Cancer cells in inhospitable brain fluids hijack iron to survive
(American Association for the Advancement of Science) In order to survive within the remote and harsh anatomical microenvironments of the central nervous system, the disseminated cancer cells that cause rare yet deadly leptomeningeal metastases (LM) hijack crucial iron micronutrients from native macrophages, researchers report. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 16, 2020 Category: International Medicine & Public Health Source Type: news

Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis
The tumor microenvironment plays a critical regulatory role in cancer progression, especially in central nervous system metastases. Cancer cells within the cerebrospinal fluid (CSF)–filled leptomeninges face substantial microenvironmental challenges, including inflammation and sparse micronutrients. To investigate the mechanism by which cancer cells in these leptomeningeal metastases (LM) overcome these constraints, we subjected CSF from five patients with LM to single-cell RNA sequencing. We found that cancer cells, but not macrophages, within the CSF express the iron-binding protein lipocalin-2 (LCN2) and its recep...
Source: ScienceNOW - July 15, 2020 Category: Science Authors: Chi, Y., Remsik, J., Kiseliovas, V., Derderian, C., Sener, U., Alghader, M., Saadeh, F., Nikishina, K., Bale, T., Iacobuzio-Donahue, C., Thomas, T., Peer, D., Mazutis, L., Boire, A. Tags: Cell Biology, Medicine, Diseases r-articles Source Type: news

Experimental Treatments for Leptomeningeal Metastases Experimental Treatments for Leptomeningeal Metastases
Novel agents that penetrate the blood-brain barrier offer new hope for effective management of leptomeningeal metastases.Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 23, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Neoplastic Meningitis Due to Lung, Breast, and Melanoma Mets Neoplastic Meningitis Due to Lung, Breast, and Melanoma Mets
Determining how to treat patients with neoplastic meningitis can be challenging. Are intra-CSF chemotherapeutic agents effective?Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 9, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Diagnosis and Radiological Findings of Neoplastic Meningitis Diagnosis and Radiological Findings of Neoplastic Meningitis
The diagnosis of neoplastic meningitis can be elusive; clinicians should consider its possibility when multilevel neurological symptoms are present.Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 2, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Leptomeningeal metastases more common in NSCLC patients with EGFR mutations
(International Association for the Study of Lung Cancer) Leptomeningeal metastases (LM), a devastating complication and predictor of poor survival in lung cancer patients, was found to be more prevalent in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations. Patients receiving tyrosine kinase inhibitors (TKIs) targeting EGFR mutations had a longer overall survival (OS) than those who did not receive TKIs, demonstrating the effectiveness of TKIs for LM therapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 15, 2016 Category: Global & Universal Source Type: news

Q&A: Valerie Harper’s Cancer
WebMD Medical News By Kathleen Doheny Reviewed by Brunilda Nazario, MD March 6, 2013 — Actress Valerie Harper, best known for her role as Rhoda Morgenstern on The Mary Tyler Moore Show  and Rhoda in the 1970s, has learned she has leptomeningeal carcinomatosis. The condition happens when cancer spreads to the brain and spinal cord. Now 73, Harper told People magazine she received the diagnosis in January. The American Cancer Society has no specific statistics on this complication. Some research estimates it happens in about 5% to 10% of patients with cancer. WebMD asked Henry S. Friedman, MD, deputy directo...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - March 7, 2013 Category: Consumer Health News Authors: mreal197 Tags: WebMD News Source Type: news