tumour cells at the site of the primary disease must be ensured while simultaneously striving to keep the long-term effects as minor as possible...
Source: Geburtshilfe und Frauenheilkunde - June 4, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Role of Diagnostic Hysteroscopy in the Evaluation of Fallopian Tube Patency: a Short Review.
Authors: Hager M, Simek IM, Promberger R, Ott J Abstract The relevance of diagnostic hysteroscopy, especially when performed in an outpatient "office" setting, in the evaluation process of infertility has increased within the last few years. Notably, several articles on a possible role for diagnostic hysteroscopy in the assessment of Fallopian tube patency have been published recently. Three relevant articles were identified. Visualizing a "flow effect" or air bubbles dispersing through the ostia, sonographically assessed shifts in cul de sac volume, and selective Fallopian tubal cannulation are...
Source: Geburtshilfe und Frauenheilkunde - June 4, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Standards Used by a Clinical and Scientific Endometriosis Center for the Diagnosis and Therapy of Patients with Endometriosis.
Authors: Burghaus S, Hildebrandt T, Fahlbusch C, Heusinger K, Antoniadis S, Lermann J, Hackl J, Häberle L, Renner SP, Fasching PA, Beckmann MW, Blum S Abstract Endometriosis is one of the most common benign gynecological diseases. The extremely heterogeneous complex of symptoms complicates the diagnosis and treatment of this disease. In most patients, there is a latency period of several years between the first occurrence of symptoms and the definitive diagnosis. This paper aims (1) to evaluate standards for the diagnosis and treatment of patients with (symptoms suspicious for) endometriosis in terms of feasib...
Source: Geburtshilfe und Frauenheilkunde - June 4, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Sexual Function and Socio-Sexual Difficulties in Women with Polycystic Ovary Syndrome (PCOS).
Conclusion Patients with PCOS should be screened for socio-sexual difficulties and emotional problems. Specialized psychological and sexological counselling can complement patient care. PMID: 31148850 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 4, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Serum Vitamin D Levels in Fertile and Infertile Women with Polycystic Ovary Syndrome.
Conclusion Serum vitamin D levels are lower in infertile women with polycystic ovary syndrome compared to fertile women. When insulin resistance or obesity was present, vitamin D levels were reduced further. Thus, in polycystic ovary syndrome, lower vitamin D levels may play a role in the pathogenesis of fertility problems. PMID: 31148851 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 4, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Endometrial Flushing Tumor Necrosis Factor Alpha and Interleukin 2 Levels in Women with Polycystic Ovary Syndrome, Leiomyoma and Endometrioma: Comparison with Healthy Controls.
Conclusion Relative to the control group, endometrial flushing fluid TNF-α levels were significantly higher in endometrioma patients and IL-2 levels were significantly lower in PCOS, leiomyoma and endometrioma patients. In benign gynecological diseases, endometrial markers related to infertility seem to show differences in endometrial flushing fluid. Future studies might identify the reference values for these markers, and endometrial markers can be used to diagnose gynecologic disorders causing infertility. PMID: 31148852 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 4, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Tuberculosis in Pregnancy - a Summary.
Authors: Wolf B, Krasselt M, de Fallois J, von Braun A, Stepan H Abstract In recent years, the incidence of tuberculosis in pregnancy in the industrialised countries has increased. Tuberculosis in pregnancy is associated with an increased risk for the mother and child. Even if no figures are available for Germany, an increase in the number of tuberculosis cases among pregnant women can be assumed due to the migratory flows; current data from the USA, for example, also show an increasing incidence of tuberculosis in pregnant women in recent years. The physiological and immunological changes that occur during pregnan...
Source: Geburtshilfe und Frauenheilkunde - April 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Pituitary Disease in Pregnancy: Special Aspects of Diagnosis and Treatment?
Authors: Petersenn S, Christ-Crain M, Droste M, Finke R, Flitsch J, Kreitschmann-Andermahr I, Luger A, Schopohl J, Stalla G Abstract The diagnosis and treatment of pituitary disease in pregnancy represents a special clinical challenge. Not least because there is very little data on the treatment of pregnant patients with pituitary disorders. A selective search of the literature was carried out with the aim of compiling evidence about the diagnosis and treatment of pituitary disease in pregnancy. The search covered the databases PubMed/MEDLINE including PubMed Central and also used the Livivo (ZB MED) search engine....
Source: Geburtshilfe und Frauenheilkunde - April 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Postpartum Depressive Disorder - Psychosomatic Aspects.
This article presents diagnostic measures and current therapeutic approaches as well as their integration in practice in order to achieve awareness of this topic in everyday clinical practice and show the pathways of appropriate treatment. Specific multiprofessional treatment approaches which centre on the mother-child relationship demonstrate successes with regard to depression in the mothers and also on the development of a secure mother-child bond and are thus a protective factor in the development of the affected children. The now well-known effects of PPD on the fathers as well as the negative impacts of paternal depr...
Source: Geburtshilfe und Frauenheilkunde - April 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality.
Conclusion This study supports GDF15 and IGFBP7 in the pathogenesis of HG and may be useful for prediction and diagnosis. The GDF15-GFRAL brainstem-activated pathway was recently identified and therapies to treat conditions of abnormal appetite are under intense investigation. Based on our findings, HG should be included. PMID: 31000883 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - April 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Influence of Different Methods of Intrapartum Analgesia on the Progress of Labour and on Perinatal Outcome.
Authors: Ortiz JU, Hammerl T, Wasmaier M, Wienerroither V, Haller B, Hamann M, Kuschel B, Lobmaier SM Abstract Background Various methods of intrapartum analgesia are available these days. Pethidine, meptazinol and epidural analgesia are among the most commonly used techniques. A relatively new one is patient-controlled intravenous analgesia with remifentanil, although the experiences published so far in Germany are limited. Our goal was to study the influence of these analgesic techniques (opioids vs. patient-controlled intravenous analgesia with remifentanil vs. epidural analgesia) on the second stage of labour a...
Source: Geburtshilfe und Frauenheilkunde - April 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Evaluation of Placental Perfusion Based on Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) and Its Predictive Value for Late-Onset Fetal Growth Restriction.
Authors: Shi H, Quan X, Liang W, Li X, Ai B, Liu H Abstract Objective The aim of this study was to investigate placental blood perfusion in middle and late pregnancy and explore its predictive value for fetal growth restriction (FGR). Methods All pregnant women included in the study were examined using placental intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI). Three IVIM parameters (D, f, D*) were obtained for each pregnant woman and analyzed using Image J software. Perfusion fraction f is a radiological marker of placental perfusion. The pulsatility index (PI) of the uterine artery is used to in...
Source: Geburtshilfe und Frauenheilkunde - April 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Induction of Labour in Growth Restricted and Small for Gestational Age Foetuses - A Historical Cohort Study.
Authors: Kehl S, Weiss C, Dammer U, Berlit S, Große-Steffen T, Faschingbauer F, Sütterlin M, Beckmann MW, Schneider MO Abstract Purpose Induction of labour for small-for-gestational-age (SGA) foetus or intrauterine growth restriction (IUGR) is common, but data are limited. The aim of this study was therefore to compare labour induction for SGA/IUGR with cases of normal foetal growth above the 10th percentile. Material and Methods This historical multicentre cohort study included singleton pregnancies at term. Labour induction for SGA/IUGR (IUGR group) was compared with cases of foetal growth above the 10...
Source: Geburtshilfe und Frauenheilkunde - April 21, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Abortion, Termination of Pregnancy, or Unterbrechung? A Non-English-native Obstetrician's View on Obstetric English Terminology.
Authors: Matsubara S PMID: 30923395 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2019 Part 1 - Implementation of Study Results of Novel Study Designs in Clinical Practice in Patients with Early Breast Cancer.
Authors: Hartkopf AD, Müller V, Wöckel A, Lux MP, Janni W, Nabieva N, Taran FA, Ettl J, Lüftner D, Belleville E, Schütz F, Fasching PA, Fehm TN, Kolberg HC, Overkamp F, Schneeweiss A, Tesch H Abstract For many years, small but significant advancements have been made time and again in the prevention and treatment of early breast cancer. The so-called panel gene analyses are becoming more and more important in prevention, since the risk due to the tested genes is better understood and as a result, concepts for integration in health care can be developed. In the adjuvant situation, the first study ...
Source: Geburtshilfe und Frauenheilkunde - March 19, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2019 Part 2 - Implementation of Novel Diagnostics and Therapeutics in Advanced Breast Cancer Patients in Clinical Practice.
Authors: Janni W, Schneeweiss A, Müller V, Wöckel A, Lux MP, Hartkopf AD, Nabieva N, Taran FA, Tesch H, Overkamp F, Lüftner D, Belleville E, Schütz F, Fasching PA, Fehm TN, Kolberg HC, Ettl J Abstract The treatment of patients with advanced breast cancer has developed further in recent years. In addition to therapeutic progress in the established subgroups (hormone receptor and HER2 status), there are now therapies which are geared to individual molecular characteristics, such as PARP inhibitor therapy in BRCA-mutated patients. In addition to this, tests are being developed which are intended to...
Source: Geburtshilfe und Frauenheilkunde - March 19, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Female Adnexal Tumour of Probable Wolffian Origin (FATWO): Review of the Literature.
Authors: Hübner TB, Schwab M, Hartmann E, Mayr D, Thurner A, Bley T, Wöckel A, Herr D Abstract FATWO (female adnexal tumour of probable Wolffian origin) denotes a rare tumour of the female adnexa which has been described in nearly 80 cases worldwide and which presumably originates in the remains of the Wolffian ducts. In 10 to 20 percent of patients, a metastasis or recurrence was seen subsequently and for this reason, a malignant potential is attributed to the FATWO. Because of the small number of cases, there is no clear therapeutic recommendation. The method of choice currently is surgical treatment wi...
Source: Geburtshilfe und Frauenheilkunde - March 19, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Predictors of a Successful Bipolar Radiofrequency Endometrial Ablation.
Authors: Eisele L, Köchli L, Städele P, Welter J, Fehr-Kuhn M, Fehr MK Abstract Introduction The study's objectives were to determine the success rate following radiofrequency endometrial ablation to treat abnormal menstrual bleeding and to assess risk factors for failure of the method. Materials and Methods 195 women who were treated with bipolar radiofrequency endometrial ablation between 01/2009 and 06/2016 were included in this prospective cohort study. Postoperative data from 187 women were collected at a median of 17.5 months (IQR 4.5-34.9; 1-82). Multivariate analyses of risk factors were performed...
Source: Geburtshilfe und Frauenheilkunde - March 19, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Assessment of the Relationship between Serum Vitamin D and Osteocalcin Levels with Metabolic Syndrome in Non-Osteoporotic Postmenopausal Women.
Authors: Guney G, Sener-Simsek B, Tokmak A, Yucel A, Buyukkagnici U, Yilmaz N, Engin-Ustun Y, Ozgu-Erdinc AS Abstract Introduction The aim of this study was to compare serum vitamin D and osteocalcin levels in non-osteoporotic postmenopausal women with and without metabolic syndrome and to analyze the relationship between serum vitamin D and osteocalcin levels and the relationships between these two factors and other clinical/biochemical parameters. Material and Method This cross-sectional study was carried out in 191 postmenopausal non-osteoporotic (T-score> - 2.5) women. Patients were divided into two groups...
Source: Geburtshilfe und Frauenheilkunde - March 19, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

An Evaluation of the Association of Reproductive History and Multiple Births during Adolescence with Postmenopausal Osteoporosis.
Conclusion Having frequent births throughout the whole reproductive age and having more than one child in adolescence has an adverse effect on postmenopausal bone mineral densities. PMID: 30880829 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - March 19, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Updated Opinion of the Uterus Commission of the Gynecological Oncology Working Group (AGO) and the Gynecological Endoscopy Working Group (AGE) of the German Society of Gynecology and Obstetrics (DGGG) on the Randomized Study Comparing Minimally Invasive with Abdominal Radical Hysterectomy for Early-stage Cervical Cancer (LACC).
Authors: Hillemanns P, Brucker S, Holthaus B, Kimmig R, Lampe B, Runnebaum I, Ulrich U, Wallwiener M, Fehm T, Tempfer C, AGO Uterus and the AGE of the DGGG Abstract In this opinion on the randomized study comparing minimally invasive with abdominal radical hysterectomy for early-stage cervical cancer (LACC), the Uterus Commission of the Gynecological Oncology Working Group (AGO) and the Gynecological Endoscopy Working Group (AGE) of the Germany Society of Gynecology and Obstetrics (DGGG) state that, based on their examination of the published data, patients with FIGO stage IA1 (with LVSI), IA2 or IB1 cervical canc...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Prevention of Cervical Cancer: Guideline of the DGGG and the DKG (S3 Level, AWMF Register Number 015/027OL, December 2017) - Part 1 with Introduction, Screening and the Pathology of Cervical Dysplasia.
Authors: Hillemanns P, Friese K, Dannecker C, Klug S, Seifert U, Iftner T, Hädicke J, Löning T, Horn L, Schmidt D, Ikenberg H, Steiner M, Freitag U, Siebert U, Sroczynski G, Sauerbrei W, Beckmann MW, Gebhardt M, Friedrich M, Münstedt K, Schneider A, Kaufmann A, Petry KU, Schäfer APA, Pawlita M, Weis J, Mehnert A, Fehr M, Grimm C, Reich O, Arbyn M, Kleijnen J, Wesselmann S, Nothacker M, Follmann M, Langer T, Jentschke M Abstract Aims Annual opportunistic screening for cervical carcinoma has been carried out in Germany since 1971. The creation of this S3 guideline meets an important need, outlined...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Prevention of Cervical Cancer: Guideline of the DGGG and the DKG (S3 Level, AWMF Register Number 015/027OL, December 2017) - Part 2 on Triage, Treatment and Follow-up.
Authors: Hillemanns P, Friese K, Dannecker C, Klug S, Seifert U, Iftner T, Hädicke J, Löning T, Horn L, Schmidt D, Ikenberg H, Steiner M, Freitag U, Siebert U, Sroczynski G, Sauerbrei W, Beckmann MW, Gebhardt M, Friedrich M, Münstedt K, Schneider A, Kaufmann A, Petry KU, Schäfer APA, Pawlita M, Weis J, Mehnert A, Fehr M, Grimm C, Reich O, Arbyn M, Kleijnen J, Wesselmann S, Nothacker M, Follmann M, Langer T, Jentschke M Abstract Aims Annual opportunistic screening for cervical carcinoma has been done in Germany since 1971. The creation of this S3 guideline meets an important need, outlined in the...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Circulating and Disseminated Tumour Cells in Breast Carcinoma: Report from the Consensus Conference on Tumour Cell Dissemination during the 38th Annual Meeting of the German Society of Senology, Berlin, 14 June 2018.
Authors: Banys-Paluchowski M, Hartkopf A, Meier-Stiegen F, Janni W, Solomayer EF, Fehm T Abstract Haematogenic dissemination of tumour cells in breast carcinoma is among the most intensively researched areas in translational oncology. Large meta-analyses have shown the prognostic relevance of the disseminated tumour cells in the bone marrow and circulating tumour cells in the peripheral blood in the adjuvant as well as metastatic setting. The current status of the research was discussed in detail during the annual meeting of the German Society of Senology in Berlin. The following conference report gives an overview...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Mechanisms of Metastasis and Cell Mobility - The Role of Metabolism.
Authors: Gründker C, Läsche M, Hellinger JW, Emons G Abstract Tumour metastasis is responsible for more than 90% of tumour-associated mortality. About one third of breast cancer patients in the early stage develop metastases. The transformation in tumour development referred to as the "metastatic cascade" or "metastatic cycle" is a complex and multi-stage event. While it is generally recognised that epithelial-mesenchymal transformation (EMT) plays a crucial role in cancer progression and metastasis, the metabolic events in this process have received little attention to date. We would ...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Treatment of Cervical Dysplasia by Clinicians Who Perform Colposcopy in German-speaking Countries - a Questionnaire-based Study.
Conclusion A differential colposcopy with two colposcopically targeted biopsies and treatment with the electrosurgical loop are the methods most frequently used by clinicians who perform colposcopy in Germany. A uniform procedure should be defined in detail within the scope of directives or guidelines. PMID: 30792549 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Prognostic Impact of Grading in FIGO IB and IIB Squamous Cell Cervical Carcinomas.
Conclusion A binary grading model for the conventional tumor grade (based on the degree of keratinization) in SCC of the uterine cervix may be suitable for the prognostic survival evaluation but failed to predict pelvic lymph node involvement. PMID: 30792550 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Mindfulness-based Stress Reduction in Pregnancy: an App-Based Programme to Improve the Health of Mothers and Children (MINDFUL/PMI Study).
Authors: Lenz B, Eichler A, Schwenke E, Buchholz VN, Hartwig C, Moll GH, Reich K, Mühle C, Volz B, Titzmann A, Beckmann MW, Heinrich H, Kornhuber J, Fasching PA Abstract Unfavourable intrauterine environmental factors increase the risk of delivery complications as well as postpartum developmental and behavioural problems in children and adolescents with ongoing effects into older age. Biomarker studies show that maternal stress and the use of alcohol and tobacco during pregnancy are associated with a higher intrauterine testosterone exposure of the child. The antenatal testosterone load, in turn, is a risk fac...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Concept Paper on the Technique of Cryopreservation, Removal and Transplantation of Ovarian Tissue for Fertility Preservation.
Authors: Beckmann MW, Lotz L, Toth B, Baston-Büst DM, Fehm T, Frambach T, Germeyer A, Goeckenjan M, Häberlin F, Henes M, Hirchenhain J, Hübner S, Korell M, Krüssel JS, Müller A, Reinsberg J, Schwab R, Seitz S, Sütterlin M, van der Ven H, van der Ven K, Winkler-Crepaz K, Wimberger P, von Wolff M, Liebenthron J, Dittrich R Abstract The cryopreservation of ovarian tissue with subsequent transplantation of the tissue represents an established method of fertility protection for female patients who have to undergo gonadotoxic therapy. The procedure can be performed at any point in the cycle ...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Can a University Reproductive Medicine Centre Be Financed Under the Pre-Existing General Conditions in Germany?
Discussion From the perspective of a university reproductive medicine centre, IVF and ICSI treatments currently cannot be performed in a cost-covering manner. At the same time, a reproductive medicine treatment cycle represents a significant financial burden on the patient couple due to only partial cost coverage by most statutory health insurance funds. This therefore demonstrates a need for action in health policy to revise and, in the interest of the patient couples, reproductive medicine centres and, not least of all, in the interest of society, to improve existing cost absorption policies and thus also benefit from th...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Fertility After Ovarian Cystectomy: How Does Surgery Affect IVF/ICSI Outcomes?
Authors: Gomez R, Schorsch M, Gerhold-Ay A, Hasenburg A, Seufert R, Skala C Abstract Introduction For patients considering undergoing assisted reproductive techniques (ART), many concerns arise when persistent ovarian cysts are found. This large study aimed to determine how ovarian cyst removal affects success rates of IVF/ICSI therapies. Methods 550 patients who underwent an IVF/ICSI treatment between 2002 and 2011 with a persistent ovarian cyst ≤ 5 cm before treatment were analyzed retrospectively. 328 patients' preference was to undergo a laparoscopic cystectomy and 222 patients opted for a cons...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Obesity Does not Compromise Ovarian Reserve Markers in Infertile Women.
Authors: Gorkem U, Kucukler FK, Togrul C, Gulen Ş Abstract Introduction In the literature, conflicting results from studies examining the relationship between obesity and ovarian reserve have been reported. The purpose of the study is to investigate whether obesity adversely affects serum concentrations of ovarian reserve markers in infertile women with different ovarian reserve status. Materials and Methods A total of 402 women were assigned to three groups according to body mass index (BMI;
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Follicular Fluid Levels of Adrenomedullin 2, Vascular Endothelial Growth Factor and its Soluble Receptors Are Associated with Ovarian Response During ART Cycles.
Authors: Ranjbaran A, Nejabati HR, Ghasemnejad T, Latifi Z, Hamdi K, Hajipour H, Raffel N, Bahrami-Asl Z, Hakimi P, Mihanfar A, Nouri M, Fattahi A Abstract Introduction Adrenomedullin 2 (ADM2) and vascular endothelial growth factor (VEGF) affect ovarian function, especially angiogenesis and follicular development. The actions of VEGF can be antagonized by its soluble receptors, soluble Fms-like tyrosine kinase-1 (sFlt-1) and soluble VEGF receptor 2 (sVEGFR-2), as they decrease its free form. In the present study, we evaluated the relationship between follicular fluid (FF) levels of AMD2, VEGF and its soluble recept...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Fertility, Pregnancy and Lactation After Bariatric Surgery - a Consensus Statement from the OEGGG.
Authors: Stopp T, Falcone V, Feichtinger M, Göbl C Abstract Bariatric surgery is recommended when other weight loss interventions, such as lifestyle modification or medications, have failed. A considerable number of women undergoing bariatric surgery are of childbearing age; hence, it is necessary to be aware of the effects of bariatric surgery on pregnancy for managing these patients. Although bariatric surgery is associated with positive effects on cardiovascular and metabolic parameters, side effects such as anaemia, the risk of developing internal hernia, altered glucose metabolism and the risk of small fo...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Statement by the OEGGG with Review of the Literature on the Mode of Delivery of Premature Infants at the Limit of Viability.
Authors: Fischer T, Mörtl M, Reif P, Kiss H, Lang U, Austrian Society for Gynaecology and Obstetrics (OEGGG) Abstract In 2017, the Austrian Society for Paediatric and Adolescent Medicine (ÖGKJ) published a guideline on the primary care of premature infants at the limit of viability. In this guideline, it is recommended that a Caesarean section be preferred as mode of delivery with regard to an early preterm birth (22 + 0 - 24 + 6 weeks of pregnancy) due to an allegedly lower perinatal risk of cerebral haemorrhage. In contrast to this, the Austrian Society for Gynaecology a...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Acute Tocolysis - a Critical Analysis of Evidence-Based Data.
The objective is to prolong the pregnancy by at least 48 hours to complete foetal lung maturation and for the in-utero transfer of the pregnant woman to a perinatal centre. The indication for tocolysis is regular, premature contractions (≥ 4/20 min) and a dynamic shortening of the cervical length/cervical opening between 22 + 0 to 33 + 6 weeks of pregnancy. In this connection, the cervical length measured on ultrasound and the determination of biomarkers in the cervicovaginal secretions can be important decision-making aids. Beta sympathomimetics should no longer be used due to ...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Cardiomyopathies and Congenital Heart Disease in Pregnancy.
Authors: Westhoff-Bleck M, Hilfiker-Kleiner D, Pankuweit S, Schieffer B Abstract Pregnancy-associated diseases of the cardiovascular system occur in up to 10% of all pregnancies and the incidence is increasing. Besides congenital heart disease or pre-existing cardiomyopathy in the mother, the clinical focus has moved especially to peripartum cardiomyopathy (PPCM) because of the condition's dramatic clinical course and the identification of the underlying mechanisms. This review article concentrates therefore on PPCM, which occurs either in the last month of pregnancy or in the first 6 months following delivery in w...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Diet and Lifestyle Before and During Pregnancy - Practical Recommendations of the Germany-wide Healthy Start - Young Family Network.
Authors: Koletzko B, Cremer M, Flothkötter M, Graf C, Hauner H, Hellmers C, Kersting M, Krawinkel M, Przyrembel H, Röbl-Mathieu M, Schiffner U, Vetter K, Weißenborn A, Wöckel A Abstract Diet and exercise before and during pregnancy affect the course of the pregnancy, the child's development and the short- and long-term health of mother and child. The Healthy Start - Young Family Network has updated the recommendations on nutrition in pregnancy that first appeared in 2012 and supplemented them with recommendations on a preconception lifestyle. The recommendations address body weight before conce...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Gestational Diabetes Mellitus (GDM) - Diagnosis, Treatment and Follow-Up. Guideline of the DDG and DGGG (S3 Level, AWMF Registry Number 057/008, February 2018).
Authors: Schäfer-Graf UM, Gembruch U, Kainer F, Groten T, Hummel S, Hösli I, Grieshop M, Kaltheuner M, Bührer C, Kautzky-Willer A, Laubner K, Bancher-Todesca D Abstract A team of experts from the fields of gynaecology and obstetrics, diabetology, internal medicine, paediatrics and midwifery from Germany, Austria and Switzerland produced a new version of the existing S3 guideline on gestational diabetes. It replaces the recommendations of the German Association for Gynaecology and Obstetrics and the German Diabetes Association on the diagnosis and treatment of gestational diabetes from 2011 and is val...
Source: Geburtshilfe und Frauenheilkunde - January 18, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Joint Guideline of the OEGGG, AGO, AGK and ÖGZ on the Diagnosis and Treatment of Cervical Intraepithelial Neoplasia and Appropriate Procedures When Cytological Specimens Are Unsatisfactory.
Joint Guideline of the OEGGG, AGO, AGK and ÖGZ on the Diagnosis and Treatment of Cervical Intraepithelial Neoplasia and Appropriate Procedures When Cytological Specimens Are Unsatisfactory. Geburtshilfe Frauenheilkd. 2018 Dec;78(12):1232-1244 Authors: Reich O, Braune G, Eppel W, Fiedler T, Graf A, Hefler L, Joura E, Kölbl H, Marth C, Pokieser W, Regitnig P, Reinthaller A, Tamussino K, Widschwendter A, Zeimet A, Kohlberger P Abstract Purpose On January 1st, 2018, the ÖGZ (Austrian Society of Cytology) revised its cytological nomenclature to make it more similar to the 2015 Bethesda system...
Source: Geburtshilfe und Frauenheilkunde - January 18, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 2 with Recommendations for the Therapy of Primary, Recurrent and Advanced Breast Cancer.
Authors: Wöckel A, Festl J, Stüber T, Brust K, Krockenberger M, Heuschmann PU, Jírů-Hillmann S, Albert US, Budach W, Follmann M, Janni W, Kopp I, Kreienberg R, Kühn T, Langer T, Nothacker M, Scharl A, Schreer I, Link H, Engel J, Fehm T, Weis J, Welt A, Steckelberg A, Feyer P, König K, Hahne A, Baumgartner T, Kreipe HH, Knoefel WT, Denkinger M, Brucker S, Lüftner D, Kubisch C, Gerlach C, Lebeau A, Siedentopf F, Petersen C, Bartsch HH, Schulz-Wendtland R, Hahn M, Hanf V, Müller-Schimpfle M, Henscher U, Roncarati R, Katalinic A, Heitmann C, Honegger C, Paradies K, Bjelic-Radisic V, Degenh...
Source: Geburtshilfe und Frauenheilkunde - December 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Number 032/034-OL, April 2018) - Part 2 with Recommendations on the Therapy and Follow-up of Endometrial Cancer, Palliative Care, Psycho-oncological/Psychosocial Care/Rehabilitation/Patient Information and Healthcare Facilities.
Authors: Emons G, Steiner E, Vordermark D, Uleer C, Bock N, Paradies K, Ortmann O, Aretz S, Mallmann P, Kurzeder C, Hagen V, van Oorschot B, Höcht S, Feyer P, Egerer G, Friedrich M, Cremer W, Prott FJ, Horn LC, Prömpeler H, Langrehr J, Leinung S, Beckmann MW, Kimmig R, Letsch A, Reinhardt M, Alt-Epping B, Kiesel L, Menke J, Gebhardt M, Steinke-Lange V, Rahner N, Lichtenegger W, Zeimet A, Hanf V, Weis J, Mueller M, Henscher U, Schmutzler RK, Meindl A, Hilpert F, Panke JE, Strnad V, Niehues C, Dauelsberg T, Niehoff P, Mayr D, Grab D, Kreißl M, Witteler R, Schorsch A, Mustea A, Petru E, Hübner J, Rose AD,...
Source: Geburtshilfe und Frauenheilkunde - December 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2018 (Part 3) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer.
Authors: Wöckel A, Lux MP, Janni W, Hartkopf AD, Nabieva N, Taran FA, Overkamp F, Hadji P, Tesch H, Ettl J, Lüftner D, Müller V, Welslau M, Belleville E, Brucker SY, Schütz F, Fasching PA, Fehm TN, Schneeweiss A, Kolberg HC Abstract In primary early breast cancer, the aim of treatment planning is to obtain an increasingly better understanding of the disease. The identification of patients with an excellent prognosis could help this group avoid unnecessary treatments. Furthermore, the planning of treatment is becoming increasingly patient-focussed. There is a growing understanding of those patien...
Source: Geburtshilfe und Frauenheilkunde - December 2, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2018 (Part 4) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Treatment Strategies for Advanced Breast Cancer.
Authors: Müller V, Wöckel A, Lux MP, Janni W, Hartkopf AD, Nabieva N, Taran FA, Hadji P, Tesch H, Ettl J, Lüftner D, Welslau M, Belleville E, Brucker SY, Schütz F, Fasching PA, Fehm TN, Kolberg HC, Schneeweiss A, Overkamp F Abstract New therapeutic developments aimed at treating women with advanced breast cancer currently focus both on identifying patients eligible for targeted therapeutic concepts and on the continuing development of immune therapies. The data on CDK4/6 inhibitors are now complete and consistent in this class of substances (palbociclib, ribociclib and abemaciclib). Further path...
Source: Geburtshilfe und Frauenheilkunde - December 2, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research