Neural Interconnections of Extracranial Nerves in Headache Surgery: Anatomical Landmarks and Clinical Implications - A Review of Literature
Plast Reconstr Surg. 2024 Apr 29. doi: 10.1097/PRS.0000000000011504. Online ahead of print.ABSTRACTHeadache disorders (HD) remain a nationwide challenge for the US healthcare system affecting nearly 60% of the US population. Surgical deactivation of the peripheral trigger site, also referred to as headache surgery, represents an effective treatment for patients with refractory HD pain or non-response to pharmacological regimes. Research stemming from other surgical specialties has underlined the clinical relevance of neural interconnections in refining diagnostic algorithms, adapting surgical techniques, and improving over...
Source: Hand Surgery - April 29, 2024 Category: Surgery Authors: Samuel Knoedler Konstantin Frank Thomas Muehlberger Ali-Farid Safi Sebastian Cotofana Filippo A G Perozzo Adriana C Panayi Bahman Guyuron Jeffrey E Janis Michael Alfertshofer Source Type: research

Emergency Department Use in Adolescent and Young Adult Cancer Early Survivors from 2006 to 2020
Conclusion: ED utilization declined as time from diagnosis elapsed, but higher utilization was associated with social determinants of health and cancer types.PMID:38682323 | DOI:10.1089/jayao.2023.0174 (Source: Ann Oncol)
Source: Ann Oncol - April 29, 2024 Category: Cancer & Oncology Authors: Karen J Wernli Eric C Haupt Neetu Chawla Thearis Osuji Ernest Shen Andrew B Smitherman Mallory Casperson Anne C Kirchhoff Bradley J Zebrack Theresa H M Keegan Lawrence Kushi Christopher Baggett Heydon K Kaddas Kathryn J Ruddy Candice A M Sauder Theodore W Source Type: research

Cerebral Venous Thrombosis in Pregnant and Postpartum Women Presenting to the Emergency Department with Headaches
CONCLUSION: Pregnant patients presenting to the emergency department with headaches do not have a significantly higher risk of CVT; however, puerperium patients have a significantly higher risk of CVT compared to the general population.PMID:38681884 | PMC:PMC11044997 | DOI:10.4103/jets.jets_92_23 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Aaron Jacob Grossberg Sagar C Galwankar Source Type: research

Long –Term Outcome After Discontinuation of CGRP-Targeting Therapy for Migraine
AbstractPurpose of reviewCalcitonin gene-related peptide (CGRP)-targeting agents are potential candidates for disease-modifying migraine drugs. However, most studies on CGRP-targeting agents have assessed efficacy outcomes rather than long-term effects after discontinuation. This review aimed to synthesize and scrutinize the latest clinical data on the outcomes after the discontinuation of CGRP-targeting therapy in patients with episodic and chronic migraine, with a particular focus on chronic migraine.Recent findingsReal-world studies involving patients with migraine have reported consistent findings of worsened headache ...
Source: Current Pain and Headache Reports - April 29, 2024 Category: Neurology Source Type: research

Poisoning by carbon monoxide
Accidental carbon monoxide (CO) poisoning causes 100 hospital admissions and 7 deaths per million UK population. Toxicity occurs mainly through the formation of carboxyhaemoglobin (COHb), causing ischaemia of vital organs. Features are non-specific and include headache, gastrointestinal upset, dizziness, weakness, convulsions, coma, chest pain and dyspnoea. Neuropsychiatric features can appear up to 40  days after the initial exposure. The diagnosis can be missed unless a history of exposure to sources of CO is elicited or a CO alarm triggered. (Source: Medicine)
Source: Medicine - April 29, 2024 Category: Internal Medicine Authors: Aravindan Veiraiah Tags: Poisonous substances Source Type: research

Untangling the mess of CGRP levels as a migraine biomarker: an in-depth literature review and analysis of our experimental experience
ConclusionsWe present valuable information for CGRP measurements in serum. ELISA kit suitability should be tested prior to the experiments. Alpha and beta-CGRP levels should be analysed separately as they can show different behaviours even within the same condition. Samples can be processed in a 24-h window if they have been kept in 4 °C and should not be stored for more than 6 months at -80°C before assayed. Patients do not need to rest before the blood extraction unless they have performed a high-endurance exercise. For comparative studies, sex and age should be accounted for as these parameters can impact CGRP concent...
Source: The Journal of Headache and Pain - April 29, 2024 Category: Neurology Source Type: research

Acupuncture versus tricyclic antidepressants in the prophylactic treatment of tension-type headaches: an indirect treatment comparison meta-analysis
ConclusionAcupuncture had similar effect as TCAs in reducing headache frequency of TTH, and acupuncture had a lower adverse events rate than amitriptyline, as shown by very low certainty of evidence. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - April 29, 2024 Category: Neurology Source Type: research

Characteristics of patients who seek medical attention for headache and those who do not: cross-sectional survey and linked medical claims data analysis in Japan
Conclusions Patients typically seek help when the pain becomes unbearable. Still, some of them did not seek medical attention while they were experiencing headache for ≥15 days per month. Therefore, it is important to raise awareness and encourage seeking early medical attention before symptoms and associated burdens become too severe to be managed effectively. (Source: BMJ Open)
Source: BMJ Open - April 29, 2024 Category: General Medicine Authors: Igarashi, H., Sano, H., Kondo, H., Shibasaki, Y., Koga, N. Tags: Open access, Neurology Source Type: research

Changes in work schedule affect headache frequency among Norwegian nurses: a 3-year-follow-up study
Conclusion Changing from night work and reducing the number of night shifts and quick returns were associated with less headache in this 3-year-follow-up of Norwegian nurses. This adds to the growing body of evidence that night work may have direct negative health consequences. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - April 28, 2024 Category: Occupational Health Authors: Kristoffersen, E. S., Waage, S., Pallesen, S., Bjorvatn, B. Tags: Workplace Source Type: research

Don ’t delay, but don’t despair: symptom duration, comorbidity and outcome after closure of spinal cerebrospinal fluid leaks
ConclusionAs patients with shorter symptom duration show a trend for a better outcome, our results promote a timely diagnosis and treatment in SIH patients. However, a significant postoperative improvement can still be expected even after a prolonged symptom duration. (Source: Journal of Neurology)
Source: Journal of Neurology - April 27, 2024 Category: Neurology Source Type: research

SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?
CONCLUSION: Alongside known risk factors (hypertension, anticoagulation, pregnancy, surgery, etc.), COVID-19 infection might represent an emerging predisposing factor for PA onset. The two cases hereby presented are both significant: the first confirms the role of "classic" vascular predisposing factors for PA, while the second demonstrates that PA might arise also in young patients without known risk factors.PMID:38676521 | DOI:10.2174/0118715303315494240419060719 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Alberto Ragni Giulia Bendotti Emilia Biamonte Beatrice Cavigiolo Enrico Gabellieri Paola Leporati Edoardo Luigi Maria Mollero Marco Gallo Source Type: research

SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?
CONCLUSION: Alongside known risk factors (hypertension, anticoagulation, pregnancy, surgery, etc.), COVID-19 infection might represent an emerging predisposing factor for PA onset. The two cases hereby presented are both significant: the first confirms the role of "classic" vascular predisposing factors for PA, while the second demonstrates that PA might arise also in young patients without known risk factors.PMID:38676521 | DOI:10.2174/0118715303315494240419060719 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Alberto Ragni Giulia Bendotti Emilia Biamonte Beatrice Cavigiolo Enrico Gabellieri Paola Leporati Edoardo Luigi Maria Mollero Marco Gallo Source Type: research

A comparative assessment of microbiocenosis of saliva and oropharynx in patients with migraine
CONCLUSION: A comparative assessment of the microbiota of a smear from the posterior wall of the oropharynx and saliva using MMSM showed the presence of dysbiosis both in the oropharynx and in the saliva of patients with migraine. However, there were fewer deviations from the norm in saliva, therefore, for diagnostic purposes, a smear from the posterior wall of the oropharynx is more significant as a biomarker for patients with migraine.PMID:38676678 | DOI:10.17116/jnevro202412404155 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: I L Naydenova A B Danilov A V Simonova A A Pilipovich E G Filatova Source Type: research

SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?
CONCLUSION: Alongside known risk factors (hypertension, anticoagulation, pregnancy, surgery, etc.), COVID-19 infection might represent an emerging predisposing factor for PA onset. The two cases hereby presented are both significant: the first confirms the role of "classic" vascular predisposing factors for PA, while the second demonstrates that PA might arise also in young patients without known risk factors.PMID:38676521 | DOI:10.2174/0118715303315494240419060719 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Alberto Ragni Giulia Bendotti Emilia Biamonte Beatrice Cavigiolo Enrico Gabellieri Paola Leporati Edoardo Luigi Maria Mollero Marco Gallo Source Type: research

SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?
CONCLUSION: Alongside known risk factors (hypertension, anticoagulation, pregnancy, surgery, etc.), COVID-19 infection might represent an emerging predisposing factor for PA onset. The two cases hereby presented are both significant: the first confirms the role of "classic" vascular predisposing factors for PA, while the second demonstrates that PA might arise also in young patients without known risk factors.PMID:38676521 | DOI:10.2174/0118715303315494240419060719 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Alberto Ragni Giulia Bendotti Emilia Biamonte Beatrice Cavigiolo Enrico Gabellieri Paola Leporati Edoardo Luigi Maria Mollero Marco Gallo Source Type: research