Oncologists Endorse Divergent ‘Best Practices’ for Disclosing Prognosis in Advanced Pediatric Cancer (RP124)
1. Describe (and self-reflect on) how clinicians may make assumptions about what prognostic information patients/families want to hear and how they want to hear it, as well as how clinicians may lack comfort in eliciting these preferences directly from patients/families.2. Recognize a deficit in s takeholder-driven guidance to encourage and support clinicians in provision of person-centered, timely prognostic communication in advanced childhood cancer and other pediatric serious illnesses. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Erica C. Kaye, Harmony Farner, Shoshana Mehler, Nidhi Mali, Kelly Bien, Justin N. Baker, Jennifer Mack Source Type: research
Dignity in the Pediatric Population: A Systematic Review
1. Participants will be able to describe the intricacies of dignity-centered care in pediatrics and develop strategies to maintain and enhance dignity in the pediatric population.2. Participants will be able to explain gaps in measurement or assessment tools specific to dignity-centered care in pediatrics and propose strategies to address existing gaps. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Allison Silverstein, Veronica Easton, Cory Barrows, Kimberly Sawyer, Rachel C. Coughlin, Nidhi Mali, Amber Kessler, Matthew Robinson, Erica Sirrine, Madison Spears, Jordan Wrigley, Justin Baker, Erica C. Kaye Source Type: research
Exploring Hybrid Hard Carbon/Bi2S3-based Negative Electrodes for Na-ion Batteries
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Bla ž Tratnik, Sergio Aina, Elena Tchernychova, Matej Gabrijelčič, Gregor Mali, M. Pilar Lobera, Maria Bernechea, Mathieu Morcrette, Alen Vizintin, Robert Dominko The study presents a hybrid hard-carbon/nanocrystalline-Bi2S3 material applicable for negative electrodes in sodium-ion batteries. Through a series of comprehensive analyzes, including electrochemical measurements,operando XRD,ex-situ solid-state NMR, and high-resolution... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - April 16, 2024 Category: Chemistry Authors: Bla ž Tratnik Source Type: research
Structure peer review to make it more robust
Nature, Published online: 16 April 2024; doi:10.1038/d41586-024-01101-9Everyone who reviews a manuscript should answer a transparent set of questions, to ensure that scientific literature is subject to reliable quality control. (Source: Nature AOP)
Source: Nature AOP - April 16, 2024 Category: Research Authors: Mario Mali čki Source Type: research
Mild Cognitive Impairment among LRRK2 and GBA1 patients with Parkinson's Disease
Mild cognitive impairment (MCI) is common in Parkinson ’s disease (PD). We aimed to assess the incidence of MCI among patients with PD, carriers of mutations in LRRK2 and GBA1 genes, based on the movement disorder society (MDS) criteria for the diagnosis of MCI in early-stage PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 16, 2024 Category: Neurology Authors: Avner Thaler, Vered Livne, Einat Rubinstein, Nurit Omer, Achinoam Socher, Batsheva Cohen, Nir Giladi, Julia C. Shirvan, Jesse M. Cedarbaum, Mali Gana-Weisz, Orly Goldstein, Avi Orr-Urtreger, Roy N. Alcalay, Anat Mirelman Source Type: research
Natural Polymer-Based Nanogel for pH-Responsive Delivery of Sorafenib Tosylate in Hemangiosarcoma
This study is promising but challenging depending on the in vivo study. The nanogel was successfully prepared and evaluated for pH-responsive release. As hemangiosarcoma commonly occurs in dogs, this formulation helps to limit the difficulties with administration.PMID:38605211 | DOI:10.1208/s12249-024-02797-8 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 11, 2024 Category: Drugs & Pharmacology Authors: Kiran K Mali Yogeshkumar N Gavhane Rita D Chakole Source Type: research
Natural Polymer-Based Nanogel for pH-Responsive Delivery of Sorafenib Tosylate in Hemangiosarcoma
This study is promising but challenging depending on the in vivo study. The nanogel was successfully prepared and evaluated for pH-responsive release. As hemangiosarcoma commonly occurs in dogs, this formulation helps to limit the difficulties with administration.PMID:38605211 | DOI:10.1208/s12249-024-02797-8 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 11, 2024 Category: Drugs & Pharmacology Authors: Kiran K Mali Yogeshkumar N Gavhane Rita D Chakole Source Type: research
Natural Polymer-Based Nanogel for pH-Responsive Delivery of Sorafenib Tosylate in Hemangiosarcoma
This study is promising but challenging depending on the in vivo study. The nanogel was successfully prepared and evaluated for pH-responsive release. As hemangiosarcoma commonly occurs in dogs, this formulation helps to limit the difficulties with administration.PMID:38605211 | DOI:10.1208/s12249-024-02797-8 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 11, 2024 Category: Drugs & Pharmacology Authors: Kiran K Mali Yogeshkumar N Gavhane Rita D Chakole Source Type: research
Natural Polymer-Based Nanogel for pH-Responsive Delivery of Sorafenib Tosylate in Hemangiosarcoma
This study is promising but challenging depending on the in vivo study. The nanogel was successfully prepared and evaluated for pH-responsive release. As hemangiosarcoma commonly occurs in dogs, this formulation helps to limit the difficulties with administration.PMID:38605211 | DOI:10.1208/s12249-024-02797-8 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 11, 2024 Category: Drugs & Pharmacology Authors: Kiran K Mali Yogeshkumar N Gavhane Rita D Chakole Source Type: research
Natural Polymer-Based Nanogel for pH-Responsive Delivery of Sorafenib Tosylate in Hemangiosarcoma
This study is promising but challenging depending on the in vivo study. The nanogel was successfully prepared and evaluated for pH-responsive release. As hemangiosarcoma commonly occurs in dogs, this formulation helps to limit the difficulties with administration.PMID:38605211 | DOI:10.1208/s12249-024-02797-8 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 11, 2024 Category: Drugs & Pharmacology Authors: Kiran K Mali Yogeshkumar N Gavhane Rita D Chakole Source Type: research
Natural Polymer-Based Nanogel for pH-Responsive Delivery of Sorafenib Tosylate in Hemangiosarcoma
This study is promising but challenging depending on the in vivo study. The nanogel was successfully prepared and evaluated for pH-responsive release. As hemangiosarcoma commonly occurs in dogs, this formulation helps to limit the difficulties with administration.PMID:38605211 | DOI:10.1208/s12249-024-02797-8 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 11, 2024 Category: Drugs & Pharmacology Authors: Kiran K Mali Yogeshkumar N Gavhane Rita D Chakole Source Type: research
Design, selective synthesis and biological activities evaluation of novel thiazol-2-ylbenzamide and thiazole-2-ylbenzimidoyl chloride derivatives
Bioorg Chem. 2024 Apr 6;147:107333. doi: 10.1016/j.bioorg.2024.107333. Online ahead of print.ABSTRACTTo promote the development and exploitation of novel antifungal agents, a series of thiazol-2-ylbenzamide derivatives (3A-3V) and thiazole-2-ylbenzimidoyl chloride derivatives (4A-4V) were designed and selective synthesis. The bioassay results showed that most of the target compounds exhibited excellent in vitro antifungal activities against five plant pathogenic fungi (Valsa mali, Sclerotinia scleotiorum, Botrytis cinerea, Rhizoctonia solani and Trichoderma viride). The antifungal effects of compounds 3B (EC50 = 0.72 mg/L)...
Source: Bioorganic Chemistry - April 10, 2024 Category: Chemistry Authors: Zonghan Xu Xiang Cheng Hongyun Cui Linmin Cao Yaping Song Xihao Chang Dandan Wang Xianhai Lv Source Type: research
Design, selective synthesis and biological activities evaluation of novel thiazol-2-ylbenzamide and thiazole-2-ylbenzimidoyl chloride derivatives
Bioorg Chem. 2024 Apr 6;147:107333. doi: 10.1016/j.bioorg.2024.107333. Online ahead of print.ABSTRACTTo promote the development and exploitation of novel antifungal agents, a series of thiazol-2-ylbenzamide derivatives (3A-3V) and thiazole-2-ylbenzimidoyl chloride derivatives (4A-4V) were designed and selective synthesis. The bioassay results showed that most of the target compounds exhibited excellent in vitro antifungal activities against five plant pathogenic fungi (Valsa mali, Sclerotinia scleotiorum, Botrytis cinerea, Rhizoctonia solani and Trichoderma viride). The antifungal effects of compounds 3B (EC50 = 0.72 mg/L)...
Source: Bioorganic Chemistry - April 10, 2024 Category: Chemistry Authors: Zonghan Xu Xiang Cheng Hongyun Cui Linmin Cao Yaping Song Xihao Chang Dandan Wang Xianhai Lv Source Type: research
Factors influencing pregnancy care and institutional delivery in rural Mali: a secondary baseline analysis of a cluster-randomised trial
Conclusion
The findings suggest that education, occupation and distance are important determinants of pregnancy and delivery care in a rural Malian context.
Trial registration number
NCT02694055. (Source: BMJ Open)
Source: BMJ Open - April 9, 2024 Category: General Medicine Authors: Ghosh, R., Konipo, A., Treleaven, E., Rozenshteyn, S., Beckerman, J., Whidden, C., Johnson, A., Kayentao, K., Liu, J. Tags: Open access, Global health Source Type: research
Increased Intracranial Arterial Pulsatility and Microvascular Brain Damage in Pseudoxanthoma Elasticum [NEUROVASCULAR/STROKE IMAGING]
CONCLUSIONS:
Patients with pseudoxanthoma elasticum have increased intracranial artery flow pulsatility and measures of small-vessel disease. Carotid siphon calcification might underlie the high prevalence of cerebrovascular disease in pseudoxanthoma elasticum. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - April 8, 2024 Category: Radiology Authors: Bartstra, J. W., van den Beukel, T., Kranenburg, G., Geurts, L. J., den Harder, A. M., Witkamp, T., Wolterink, J. M., Zwanenburg, J. J. M., van Valen, E., Koek, H. L., Mali, W. P. T. M., de Jong, P. A., Hendrikse, J., Spiering, W. Tags: NEUROVASCULAR/STROKE IMAGING Source Type: research
