Hormonal Contraception. Guideline of the DGGG, OEGGG and SGGG (S3 Level, AWMF Registry Number 015/015, January 2020)
Geburtshilfe Frauenheilkd. 2021 Feb;81(2):152-182. doi: 10.1055/a-1259-1609. Epub 2021 Feb 8.ABSTRACTAims This is an official interdisciplinary guideline published and coordinated by the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (OEGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The guideline was developed for use in German-speaking regions and is backed by numerous professional societies and organizations. The aim of this guideline is to provide an evidence- and consensus-based overview of the diagnostic approach and the management of hormonal ...
Source: Geburtshilfe und Frauenheilkunde - February 24, 2021 Category: OBGYN Authors: Sebastian Franik Rupert Bauersachs Jan Beyer-Westendorf Tina Buchholz Kai B ühling Hans-Christoph Diener Anke Erath Ronald Fischer Stefanie F örderreuther Heiko B G Franz Viola Hach-Wunderle Peymann Hadji Werner Harlfinger Cornelia Jaursch-Hancke Klaus Source Type: research

Quo Vadis Urogynecology 2020 - Innovative Treatment Concepts for Urinary Incontinence and Pelvic Organ Prolapse.
Authors: Naumann G Abstract The current treatment for urinary incontinence and pelvic organ prolapse includes a wide range of innovative options for conservative and surgical therapies. Initial treatment for pelvic floor dysfunction consists of individualized topical estrogen therapy and professional training in passive and active pelvic floor exercises with biofeedback, vibration plates, and a number of vaginal devices. The method of choice for the surgical repair of stress urinary incontinence consists of placement of a suburethral sling. A number of different methods are available for the surgical treatment of p...
Source: Geburtshilfe und Frauenheilkunde - February 14, 2021 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Does Nutrition Affect Endometriosis?
Authors: Helbig M, Vesper AS, Beyer I, Fehm T Abstract Endometriosis is a hormone-related, chronic inflammation in women of childbearing age. The aetiology and pathogenesis of endometriosis are not yet fully understood. For other illnesses classed as lifestyle diseases, the link between nutrition and pathogenesis has already been researched and proven. With regard to these findings, the question continues to arise as to whether and how a specific diet and lifestyle could also influence pathogenesis and the progression of endometriosis. The aim of this review is to examine the data and determine what influence nutri...
Source: Geburtshilfe und Frauenheilkunde - February 14, 2021 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Impact of Preoperative Assessment and Planning on the Outcome of Benign Hysterectomy - a Systematic Review.
Authors: Björkström LM, Wodlin NB, Nilsson L, Kjølhede P Abstract Knowledge concerning the impact of preoperative planning, patient information and patient factors on the outcome of benign hysterectomy is incomplete. This systematic review summarizes the current knowledge on the effect of preoperative planning and of preoperative patient factors on the outcome of benign hysterectomy. The PubMed/PubMed Central/MEDLINE, Scopus, Web of Science, TRIP Medical Database, Prospero and the Cochrane Library databases were searched. Inclusion criteria were prospective trials, hysterectomy for benign disease, ...
Source: Geburtshilfe und Frauenheilkunde - February 14, 2021 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Study on E-Cigarettes and Pregnancy (STEP) - Results of a Mixed Methods Study on Risk Perception of E-Cigarette Use During Pregnancy.
Conclusion When considering future prevention strategies, the potential health risks and disputed effectiveness of e-cigarettes as a tool for smoking cessation need to be taken into account and critically discussed. PMID: 33574625 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - February 14, 2021 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

COVID-19 Treatment: Drug Safety Prior to Conception and During Pregnancy and Breastfeeding.
Authors: Cavalcante MB, Cavalcante CTMB, Braga ACS, Andrade DA, Montenegro MA, Santos PAN, Motoyama PVP, Rocha MG, Dib LA, Araujo Júnior E Abstract In December 2019, a new viral respiratory infection known as coronavirus disease 2019 (COVID-19) was first diagnosed in the city of Wuhan, China. COVID-19 quickly spread across the world, leading the World Health Organization to declare it a pandemic on March 11, 2020. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a similar virus to those involved in other epidemics such as severe acute respiratory syndrome coronavirus...
Source: Geburtshilfe und Frauenheilkunde - January 26, 2021 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

17-Hydroxyprogesterone Caproate for the Prevention of Recurrent Preterm Birth - A Systematic Review and Meta-analysis Taking into Account the PROLONG Trial.
Conclusion Based on the currently available data, 17-OHPC cannot be recommended for the prevention of recurrent preterm birth. Further randomized, placebo-controlled studies with clearly defined, comparable risk factors are required to identify the group of pregnant women which could benefit from the use of 17-OHPC to prevent preterm birth. PMID: 33487666 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - January 26, 2021 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Outpatient Induction of Labor - Are Balloon Catheters an Appropriate Method?
Authors: Rath W, Stelzl P, Kehl S Abstract As the number of labor inductions in high-income countries has steadily risen, hospital costs and the additional burden on obstetric staff have also increased. Outpatient induction of labor is therefore becoming increasingly important. It has been estimated that 20 - 50% of all pregnant women requiring induction would be eligible for outpatient induction. The use of balloon catheters in patients with an unripe cervix has been shown to be an effective and safe method of cervical priming. Balloon catheters are as effective as the vaginal administration of prostaglandin E...
Source: Geburtshilfe und Frauenheilkunde - January 26, 2021 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Cell-free DNA Testing in Routine Practice: Characterisation of a Cohort with Positive Results for Trisomies, Sex Chromosome Anomalies and Microdeletions.
Conclusions Despite the excellent specificity of cfDNA tests, the PPV for aneuploidies other than T21 is low in routine practice. In discordance with the current guidelines, cfDNA test is often used without a previous detailed anomaly scan. Our data provide valuable information to assist patient counselling and shared decision making. PMID: 33487668 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - January 26, 2021 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

HyperEmesis Level Prediction (HELP Score) Identifies Patients with Indicators of Severe Disease: a Validation Study.
Conclusion This study provides a novel tool that should be implemented to determine the need for intervention for NVP that may be overlooked using PUQE or empirical assessment. PMID: 33487669 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - January 26, 2021 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Correction: Residual Axillary Burden After Neoadjuvant Chemotherapy (NACT) in Early Breast Cancer in Patients with a priori Clinically Occult Nodal Metastases - a transSENTINA Analysis.
Authors: Kolberg HC, Kühn T, Krajewska M, Bauerfeind I, Fehm TN, Fleige B, Helms G, Lebeau A, Stäbler A, Schmatloch S, Hauschild M, Schwentner L, Schrenk P, Loibl S, Untch M, Kolberg-Liedtke C Abstract [This corrects the article DOI: 10.1055/a-1298-3453.]. PMID: 33335331 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 20, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Treatment of Recurrent Epithelial Ovarian Cancer.
Authors: Claussen C, Rody A, Hanker L Abstract Epithelial ovarian cancer is the most common cause of death from gynecological tumors. Most patients with advanced ovarian cancer develop recurrence after concluding first-line therapy, making further lines of therapy necessary. The choice of therapy depends on various criteria such as tumor biology, the patient's general condition (ECOG), toxicity, previous chemotherapy, and response to chemotherapy. The platinum-free or treatment-free interval determines the potential response to repeat platinum-based therapy. If patients have late recurrence, i.e.> 6 month...
Source: Geburtshilfe und Frauenheilkunde - December 10, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Obesity in Gynecologic Oncology.
Authors: Kölbl H, Bartl T Abstract The decades-long global obesity epidemic has resulted in steady increase in the incidence of obesity-related malignancies. The associated diagnostic and therapeutic implications present a clinical challenge for gynecologic oncology treatment strategies. Recent studies have provided solid evidence for an independent, linear, positive correlation between a pathologically increased body mass index and the probability of developing endometrial or postmenopausal breast cancer. The pathogenesis is complex and the subject of current research. Proposed causes include pathologically i...
Source: Geburtshilfe und Frauenheilkunde - December 10, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Status of Sentinel Lymph Node Biopsy in Vulvar and Cervical Cancer.
Authors: Waldschmidt J, Jung L, Juhasz-Böss I Abstract Assessment of lymphatic metastasis is an essential component of solid tumour staging. Sentinel lymph node (SLN) biopsy is a minimally invasive procedure that allows regional lymph node involvement by tumour to be estimated by selectively examining the sentinel lymph node while minimising the morbidity of systematic lymph node dissection. Within the group of genital cancers, the diagnostic value of SLN biopsy is rated differently. For selected patients with early-stage vulvar cancer (unifocal primary tumour
Source: Geburtshilfe und Frauenheilkunde - December 10, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Pelvic Lymphadenectomy in Vulvar Cancer - Does it make sense?
Authors: Woelber L, Bommert M, Prieske K, Fischer I, Zu Eulenburg C, Vettorazzi E, Harter P, Jueckstock J, Hilpert F, de Gregorio N, Iborra S, Sehouli J, Ignatov A, Hillemanns P, Fuerst S, Strauss HG, Baumann K, Beckmann M, Mustea A, Meier W, Wimberger P, Hanker L, Canzler U, Fehm T, Luyten A, Hellriegel M, Kosse J, Heiss C, Hantschmann P, Mallmann P, Tanner B, Pfisterer J, Mahner S, Schmalfeldt B, Jaeger A Abstract Since the publication of the updated German guideline in 2015, the recommendations for performing pelvic lymphadenectomy (LAE) in patients with vulvar cancer (VSCC) have changed considerably. The guidel...
Source: Geburtshilfe und Frauenheilkunde - December 10, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Residual Axillary Burden After Neoadjuvant Chemotherapy (NACT) in Early Breast Cancer in Patients with a priori Clinically Occult Nodal Metastases - a transSENTINA Analysis.
Conclusions Patients in the SENTINA trial with clinically negative axilla and involved SLNs still carried a significant risk of nodal metastases after NACT. However, the risk of residual axillary burden was particularly low in TN and HER/2 positive tumors in case of a breast pCR. PMID: 33293731 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 10, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Correction: Treatment Landscape and Prognosis After Treatment with Trastuzumab Emtansine.
Authors: Laakmann E, Emons J, Taran FA, Janni W, Uhrig S, Overkamp F, Kolberg HC, Hadji P, Tesch H, Häberle L, Ettl J, Lüftner D, Wallwiener M, Schulmeyer C, Müller V, Beckmann MW, Belleville E, Wimberger P, Hielscher C, Kurbacher C, Wuerstlein R, Thomssen C, Untch M, Volz B, Fasching PA, Fehm TN, Wallwiener D, Brucker SY, Schneeweiss A, Lux MP, Hartkopf AD Abstract [This corrects the article DOI: 10.1055/a-1286-2917.]. PMID: 33262544 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 4, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Liquid Biopsy in Breast Cancer.
Authors: Banys-Paluchowski M, Krawczyk N, Fehm T Abstract In recent years, the blood-based analysis of circulating tumour cells (CTCs) and nucleic acids (DNA/RNA), otherwise known as liquid biopsy, has become increasingly important in breast cancer. Numerous trials have already underscored the high prognostic significance of CTC detection in both early and metastatic stages. Moreover, the changes in CTC levels and circulating tumour DNA (ctDNA) during the course of the disease correlate with the response to treatment. Research currently focuses on liquid-biopsy based therapeutic interventions in metastatic breast c...
Source: Geburtshilfe und Frauenheilkunde - November 13, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2020 Part 3 - Early Breast Cancer.
Authors: Huober J, Schneeweiss A, Hartkopf AD, Müller V, Lux MP, Janni W, Ettl J, Belleville E, Thill M, Fasching PA, Kolberg HC, Schulmeyer CE, Welslau M, Overkamp F, Tesch H, Fehm TN, Lüftner D, Schütz F, Wöckel A Abstract The treatment of patients with early breast cancer has always been characterised by escalation by new therapies and de-escalation through identification of better treatment regimens or introduction of better tools to estimate prognosis. Efforts in some of these areas in the last few years have led to solid data. The results of the large studies of de-escalation through use o...
Source: Geburtshilfe und Frauenheilkunde - November 13, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2020 Part 4 - Advanced Breast Cancer.
Authors: Tesch H, Müller V, Wöckel A, Ettl J, Belleville E, Schütz F, Hartkopf A, Thill M, Huober J, Fasching PA, Kolberg HC, Schulmeyer CE, Welslau M, Overkamp F, Fehm TN, Lux MP, Schneeweiss A, Lüftner D, Janni W Abstract Substances with good effectiveness that intervene in specific signalling pathways have been used increasingly in recent years in the treatment of patients with advanced breast cancer, and new therapies and approaches have now been added, which actually relate to quite specific changes, such as the treatment of patients with HR+/HER2 tumours with a PIK3CA mutation. The treatme...
Source: Geburtshilfe und Frauenheilkunde - November 13, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

HLA-J, a Non-Pseudogene as a New Prognostic Marker for Therapy Response and Survival in Breast Cancer.
Authors: Würfel FM, Wirtz RM, Winterhalter C, Taffurelli M, Santini D, Mandrioli A, Veltrup E, Rübner M, Fasching PA, Würfel W, Zamagni C Abstract The human leukocyte antigen (HLA) genes are cell-surface proteins, essential for immune cell interaction. HLA-G is known for their high immunosuppressive effect and its potential as predictive marker in breast cancer. However, nothing is known about the HLA-J and its immunosuppressive, prognostic and predictive features, as it is assumed to be a "pseudogene" by in silico sequence interpretation. HLA-J, ESR1, ERBB2, KRT5 and KRT20 mRNA expression ...
Source: Geburtshilfe und Frauenheilkunde - November 13, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Treatment Landscape and Prognosis After Treatment with Trastuzumab Emtansine.
Conclusions Therapy options after T-DM1 in a real-world setting seem to exhibit a relevant clinical efficacy, supporting the concept of continuous anti-HER2 treatments in the advanced therapy setting for breast cancer patients. Novel therapies are needed to improve the rather short median progression-free survival. PMID: 33173241 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - November 13, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Academisation of the Midwifery Profession and the Implementation of Higher Education in the Context of the New Requirements for Licensure.
Authors: Graf J, Simoes E, Blaschke S, Plappert CF, Hill J, Riefert MJ, Abele H Abstract The academization of the midwifery profession poses great challenges for Germany, especially due to the tight timelines: Corresponding courses of study can in principle be offered at both universities and technical colleges - although contrary to the recommendations of the Science Council. This means that there is a heterogeneity in midwifery qualifications and promotes a discussion regarding coherent study concepts. This process must be accompanied with great care so that midwifery courses of study are not designed to be of po...
Source: Geburtshilfe und Frauenheilkunde - October 6, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Fetal Growth Restriction - Diagnostic Work-up, Management and Delivery.
Authors: Schlembach D Abstract Fetal or intrauterine growth restriction (FGR/IUGR) affects approximately 5 - 8% of all pregnancies and refers to a fetus not exploiting its genetically determined growth potential. Not only a major cause of perinatal morbidity and mortality, it also predisposes these fetuses to the development of chronic disorders in later life. Apart from the timely diagnosis and identification of the causes of FGR, the obstetric challenge primarily entails continued antenatal management with optimum timing of delivery. In order to minimise premature birth morbidity, intensive fetal monitoring a...
Source: Geburtshilfe und Frauenheilkunde - October 6, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Lung Sonography in Obstetrics during COVID-19.
Authors: Recker F, Weber E, Strizek B, Gembruch U, Seibel A Abstract In the current coronavirus SARS-CoV-2 pandemic, certain patients are becoming seriously ill. Lung pathologies are common, and some patients even go on to develop acute respiratory distress syndrome (ARDS), which requires intubation and artificial respiration of the critically ill patient. Imaging of the lung is absolutely necessary to obtain a diagnosis, assess the course of disease and for treatment. Particularly in gynecology and obstetrics (OBGYN), ultrasound scans of the lung can be a useful additional tool when caring for pregnant patients in...
Source: Geburtshilfe und Frauenheilkunde - October 6, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Delivery of Twin Gestation ( ≥ 32.0 Weeks): The Vaginal Route as a Practicable and Safe Alternative to Cesarean Section.
Conclusion Vaginal delivery in twin pregnancies is a practicable and safe option in specific defined conditions and when the appropriate infrastructure and clinical experience is available. PMID: 33012835 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - October 6, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Current Approach for External Cephalic Version in Germany.
Conclusion The approach used in Germany to carry out external cephalic version is based on the (expired) German guideline on breech presentation. Based on the evidence obtained, a number of individual recommendations should be re-evaluated. More recent international guidelines could be useful to update the standard procedure. PMID: 33012836 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - October 6, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Significance of Preoperative Computed Tomography for Predicting Optimal Cytoreduction in Advanced Ovarian Cancer.
Conclusion Although risk parameters for suboptimal tumour reduction can be identified by CT of the abdomen, surgical exploration with histological confirmation of the diagnosis is essential because of the poor diagnostic accuracy. PMID: 32905205 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 11, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Expansile Endocervical Crypt Involvement by CIN2  - 3 as a Risk Factor for High Grade Cytology Recurrence After Cold Coagulation Cervical Treatment.
Conclusions Expansile ECI is a risk factor that increases the likelihood of high grade cytology recurrence following cold coagulation. Deeper pretreatment cervical punch biopsies need to be taken so as not to miss expansile ECI prior to ablative treatment. PMID: 32905285 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 11, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Prevalence of BRCA1 and BRCA2 Mutations in Patients with Primary Ovarian Cancer - Does the German Checklist for Detecting the Risk of Hereditary Breast and Ovarian Cancer Adequately Depict the Need for Consultation?
Conclusions The BRCA1/2 mutation prevalence in EOC patients positively correlates with a rising checklist score. Already with singular EOC, the prevalence of a BRCA1/2 mutation exceeds the required 10% threshold. Our data support the recommendation of the S3 guidelines Ovarian Cancer of offering genetic testing to all patients with EOC. Optimisation of the checklist with clear identification of the testing indication in this population should therefore be aimed for. PMID: 32905297 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 11, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Trastuzumab Biosimilars in the Therapy of Breast Cancer - "Real World" Experiences from four Bavarian University Breast Centres.
Trastuzumab Biosimilars in the Therapy of Breast Cancer - "Real World" Experiences from four Bavarian University Breast Centres. Geburtshilfe Frauenheilkd. 2020 Sep;80(9):924-931 Authors: Hester A, Gaß P, Fasching PA, Krämer AK, Ettl J, Diessner J, Wöckel A, Egger T, Stock K, Redlin J, Andraschko M, Harbeck N, Würstlein R Abstract Introduction With the introduction of the first trastuzumab biosimilar in the summer of 2018, biosimilar antibodies for breast cancer have found their way into the area of gynaecological oncology. The switch of anti-human epidermal growth factor...
Source: Geburtshilfe und Frauenheilkunde - September 11, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Statement of the AGO and AG-CPC on the Aftercare/Follow-up for Surgical Procedures of the Lower Genital Tract after the Introduction of a New Cancer Screening Guideline.
Authors: Hillemanns P, Tempfer C, Beckmann MW, Küppers V, Quaas J Abstract The new guideline on organized cancer screening programs has been in force in Germany since January 1st, 2020. The guideline has amended earlier recommendations on cytological examinations, which were previously carried out annually during screening. The guidelines-based recommendations on the appropriate follow-up for preinvasive and invasive lesions of the uterine cervix and endometrium are briefly outlined and differentiated from screening cytology and Pap/HPV co-testing as described in the guideline on organized cancer screening pro...
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

COVID-19 During Pregnancy and Puerperium - A Review by the Austrian Society of Gynaecology and Obstetrics (OEGGG).
Authors: Klaritsch P, Ciresa-König A, Pristauz-Telsnigg G, board of the OEGGG Abstract After the first case of COVID-19 pneumonia was reported in Wuhan, Hubei Province, China, in December 2019, the infection quickly spread to the rest of China and then to the wider world. The available information on pregnant women infected with COVID-19 is now significantly greater. There are now several case series and systematic reviews of cohorts, some of which include more than 100 cases. This review evaluates the scientific literature available until May 1, 2020 and discusses common questions about COVID-19 in the conte...
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Pregnancy Outcomes Following Letrozole Use in Frozen-thawed Embryo Transfer Cycles: A Systematic Review and Meta-analysis.
Authors: Chen D, Shen X, Fu Y, Ding C, Zhong Y, Zhou C Abstract While widely used for ovulation induction in assisted reproductive technology, the clinical efficacy of letrozole for endometrial preparation prior to frozen-thawed embryo transfer (FET) cycles remains yet to be elucidated. We performed a meta-analysis to compare pregnancy outcomes after letrozole use with those of other endometrial preparation protocols in patients undergoing FET. PubMed, Scopus, Embase and the Cochrane Library were searched for eligible studies. Clinical pregnancy rate (CPR), live birth rate (LBR) and birth defect rate (BDR) were ana...
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Sociodemographic Differences in Health Awareness and Oral Health in Pregnant Women.
Conclusion The rate of awareness of the risks and consequences of pregnancy for oral health must be increased. The main aim for primary prophylaxis should be a reduction in the periodontal bacteria and caries of the mother and father. PMID: 32817990 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Impact of Transferring a Poor Quality Embryo Along with a Good Quality Embryo on Pregnancy Outcomes in IVF/ICSI Cycles: a Retrospective Study.
Conclusion DET with mixed quality embryos results with lower clinical pregnancy and live birth rates compared with DET with two good quality embryos at the blastocyst stage. At cleavage stage transfer, there is no difference in live birth rates between the two groups. PMID: 32817991 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Tacrolimus Improves the Implantation Rate in Patients with Elevated Th1/2 Helper Cell Ratio and Repeated Implantation Failure (RIF).
Conclusions Our findings suggest that RIF patients with a higher Th1/Th2 ratio could be candidates for tacrolimus therapy and that this immunosuppressive drug could be acting through upregulation of LIF, IL-10, and IL-17. PMID: 32817992 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 22, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Correction: Hydroxychloroquine as a Preventive and Therapeutic Option in Preeclampsia - a Literature Review.
Authors: Deharde D, Klockenbusch W, Schmitz R, Brand M, Köster HA, Oelmeier de Murcia K PMID: 32792706 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 16, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Hydroxychloroquine as a Preventive and Therapeutic Option in Preeclampsia - a Literature Review.
Authors: Deharde D, Klockenbusch W, Schmitz R, Brand M, Köster HA, de KO Abstract Preeclampsia is one of the most feared complications of pregnancy and puerperium and represents a serious threat to mother and child. In addition, a history of preeclampsia increases the risk of future cardiovascular events. New diagnostic and therapeutic approaches are needed. New therapeutic options are currently being discussed, one of which is the administration of hydroxychloroquine. It is an antimalarial drug which is also used to treat rheumatological disease and its use in pregnancy is considered safe. A reduced incidence...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Rare Ectopic Pregnancies - A Literature Review for the Period 2007  - 2019 on Locations Outside the Uterus and Fallopian Tubes.
We present an overview of potential very rare locations of ectopic pregnancies, their symptoms, diagnosis and treatment, based on a systematic analysis of case reports. A literature review of the databases PubMed, Livivo and Google Scholar for the period 2007 to 2019 was carried out. A total of 113 publications were included in our review. These studies describe EP implantations in the posterior cul-de-sac, on the uterine serosa and uterine ligaments, in the vicinity of almost all intraperitoneal organs, on the abdominal wall as well as in retroperitoneal sites. The most common presenting symptom was abdominal pain occurri...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Continuous Body Temperature Monitoring to Improve the Diagnosis of Female Infertility.
Conclusions Continuous body temperature monitoring with a vaginal biosensor can improve the standard diagnostic procedures used to determine ovulatory dysfunction, especially if dysfunction is due to luteal phase deficiency and polycystic ovary syndrome. Analysis of the lowest daily body temperature combined with the basal body temperature measurements used in fertility awareness methods may be equieffective to continuous body temperature measurements with OvulaRing. The results of this study show that a revised diagnostic approach using fewer hormonal assessments combined with continuous body temperature monitoring can re...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Factors Influencing Success Rate of Intracytoplasmic Sperm Injection with Azoospermic Male Patients.
Authors: Rehnitz J, Rösner S, Harsch J, Dietrich J, Bruckner T, Capp E, Strowitzki T, Germeyer A Abstract Introduction Azoospermia affects about 1% of men, of whom up to 15% inquire about infertility treatment. Information about predictive factors for these couples is very limited. Patients, Materials and Methods We performed a retrospective analysis of the clinical records of 118 cycles of intracytoplasmic sperm injection treatment after testicular sperm extraction for male azoospermia carried out between January 2008 and October 2015. Of those, 66 were first, 35 second, and 17 third cycles. Statistical signi...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Factors Influencing Postoperative Recovery and Time Off Work of Patients with Benign Indications for Surgery - Results of a Prospective Study.
Authors: Strozyk S, Wernecke KD, Sehouli J, David M Abstract Objectives The study aimed to answer a number of questions: Which medical, psychological and sociodemographic factors affect the recovery of women after gynecological surgery for benign indications? Does patients' health-related quality of life improve after surgical intervention? How long are patients signed off work postoperatively? How do patients assess their own capacity to work? Method Study population: All women between the ages of 18 and 67 years who underwent gynecological surgery for benign indications at the Charité Campus Virchow Clinic...
Source: Geburtshilfe und Frauenheilkunde - July 19, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

ABC5 International Consensus Conference on Advanced Breast Cancer, Lisbon, 16 November 2019: Commentary by the German panel of experts on the ABC5 voting results.
We present a commentary on the voting results of the ABC5 panelists in Lisbon by a working group of German breast cancer specialists together with the implications for routine clinical care in Germany. The commentary is based on the recommendations of the Breast Commission of the German Gynecological Oncology Working Group (AGO). This commentary is useful, it includes country-specific features for the ABC consensus. PMID: 32565549 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Association between Obesity and Premenopausal Breast Cancer According to Intrinsic Subtypes - a Systematic Review.
Conclusion Higher BMI might influence aggressive tumor characteristics among premenopausal women and has divergent impacts on the risk of different breast cancer subtypes. Further research is needed to confirm these results and to evaluate potential pathophysiologic mechanisms for the relationship between obesity and aggressive premenopausal breast cancer subtypes. PMID: 32565550 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - June 23, 2020 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research