Dramatic improvement in refractory myasthenia gravis with eculizumab treatment: a case report
(Source: Journal of Neurology)
Source: Journal of Neurology - February 23, 2024 Category: Neurology Source Type: research
Ravulizumab in myasthenic crisis: the first case report
(Source: Journal of Neurology)
Source: Journal of Neurology - February 23, 2024 Category: Neurology Source Type: research
A case of IgG4-related ophthalmic disease after SARS-CoV-2 vaccination: case report and literature review
In conclusion, our case represents the first case of proven IgG4-ROD after COVID-19 vaccination. We believe that IgG4-ROD and SARS-CoV-2 infection or vaccination are closely related, and the immune system disorder caused by SARS-CoV-2 infection or vaccination may be a key factor in the pathogenesis of IgG4-RD. But for now, there is no direct evidence that there is a causal relationship between SARS-CoV-2 infection or vaccination and IgG4-ROD, which still needs more research and exploration to confirm. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 22, 2024 Category: Allergy & Immunology Source Type: research
How to assess blepharoptosis via telemedicine: method and its reliability
ConclusionsVideo consultation is an efficient and reliable way to assess patients with ptosis, with 95% of reliability. Although a thorough ptosis assessment is advised, there was no difference between the accuracy of diagnosis on those who did not have the full suggested assessment. (Source: International Ophthalmology)
Source: International Ophthalmology - February 22, 2024 Category: Opthalmology Source Type: research
Role of plasma exchange in myasthenia gravis in the shortage of immunoglublins
Med Clin (Barc). 2024 Feb 20:S0025-7753(24)00008-3. doi: 10.1016/j.medcli.2023.11.033. Online ahead of print.NO ABSTRACTPMID:38383271 | DOI:10.1016/j.medcli.2023.11.033 (Source: Medicina Clinica)
Source: Medicina Clinica - February 21, 2024 Category: General Medicine Authors: Ingrid Magnolia Parra Salinas Jos é Antonio García Erce Source Type: research
An angel or a devil? Current view on the role of CD8+ T cells in the pathogenesis of myasthenia gravis
Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that affect the neuromuscular junction. Several subtyp... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 20, 2024 Category: Research Authors: Yong Peng, Huan Yang, Quan Chen, Hong Jin, Ya-hui Xue, Miao-qiao Du, Shu Liu and Shun-yu Yao Tags: Review Source Type: research
Dropped head syndrome in anti ‐MuSK antibody‐positive myasthenia gravis with possible concurrent axial myopathy
ConclusionThymoma-negative MuSK-MG, demonstrating treatment-refractory DHS, may present with concurrent axial myopathy. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - February 19, 2024 Category: Neurology Authors: So Okubo,
Mitsuhiro Kainaga,
Shin ‐ichi Tokushige,
Ayumi Uchibori,
Chizuko Oishi,
Teruyuki Hirano,
Yaeko Ichikawa Tags: CASE REPORT Source Type: research
"Ooh...He's Got Double Vision:" Lithium-Induced Ocular Myasthenia Gravis in An Older Adult Male
Lithium is widely used in the geriatric patient population for the maintenance of bipolar disorder as a relatively safe option that is neuroprotective. However, it is still important to obtain a thorough history of patients' medical conditions and be aware of and educate patients on side effects both generally and specific to patients' comorbidities. Even when lithium is within therapeutic range on labs, the overall incidence of side effects on the nervous system ranges from 35% to 50%. Neurologic effects include a postural tremor and cognitive effects (dysphoria, slowed reaction times, impaired memory). (Source: The Ameri...
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Zobia Chunara, Erica Garcia-Pittman Tags: Poster # EI44 Source Type: research
Epidemiology of myasthenia gravis in the United States
We report crude incidence and prevalence and calculated age-and sex-standardized estimates for the USA based on the 2017 American Community Survey. We estimated the number of adult cases during 2021 by extrapolating from the stratified estimates to the population size from the 2021 American Community Survey.ResultsFrom the US commercially/Medicare-insured cohort, we calculated an age-and sex-standardized incidence of 68.5 new cases per million person-years with an adjusted prevalence of 316.4 per million. Within the Medicaid-insured population, similar yet slightly lower numbers emerged: the adjusted incidence was 49.7 new...
Source: Frontiers in Neurology - February 16, 2024 Category: Neurology Source Type: research
Therapeutic Effect and Side Effects of Pharmacotherapy in Patients With Parkinson Disease and Myasthenia Gravis: A Systematic Review of Case Reports and Case Series Studies
Clin Ther. 2024 Feb 14:S0149-2918(24)00014-6. doi: 10.1016/j.clinthera.2024.01.003. Online ahead of print.ABSTRACTPURPOSE: The co-existence of Parkinson disease (PD) and myasthenia gravis (MG) in an individual should be exceptionally rare. The purpose of this study was to systematically review the current literature regarding the therapeutic effect and side effects of pharmacotherapy on patients with PD and MG.METHODS: Five bioscience and engineering databases (MEDLINE via PubMed, Cochrane Library, Scopus, EMBASE, and China National Knowledge Infrastructure) were searched from inception through February 21, 2022. Case repo...
Source: Clinical Therapeutics - February 15, 2024 Category: Drugs & Pharmacology Authors: Haoyu Xie Yadi Liu Cindy Schmidt Jung Hung Chien Chuhuai Wang Source Type: research
Therapeutic Effect and Side Effects of Pharmacotherapy in Patients With Parkinson Disease and Myasthenia Gravis: A Systematic Review of Case Reports and Case Series Studies
Clin Ther. 2024 Feb 14:S0149-2918(24)00014-6. doi: 10.1016/j.clinthera.2024.01.003. Online ahead of print.ABSTRACTPURPOSE: The co-existence of Parkinson disease (PD) and myasthenia gravis (MG) in an individual should be exceptionally rare. The purpose of this study was to systematically review the current literature regarding the therapeutic effect and side effects of pharmacotherapy on patients with PD and MG.METHODS: Five bioscience and engineering databases (MEDLINE via PubMed, Cochrane Library, Scopus, EMBASE, and China National Knowledge Infrastructure) were searched from inception through February 21, 2022. Case repo...
Source: Clinical Therapeutics - February 15, 2024 Category: Drugs & Pharmacology Authors: Haoyu Xie Yadi Liu Cindy Schmidt Jung Hung Chien Chuhuai Wang Source Type: research
Expanding the genetic and phenotypic spectrum of congenital myasthenic syndrome: new homozygous VAMP1 splicing variants in 2 novel individuals
In conclusion, our data expand both genetic and phenotypic spectrum associated withVAMP1 variants. (Source: Journal of Human Genetics)
Source: Journal of Human Genetics - February 14, 2024 Category: Genetics & Stem Cells Source Type: research
Normalized circulating Tfh and Th17 associates with improvement in myasthenia gravis treated with ofatumumab
ConclusionsAbnormal expansion of cTfh and cTh17 cells may be key features in the immunopathology of MG. Their levels returned to normal after BCDT, which was closely correlated with clinical amelioration. This result suggests that these two T-cell subsets may be targets for BCDT treatment of MG. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 13, 2024 Category: Allergy & Immunology Source Type: research
Defective autophagy and autophagy activators in Myasthenia Gravis: a rare entity and unusual scenario
Autophagy. 2024 Feb 12. doi: 10.1080/15548627.2024.2315893. Online ahead of print.ABSTRACTMyasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) that results from autoantibodies against nicotinic acetylcholine receptors (nAchRs) at NMJs. These autoantibodies are mainly originated from autoreactive B cells that bind and destroy nAchRs at NMJs preventing nerve impulses from activating the end-plates of skeletal muscle. Indeed, immune dysregulation plays a crucial role in the pathogenesis of MG. Autoreactive B cells are increased in MG due to the defect in the central and peripheral tolerance mech...
Source: Autophagy - February 12, 2024 Category: Cytology Authors: Ghassan M Sulaiman Hayder M Al-Kuraishy Majid S Jabir Hamdoon A Mohammed Ali I Al-Gareeb Salim Albukhaty Daniel J Klionsky Mosleh M Abomughaid Source Type: research
