Q&A: Valerie Harper’s Cancer

WebMD Medical News By Kathleen Doheny Reviewed by Brunilda Nazario, MD March 6, 2013 — Actress Valerie Harper, best known for her role as Rhoda Morgenstern on The Mary Tyler Moore Show  and Rhoda in the 1970s, has learned she has leptomeningeal carcinomatosis. The condition happens when cancer spreads to the brain and spinal cord. Now 73, Harper told People magazine she received the diagnosis in January. The American Cancer Society has no specific statistics on this complication. Some research estimates it happens in about 5% to 10% of patients with cancer. WebMD asked Henry S. Friedman, MD, deputy director of The Preston Robert Tisch Brain Tumor Center at Duke University, for more details. He does not treat Harper. Q: What is leptomeningeal carcinomatosis? It is also called neoplastic meningitis. They mean the same thing. There are tumor cells that are in the spinal fluid. They come from either a primary brain tumor or an extraneural [outside the brain] cancer. The extraneural cancer in this case might have been the lung cancer [reportedly diagnosed in Harper in 2009]. Q: How do the cancer cells spread? They enter the spinal fluid, usually through the blood vessels in the brain. Once in the spinal fluid, the cells have a great roadway up and down the brain and the spine. Q: Is there a typical age for getting this? You can get neoplastic meningitis as a little child all the way up to adulthood. Q: What are the symptoms? There are many symptoms. There can be v...
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