Rare Esophageal Leptomeningeal Metastases Detected on 18F-FDG PET/CT
A 62-year-old man with a history of locally advanced poorly differentiated adenocarcinoma of the gastroesophageal junction had received induction chemotherapy and concurrent chemoradiation. A 6-month follow-up FDG PET/CT revealed nearly resolved primary malignancy, but new hypermetabolic mediastinal lymph node metastasis and abnormal hypermetabolism in the cerebellum region. Brain MRI and lumbar puncture confirmed leptomeningeal metastasis. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - March 12, 2020 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Nivolumab efficacy in leptomeningeal metastasis of renal cell carcinoma: a case report.
CONCLUSIONS: Meningeal carcinomatosis metastasis from renal cancer is a rare condition. Diagnosis is often challenging: the onset of nonspecific presenting symptoms could be initially attributed to bone involvement, side effects of oncologic therapy, or paraneoplastic syndromes. Our case suggests that nivolumab could be an effective and safe treatment option in patients with pretreated renal cancer with leptomeningeal metastasis. PMID: 32041500 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - February 13, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

New Assay Helps Diagnose Leptomeningeal Metastases
No abstract available (Source: Neurology Today)
Source: Neurology Today - January 23, 2020 Category: Neurology Tags: In the Pipeline Source Type: research

Leptomeningeal metastasis from solid tumors
Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on LM arising from solid tumors with a goal of providing the reader an understanding of the epidemiology, pathophysiology, clinical presentation, prognostication, current management and future directions. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - January 22, 2020 Category: Neurology Authors: Jigisha P. Thakkar, Priya Kumthekar, Karan S. Dixit, Roger Stupp, Rimas V. Lukas Tags: Review Article Source Type: research

Dual Targeting of the Epidermal Growth Factor Receptor Using Combination of Nimotuzumab and Erlotinib in Advanced Non-Small-Cell Lung Cancer with Leptomeningeal Metastases: A Report of Three Cases
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - January 20, 2020 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

Contrast-enhanced modified 3D T1-weighted TSE black-blood imaging can improve detection of infectious and neoplastic meningitis
ConclusionsT1-mVISTA may be an adequate and probably better alternative to T1-MP-RAGE for detection of leptomeningeal diseases.Key Points•Black-blood T1-mVISTA showed a significant higher sensitivity for the detection of leptomeningeal enhancement compared with MP-RAGE without losses regarding specificity.•Diagnostic confidence was assessed significantly higher in T1-mVISTA.•T1-mVISTA should be considered a supplement or an alternative to T1-MP-RAGE in patients with suspected leptomeningeal diseases. (Source: European Radiology)
Source: European Radiology - January 13, 2020 Category: Radiology Source Type: research

Detection of circulating tumor DNA from non ‐small cell lung cancer brain metastasis in cerebrospinal fluid samples
ConclusionSequencing of CSF ctDNA revealed specific mutation patterns in driver genes among patients with NSCLC and brain metastasis.Key pointsIn some small ‐sample studies, the importance of cerebrospinal fluid in guiding the treatment of cancerous brain lesions has been verified in that it may reflect genomic mutations of brain tumors relatively accurately.Cerebrospinal fluid is a new form of liquid biopsy that can be helpful in improving the management of patients with brain metastasis from non ‐small cell lung cancer by detecting genetic abnormalities specific to brain metastases. (Source: Thoracic Cancer)
Source: Thoracic Cancer - January 12, 2020 Category: Cancer & Oncology Authors: Chunhua Ma, Xueling Yang, Wenge Xing, Haipeng Yu, Tongguo Si, Zhi Guo Tags: ORIGINAL ARTICLE Source Type: research

Radiological evaluation of newly diagnosed non-brainstem pediatric high-grade glioma in the HERBY phase II trial.
CONCLUSIONS: This study has shown that the poor outcome of midline tumors (compared to cerebral) may be related to 1) lesser surgical resection, 2) H3 K27M histone mutations, and 3) higher leptomeningeal dissemination. PMID: 31924736 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - January 9, 2020 Category: Cancer & Oncology Authors: Rodriguez Gutierrez D, Jones C, Varlet P, Mackay A, Warren D, Warmuth-Metz M, Sánchez Aliaga E, Calmon R, Hargrave DR, Cañete A, Massimino M, Azizi AA, Le Deley MC, Saran F, Rousseau RF, Zahlmann G, Garcia J, Vassal G, Grill J, Morgan PS, Jaspan T Tags: Clin Cancer Res Source Type: research

Evaluating the cerebrospinal fluid ctDNA detection by next-generation sequencing in the diagnosis of meningeal Carcinomatosis
Meningeal carcinomatosis (MC) is the most severe form of brain metastasis and causes significant morbidity and mortality. Currently, the diagnosis of MC is routinely confirmed on the basis of clinical manifest... (Source: BMC Neurology)
Source: BMC Neurology - December 19, 2019 Category: Neurology Authors: Yue Zhao, Jun-Ying He, Yue-Li Zou, Xiao-Su Guo, Jun-Zhao Cui, Li Guo and Hui Bu Tags: Research article Source Type: research

Management of leptomeningeal metastases in non-small cell lung cancer
Shekar Patil, Krishna Kumar RathnumIndian Journal of Cancer 2019 56(5):1-9 In leptomeningeal metastasis (LM), malignant lung cancer cells reach the sanctuary site of the leptomeningeal space through haematogenous or lymphatic route and thrive in the leptomeninges because of restricted access of chemotherapeutic agents across the blood brain barrier. The incidence of LM is 3%–5% in non-small cell lung cancer (NSCLC) patients; the incidence is higher in patients with anaplastic lymphoma kinase (ALK) gene rearrangement or epidermal growth factor receptor (EGFR) mutations. However, the real-...
Source: Indian Journal of Cancer - November 28, 2019 Category: Cancer & Oncology Authors: Shekar Patil Krishna Kumar Rathnum Source Type: research

Management of CNS metastases in patients with EGFR mutation-positive NSCLC
Vijith Shetty, Suresh BabuIndian Journal of Cancer 2019 56(5):31-37 Central nervous system (CNS) metastases are a frequent and severe complication associated with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). The first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) have shown considerable efficacy in EGFR-mutated NSCLC. However, their limited potential to cross the blood–brain barrier (BBB) renders them less effective in the management of CNS metastases in NSCLC. Osimertinib, a third-generation irreversible EGFR-TKI with good potential to cross the BBB, has...
Source: Indian Journal of Cancer - November 28, 2019 Category: Cancer & Oncology Authors: Vijith Shetty Suresh Babu Source Type: research

Metastatic meningeal carcinomatosis from lung cancer: Report of a rare case
Meningeal carcinomatosis (MC) refers to the diffuse or multifocal spread or infiltration of malignant tumors in the pia mater. It is a special distribution type of metastatic tumors in the central nervous system and one of the important reasons of death caused by metastatic malignant tumors. Here, we report a rare case of metastatic meningeal carcinomatosis from the lung cancer. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 16, 2019 Category: Cancer & Oncology Authors: Hui Liu, Li Liu, Xiaochen Zhang, Song Jin Tags: CASE REPORT Source Type: research

Radiotherapy in Leptomeningeal Disease: A Systematic Review of Randomized and Non-randomized Trials
Conclusions: LMD is a devastating complication of cancer with reported survivals ranging from 2 to 4 months. Based on this systematic review, the recommendation for the treatment of LMD is for multimodality discussion of cases and treatment, including the use of radiotherapy, for LMD. However, with continued advances in systemic therapy as well as imaging advances, the landscape of LMD is evolving rapidly and the role of RT will likely also continue to evolve and advance. There is limited high-quality evidence to guide the optimal use of RT for the treatment of LMD, and there is a great need for prospective, histology spec...
Source: Frontiers in Oncology - November 14, 2019 Category: Cancer & Oncology Source Type: research

One-year prognosis of non-traumatic cortical subarachnoid haemorrhage: a prospective series of 34 patients
ConclusionsThe most frequent causes of cSAH in our series were cerebral amyloid angiopathy, ischaemic stroke, and vasculitis. This type of haemorrhage has a worse prognosis than other non-aneurysmal cSAH. There are numerous possible causes, and prognosis depends on the aetiology. In elderly patients, intracranial haemorrhage is frequently associated with cognitive impairment.ResumenIntroducciónLas hemorragias subaracnoideas corticales (HSAc) tienen numerosas etiologías. No hay estudios prospectivos que indiquen su evolución a largo plazo. El objetivo de este trabajo es describir las características clínicas y etiológ...
Source: Neurologia - November 5, 2019 Category: Neurology Source Type: research

Bilateral hearing loss as presentation in meningeal carcinomatosis.
Authors: Trigo López J, Martínez Pías E, Pedraza Hueso MI PMID: 31635849 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - October 23, 2019 Category: General Medicine Tags: Med Clin (Barc) Source Type: research