Machine-learning study finds EEG brain signatures that predict response to antidepressant treatments
This study takes previous research showing that we can predict who benefits from an antidepressant and actually brings it to the point of practical utility,” said Amit Etkin, MD, PhD, professor of psychiatry and behavioral sciences at Stanford. “I will be surprised if this isn’t used by clinicians within the next five years.”
Instead of functional magnetic resonance imaging, an expensive technology often used in studies to image brain activity, the scientists turned to electroencephalography, or EEG, a much less costly technology…
The paper is one of several based on data from a federally funded depression study ...
Source: SharpBrains - February 18, 2020 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness Technology algorithm Amit Etkin antidepressant antidepressants brain brain-activity brain-wave signature depression depression-treatment EEG electrical activity electroencephalography Source Type: blogs
World ’s First Portable MRI Cleared by FDA
Magnetic resonance imaging (MRI) has revolutionized medicine, but MRI scanners are so demanding that access to them is still a challenge. MRI machines typically require specially built rooms with magnet quench vent pipes, entry systems that check people for metals attracted to magnets, and specific protocols to ensure safety. Patients, therefore, have to be brought to the MRI scanners rather than the other way around.
This is about to change in many cases, as Hyperfine, a company with offices in New York City and St Guilford, Connecticut, won FDA clearance for the first MRI scanner that can be wheeled to the patient bed...
Source: Medgadget - February 17, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Emergency Medicine Neurology Neurosurgery Radiology Source Type: blogs
MRI Technique Predicts Future Alcohol Abuse in Teenagers
The objective of the technique is to establish a possible neural marker that could identify which teenagers would abuse alcohol when they entered adulthood and devise interventions that might delay alcohol use. The researchers used BOLD MRI on 29 participants who drank minimal alcohol between the ages of 12 and 14, and over the course of the study, 15 had evolved into binge drinkers. The BOLD inhibitory control test was used to determine blood flow changes that happened in tandem with neuron activation. In the group ’s initial imaging round at age 18, participants were asked to press a button when they saw any shape th...
Source: radRounds - January 18, 2020 Category: Radiology Authors: Julie Morse Source Type: blogs
Fight Aging! Newsletter, January 13th 2020
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - January 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Tau is More Harmful to the Brain than Amyloid in Alzheimer's Disease
Alzheimer's disease is a condition characterized by amyloid aggregation, chronic inflammation in brain tissue, and tau aggregation, these aspects of the condition progressing at different paces and interacting with one another in complex ways that are yet to be fully understood. Amyloid aggregation is widely thought to be the initial, triggering pathology. Tau aggregation is found in the later stages of Alzheimer's disease, once cell death begins in earnest, and the evidence suggests that this form of pathology is driven by chronic inflammation in the brain. Removal of senescent supporting cells in the brain, thereby reduc...
Source: Fight Aging! - January 9, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
More Aggressive Blood Pressure Control Reduces the Structural Damage Done to the Brain
Hypertension, raised blood pressure, is very damaging to tissues and organ function throughout the body. It significantly increases the pace at which capillaries rupture, leading to small areas of cell death. The loss of function adds up, particularly in the brain, where this damage shows up as white matter lesions in imaging. The study here illustrates the damage done, and reinforces the message that control of blood pressure is very important for long term health. It has already been shown to reduce mortality, and the work here gives some insight into the mechanisms by which this reduction occurs.
It's been esti...
Source: Fight Aging! - January 3, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cardiology MCQ – Low gradient severe AS
Cardiology MCQ – Low gradient severe AS
Investigation to identify low flow low gradient severe aortic stenosis:
Global longitudinal strain
Dobutamine echocardiography
Cardiac magnetic resonance imaging
Tissue Doppler imaging
Click here the answer and discussion (Source: Cardiophile MD)
Source: Cardiophile MD - December 29, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
MRI Shows Us the Neural Underworking of Depression
Two teams of researchers are using magnetic resonance imaging (MRI) to examine the neural patterns associated with major depressive disorder (MDD). Both groups presented their findings at the most recent Radiological Society of North America annual meeting in Chicago. Centers for Disease Control estimates that 16 millionAmerican adults suffer from depression every year. Depression is commonly linked with anxiety, and many patients turn to therapy or medication to diminish symptoms. In an attempt to better understand how depression operates in the brain, researchers from Columbia University ’s department of psychiatry...
Source: radRounds - December 23, 2019 Category: Radiology Authors: Julie Morse Source Type: blogs
Is Mammography + MRI the Key for Early Detection of Breast Cancer?
Dense breast tissue not only increases a woman ’s risk of developing cancer, it also makes it more difficult for physicians to identify possible tumors. However, emerging research from University Medical Center Utrecht in the Netherlands has found that implementing magnetic resonance imaging (MRI) screening in addition to mammography can be a more effective cancer diagnosis method in patients with dense breast tissue than mammography alone. Over the course of two years, the group of researchers led by Carla van Gils evaluated 40,000 women with immense dense breast tissue with mammography and 4,783 were designated to rec...
Source: radRounds - December 23, 2019 Category: Radiology Authors: Julie Morse Source Type: blogs
Fight Aging! Newsletter, December 23rd 2019
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons.
Epige...
Source: Fight Aging! - December 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Blood-Brain Barrier Dysfunction Causes Chronic Inflammation and Neurodegeneration
Numerous lines of evidence point to the characteristic increase in chronic inflammation that takes place in old age to be of great importance in the progression of neurodegenerative conditions. A fair degree of that inflammation in the brain results from dysfunction of the blood-brain barrier, a layer of cells lining blood vessels in the central nervous system that normally acts to prevent unwanted and potentially harmful molecules and cells from entering the brain. The work reported here builds on more than a decade of investigation of the age-related decline of the blood-brain barrier, and consequent inflammation in the ...
Source: Fight Aging! - December 16, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 18th 2019
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MRI Shows How Excessive Screen Time Impacts White Matter in Young Children
A new magnetic resonance imaging (MRI) cross-sectional studyusing diffusion tensor imaging (DTI) has found that young children who spend more than an hour a day in front of a screen have more disorganized and underdeveloped white matter than children with lower screen time quotas. The American Academy of Pediatrics (AAP) recommends an hour of daily screen time, and warns that children who spend more than two hours in front of a screen are at risk for a variety of developmental delays, such as impaired cognition, language delay, poor sleep, and decreased parent-child engagement. To understand the repercussions of excess...
Source: radRounds - November 15, 2019 Category: Radiology Authors: Julie Morse Source Type: blogs
Chronic fatigue syndrome: Gradually figuring out what ’s wrong
In 1983, a health professional in her 30s walked into my office and said, “I’ve been healthy all of my life. A year ago, I came down with some kind of virus — sore throat, aching muscles, swollen lymph glands, fever. My fatigue was so bad I was in bed for nearly a week. Many of the symptoms gradually improved, but the terrible fatigue and difficulty thinking have not gotten better. They’re so bad I can’t fulfill my responsibilities at home or at work. This illness is affecting my brain, stealing my energy, and affecting my immune system. It’s keeping me from realizing my dreams.”
There’s a piece of advice a...
Source: Harvard Health Blog - November 14, 2019 Category: Consumer Health News Authors: Anthony Komaroff, MD Tags: Fatigue Health Source Type: blogs
Cardiovascular Aging Contributes to Brain Aging
The brain is an energy-hungry organ, and is sensitive to reductions in the blood supply of oxygen and nutrients. Cardiovascular aging can reduce that supply, whether through conditions such as heart failure, or the progressive loss of density in capillary networks that occurs throughout the body with advancing age, or an accelerated pace of rupture of tiny vessels in the brain, or disruption of the blood-brain barrier, allowing unwanted molecules and cells to enter the brain. Thus, as researchers here note, we would expect to see correlations between cardiovascular disease, or risk factors for cardiovascular disease, and d...
Source: Fight Aging! - November 11, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
