GSE202379 Single Nuclei RNA-Seq to map progression of non-alcoholic fatty liver disease (NAFLD) in patients II
Contributors : Christopher Gribben ; Vasileios Galanakis ; Alex Calderwood ; Ruben Chazarra Gil ; Irina Mohorianu ; Ludovic VallierSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNon-alcoholic fatty liver disease (NAFLD) is of increasing prevalence and concern. NAFLD can progress to non-alcoholic steatohepatitis (NASH), to cirrhosis and finally to end-stage liver disease where liver transplantation is required. We aimed to characterise this progression by performing single nuclei transcriptomic analysis of liver biopsies taken from patients across the disease spectrum. We have o...
Source: GEO: Gene Expression Omnibus - April 4, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Genes, Vol. 15, Pages 455: Relevance of PNPLA3, TM6SF2, HSD17B13, and GCKR Variants to MASLD Severity in an Egyptian Population
This study offers evidence for the association of the PNPLA3 rs738409 C>G variant with MASLD among Egyptians and for the association of the PNPLA3 rs738409 G allele, the TM6SF2 rs58542926 T allele, and the GCKR rs1260326 C allele with some parameters of cardiometabolic criteria. (Source: Genes)
Source: Genes - April 4, 2024 Category: Genetics & Stem Cells Authors: Nehal Elmansoury Ahmed A. Megahed Ahmed Kamal Nefertiti El-Nikhely Marina Labane Manal Abdelmageed Ann K. Daly Ahmed Wahid Tags: Article Source Type: research

Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH
This study highlights the impact of CypD loss-of-function on the development of HCC, one of t he most severe disease outcomes. (Source: PLoS One)
Source: PLoS One - April 4, 2024 Category: Biomedical Science Authors: Winston T. Stauffer Source Type: research

Association of the habitual dietary intake with the fatty liver index and effect modification by metabotypes in the population-based KORA-Fit study
Non-alcoholic fatty liver disease (NAFLD) is an emerging threat for public health with diet being a major risk factor in disease development and progression. However, the effects of habitual food consumption o... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 4, 2024 Category: Lipidology Authors: M. Schepp, D. Freuer, N. Wawro, A. Peters, M. Heier, D. Teupser, C. Meisinger and J. Linseisen Tags: Research Source Type: research

The effects of food insecurity on hepatic steatosis and fibrosis in people with HIV
Food insecurity (FI) is a risk factor for nonalcoholic fatty liver disease (NAFLD) and advanced fibrosis in the general population, but its impact on liver disease in people with HIV (PWH) is unknown. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 4, 2024 Category: Gastroenterology Authors: Ani Kardashian, Audrey Lloyd, Eduardo Vilar-Gomez, Susanna Naggie, Mark S. Sulkowski, Tinsay Woreta, Jordan E. Lake, Holly Crandall, Rohit Loomba, Laura A. Wilson, Richard K. Sterling, Sonya Heath, Samer Gawrieh, Naga P. Chalasani, Jennifer C. Price, HIV Source Type: research

Know Your Guidelines Series: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings
South Med J. 2024 Apr;117(4):206-207. doi: 10.14423/SMJ.0000000000001669.NO ABSTRACTPMID:38569610 | DOI:10.14423/SMJ.0000000000001669 (Source: Southern Medical Journal)
Source: Southern Medical Journal - April 3, 2024 Category: General Medicine Authors: Desiree C Burroughs-Ray Samantha Whitwell Nathan Williams Hira Imran Christopher D Jackson Source Type: research