Results From a Small, Informal Trial of Telomerase and Klotho Gene Therapy for Alzheimer's Disease
Bioviva was at one point developing telomerase gene therapies, work that has transitioned into the medical tourism industry via Integrated Health Systems rather than proceeding towards regulatory approval. The institutional communities of science and funding strongly disapproved of the self-experiment undertaken by the Bioviva founder, and the way that self-experiment was popularized in order to build the company. I think this a pity, given the long history of self-experimentation by noted figures in the scientific community. Nonetheless, we live in an era that frowns upon self-experimentation as a part of the path to prog...
Source: Fight Aging! - November 17, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Toothache, incidental Wide Complex Tachycardia
Discussion by our ElectrophysiologistSmith: “I thought that the wide complex tachy (WCT) could be AVRT or VT” EP: " Antidromic AVRT morphology would essentially be the same as “VT” originating from ventricular the insertion site of the accessory pathway. Therefore, traditional criteria for SVT with aberrancy do not apply to antidromic AVRT (except, that negative concordance can never be AVRT!) " Smith: “But then when the patient converted and had PVCs of exactly the same morphology as the WCT, that it must be VT and not AVRT ” EP: " In cases of intermittent pre-excitation, you cou...
Source: Dr. Smith's ECG Blog - November 17, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
It ’s Elementary: Celebrating National Chemistry Week
Happy National Chemistry Week! In honor of this celebration, we’re showcasing posts that focus on elements crucial for human health and scientific exploration. NIGMS-supported scientists are studying how each of these elements (and many others) can impact human health. Check out the list below to learn more, and let us know what your favorite element is in the comments section!
Credit: Adapted from Compound Interest. CC BY-NC-ND 4.0.
Helium: An Abundant History and a Shortage Threatening Scientific Tools
Scientists first discovered helium burning on the surface of the sun. Today, liquid helium plays an essential r...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 20, 2021 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Source Type: blogs
Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Earlier Hypertension Correlates with Smaller Later Brain Volume and Raised Risk of Dementia
The increased blood pressure of hypertension causes structural damage to delicate tissues throughout the body, particularly in the brain. Beyond the matter of an increased pace of rupture of capillaries, killing tiny volumes of brain tissue, the blood-brain barrier is disrupted by pressure damage, allowing unwanted molecules and cells into the brain to provoke chronic inflammation and disruption of function. Blood pressure is so influential on health that lowering blood pressure via antihypertensive medication, an approach that does not in any way address the underlying causes of the problem, produces a reduction in mortal...
Source: Fight Aging! - October 11, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Swoop Portable MRI: Interview with David Scott, President and CEO of Hyperfine
Hyperfine, a company based in St Guilford, Connecticut, created Swoop, a portable MRI scanner. The device received FDA approval as the first bedside MRI scanner in 2020, and a recent study has shown that it can help to accurately spot hemorrhagic stroke, detecting 85 of 88 blood-negative cases (96.6% specificity).
Rapid detection is important for successful treatment of strokes, and helps ensure the best outcomes for patients. The device can be wheeled up to a patient’s bed and powered through a standard wall outlet. This is beneficial for critically ill patients, who may be risky to move. Clinicians can acquire and v...
Source: Medgadget - October 1, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Emergency Medicine Neurology Orthopedic Surgery Pediatrics Radiology Source Type: blogs
Five thoughts to think about when thinking about the speed of thought
This article was originally published on The Conversation.
News in Context:
Award-winning image shows neuroimaging progress in a century
Neuroplasticity as seen by one of its earliest scientist proponents: Neuroscience pioneer Santiago Ramón y Cajal
Can you grow your hippocampus? Yes. Here’s how, and why it matters
The post Five thoughts to think about when thinking about the speed of thought appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - September 21, 2021 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health Education & Lifelong Learning cognitive electroencephalography functional magnetic resonance imaging movement myelination Neurons perception reaction-time speed of thought thinking thoughts Source Type: blogs
Is There A Place For Facebook In Healthcare?
Data privacy scandals, help in rigging elections, spreading fake news on COVID and vaccines: Facebook has been through a lot and users are not happy with the social media giant’s performance. However, Mark Zuckerberg’s company does not only have a political and social impact, but it’s also getting quite relevant in healthcare.
We looked around what Facebook currently does in healthcare and evaluated whether those are viable ways to follow in the future.
Facebook: from trust issues to healthcare
The social media machine built on “sophisticated, computer-driven engines for extracting users’ person...
Source: The Medical Futurist - September 7, 2021 Category: Information Technology Authors: berci.mesko Tags: Bioethics Security & Privacy AI facebook future Health Healthcare Innovation social media technology VR fake news smart healthcare Mark Zuckerberg Source Type: blogs
Reading Aloud without a Mask, Olfactory Bulbs, Omega Variant
Conclusion and recommendation:" Ineligibility because of age and lack of vaccination contribute to persistent elevated risk for outbreaks in schools, especially as new SARS-CoV-2 variants emerge. However, implementation of multiple prevention strategies within schools can mitigate this risk. "Olfactory Bulbs Speaking of smell,over 20 papers show MRI signal abnormalities in the olfactory bulbs of COVID-19 patients with anosmia (loss of smell). This isn ' t new, but anosmia has been reported inbreakthroughcasesas well. The images below show some resolution in a patient from time 1 to time 2.Magnetic Resonance Imaging Al...
Source: The Neurocritic - August 31, 2021 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
Virtual Reality System to Entertain During MRI Scans
Researchers at King’s College London developed a virtual reality system that is intended to distract and calm patients who find MRI scans challenging, including children and other vulnerable individuals. The patient wears a specialized VR headset during the scan and can interact with the system merely by moving the eyes, allowing them to play games or select various options, including watching videos or interacting with a caregiver or companion over a video link. The technology is intended to make the scans more enjoyable for patients and reduce the likelihood that a scan will be unsuccessful because a patient moves or r...
Source: Medgadget - August 18, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Radiology Source Type: blogs
Aortic Stiffness Correlates with Cognitive Decline in Older Individuals
Many aspects of aging correlate with one another, only some of which are directly causally connected, rather than emerging from the same underlying cell and tissue damage that drives aging as a whole. We might expect dysfunction in the vascular system to contribute directly to neurodegeneration and loss of function in the brain. Stiffening of blood vessel walls causes hypertension, which in turn leads to a greater pace of rupture of capillaries throughout the body. Each of these events is individually insignificant, a very tiny stroke in effect, but this adds up over time. The more structural damage to the brain, the worse...
Source: Fight Aging! - July 22, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Vaccine associated myocarditis revisited with COVID-19 mRNA vaccines
When I had reviewed the topic of vaccine associated myocarditis for an editorial in the BMH Medical Journal in 2017, most of the cases were associated with small pox vaccination [1]. There were also reports of streptococcal pneumonia vaccine and influenza vaccine associated myocarditis. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) used in the vaccine were also implicated in some cases [2,3].
While the large scale vaccination for small pox in an attempt to prepare for potential bioterrorism was the association in 2003 [4], COVID-19 mRNA vaccines are currently in the limelight for vaccine induced myocarditis...
Source: Cardiophile MD - July 22, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens.
Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Segmental approach to congenital heart disease
Segmental approach is used routinely in the echocardiographic evaluation of congenital heart disease. It is also useful in other cardiac imaging modalities used for evaluation of congenital heart disease like computed tomography and magnetic resonance imaging. Chest X-ray is useful in evaluating the cardiac position and visceral situs as it gives an overview of cardiac position in the thorax, position of left and right bronchi, aortic arch, liver and stomach air bubble [1].
Here is a chest X-ray in mesocardia with levo transposition of great arteries:
X-ray chest PA showing mesocardia with L-TGA and L-posed aorta seen as ...
Source: Cardiophile MD - July 17, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Echocardiography Source Type: blogs
Why Do Some Older People Retain a Good Memory?
The myriad ways in which the brain changes with age are in some ways very well explored, but overall still a dark forest, little understood in fine detail. One approach to gain greater understanding of the processes that cause declining cognitive function with age is to compare people with good function and people with poor function, first categorizing, and then secondly assessing the properties of the brain, as best researchers are able to do so, given limited access to the inside of the cranium. Today's research materials are an example of this sort of research, focused on trying to better understand why some older peopl...
Source: Fight Aging! - July 13, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
