Mechanistic Modeling of Intrathecal Chemotherapy Pharmacokinetics in the Human Central Nervous System

CONCLUSIONS: CNS PBPK modeling, in line with available clinical efficacy data, confirms the therapeutic value of intrathecal chemotherapy with antibody or small molecule drugs for treating neoplastic meningitis and warrants further clinical investigation of intrathecal antibody drugs to treat brain parenchyma tumors. Compared to intraventricular injection, intraventricular 24-h infusion may mitigate neurotoxicity while retaining potential efficacy.PMID:38289997 | DOI:10.1158/1078-0432.CCR-23-3062
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Source Type: research