Fatal myasthenia gravis (MG) associated with myositis and myocarditis in a patient with pre-existing MG treated by adjuvant nivolumab for a stage III melanoma.
Dear Editor (Source: European Journal of Cancer)
Source: European Journal of Cancer - May 6, 2024 Category: Cancer & Oncology Authors: J. Emile, C. Cauquil, D. Carpentier, E. Routier, Caroline Robert Tags: Letter to the Editor Source Type: research
Systemic Inflammatory Response Index, a Potential Inflammatory Biomarker in Disease Severity of Myasthenia Gravis: A Pilot Retrospective Study
CONCLUSION: Our findings indicate a strong independent association between SIRI and disease severity in MG, suggesting SIRI's potential as a valuable biomarker for MG with superior clinical benefit to currently utilized markers.PMID:38686359 | PMC:PMC11057634 | DOI:10.2147/JIR.S449324 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Suwen Huang Yanchu Wang Jinrong Zhu Shengqi Li Shenyi Lin Wei Xie Siyao Chen Yukai Wang Lingsheng Wang Qiaoqiao Jin Yiyun Weng Dehao Yang Source Type: research
Epidemiology, Patient Characteristics, and Treatment Patterns of Myasthenia Gravis in Taiwan: A Population-Based Study
ConclusionThe prevalence of MG increased steadily in Taiwan, and the treatment of patients with MG was consistent with guidelines. Despite a high treatment rate, patients still experienced MG-related events, highlighting the limitation of current treatments and emphasizing the need for early intervention and novel treatment approaches. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 27, 2024 Category: Neurology Source Type: research
Dental Adverse Effects of Anti-CD20 Therapies
ConclusionTo our knowledge, this is the first case series reporting dental conditions developed in patients long-term treated with anti-CD20 treatments. This issue, literature data, and Vigilyze ® analysis might be considered a safety signal that necessitates being confirmed with more robust data, such as a retrospective study with a control group. Meanwhile, proactive measures are essential like frequent dental checkups and dental hygienic measures to prevent oral health problems associat ed with anti-CD20 therapies. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 26, 2024 Category: Neurology Source Type: research
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Aging)
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Aging)
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
Systemic Inflammatory Response Index, a Potential Inflammatory Biomarker in Disease Severity of Myasthenia Gravis: A Pilot Retrospective Study
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 25, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Taste disorders and alopecia in myasthenia gravis
Non-motor symptoms in myasthenia gravis (MG) are rarely confirmed. Although there are some small cohort studies, a large-systemic survey has not yet been performed. (Source: BMC Neurology)
Source: BMC Neurology - April 25, 2024 Category: Neurology Authors: Akiyuki Uzawa, Shigeaki Suzuki, Satoshi Kuwabara, Hiroyuki Akamine, Yosuke Onishi, Manato Yasuda, Yukiko Ozawa, Naoki Kawaguchi, Tomoya Kubota, Masanori P. Takahashi, Yasushi Suzuki, Genya Watanabe, Takashi Kimura, Takamichi Sugimoto, Makoto Samukawa, Nao Tags: Research Source Type: research
Eculizumab in Adolescent Patients with Refractory Generalized Myasthenia Gravis: A Phase 3, Open-Label, Multicenter Study
This study evaluated the efficacy and safety of eculizumab, a terminal complement C5 inhibitor. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 25, 2024 Category: Neurology Authors: John F. Brandsema, Matthew Ginsberg, Hideki Hoshino, Masakazu Mimaki, Satoru Nagata, Vamshi K. Rao, Katherine Ruzhansky, Niraja Suresh, Emmanuelle Tiongson, Hideo Yamanouchi, Glen Frick, Eden Hicks, Serena Liao, James F. Howard, MG 303 Study Group Tags: Research Paper Source Type: research
The analysis of factors affecting medication adherence in patients with myasthenia gravis: a cross-sectional study
CONCLUSION: Our study shows that taking medication irregularly and concerns of taking medicine are the risk factors for medication adherence. Meanwhile, the necessity of talking medicine and self-efficacy for taking medications under difficult circumstances are the protective factors for medication adherence. Our findings can help medical staff to enhance patients' medication adherence by informing patients necessary medical knowledge, emphasizing the necessity for medication, relieving patients' concerns regarding medication, and improving the self-efficacy for taking medications under difficult circumstances.PMID:3865474...
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Yining Su Xinxian Wang Yuemeng Xing Zhenni Wang Hailing Bu Xiaoyan Cui Yunying Yang Bingxing Cai Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
