Updated Opinion of the Uterus Commission of the Gynecological Oncology Working Group (AGO) and the Gynecological Endoscopy Working Group (AGE) of the German Society of Gynecology and Obstetrics (DGGG) on the Randomized Study Comparing Minimally Invasive with Abdominal Radical Hysterectomy for Early-stage Cervical Cancer (LACC).
Authors: Hillemanns P, Brucker S, Holthaus B, Kimmig R, Lampe B, Runnebaum I, Ulrich U, Wallwiener M, Fehm T, Tempfer C, AGO Uterus and the AGE of the DGGG Abstract In this opinion on the randomized study comparing minimally invasive with abdominal radical hysterectomy for early-stage cervical cancer (LACC), the Uterus Commission of the Gynecological Oncology Working Group (AGO) and the Gynecological Endoscopy Working Group (AGE) of the Germany Society of Gynecology and Obstetrics (DGGG) state that, based on their examination of the published data, patients with FIGO stage IA1 (with LVSI), IA2 or IB1 cervical canc...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Prevention of Cervical Cancer: Guideline of the DGGG and the DKG (S3 Level, AWMF Register Number 015/027OL, December 2017) - Part 1 with Introduction, Screening and the Pathology of Cervical Dysplasia.
Authors: Hillemanns P, Friese K, Dannecker C, Klug S, Seifert U, Iftner T, Hädicke J, Löning T, Horn L, Schmidt D, Ikenberg H, Steiner M, Freitag U, Siebert U, Sroczynski G, Sauerbrei W, Beckmann MW, Gebhardt M, Friedrich M, Münstedt K, Schneider A, Kaufmann A, Petry KU, Schäfer APA, Pawlita M, Weis J, Mehnert A, Fehr M, Grimm C, Reich O, Arbyn M, Kleijnen J, Wesselmann S, Nothacker M, Follmann M, Langer T, Jentschke M Abstract Aims Annual opportunistic screening for cervical carcinoma has been carried out in Germany since 1971. The creation of this S3 guideline meets an important need, outlined...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Prevention of Cervical Cancer: Guideline of the DGGG and the DKG (S3 Level, AWMF Register Number 015/027OL, December 2017) - Part 2 on Triage, Treatment and Follow-up.
Authors: Hillemanns P, Friese K, Dannecker C, Klug S, Seifert U, Iftner T, Hädicke J, Löning T, Horn L, Schmidt D, Ikenberg H, Steiner M, Freitag U, Siebert U, Sroczynski G, Sauerbrei W, Beckmann MW, Gebhardt M, Friedrich M, Münstedt K, Schneider A, Kaufmann A, Petry KU, Schäfer APA, Pawlita M, Weis J, Mehnert A, Fehr M, Grimm C, Reich O, Arbyn M, Kleijnen J, Wesselmann S, Nothacker M, Follmann M, Langer T, Jentschke M Abstract Aims Annual opportunistic screening for cervical carcinoma has been done in Germany since 1971. The creation of this S3 guideline meets an important need, outlined in the...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Circulating and Disseminated Tumour Cells in Breast Carcinoma: Report from the Consensus Conference on Tumour Cell Dissemination during the 38th Annual Meeting of the German Society of Senology, Berlin, 14 June 2018.
Authors: Banys-Paluchowski M, Hartkopf A, Meier-Stiegen F, Janni W, Solomayer EF, Fehm T Abstract Haematogenic dissemination of tumour cells in breast carcinoma is among the most intensively researched areas in translational oncology. Large meta-analyses have shown the prognostic relevance of the disseminated tumour cells in the bone marrow and circulating tumour cells in the peripheral blood in the adjuvant as well as metastatic setting. The current status of the research was discussed in detail during the annual meeting of the German Society of Senology in Berlin. The following conference report gives an overview...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Mechanisms of Metastasis and Cell Mobility - The Role of Metabolism.
Authors: Gründker C, Läsche M, Hellinger JW, Emons G Abstract Tumour metastasis is responsible for more than 90% of tumour-associated mortality. About one third of breast cancer patients in the early stage develop metastases. The transformation in tumour development referred to as the "metastatic cascade" or "metastatic cycle" is a complex and multi-stage event. While it is generally recognised that epithelial-mesenchymal transformation (EMT) plays a crucial role in cancer progression and metastasis, the metabolic events in this process have received little attention to date. We would ...
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Treatment of Cervical Dysplasia by Clinicians Who Perform Colposcopy in German-speaking Countries - a Questionnaire-based Study.
Conclusion A differential colposcopy with two colposcopically targeted biopsies and treatment with the electrosurgical loop are the methods most frequently used by clinicians who perform colposcopy in Germany. A uniform procedure should be defined in detail within the scope of directives or guidelines. PMID: 30792549 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

The Prognostic Impact of Grading in FIGO IB and IIB Squamous Cell Cervical Carcinomas.
Conclusion A binary grading model for the conventional tumor grade (based on the degree of keratinization) in SCC of the uterine cervix may be suitable for the prognostic survival evaluation but failed to predict pelvic lymph node involvement. PMID: 30792550 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - February 23, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Mindfulness-based Stress Reduction in Pregnancy: an App-Based Programme to Improve the Health of Mothers and Children (MINDFUL/PMI Study).
Authors: Lenz B, Eichler A, Schwenke E, Buchholz VN, Hartwig C, Moll GH, Reich K, Mühle C, Volz B, Titzmann A, Beckmann MW, Heinrich H, Kornhuber J, Fasching PA Abstract Unfavourable intrauterine environmental factors increase the risk of delivery complications as well as postpartum developmental and behavioural problems in children and adolescents with ongoing effects into older age. Biomarker studies show that maternal stress and the use of alcohol and tobacco during pregnancy are associated with a higher intrauterine testosterone exposure of the child. The antenatal testosterone load, in turn, is a risk fac...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Concept Paper on the Technique of Cryopreservation, Removal and Transplantation of Ovarian Tissue for Fertility Preservation.
Authors: Beckmann MW, Lotz L, Toth B, Baston-Büst DM, Fehm T, Frambach T, Germeyer A, Goeckenjan M, Häberlin F, Henes M, Hirchenhain J, Hübner S, Korell M, Krüssel JS, Müller A, Reinsberg J, Schwab R, Seitz S, Sütterlin M, van der Ven H, van der Ven K, Winkler-Crepaz K, Wimberger P, von Wolff M, Liebenthron J, Dittrich R Abstract The cryopreservation of ovarian tissue with subsequent transplantation of the tissue represents an established method of fertility protection for female patients who have to undergo gonadotoxic therapy. The procedure can be performed at any point in the cycle ...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Can a University Reproductive Medicine Centre Be Financed Under the Pre-Existing General Conditions in Germany?
Discussion From the perspective of a university reproductive medicine centre, IVF and ICSI treatments currently cannot be performed in a cost-covering manner. At the same time, a reproductive medicine treatment cycle represents a significant financial burden on the patient couple due to only partial cost coverage by most statutory health insurance funds. This therefore demonstrates a need for action in health policy to revise and, in the interest of the patient couples, reproductive medicine centres and, not least of all, in the interest of society, to improve existing cost absorption policies and thus also benefit from th...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Fertility After Ovarian Cystectomy: How Does Surgery Affect IVF/ICSI Outcomes?
Authors: Gomez R, Schorsch M, Gerhold-Ay A, Hasenburg A, Seufert R, Skala C Abstract Introduction For patients considering undergoing assisted reproductive techniques (ART), many concerns arise when persistent ovarian cysts are found. This large study aimed to determine how ovarian cyst removal affects success rates of IVF/ICSI therapies. Methods 550 patients who underwent an IVF/ICSI treatment between 2002 and 2011 with a persistent ovarian cyst ≤ 5 cm before treatment were analyzed retrospectively. 328 patients' preference was to undergo a laparoscopic cystectomy and 222 patients opted for a cons...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Obesity Does not Compromise Ovarian Reserve Markers in Infertile Women.
Authors: Gorkem U, Kucukler FK, Togrul C, Gulen Ş Abstract Introduction In the literature, conflicting results from studies examining the relationship between obesity and ovarian reserve have been reported. The purpose of the study is to investigate whether obesity adversely affects serum concentrations of ovarian reserve markers in infertile women with different ovarian reserve status. Materials and Methods A total of 402 women were assigned to three groups according to body mass index (BMI;
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Follicular Fluid Levels of Adrenomedullin 2, Vascular Endothelial Growth Factor and its Soluble Receptors Are Associated with Ovarian Response During ART Cycles.
Authors: Ranjbaran A, Nejabati HR, Ghasemnejad T, Latifi Z, Hamdi K, Hajipour H, Raffel N, Bahrami-Asl Z, Hakimi P, Mihanfar A, Nouri M, Fattahi A Abstract Introduction Adrenomedullin 2 (ADM2) and vascular endothelial growth factor (VEGF) affect ovarian function, especially angiogenesis and follicular development. The actions of VEGF can be antagonized by its soluble receptors, soluble Fms-like tyrosine kinase-1 (sFlt-1) and soluble VEGF receptor 2 (sVEGFR-2), as they decrease its free form. In the present study, we evaluated the relationship between follicular fluid (FF) levels of AMD2, VEGF and its soluble recept...
Source: Geburtshilfe und Frauenheilkunde - January 30, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Fertility, Pregnancy and Lactation After Bariatric Surgery - a Consensus Statement from the OEGGG.
Authors: Stopp T, Falcone V, Feichtinger M, Göbl C Abstract Bariatric surgery is recommended when other weight loss interventions, such as lifestyle modification or medications, have failed. A considerable number of women undergoing bariatric surgery are of childbearing age; hence, it is necessary to be aware of the effects of bariatric surgery on pregnancy for managing these patients. Although bariatric surgery is associated with positive effects on cardiovascular and metabolic parameters, side effects such as anaemia, the risk of developing internal hernia, altered glucose metabolism and the risk of small fo...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Statement by the OEGGG with Review of the Literature on the Mode of Delivery of Premature Infants at the Limit of Viability.
Authors: Fischer T, Mörtl M, Reif P, Kiss H, Lang U, Austrian Society for Gynaecology and Obstetrics (OEGGG) Abstract In 2017, the Austrian Society for Paediatric and Adolescent Medicine (ÖGKJ) published a guideline on the primary care of premature infants at the limit of viability. In this guideline, it is recommended that a Caesarean section be preferred as mode of delivery with regard to an early preterm birth (22 + 0 - 24 + 6 weeks of pregnancy) due to an allegedly lower perinatal risk of cerebral haemorrhage. In contrast to this, the Austrian Society for Gynaecology a...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Acute Tocolysis - a Critical Analysis of Evidence-Based Data.
The objective is to prolong the pregnancy by at least 48 hours to complete foetal lung maturation and for the in-utero transfer of the pregnant woman to a perinatal centre. The indication for tocolysis is regular, premature contractions (≥ 4/20 min) and a dynamic shortening of the cervical length/cervical opening between 22 + 0 to 33 + 6 weeks of pregnancy. In this connection, the cervical length measured on ultrasound and the determination of biomarkers in the cervicovaginal secretions can be important decision-making aids. Beta sympathomimetics should no longer be used due to ...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Cardiomyopathies and Congenital Heart Disease in Pregnancy.
Authors: Westhoff-Bleck M, Hilfiker-Kleiner D, Pankuweit S, Schieffer B Abstract Pregnancy-associated diseases of the cardiovascular system occur in up to 10% of all pregnancies and the incidence is increasing. Besides congenital heart disease or pre-existing cardiomyopathy in the mother, the clinical focus has moved especially to peripartum cardiomyopathy (PPCM) because of the condition's dramatic clinical course and the identification of the underlying mechanisms. This review article concentrates therefore on PPCM, which occurs either in the last month of pregnancy or in the first 6 months following delivery in w...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Diet and Lifestyle Before and During Pregnancy - Practical Recommendations of the Germany-wide Healthy Start - Young Family Network.
Authors: Koletzko B, Cremer M, Flothkötter M, Graf C, Hauner H, Hellmers C, Kersting M, Krawinkel M, Przyrembel H, Röbl-Mathieu M, Schiffner U, Vetter K, Weißenborn A, Wöckel A Abstract Diet and exercise before and during pregnancy affect the course of the pregnancy, the child's development and the short- and long-term health of mother and child. The Healthy Start - Young Family Network has updated the recommendations on nutrition in pregnancy that first appeared in 2012 and supplemented them with recommendations on a preconception lifestyle. The recommendations address body weight before conce...
Source: Geburtshilfe und Frauenheilkunde - January 20, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Gestational Diabetes Mellitus (GDM) - Diagnosis, Treatment and Follow-Up. Guideline of the DDG and DGGG (S3 Level, AWMF Registry Number 057/008, February 2018).
Authors: Schäfer-Graf UM, Gembruch U, Kainer F, Groten T, Hummel S, Hösli I, Grieshop M, Kaltheuner M, Bührer C, Kautzky-Willer A, Laubner K, Bancher-Todesca D Abstract A team of experts from the fields of gynaecology and obstetrics, diabetology, internal medicine, paediatrics and midwifery from Germany, Austria and Switzerland produced a new version of the existing S3 guideline on gestational diabetes. It replaces the recommendations of the German Association for Gynaecology and Obstetrics and the German Diabetes Association on the diagnosis and treatment of gestational diabetes from 2011 and is val...
Source: Geburtshilfe und Frauenheilkunde - January 18, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Joint Guideline of the OEGGG, AGO, AGK and ÖGZ on the Diagnosis and Treatment of Cervical Intraepithelial Neoplasia and Appropriate Procedures When Cytological Specimens Are Unsatisfactory.
Joint Guideline of the OEGGG, AGO, AGK and ÖGZ on the Diagnosis and Treatment of Cervical Intraepithelial Neoplasia and Appropriate Procedures When Cytological Specimens Are Unsatisfactory. Geburtshilfe Frauenheilkd. 2018 Dec;78(12):1232-1244 Authors: Reich O, Braune G, Eppel W, Fiedler T, Graf A, Hefler L, Joura E, Kölbl H, Marth C, Pokieser W, Regitnig P, Reinthaller A, Tamussino K, Widschwendter A, Zeimet A, Kohlberger P Abstract Purpose On January 1st, 2018, the ÖGZ (Austrian Society of Cytology) revised its cytological nomenclature to make it more similar to the 2015 Bethesda system...
Source: Geburtshilfe und Frauenheilkunde - January 18, 2019 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 2 with Recommendations for the Therapy of Primary, Recurrent and Advanced Breast Cancer.
Authors: Wöckel A, Festl J, Stüber T, Brust K, Krockenberger M, Heuschmann PU, Jírů-Hillmann S, Albert US, Budach W, Follmann M, Janni W, Kopp I, Kreienberg R, Kühn T, Langer T, Nothacker M, Scharl A, Schreer I, Link H, Engel J, Fehm T, Weis J, Welt A, Steckelberg A, Feyer P, König K, Hahne A, Baumgartner T, Kreipe HH, Knoefel WT, Denkinger M, Brucker S, Lüftner D, Kubisch C, Gerlach C, Lebeau A, Siedentopf F, Petersen C, Bartsch HH, Schulz-Wendtland R, Hahn M, Hanf V, Müller-Schimpfle M, Henscher U, Roncarati R, Katalinic A, Heitmann C, Honegger C, Paradies K, Bjelic-Radisic V, Degenh...
Source: Geburtshilfe und Frauenheilkunde - December 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Number 032/034-OL, April 2018) - Part 2 with Recommendations on the Therapy and Follow-up of Endometrial Cancer, Palliative Care, Psycho-oncological/Psychosocial Care/Rehabilitation/Patient Information and Healthcare Facilities.
Authors: Emons G, Steiner E, Vordermark D, Uleer C, Bock N, Paradies K, Ortmann O, Aretz S, Mallmann P, Kurzeder C, Hagen V, van Oorschot B, Höcht S, Feyer P, Egerer G, Friedrich M, Cremer W, Prott FJ, Horn LC, Prömpeler H, Langrehr J, Leinung S, Beckmann MW, Kimmig R, Letsch A, Reinhardt M, Alt-Epping B, Kiesel L, Menke J, Gebhardt M, Steinke-Lange V, Rahner N, Lichtenegger W, Zeimet A, Hanf V, Weis J, Mueller M, Henscher U, Schmutzler RK, Meindl A, Hilpert F, Panke JE, Strnad V, Niehues C, Dauelsberg T, Niehoff P, Mayr D, Grab D, Kreißl M, Witteler R, Schorsch A, Mustea A, Petru E, Hübner J, Rose AD,...
Source: Geburtshilfe und Frauenheilkunde - December 27, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2018 (Part 3) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer.
Authors: Wöckel A, Lux MP, Janni W, Hartkopf AD, Nabieva N, Taran FA, Overkamp F, Hadji P, Tesch H, Ettl J, Lüftner D, Müller V, Welslau M, Belleville E, Brucker SY, Schütz F, Fasching PA, Fehm TN, Schneeweiss A, Kolberg HC Abstract In primary early breast cancer, the aim of treatment planning is to obtain an increasingly better understanding of the disease. The identification of patients with an excellent prognosis could help this group avoid unnecessary treatments. Furthermore, the planning of treatment is becoming increasingly patient-focussed. There is a growing understanding of those patien...
Source: Geburtshilfe und Frauenheilkunde - December 2, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Update Breast Cancer 2018 (Part 4) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Treatment Strategies for Advanced Breast Cancer.
Authors: Müller V, Wöckel A, Lux MP, Janni W, Hartkopf AD, Nabieva N, Taran FA, Hadji P, Tesch H, Ettl J, Lüftner D, Welslau M, Belleville E, Brucker SY, Schütz F, Fasching PA, Fehm TN, Kolberg HC, Schneeweiss A, Overkamp F Abstract New therapeutic developments aimed at treating women with advanced breast cancer currently focus both on identifying patients eligible for targeted therapeutic concepts and on the continuing development of immune therapies. The data on CDK4/6 inhibitors are now complete and consistent in this class of substances (palbociclib, ribociclib and abemaciclib). Further path...
Source: Geburtshilfe und Frauenheilkunde - December 2, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Supportive Infusions in Integrative Breast and Gynecological Oncology - Report on Patients' Satisfaction and Self-reported Effects and Side Effects.
Conclusions Therapy with IMed infusions in women with BC or gynecological cancer requires the same standards set for drug therapy. Although vitamins represent dietary supplements, appropriate assessment of the patient's medical history is needed and patients must receive appropriate information. For this purpose, standardized processes, as in the context of an IMed consultancy service, are helpful. PMID: 30498280 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - December 2, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Axillary Surgery in Breast Cancer Patients Treated with Breast-Conserving Surgery at German Breast Cancer Centers Within the Last 14 Years - Comparison of a University Center and a Community Hospital.
Authors: de Gregorio A, Widschwendter P, Albrecht S, de Gregorio N, Friedl TWP, Huober J, Janni W, Ebner FK Abstract Background Guideline recommendations for axillary surgical approach in breast cancer (BC) treatment changed over the last decade. Methods Data from all invasive BC patients (n = 5344) treated with breast conserving surgery (BCS) at the breast cancer centers of the University Hospital Ulm (U-BCC) and the community hospital Dachau (D-BCC) were included into a retrospective analysis for assessing information on axillary surgery between 2003 and 2016 based on the documented cancer registry ...
Source: Geburtshilfe und Frauenheilkunde - December 2, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 1 with Recommendations for the Screening, Diagnosis and Therapy of Breast Cancer.
Authors: Wöckel A, Festl J, Stüber T, Brust K, Stangl S, Heuschmann PU, Albert US, Budach W, Follmann M, Janni W, Kopp I, Kreienberg R, Kühn T, Langer T, Nothacker M, Scharl A, Schreer I, Link H, Engel J, Fehm T, Weis J, Welt A, Steckelberg A, Feyer P, König K, Hahne A, Kreipe HH, Knoefel WT, Denkinger M, Brucker S, Lüftner D, Kubisch C, Gerlach C, Lebeau A, Siedentopf F, Petersen C, Bartsch HH, Schulz-Wendtland R, Hahn M, Hanf V, Müller-Schimpfle M, Henscher U, Roncarati R, Katalinic A, Heitmann C, Honegger C, Paradies K, Bjelic-Radisic V, Degenhardt F, Wenz F, Rick O, Hölzel D, Zaiss M,...
Source: Geburtshilfe und Frauenheilkunde - October 31, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Possible Reasons for Discontinuation of Therapy: an Analysis of 571  071 Treatment Cycles From the German IVF Registry.
Conclusion The results make it possible to provide couples with individual counselling. They offer an option for preparing for the emotional and physical hurdles. PMID: 30364331 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - October 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Management of Urethral Lesions and Urethrovaginal Fistula Formation Following Placement of a Tension-Free Suburethral Sling: Evaluation From a University Continence and Pelvic Floor Centre.
Conclusion The rare but relevant complications of a urethral erosion, transurethral tape position or urethrovaginal fistula formation status post TVT/TOT placement can be successfully managed via vaginal surgery. Persistent postoperative urinary incontinence with the need for a two-phase repeat TVT placement following sufficient wound healing must be preoperatively clarified. PMID: 30364366 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - October 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. Guideline (S3-Level, AWMF Registry Nummer 032/034-OL, April 2018) - Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer.
Authors: Emons G, Steiner E, Vordermark D, Uleer C, Bock N, Paradies K, Ortmann O, Aretz S, Mallmann P, Kurzeder C, Hagen V, van Oorschot B, Höcht S, Feyer P, Egerer G, Friedrich M, Cremer W, Prott FJ, Horn LC, Prömpeler H, Langrehr J, Leinung S, Beckmann MW, Kimmig R, Letsch A, Reinhardt M, Alt-Epping B, Kiesel L, Menke J, Gebhardt M, Steinke-Lange V, Rahner N, Lichtenegger W, Zeimet A, Hanf V, Weis J, Mueller M, Henscher U, Schmutzler RK, Meindl A, Hilpert F, Panke JE, Strnad V, Niehues C, Dauelsberg T, Niehoff P, Mayr D, Grab D, Kreißl M, Witteler R, Schorsch A, Mustea A, Petru E, Hübner J, Rose AD,...
Source: Geburtshilfe und Frauenheilkunde - October 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Low-grade Serous Ovarian Carcinoma.
Authors: Ricciardi E, Baert T, Ataseven B, Heitz F, Prader S, Bommert M, Schneider S, du Bois A, Harter P Abstract In the early 2000s a two-tier grading system was introduced for serous ovarian cancer. Since then, we have increasingly come to accept that low-grade serous ovarian carcinoma (LGSOC) is a separate entity with a unique mutational landscape and clinical behaviour. As less than 10% of serous carcinomas of the ovary are low-grade, they are present in only a small number of patients in clinical trials for ovarian cancer. Therefore the current treatment of LGSOC is based on smaller trials, retrospective seri...
Source: Geburtshilfe und Frauenheilkunde - October 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Situation of Adolescent Contraceptive Use in Germany.
This article presents the data from the subset of adolescent girls aged 14 to 19 years (n = 2699) out of the total of 18 521 women surveyed. Results The girls surveyed were familiar with at least the name of more than five different methods of contraception (average 5.3). The doctors assumed that the respondents would know only 4.2 different methods. When asked explicitly about how the individual methods of contraception work, clear deficits became evident. This applies not only to the entire population of respondents, but also the users of the respective contraceptive method. In addition, a strong interest...
Source: Geburtshilfe und Frauenheilkunde - October 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Statement of the Uterus Committee of the Gynaecological Oncology Working Group (AGO) on the PORTEC-3 study.
Authors: Emons G, Tempfer C, Battista MJ, Mustea A, Vordermark D Abstract The data on the adjuvant therapy of endometrial cancer (EC) are inconsistent. Recent studies of this topic such as PORTEC-3, GOG-258 and GOG-249 investigated the value of adjuvant radiotherapy, adjuvant chemotherapy and combined adjuvant chemoradiotherapy followed by chemotherapy in patients with endometrial cancer and an increased risk of recurrence. With this statement, the Uterus Committee of the Gynaecological Oncology Working Group (AGO) wishes therefore to interpret the new data and discuss them against the background of the new S3 guid...
Source: Geburtshilfe und Frauenheilkunde - October 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Gestational Diabetes - Major New Clinically Relevant Aspects.
Authors: Schäfer-Graf UM Abstract The implementation of screening for gestational diabetes (GDM) in the German Prenatal Care guidelines of 2012 and the publication of numerous new studies have led to clinically relevant changes in the care of pregnant women with GDM to whom consideration was given in the new S3 Guideline on the Diagnosis, Management and Follow-up of Gestational Diabetes (AWMF 057/008) published in March this year. Certain aspects are addressed and discussed on the basis of additional background information. PMID: 30364451 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - October 28, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Correction: Placenta - Worth Trying? Human Maternal Placentophagy: Possible Benefit and Potential Risks.
Authors: Johnson SK, Pastuschek J, Rödel J, Markert UR, Groten T PMID: 30344334 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - October 23, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion.
Authors: Zhao X, Jiang Y, Wang L, Li Z, Li Q, Feng X Abstract Recurrent spontaneous abortion is a global problem, and unexplained recurrent abortion triggered by immunological factors is an important focus of current research. Helper T lymphocytes (Th cells) and regulatory T lymphocytes (Treg cells) are central in human immune regulation and play a complex role in pregnancy. Natural killer cells (NK cells) exist in the endometrium and cooperate with T lymphocytes to create immune tolerance at the maternal-fetal interface, which is essential for successful pregnancy. This review has analyzed studies on Th17 cell, Tr...
Source: Geburtshilfe und Frauenheilkunde - September 29, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Placenta - Worth Trying? Human Maternal Placentophagia: Possible Benefit and Potential Risks.
Authors: Johnson SK, Pastuschek J, Rödel J, Markert UR, Groten T Abstract The use of placenta preparations as an individual puerperal remedy can be traced back to historical, traditional practices in Western and Asian medicine. To evaluate the ingestion of processed placenta as a puerperal remedy, the potential risks (trace elements, microorganisms) and possible benefit (hormones in the placental tissue) of such a practice are discussed in this article based on a literature review. PMID: 30258243 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 29, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Changes in the Detection and Management of Foetal Trisomies over Time.
Conclusion The time of intrauterine diagnosis of trisomy 21/18/13 has not changed in the past 10 years. The frequency of termination of a pregnancy increased slightly and the time of termination remained unchanged. PMID: 30258244 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 29, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Foetal Doppler Parameters as a Prognostic Marker Before Induction of Labour.
Authors: Widschwendter P, Lato K, Friedl TWP, Janni W, Friebe-Hoffmann U Abstract Introduction The value of foetal Doppler ultrasonography before induction of labour for prognostic assessment of the duration of labour and foetal outcome is presented. Patients and Methods Doppler ultrasound of the foetal middle cerebral artery (MCA) and of the umbilical artery (UA) was performed in addition to evaluation of the Bishop score in 49 women around the expected date of confinement (38 + 0 - 42 + 0 weeks of gestation) prior to planned pharmacological induction of labour. These parameters wer...
Source: Geburtshilfe und Frauenheilkunde - September 29, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum.
Conclusion The findings of this study support the hypothesis that GDF15 is involved in the pathogenesis of both familial and recurrent cases of HG. The findings may be applicable when counseling women with a familial history of HG or recurrent HG. The GDF15-GFRAL brainstem-activated pathway was recently identified and therapies to treat conditions of abnormal appetite are under development. Based on our findings, patients carrying GDF15 variants associated with GDF15 overexpression should be included in future studies of GDF15-GFRAL-based therapeutics. If safe, this approach could reduce maternal and fetal morbidity. P...
Source: Geburtshilfe und Frauenheilkunde - September 29, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Methylenetetrahydrofolate Reductase Polymorphisms and Pregnancy Outcome.
Conclusion MTHFR polymorphisms are potential risk factors for adverse pregnancy outcomes. PMID: 30258247 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 29, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Comment on the LACC Trial Investigating Early-stage Cervical Cancer by the Uterus Commission of the Study Group for Gynecologic Oncology (AGO) and the Study Group for Gynecologic Endoscopy (AGE) of the German Society for Gynecology and Obstetrics (DGGG).
Authors: Hillemanns P, Brucker S, Holthaus B, Lampe B, Runnebaum I, Ulrich U, Wallwiener M, Solomayer E, Fehm T, Tempfer C PMID: 30158715 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 1, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Neoadjuvant Therapy of Cervical Carcinoma with the Angiogenesis Inhibitor Bevacizumab: a Single-Centre Analysis.
Discussion Overall, combined therapy with bevacizumab led to a better clinical response. Operability was therefore improved more often. Because of the small patient cohort, larger prospective studies are necessary to validate the effect of neoadjuvant combined therapy with bevacizumab. PMID: 30158716 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - September 1, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Foetal Morbidity Depending on the Day and Time of Delivery.
Authors: von Ehr J, Wiebking N, Kundu S, von Kaisenberg C, Hillemanns P, Soergel P Abstract Introduction It is known that perinatal mortality is increased with births at night and at the weekend. The aim of the study was to investigate whether there is also an association between the time of delivery (weekday, night, weekend) and perinatal morbidity. Material and Methods All births at Hannover Medical College between 2000 and 2014 were included in a retrospective data analysis. Multiple births, primary sections, severe foetal malformations and intrauterine deaths were not included. A 5-minute Apgar score ≤&thins...
Source: Geburtshilfe und Frauenheilkunde - September 1, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

A Novel Technique for Mapping the Vascularity of Labia Minora Prior to Labiaplasty: Cold Light Illumination.
Discussion This novel technique to assess labial vascularity using a cold light source could be very useful to reduce dehiscence by avoiding excessive resection of highly vascularized tissue. Most units can easily access a cold light source, which can be used to assess labial vascularity prior to labiaplasty. PMID: 30140106 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 26, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Rescue Adjuvant Vaginal Progesterone May Improve Outcomes in Cervical Cerclage Failure.
Conclusion Women with cervical shortening despite the presence of cervical cerclage may benefit from further TVUS cervical length surveillance and the administration of vaginal progesterone if further cervical shortening occurs. Despite both groups having clinically significant shortened cervical lengths and cervical cerclage in situ, adjunct vaginal progesterone treatment resulted in older gestational age at birth and higher birth weight. Further investigation and confirmation of this finding in a larger prospective trial is warranted to explore this potential benefit for the management of preterm birth in future. PMI...
Source: Geburtshilfe und Frauenheilkunde - August 26, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Ramadan Observance during Pregnancy in Germany: a Challenge for Prenatal Care.
Conclusion: To ensure that pregnant Muslim women living in Germany can make their fasting decision based on objective information, it is necessary to raise awareness about Ramadan fasting during pregnancy among medical professionals in Germany. PMID: 30057424 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Endometriosis and Beta-hCG >  775 IU/l Increase the Risk of Non-tube-preserving Surgery for Tubal Pregnancy.
Conclusion: Endometriosis and a beta-hCG value of more than 775 IU/l significantly increased the risk for non-tube-preserving surgery in women with tubal pregnancy. PMID: 30057425 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Perinatal Outcome in Women with a Vietnamese Migration Background - Retrospective Comparative Data Analysis of 3000 Deliveries.
Authors: Boxall N, David M, Schalinski E, Breckenkamp J, Razum O, Hellmeyer L Abstract Introduction: Perinatal data of women with a Vietnamese migration background have not been systematically studied in Germany to date. Numerous details of important maternal and child outcomes were compared and analysed. The study's primary parameters were the frequency of and indication for c-section. Methodology: The perinatal data from a Berlin hospital were analysed retrospectively. The women (Vietnamese migration background vs. autochthonous) were grouped using name analysis. Datasets of 3002 women giving birth, including...
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Using Probability for Pathological Complete Response (pCR) as a Decision Support Marker for Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer Patients - a Survey Among Physicians.
Conclusions: The vast majority of the long-term experienced physicians would embrace the implementation of a further method such as the prediction of pCR probability in clinical routine to support decision making regarding the necessity of neoadjuvant chemotherapy. The cut-off of around 30% pCR probability seems to be a realizable rate to distinguish patient groups. PMID: 30057427 [PubMed] (Source: Geburtshilfe und Frauenheilkunde)
Source: Geburtshilfe und Frauenheilkunde - August 5, 2018 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research