Non-alcoholic Fatty Liver Diseases (NAFLD) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Molecules, Vol. 29, Pages 1859: A Systematic Review of Statins for the Treatment of Nonalcoholic Steatohepatitis: Safety, Efficacy, and Mechanism of Action
Bing Liu Nonalcoholic fatty liver disease (NAFLD) is the liver component of a cluster of conditions, while its subtype, nonalcoholic steatohepatitis (NASH), emerges as a potentially progressive liver disorder that harbors the risk of evolving into cirrhosis and culminating in hepatocellular carcinoma (HCC). NASH and cardiovascular disease (CVD) have common risk factors, but compared to liver-related causes, the most common cause of death in NASH patients is CVD. Within the pharmacological armamentarium, statins, celebrated for their lipid-modulating prowess, have now garnered attention for their expansive therapeutic ...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Shiqin Zhang Xiaoling Ren Bingzheng Zhang Tian Lan Bing Liu Tags: Review Source Type: research

The association between score of plant-based diet and non-alcoholic fatty liver disease in adults
Plant-based diet(PDI) as resource of antioxidants and anti-inflammatory phytochemicals, that was considered to protect against onset and development of Non-alcoholic fatty liver disease (NAFLD). (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - April 19, 2024 Category: Nutrition Authors: Azadeh Fallah, Hamid abdolazimi, Zahra Darabi, Nasir Talenezhad, Farhang Mirzavandi, Shahab Rahimpour, Mahdieh Hosseinzadeh Source Type: research

Metabolomics of Mice with Type 2 Diabetes and Nonalcoholic Fatty Liver Treated by Acupuncture
CONCLUSION: Our study shows that acupuncture can regulate the liver metabolism mode of T2DM in NAFLD mice. It can reduce blood glucose and lipid accumulation in the liver, and these findings provide a new idea and theoretical basis for acupuncture in the treatment of diseases related to glucose and lipid metabolism.PMID:38633528 | PMC:PMC11023731 | DOI:10.1155/2024/5568337 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 18, 2024 Category: Endocrinology Authors: Yihui Guo Liying Zhang Mengyuan Li Linan Lin Fuyu Xue Wanning Gao Xiaoru Xu Haipeng Huang Source Type: research

Molecular Genealogy of Metabolic-associated Hepatocellular Carcinoma
In conclusion, deciphering the intricate interactions among metabolic processes, genetic predispositions, inflammatory responses, immune regulation, and microbial ecology is imperative for the development of novel therapeutic and preventative measures against metabolic-associated HCC. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - April 18, 2024 Category: Gastroenterology Authors: Kodama, Takahiro Takehara, Tetsuo Tags: Review Article Source Type: research

O-GlcNAcylation promotes the progression of nonalcoholic fatty liver disease by upregulating the expression and function of CD36
Nonalcoholic fatty liver disease (NAFLD) and its progressive variant, nonalcoholic steatohepatitis (NASH), constitute a burgeoning worldwide epidemic with no FDA-approved pharmacotherapies. The multifunctional immunometabolic receptor, fatty acid translocase CD36 (CD36), plays an important role in the progression of hepatic steatosis. O-GlcNAcylation is a crucial posttranslational modification that mediates the distribution and function of CD36, but its involvement in NAFLD remains poorly understood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 18, 2024 Category: Biomedical Science Authors: Hanlong Zhu, Tianming Zhao, Si Zhao, Suzhen Yang, Kang Jiang, Shupei Li, Ying Kang, Zhuoxin Yang, Jiajia Shen, Si Shen, Hui Tao, Ji Xuan, Miaofang Yang, Bing Xu, Fangyu Wang, Mingzuo Jiang Source Type: research

The Influence of Emodin Succinyl Ethyl Ester on Non-Alcoholic Steatohepatitis Induced by a Diet High in Fructose, Cholesterol, and Fat in Mice
In this study, after 12 weeks of induction, the mice were treated with emodin succinyl ethyl ester (ESEE) for four weeks at doses of 10/30/90 mg/kg/day. The blood analysis of experimental endpoints showed that ESEE exhibited significant therapeutic effects on the progression of disorders of glycolipid metabolism and the induced liver injury in the model animals. Histopathological diagnosis of the liver and total triglyceride measurements revealed that ESEE had a significant therapeutic effect on the histopathological features of nonalcoholic fatty liver disease/hepatitis, such as cellular steatosis and activation of intrah...
Source: Biological and Pharmaceutical Bulletin - April 17, 2024 Category: Drugs & Pharmacology Authors: Yanxue Wang Liang Li Lingling Chen Jinlei Xia Tongli Wang Lei Han Liang Cao Zhenzhong Wang Wei Xiao Shan Jiang Source Type: research

Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells
Toxicol Lett. 2024 Apr 15:S0378-4274(24)00067-5. doi: 10.1016/j.toxlet.2024.04.002. Online ahead of print.ABSTRACTMitochondrial fatty acid oxidation (mtFAO) plays an important role in hepatic energy metabolism. Severe mtFAO injury leads to nonalcoholic fatty liver disease (NAFLD) and liver failure. Several drugs have been withdrawn owing to safety issues, such as induction of fatty liver disease through mtFAO disruption. For instance, the antimicrobial triclocarban (TCC), an environmental contaminant that was removed from the market due to its unknown safety in humans, induces NAFLD in rats and promotes hepatic FAO in mice...
Source: Toxicology Letters - April 17, 2024 Category: Toxicology Authors: Hitoshi Nakamura Toshikatsu Matsui Tadahiro Shinozawa Source Type: research

Association between Per- and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: a nested case-control study in northwest China
In conclusion, our findings suggest that individual and co-exposure to PFAS is associated with a risk of NAFLD onset.PMID:38631453 | DOI:10.1016/j.envpol.2024.123937 (Source: Environmental Pollution)
Source: Environmental Pollution - April 17, 2024 Category: Environmental Health Authors: Yuanqin Wu Zhiyuan Cheng Wei Zhang Chun Yin Jianyun Sun Honghao Hua Xianzhen Long Xijiang Wu Yufeng Wang Xiaoyu Ren Desheng Zhang Yana Bai Yongjun Li Ning Cheng Source Type: research

Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells
Toxicol Lett. 2024 Apr 15;396:11-18. doi: 10.1016/j.toxlet.2024.04.002. Online ahead of print.ABSTRACTMitochondrial fatty acid oxidation (mtFAO) plays an important role in hepatic energy metabolism. Severe mtFAO injury leads to nonalcoholic fatty liver disease (NAFLD) and liver failure. Several drugs have been withdrawn owing to safety issues, such as induction of fatty liver disease through mtFAO disruption. For instance, the antimicrobial triclocarban (TCC), an environmental contaminant that was removed from the market due to its unknown safety in humans, induces NAFLD in rats and promotes hepatic FAO in mice. Therefore,...
Source: Toxicology Letters - April 17, 2024 Category: Toxicology Authors: Hitoshi Nakamura Toshikatsu Matsui Tadahiro Shinozawa Source Type: research

From the Editor ’s Desk...
Metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced non-alcoholic fatty liver disease (NAFLD). However, given that MASLD requires at least one cardiometabolic risk factor, questions were raised as to whether new evidence would need to be generated for MASLD. In this issue, Younossi and coworkers compared the clinical profile and outcomes of NAFLD to MASLD using a tertiary-care NAFLD database and NHANES-III. Ninety-nine percent of included patients met MASLD criteria while 95% met MASLD criteria on BMI only. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 17, 2024 Category: Gastroenterology Authors: Patrizia Burra, Frank Tacke, Vlad Ratziu, Stefan Zeuzem, Bruno Sangro, Paolo Angeli Tags: From the Editor's Desk Source Type: research

Italian guidelines for the management of adult individuals with overweight and obesity and metabolic comorbidities that are resistant to behavioral treatment
ConclusionThe present GL is directed to all physicians addressing people with obesity —working in hospitals, territorial services or private practice—and to general practitioners and patients. The recommendations should also consider the patient’s preferences and the available resources and expertise. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 17, 2024 Category: Endocrinology Source Type: research