Natural Polymer-Based Nanogel for pH-Responsive Delivery of Sorafenib Tosylate in Hemangiosarcoma
This study is promising but challenging depending on the in vivo study. The nanogel was successfully prepared and evaluated for pH-responsive release. As hemangiosarcoma commonly occurs in dogs, this formulation helps to limit the difficulties with administration.PMID:38605211 | DOI:10.1208/s12249-024-02797-8 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 11, 2024 Category: Drugs & Pharmacology Authors: Kiran K Mali Yogeshkumar N Gavhane Rita D Chakole Source Type: research
Design, selective synthesis and biological activities evaluation of novel thiazol-2-ylbenzamide and thiazole-2-ylbenzimidoyl chloride derivatives
Bioorg Chem. 2024 Apr 6;147:107333. doi: 10.1016/j.bioorg.2024.107333. Online ahead of print.ABSTRACTTo promote the development and exploitation of novel antifungal agents, a series of thiazol-2-ylbenzamide derivatives (3A-3V) and thiazole-2-ylbenzimidoyl chloride derivatives (4A-4V) were designed and selective synthesis. The bioassay results showed that most of the target compounds exhibited excellent in vitro antifungal activities against five plant pathogenic fungi (Valsa mali, Sclerotinia scleotiorum, Botrytis cinerea, Rhizoctonia solani and Trichoderma viride). The antifungal effects of compounds 3B (EC50 = 0.72 mg/L)...
Source: Bioorganic Chemistry - April 10, 2024 Category: Chemistry Authors: Zonghan Xu Xiang Cheng Hongyun Cui Linmin Cao Yaping Song Xihao Chang Dandan Wang Xianhai Lv Source Type: research
Design, selective synthesis and biological activities evaluation of novel thiazol-2-ylbenzamide and thiazole-2-ylbenzimidoyl chloride derivatives
Bioorg Chem. 2024 Apr 6;147:107333. doi: 10.1016/j.bioorg.2024.107333. Online ahead of print.ABSTRACTTo promote the development and exploitation of novel antifungal agents, a series of thiazol-2-ylbenzamide derivatives (3A-3V) and thiazole-2-ylbenzimidoyl chloride derivatives (4A-4V) were designed and selective synthesis. The bioassay results showed that most of the target compounds exhibited excellent in vitro antifungal activities against five plant pathogenic fungi (Valsa mali, Sclerotinia scleotiorum, Botrytis cinerea, Rhizoctonia solani and Trichoderma viride). The antifungal effects of compounds 3B (EC50 = 0.72 mg/L)...
Source: Bioorganic Chemistry - April 10, 2024 Category: Chemistry Authors: Zonghan Xu Xiang Cheng Hongyun Cui Linmin Cao Yaping Song Xihao Chang Dandan Wang Xianhai Lv Source Type: research
Factors influencing pregnancy care and institutional delivery in rural Mali: a secondary baseline analysis of a cluster-randomised trial
Conclusion
The findings suggest that education, occupation and distance are important determinants of pregnancy and delivery care in a rural Malian context.
Trial registration number
NCT02694055. (Source: BMJ Open)
Source: BMJ Open - April 9, 2024 Category: General Medicine Authors: Ghosh, R., Konipo, A., Treleaven, E., Rozenshteyn, S., Beckerman, J., Whidden, C., Johnson, A., Kayentao, K., Liu, J. Tags: Open access, Global health Source Type: research
Increased Intracranial Arterial Pulsatility and Microvascular Brain Damage in Pseudoxanthoma Elasticum [NEUROVASCULAR/STROKE IMAGING]
CONCLUSIONS:
Patients with pseudoxanthoma elasticum have increased intracranial artery flow pulsatility and measures of small-vessel disease. Carotid siphon calcification might underlie the high prevalence of cerebrovascular disease in pseudoxanthoma elasticum. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 8, 2024 Category: Radiology Authors: Bartstra, J. W., van den Beukel, T., Kranenburg, G., Geurts, L. J., den Harder, A. M., Witkamp, T., Wolterink, J. M., Zwanenburg, J. J. M., van Valen, E., Koek, H. L., Mali, W. P. T. M., de Jong, P. A., Hendrikse, J., Spiering, W. Tags: NEUROVASCULAR/STROKE IMAGING Source Type: research
Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats
Mol Cell Biochem. 2024 Apr 5. doi: 10.1007/s11010-024-04994-2. Online ahead of print.ABSTRACTBacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocytes and endothelial cells, that lead to tissue injury and organ failure. The aim of this study was to explore the anti-inflammatory, antioxidant, and cytoprotective properties of two bile acids, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in LPS-induced endotoxemia in rats. The expe...
Source: Molecular and Cellular Biochemistry - April 5, 2024 Category: Biochemistry Authors: T Milivojac M Grabe ž A Krivoku ća U Mali čević M Gaji ć Bojić Đ Đukanović S Uletilovi ć N Mandi ć-Kovačević T Cvjetkovi ć M Barud žija N Vojinovi ć A Šmitran Lj Amid žić M P Stojiljkovi ć M Čolić M Mikov R Škrbić Source Type: research
Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats
Mol Cell Biochem. 2024 Apr 5. doi: 10.1007/s11010-024-04994-2. Online ahead of print.ABSTRACTBacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocytes and endothelial cells, that lead to tissue injury and organ failure. The aim of this study was to explore the anti-inflammatory, antioxidant, and cytoprotective properties of two bile acids, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in LPS-induced endotoxemia in rats. The expe...
Source: Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: T Milivojac M Grabe ž A Krivoku ća U Mali čević M Gaji ć Bojić Đ Đukanović S Uletilovi ć N Mandi ć-Kovačević T Cvjetkovi ć M Barud žija N Vojinovi ć A Šmitran Lj Amid žić M P Stojiljkovi ć M Čolić M Mikov R Škrbić Source Type: research
Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats
Mol Cell Biochem. 2024 Apr 5. doi: 10.1007/s11010-024-04994-2. Online ahead of print.ABSTRACTBacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocytes and endothelial cells, that lead to tissue injury and organ failure. The aim of this study was to explore the anti-inflammatory, antioxidant, and cytoprotective properties of two bile acids, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in LPS-induced endotoxemia in rats. The expe...
Source: Molecular and Cellular Biochemistry - April 5, 2024 Category: Biochemistry Authors: T Milivojac M Grabe ž A Krivoku ća U Mali čević M Gaji ć Bojić Đ Đukanović S Uletilovi ć N Mandi ć-Kovačević T Cvjetkovi ć M Barud žija N Vojinovi ć A Šmitran Lj Amid žić M P Stojiljkovi ć M Čolić M Mikov R Škrbić Source Type: research
Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats
Mol Cell Biochem. 2024 Apr 5. doi: 10.1007/s11010-024-04994-2. Online ahead of print.ABSTRACTBacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocytes and endothelial cells, that lead to tissue injury and organ failure. The aim of this study was to explore the anti-inflammatory, antioxidant, and cytoprotective properties of two bile acids, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in LPS-induced endotoxemia in rats. The expe...
Source: Molecular Medicine - April 5, 2024 Category: Molecular Biology Authors: T Milivojac M Grabe ž A Krivoku ća U Mali čević M Gaji ć Bojić Đ Đukanović S Uletilovi ć N Mandi ć-Kovačević T Cvjetkovi ć M Barud žija N Vojinovi ć A Šmitran Lj Amid žić M P Stojiljkovi ć M Čolić M Mikov R Škrbić Source Type: research
Population-specific variations in < em > KCNH2 < /em > predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy
Antimicrob Agents Chemother. 2024 Mar 28:e0139023. doi: 10.1128/aac.01390-23. Online ahead of print.ABSTRACTDihydroartemisinin-piperaquine is efficacious for the treatment of uncomplicated malaria and its use is increasing globally. Despite the positive results in fighting malaria, inhibition of the Kv11.1 channel (hERG; encoded by the KCNH2 gene) by piperaquine has raised concerns about cardiac safety. Whether genetic factors could modulate the risk of piperaquine-mediated QT prolongations remained unclear. Here, we first profiled the genetic landscape of KCNH2 variability using data from 141,614 individuals. Overall, we ...
Source: Antimicrobial Agents and Chemotherapy - March 28, 2024 Category: Microbiology Authors: Mahamadou D Camara Yitian Zhou Antoine Dara Mamadou M T ékété Ta ís Nóbrega de Sousa S ékou Sissoko Laurent Demb élé Nouhoun Ouologuem Amadou Hamidou Togo Mohamed L Alhousseini Bakary Fofana Issaka Sagara Abdoulaye A Djimde Pedro J Gil Volker M La Source Type: research
Population-specific variations in < em > KCNH2 < /em > predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy
Antimicrob Agents Chemother. 2024 Mar 28:e0139023. doi: 10.1128/aac.01390-23. Online ahead of print.ABSTRACTDihydroartemisinin-piperaquine is efficacious for the treatment of uncomplicated malaria and its use is increasing globally. Despite the positive results in fighting malaria, inhibition of the Kv11.1 channel (hERG; encoded by the KCNH2 gene) by piperaquine has raised concerns about cardiac safety. Whether genetic factors could modulate the risk of piperaquine-mediated QT prolongations remained unclear. Here, we first profiled the genetic landscape of KCNH2 variability using data from 141,614 individuals. Overall, we ...
Source: Antimicrobial Agents and Chemotherapy - March 28, 2024 Category: Microbiology Authors: Mahamadou D Camara Yitian Zhou Antoine Dara Mamadou M T ékété Ta ís Nóbrega de Sousa S ékou Sissoko Laurent Demb élé Nouhoun Ouologuem Amadou Hamidou Togo Mohamed L Alhousseini Bakary Fofana Issaka Sagara Abdoulaye A Djimde Pedro J Gil Volker M La Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
