Non-alcoholic Fatty Liver Diseases (NAFLD) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Oxymatrine alleviates high-fat diet/streptozotocin-induced non-alcoholic fatty liver disease in C57BL/6  J mice by modulating oxidative stress, inflammation and fibrosis
In conclusion, OMT improved liver impairment effectively in diabetic mice by suppressing oxidative stress, inflammation and fibrosis. These results suggest that OMT may represent a novel therapy for NAFLD with diabetes.PMID:38537582 | DOI:10.1016/j.biopha.2024.116491 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 27, 2024 Category: Drugs & Pharmacology Authors: Di Lou Qing Fang Yinghao He Ruyu Ma Xinyan Wang Hanbing Li Minyou Qi Source Type: research

GLP-1/GLP-1RAs: New Options for the Drug Treatment of NAFLD
Curr Pharm Des. 2024;30(2):100-114. doi: 10.2174/0113816128283153231226103218.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) has recently emerged as a global public health concern. Currently, the cornerstone of NAFLD treatment is lifestyle modification and, if necessary, weight loss. However, compliance is a challenge, and this approach alone may not be sufficient to halt and treat the more serious disease development, so medication is urgently needed. Nevertheless, no medicines are approved to treat NAFLD. Glucagon-like peptide-1 (GLP-1) is an enteropeptide hormone that inhibits glucagon synthesis, promotes insulin sec...
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Haoran Jiang Linquan Zang Source Type: research

Trimethylamine-N-oxide, a New Risk Factor for Non-alcoholic Fatty Liver Disease Changes the Expression of miRNA-34a, and miRNA-122 in the Fatty Liver Cell Model
This study investigated the expression of miRNA-34a, miRNA-122, and miRNA-192 in the fatty liver cell model treated with different concentrations of TMAO. A fatty liver cell model was developed by exposing HepG2 cells to a mixture of palmitate and oleate in a ratio of 1:2 at a final concentration of 1200 μM for 24 h. The confirmed fatty liver cells were treated with 37.5, 75, 150, and 300 μM of TMAO for 24 h. RT-qPCR was used to quantify the expression of microRNAs in a cellular model. The cellular expression of all microRNAs was significantly higher in treated fatty liver cells compared to normal HepG2 cells (P < 0.0...
Source: Biochemical Genetics - March 27, 2024 Category: Genetics & Stem Cells Authors: Zhila Bahramirad Mohammad Raman Moloudi Mohammad Moradzad Alina Abdollahi Zakaria Vahabzadeh Source Type: research

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases
Curr Issues Mol Biol. 2024 Mar 11;46(3):2320-2342. doi: 10.3390/cimb46030148.ABSTRACTRare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural abundance that is primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns in the field of ginseng research and development, as well as ginsenoside-related dietary supplements and natural products. Ginsenosides Rb1, Rb2, and Rc are generally used as a substrate to generate CK via several...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Md Niaj Morshed Reshmi Akter Md Rezaul Karim Safia Iqbal Se Chan Kang Deok Chun Yang Source Type: research

Identification of diagnostic gene signatures and molecular mechanisms for non-alcoholic fatty liver disease and Alzheimer's disease through machine learning algorithms
CONCLUSION: This study highlights GADD45G and NUPR1 as key biomarkers for NAFLD and AD, and provides novel insights into their molecular connections. These findings revealed potential therapeutic targets, particularly in macrophage-mediated pathways, thus enriching our understanding of these complex diseases.PMID:38537674 | DOI:10.1016/j.cca.2024.117892 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 27, 2024 Category: Chemistry Authors: Liqing Jiang Qian Wang Yingsong Jiang Dadi Peng Kezhen Zong Shan Li Wenyuan Xie Cheng Zhang Kaili Li Zhongjun Wu Zuotian Huang Source Type: research