Gut microbiota-derived butyrate restores impaired regulatory T cells in patients with AChR myasthenia gravis via mTOR-mediated autophagy
More than 80% of patients with myasthenia gravis (MG) are positive for anti-acetylcholine receptor (AChR) antibodies. Regulatory T cells (Tregs) suppress overproduction of these antibodies, and patients with A... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 3, 2024 Category: Molecular Biology Authors: Long He, Zhuotai Zhong, Shuting Wen, Peiwu Li, Qilong Jiang and Fengbin Liu Tags: Research Source Type: research
Autoimmunity in thymic epithelial tumors: a not yet clarified pathologic paradigm associated with several unmet clinical needs
Thymic epithelial tumors (TETs) are rare mediastinal cancers originating from the thymus, classified in two main histotypes: thymoma and thymic carcinoma (TC). TETs affect a primary lymphoid organ playing a critical role in keeping T-cell homeostasis and ensuring an adequate immunological tolerance against “self”. In particular, thymomas and not TC are frequently associated with autoimmune diseases (ADs), with Myasthenia Gravis being the most common AD present in 30% of patients with thymoma. This comorbidity, in addition to negatively affecting the quality and duration of patients’ life, reduces the spectrum of the ...
Source: Frontiers in Immunology - April 2, 2024 Category: Allergy & Immunology Source Type: research
Oral salbutamol for symptomatic treatment in MuSK antibody-positive myasthenia gravis: a single-centre experience
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 2, 2024 Category: Neurology Source Type: research
Improving Outcome in Severe Myasthenia Gravis and Guillain –Barré Syndrome
Semin Neurol DOI: 10.1055/s-0044-1785509When progressive and severe, myasthenia gravis and Guillain–Barré syndrome may have the potential for fatal and unfavorable clinical outcomes. Regardless of important differences in their clinical course, the development of weakness of oropharyngeal muscles and respiratory failure with requirement of mechanical ventilation is the main driver of poor prognosis in both conditions. The need for prolonged mechanical ventilation is particularly relevant because it immobilizes the patient and care becomes extraordinarily complex due to daily risks of systemic complications. Additionally...
Source: Seminars in Neurology - April 1, 2024 Category: Neurology Authors: Hawkes, Maximiliano A. Wijdicks, Eelco F. M. Tags: Review Article Source Type: research
Clinical Features and Prognostic Analysis of MuSK-Antibody-Positive Myasthenia Gravis versus Double-Seropositive Myasthenia Gravis: A Single-Center Study from Central South China
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - March 29, 2024 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Rozanolixizumab: A New Therapy in the Treatment of Myasthenia Gravis
CONCLUSION/RELEVANCE: The approval of rozanolixizumab represents an advancement in therapy for generalized myasthenia gravis. The provision of individualized, targeted, and well-tolerated treatment is valuable for the patients whose myasthenia gravis is not well controlled and who are seeking a medication with a rapid onset of action to improve their symptoms and overall quality of life.PMID:38533739 | DOI:10.1177/10600280241239048 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 27, 2024 Category: Drugs & Pharmacology Authors: Emily M Hitt Source Type: research
Rozanolixizumab: A New Therapy in the Treatment of Myasthenia Gravis
CONCLUSION/RELEVANCE: The approval of rozanolixizumab represents an advancement in therapy for generalized myasthenia gravis. The provision of individualized, targeted, and well-tolerated treatment is valuable for the patients whose myasthenia gravis is not well controlled and who are seeking a medication with a rapid onset of action to improve their symptoms and overall quality of life.PMID:38533739 | DOI:10.1177/10600280241239048 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 27, 2024 Category: Drugs & Pharmacology Authors: Emily M Hitt Source Type: research
The Intricate Dance of Non-Coding RNAs in Myasthenia Gravis Pathogenesis and Treatment
Myasthenia gravis (MG) stands as a perplexing autoimmune disorder affecting the neuromuscular junction, driven by a multitude of antibodies targeting postsynaptic elements. However, the mystery of MG pathogenesis has yet to be completely uncovered, and its heterogeneity also challenges diagnosis and treatment. Growing evidence shows the differential expression of non-coding RNAs (ncRNAs) in MG has played an essential role in the development of MG in recent years. Remarkably, these aberrantly expressed ncRNAs exhibit distinct profiles within diverse clinical subgroups and among patients harboring various antibody types. Fur...
Source: Frontiers in Immunology - March 27, 2024 Category: Allergy & Immunology Source Type: research
Case report: A novel case of paraneoplastic voltage gated calcium channel antibodies secondary to appendiceal adenocarcinoma
Voltage gated calcium channels (VGCCs) play a critical role in neural transmission. Antibodies that target these ion channels can disrupt cellular signal transmission resulting in various clinical presentations. VGCC antibodies are most commonly associated with paraneoplastic syndromes such as Lambert-Eatons myasthenic syndrome. Here, we report a 47-year-old female with Stage IV appendiceal adenocarcinoma status post appendectomy and right hemicolectomy, who presented with progressive memory impairment, aphasia, ataxia, weakness, and headache. Neurologic exam was notable for right-sided parietal drift, decreased right arm ...
Source: Frontiers in Neurology - March 27, 2024 Category: Neurology Source Type: research
The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database
CONCLUSIONS: The study showed that more than two involved structures are a negative independent prognostic factor in infiltrative thymic epithelial tumors that could be used for prognostic stratification.PMID:38530530 | DOI:10.1245/s10434-024-15194-z (Source: Ann Oncol)
Source: Ann Oncol - March 26, 2024 Category: Cancer & Oncology Authors: Marco Chiappetta Filippo Lococo Carolina Sassorossi Clemens Aigner Till Ploenes Dirk Van Raemdonck Cedric Vanluyten Paul Van Schil Apostolos C Agrafiotis Francesco Guerrera Paraskevas Lyberis Monica Casiraghi Lorenzo Spiaggiari Charalambos Zisis Christina Source Type: research
VAMP1-Related Congenital Myasthenic Syndrome: A Case Report and Literature Review
Neuropediatrics DOI: 10.1055/s-0044-1782675Congenital myasthenic syndrome-25 (CMS-25) is an autosomal recessive neuromuscular disorder caused by a homozygous mutation in VAMP1 gene. To date, only eight types of allelic variants in VAMP1 gene have been reported in 12 cases of CMS-25. Here, we report on an 8-year-old boy with motor developmental delay, axial hypotonia, myopathic face, muscle weakness, strabismus, ptosis, pectus carinatum, kyphoscoliosis, joint contractures, joint laxity, seizures, and recurrent nephrolithiasis. He also had feeding difficulties and recurrent aspiration pneumonia. Brain magnetic resonance imag...
Source: Neuropediatrics - March 26, 2024 Category: Neurology Authors: Y ıldırım, Miraç Yarenci, G ülçin Bilicen Gen ç, Mustafa Berk U çar, Çiğdem İlter Bayav, Secahattin Tekin, Merve Nur Bekta ş, Ömer Teber, Serap Tags: Short Communication Source Type: research
Promising therapies for the treatment of myasthenia gravis
Expert Opin Pharmacother. 2024 Mar 25:1-14. doi: 10.1080/14656566.2024.2332610. Online ahead of print.ABSTRACTINTRODUCTION: Myasthenia gravis (MG) is an autoimmune condition targeting the neuromuscular junction, which manifests with neuromuscular symptoms of varying severity and significant morbidity. The mainstay of treatment in MG is mitigation of the immune cascade with steroids and non-steroidal immunosuppressive therapies. The therapeutic strategies in MG are transitioning from broad and indiscriminate immunosuppression to novel agents targeting key steps in MG pathogenesis, including T cell activation, B cell prolife...
Source: Expert Opinion on Pharmacotherapy - March 25, 2024 Category: Drugs & Pharmacology Authors: Sanem Pinar Uysal John A Morren Source Type: research
