Therapeutic potential of natural killer cells in neuroimmunological diseases
Biomed Pharmacother. 2024 Mar 1;173:116371. doi: 10.1016/j.biopha.2024.116371. Online ahead of print.ABSTRACTNatural killer (NK) cells, a major component of the innate immune system, have prominent immunoregulatory, antitumor proliferation, and antiviral activities. NK cells act as a double-edged sword with therapeutic potential in neurological autoimmunity. Emerging evidence has identified NK cells are involved in the development and progression of neuroimmunological diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, autoimmune encephalitis, Guillain-Barré Syndrome, chronic inflammatory demyeli...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 2, 2024 Category: Drugs & Pharmacology Authors: Qing Zhang Jing Lin Mengge Yang Zhijun Li Min Zhang Bitao Bu Source Type: research
Constructing and Validating a Nomogram Model for Short-Term Prognosis of Patients with AChR-Ab+ GMG
ConclusionThe constructed nomogram, based on key patient indicators, shows promise as a clinically useful tool for predicting the short-term efficacy of treatment of AChR-Ab+ GMG. Validation in larger, multicenter cohorts is needed to further substantiate its applicability. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 1, 2024 Category: Neurology Source Type: research
Peripheral nervous system and neuromuscular disorders in the emergency department: A review
CONCLUSIONS: Fortunately, early diagnosis and management can improve prognosis. This article provides a comprehensive review of acute presentations in neuromuscular disorders relevant for the emergency physician.PMID:38419365 | DOI:10.1111/acem.14861 (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - February 29, 2024 Category: Emergency Medicine Authors: Ajith Sivadasan Miguel A Cortel-LeBlanc Achelle Cortel-LeBlanc Hans Katzberg Source Type: research
Stereotypic T cell receptor clonotypes in the thymus and peripheral blood of Myasthenia gravis patients
In this study, thymus and peripheral blood (PB) samples were collected from ten AChR antibody-positive MG patients. T cell receptor (TCR) repertoires were analyzed using next-generation sequencing (NGS), and compared with that of an age and sex matched control group generated from a public database. Certain V genes and VJ gene recombination pairs were significantly upregulated in the TCR chains of αβ-T cells in the PB of MG patients compared to the control group. Furthermore, the TCR chains found in the thymi of MG patients had a weighted distribution to longer CDR3 lengths when compared to the PB of MG patients, and the...
Source: Cancer Control - February 29, 2024 Category: Cancer & Oncology Authors: Yonghee Lee Seung Woo Kim Eunjae Lee Ha Young Shin MinGi Kim Chang Young Lee Byung Jo Park Ha Eun Kim Young Ho Yang Jinny Choi Soyeon Ju Jungheum Park Namphil Kim Jaewon Choi Jin Gu Lee Sunghoon Kwon Junho Chung Source Type: research
Thymoma-associated autoimmune encephalitis with myasthenia gravis: Case series and literature review
CONCLUSIONS: There was no significant difference in the clinical manifestations between these patients and others with only TAMG or TAAE. TAAE was commonly associated with AMPAR2-Ab. Significantly, AE more commonly heralded thymoma recurrences than MG onset. And the intervals of thymectomy and MG or AE onset had different meanings for thymoma recurrence and prognoses of patients.PMID:38421083 | DOI:10.1111/cns.14568 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Miao Su Qiuyan Luo Zichao Wu Huiyu Feng Hongyan Zhou Source Type: research
Peripheral nervous system and neuromuscular disorders in the emergency department: A review
CONCLUSIONS: Fortunately, early diagnosis and management can improve prognosis. This article provides a comprehensive review of acute presentations in neuromuscular disorders relevant for the emergency physician.PMID:38419365 | DOI:10.1111/acem.14861 (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - February 29, 2024 Category: Emergency Medicine Authors: Ajith Sivadasan Miguel A Cortel-LeBlanc Achelle Cortel-LeBlanc Hans Katzberg Source Type: research
Shrinking lung syndrome mimicking diaphragmatic palsy in systemic lupus erythematosus
Pract Neurol. 2024 Feb 29:pn-2023-003989. doi: 10.1136/pn-2023-003989. Online ahead of print.ABSTRACTA 25-year-old woman presented with 1 year of progressive orthopnoea, initially explained as bilateral diaphragmatic paresis caused by seronegative myasthenia gravis. She required assisted ventilation and received pyridostigmine and corticosteroids. She had minimal (particularly proximal) symmetrical tetraparesis with apparent bilateral diaphragmatic weakness, but had normal sensation. Further investigation suggested an overlap myositis with shrinking lung syndrome from systemic lupus erythematosus. She improved following im...
Source: Practical Neurology - February 29, 2024 Category: Neurology Authors: Shivam Mirg Animesh Das Awadh Kishor Pandit M C Sharma Achal K Srivastava Source Type: research
Thymoma-associated autoimmune encephalitis with myasthenia gravis: Case series and literature review
CONCLUSIONS: There was no significant difference in the clinical manifestations between these patients and others with only TAMG or TAAE. TAAE was commonly associated with AMPAR2-Ab. Significantly, AE more commonly heralded thymoma recurrences than MG onset. And the intervals of thymectomy and MG or AE onset had different meanings for thymoma recurrence and prognoses of patients.PMID:38421083 | DOI:10.1111/cns.14568 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Miao Su Qiuyan Luo Zichao Wu Huiyu Feng Hongyan Zhou Source Type: research
Shrinking lung syndrome mimicking diaphragmatic palsy in systemic lupus erythematosus
Pract Neurol. 2024 Feb 29:pn-2023-003989. doi: 10.1136/pn-2023-003989. Online ahead of print.ABSTRACTA 25-year-old woman presented with 1 year of progressive orthopnoea, initially explained as bilateral diaphragmatic paresis caused by seronegative myasthenia gravis. She required assisted ventilation and received pyridostigmine and corticosteroids. She had minimal (particularly proximal) symmetrical tetraparesis with apparent bilateral diaphragmatic weakness, but had normal sensation. Further investigation suggested an overlap myositis with shrinking lung syndrome from systemic lupus erythematosus. She improved following im...
Source: Practical Neurology - February 29, 2024 Category: Neurology Authors: Shivam Mirg Animesh Das Awadh Kishor Pandit M C Sharma Achal K Srivastava Source Type: research
Shrinking lung syndrome mimicking diaphragmatic palsy in systemic lupus erythematosus
Pract Neurol. 2024 Feb 29:pn-2023-003989. doi: 10.1136/pn-2023-003989. Online ahead of print.ABSTRACTA 25-year-old woman presented with 1 year of progressive orthopnoea, initially explained as bilateral diaphragmatic paresis caused by seronegative myasthenia gravis. She required assisted ventilation and received pyridostigmine and corticosteroids. She had minimal (particularly proximal) symmetrical tetraparesis with apparent bilateral diaphragmatic weakness, but had normal sensation. Further investigation suggested an overlap myositis with shrinking lung syndrome from systemic lupus erythematosus. She improved following im...
Source: Practical Neurology - February 29, 2024 Category: Neurology Authors: Shivam Mirg Animesh Das Awadh Kishor Pandit M C Sharma Achal K Srivastava Source Type: research
Shrinking lung syndrome mimicking diaphragmatic palsy in systemic lupus erythematosus
Pract Neurol. 2024 Feb 29:pn-2023-003989. doi: 10.1136/pn-2023-003989. Online ahead of print.ABSTRACTA 25-year-old woman presented with 1 year of progressive orthopnoea, initially explained as bilateral diaphragmatic paresis caused by seronegative myasthenia gravis. She required assisted ventilation and received pyridostigmine and corticosteroids. She had minimal (particularly proximal) symmetrical tetraparesis with apparent bilateral diaphragmatic weakness, but had normal sensation. Further investigation suggested an overlap myositis with shrinking lung syndrome from systemic lupus erythematosus. She improved following im...
Source: Practical Neurology - February 29, 2024 Category: Neurology Authors: Shivam Mirg Animesh Das Awadh Kishor Pandit M C Sharma Achal K Srivastava Source Type: research
Shrinking lung syndrome mimicking diaphragmatic palsy in systemic lupus erythematosus
Pract Neurol. 2024 Feb 29:pn-2023-003989. doi: 10.1136/pn-2023-003989. Online ahead of print.ABSTRACTA 25-year-old woman presented with 1 year of progressive orthopnoea, initially explained as bilateral diaphragmatic paresis caused by seronegative myasthenia gravis. She required assisted ventilation and received pyridostigmine and corticosteroids. She had minimal (particularly proximal) symmetrical tetraparesis with apparent bilateral diaphragmatic weakness, but had normal sensation. Further investigation suggested an overlap myositis with shrinking lung syndrome from systemic lupus erythematosus. She improved following im...
Source: Practical Neurology - February 29, 2024 Category: Neurology Authors: Shivam Mirg Animesh Das Awadh Kishor Pandit M C Sharma Achal K Srivastava Source Type: research
Interactions Between Extracellular Vesicles and Autophagy in Neuroimmune Disorders
AbstractNeuroimmune disorders, such as multiple sclerosis, neuromyelitis optica spectrum disorder, myasthenia gravis, and Guillain –Barré syndrome, are characterized by the dysfunction of both the immune system and the nervous system. Increasing evidence suggests that extracellular vesicles and autophagy are closely associated with the pathogenesis of these disorders. In this review, we summarize the current understanding of the interactions between extracellular vesicles and autophagy in neuroimmune disorders and discuss their potential diagnostic and therapeutic applications. Here we highlight the need for further res...
Source: Neuroscience Bulletin - February 29, 2024 Category: Neuroscience Source Type: research
Clinicopathological predictors of postoperative long-term myasthenic status in resected thymoma with myasthenia gravis
ConclusionThe WHO type of thymoma is an informative predictor of postoperative MG status in patients with MG-related thymoma. (Source: Surgery Today)
Source: Surgery Today - February 28, 2024 Category: Surgery Source Type: research
