Interventions for improving coverage of childhood immunisation in low- and middle-income countries
CONCLUSIONS: Health education, home-based records, a combination of involvement of community leaders with health provider intervention, and integration of immunisation services may improve vaccine uptake. The certainty of the evidence for the included interventions ranged from moderate to very low. Low certainty of the evidence implies that the true effect of the interventions might be markedly different from the estimated effect. Further, more rigorous RCTs are, therefore, required to generate high-certainty evidence to inform policy and practice.PMID:38054505 | PMC:PMC10698843 | DOI:10.1002/14651858.CD008145.pub4 (Source...
Source: Cochrane Database of Systematic Reviews - December 6, 2023 Category: General Medicine Authors: Angela Oyo-Ita Olabisi Oduwole Dachi Arikpo Emmanuel E Effa Ekpereonne B Esu Yusentha Balakrishna Moriam T Chibuzor Chioma M Oringanje Chukwuemeka E Nwachukwu Charles S Wiysonge Martin M Meremikwu Source Type: research
Interventions for improving coverage of childhood immunisation in low- and middle-income countries
CONCLUSIONS: Health education, home-based records, a combination of involvement of community leaders with health provider intervention, and integration of immunisation services may improve vaccine uptake. The certainty of the evidence for the included interventions ranged from moderate to very low. Low certainty of the evidence implies that the true effect of the interventions might be markedly different from the estimated effect. Further, more rigorous RCTs are, therefore, required to generate high-certainty evidence to inform policy and practice.PMID:38054505 | PMC:PMC10698843 | DOI:10.1002/14651858.CD008145.pub4 (Source...
Source: Cochrane Database of Systematic Reviews - December 6, 2023 Category: General Medicine Authors: Angela Oyo-Ita Olabisi Oduwole Dachi Arikpo Emmanuel E Effa Ekpereonne B Esu Yusentha Balakrishna Moriam T Chibuzor Chioma M Oringanje Chukwuemeka E Nwachukwu Charles S Wiysonge Martin M Meremikwu Source Type: research
Exploratory analysis of the knowledge, attitudes and perceptions of healthcare workers about arboviruses in the context of surveillance in the Republic of Guinea
ConclusionThis study highlights the imperative requirement for comprehensive training targeting HCWs to enhance their capacity for early case detection within healthcare facilities. Additionally, there is a crucial need for analogous studies adopting a mixed-methods approach across all healthcare regions in Guinea. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 4, 2023 Category: Tropical Medicine Authors: Salifou Talassone Bangoura Source Type: research
Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer
Transl Oncol. 2023 Dec 1;40:101846. doi: 10.1016/j.tranon.2023.101846. Online ahead of print.ABSTRACTThe treatment of cancer patients has been mainly followed using chemotherapy and it is a gold standard in improving prognosis and survival rate of patients. Oxaliplatin (OXA) is a third-platinum anti-cancer agent that reduces DNA synthesis in cancer cells to interfere with their growth and cell cycle progression. In spite of promising results of using OXA in cancer chemotherapy, the process of drug resistance has made some challenges. OXA is commonly applied in treatment of colorectal cancer (CRC) as a malignancy of gastroi...
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Mehrdad Hashemi Nastaran Esbati Mohsen Rashidi Sadaf Gholami Rasoul Raesi Seyed Shahabadin Bidoki Mohammad Ali Sheikh Beig Goharrizi Yasamin Sadat Mousavi Motlagh Ramin Khorrami Alireza Tavakolpournegari Noushin Nabavi Rongjun Zou Leila Mohammadnahal Mali Source Type: research
Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer
Transl Oncol. 2023 Dec 1;40:101846. doi: 10.1016/j.tranon.2023.101846. Online ahead of print.ABSTRACTThe treatment of cancer patients has been mainly followed using chemotherapy and it is a gold standard in improving prognosis and survival rate of patients. Oxaliplatin (OXA) is a third-platinum anti-cancer agent that reduces DNA synthesis in cancer cells to interfere with their growth and cell cycle progression. In spite of promising results of using OXA in cancer chemotherapy, the process of drug resistance has made some challenges. OXA is commonly applied in treatment of colorectal cancer (CRC) as a malignancy of gastroi...
Source: Cancer Control - December 2, 2023 Category: Cancer & Oncology Authors: Mehrdad Hashemi Nastaran Esbati Mohsen Rashidi Sadaf Gholami Rasoul Raesi Seyed Shahabadin Bidoki Mohammad Ali Sheikh Beig Goharrizi Yasamin Sadat Mousavi Motlagh Ramin Khorrami Alireza Tavakolpournegari Noushin Nabavi Rongjun Zou Leila Mohammadnahal Mali Source Type: research
Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer
Transl Oncol. 2023 Dec 1;40:101846. doi: 10.1016/j.tranon.2023.101846. Online ahead of print.ABSTRACTThe treatment of cancer patients has been mainly followed using chemotherapy and it is a gold standard in improving prognosis and survival rate of patients. Oxaliplatin (OXA) is a third-platinum anti-cancer agent that reduces DNA synthesis in cancer cells to interfere with their growth and cell cycle progression. In spite of promising results of using OXA in cancer chemotherapy, the process of drug resistance has made some challenges. OXA is commonly applied in treatment of colorectal cancer (CRC) as a malignancy of gastroi...
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Mehrdad Hashemi Nastaran Esbati Mohsen Rashidi Sadaf Gholami Rasoul Raesi Seyed Shahabadin Bidoki Mohammad Ali Sheikh Beig Goharrizi Yasamin Sadat Mousavi Motlagh Ramin Khorrami Alireza Tavakolpournegari Noushin Nabavi Rongjun Zou Leila Mohammadnahal Mali Source Type: research
An efficient screening system of disease-resistant genes from wild apple, Malus sieversii in response to Valsa mali pathogenic fungus
For molecular breeding of future apples, wild apple (Malus sieversii), the primary progenitor of domesticated apples, provides abundant genetic diversity and disease-resistance traits. Valsa canker (caused by the... (Source: Plant Methods)
Source: Plant Methods - December 2, 2023 Category: Biology Authors: Xuejing Wen, Jiangxue Yuan, Tohir A. Bozorov, Abdul Waheed, Gulnaz Kahar, Yakupjan Haxim, Xiaojie Liu, Lili Huang and Daoyuan Zhang Tags: Methodology Source Type: research
The rapid construction and biological evaluation of densely substituted pyrrolo[1,2-a]indoles via a BF3 ·OEt2-assisted cascade approach
Org. Biomol. Chem., 2023, Advance Article DOI: 10.1039/D3OB01457F, PaperGhanshyam Mali, Vinay Kumar Yadav, Himani Priya, Manjari Shukla, Peeyush Pandey, Akhilesh Kumar, Manikandan Paranjothy, Sudipta Bhattacharyya, Rohan D. Erande BF3 ·OEt2-promoted cascade reactions revealed varied derivatives of pyrrolo[1,2-a]indoles, supported by DFT, whose biological investigation highlights anti-mycobacterial therapeutic leads. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - December 1, 2023 Category: Molecular Biology Authors: Ghanshyam Mali Source Type: research
HPR196 Loss of Exclusivity (LOE): Impact Analysis across Europe-5 and Select Nordic Countries
The financial impact of Loss of Exclusivity (LoE) on pharmaceutical companies can be significant and can vary depending on specific drug and market conditions. The aim of this research was to characterize the impact of LoE and company mitigation strategies on list prices in 8 European Countries; mainly Europe-5 and Denmark, Sweden, and Norway. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: P.K. Mali, M. Labban Source Type: research
On-surface synthesis of aromatic cyclo[10]carbon and cyclo[14]carbon
Nature, Published online: 29 November 2023; doi:10.1038/s41586-023-06741-xWe provide a modified strategy for the on-surface synthesis of cyclocarbons with 10 or 14 carbon atoms that provides a route for characterizing annular carbon allotropes. (Source: Nature AOP)
Source: Nature AOP - November 29, 2023 Category: Research Authors: Luye Sun Wei Zheng Wenze Gao Faming Kang Mali Zhao Wei Xu Source Type: research
Master statistical analysis plan: attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia
This manuscript is a master statistical analysis plan for each of three-cluster randomized controlled trials to evaluate the efficacy of attractive targeted sugar baits (ATSB) described in an already published... (Source: Trials)
Source: Trials - November 29, 2023 Category: General Medicine Authors: Joshua Yukich, Thomas P. Eisele, Feiko terKuile, Ruth Ashton, Sarah Staedke, Angela F. Harris, Paul C. D. Johnson, Sophie Sarrassat, Maia Lesosky, John Bradley, Immo Kleinschmidt and Megan Littrell Tags: Research Source Type: research
Self-assembly of Discrete Oligomers of Naphthalenediimides in Bulk and on Surfaces
Chemistry. 2023 Nov 27:e202303107. doi: 10.1002/chem.202303107. Online ahead of print.ABSTRACTHere we report on the synthesis of discrete oligomers of alkyl-bridged naphthalenediimides (NDIs) and study their molecular nanostructures both in bulk, in solution and at the solid-liquid interface. Via an iterative synthesis method, multiple NDI cores were bridged with short and saturated alkyl-diamines (C3 and C12) or long and unsaturated alkyl-diamines (u2C33 to u8C100) at their imide termini. The strong intermolecular interaction between the NDI cores was observed by probing their photophysical properties in solution. In bulk...
Source: Chemistry - November 27, 2023 Category: Chemistry Authors: Christiaan Corbet Bart van den Bersselaar Bas de Waal Robby Reynaerts Kunal Mali Steven de Feyter Alain Jonas E W Meijer Ghislaine Vantomme Source Type: research
Self-assembly of Discrete Oligomers of Naphthalenediimides in Bulk and on Surfaces
Chemistry. 2023 Nov 27:e202303107. doi: 10.1002/chem.202303107. Online ahead of print.ABSTRACTHere we report on the synthesis of discrete oligomers of alkyl-bridged naphthalenediimides (NDIs) and study their molecular nanostructures both in bulk, in solution and at the solid-liquid interface. Via an iterative synthesis method, multiple NDI cores were bridged with short and saturated alkyl-diamines (C3 and C12) or long and unsaturated alkyl-diamines (u2C33 to u8C100) at their imide termini. The strong intermolecular interaction between the NDI cores was observed by probing their photophysical properties in solution. In bulk...
Source: Chemistry - November 27, 2023 Category: Chemistry Authors: Christiaan Corbet Bart van den Bersselaar Bas de Waal Robby Reynaerts Kunal Mali Steven de Feyter Alain Jonas E W Meijer Ghislaine Vantomme Source Type: research
