Updates in the Management of Uveal Melanoma
Cancer J. 2024 Mar-Apr 01;30(2):92-101. doi: 10.1097/PPO.0000000000000708.ABSTRACTUveal melanoma (UM), arising from intraocular melanocytes, poses a complex clinical challenge with a substantial risk of distant metastasis, often to the liver. Molecular profiling, encompassing genetic, cytogenetic, gene expression, and immunological subsets, plays a pivotal role in determining prognoses. The evolving landscape includes promising systemic treatments, such as tebentafusp, a novel immune-modulating bispecific fusion protein, and targeted therapies. Combined regional and systemic approaches, including immune checkpoint inhibito...
Source: Cancer Journal - March 25, 2024 Category: Cancer & Oncology Authors: Mali Barbi Richard D Carvajal Craig E Devoe Source Type: research
Updates in the Management of Uveal Melanoma
Cancer J. 2024 Mar-Apr 01;30(2):92-101. doi: 10.1097/PPO.0000000000000708.ABSTRACTUveal melanoma (UM), arising from intraocular melanocytes, poses a complex clinical challenge with a substantial risk of distant metastasis, often to the liver. Molecular profiling, encompassing genetic, cytogenetic, gene expression, and immunological subsets, plays a pivotal role in determining prognoses. The evolving landscape includes promising systemic treatments, such as tebentafusp, a novel immune-modulating bispecific fusion protein, and targeted therapies. Combined regional and systemic approaches, including immune checkpoint inhibito...
Source: Cancer Journal - March 25, 2024 Category: Cancer & Oncology Authors: Mali Barbi Richard D Carvajal Craig E Devoe Source Type: research
Updates in the Management of Uveal Melanoma
Cancer J. 2024 Mar-Apr 01;30(2):92-101. doi: 10.1097/PPO.0000000000000708.ABSTRACTUveal melanoma (UM), arising from intraocular melanocytes, poses a complex clinical challenge with a substantial risk of distant metastasis, often to the liver. Molecular profiling, encompassing genetic, cytogenetic, gene expression, and immunological subsets, plays a pivotal role in determining prognoses. The evolving landscape includes promising systemic treatments, such as tebentafusp, a novel immune-modulating bispecific fusion protein, and targeted therapies. Combined regional and systemic approaches, including immune checkpoint inhibito...
Source: Cancer Journal - March 25, 2024 Category: Cancer & Oncology Authors: Mali Barbi Richard D Carvajal Craig E Devoe Source Type: research
Updates in the Management of Uveal Melanoma
Cancer J. 2024 Mar-Apr 01;30(2):92-101. doi: 10.1097/PPO.0000000000000708.ABSTRACTUveal melanoma (UM), arising from intraocular melanocytes, poses a complex clinical challenge with a substantial risk of distant metastasis, often to the liver. Molecular profiling, encompassing genetic, cytogenetic, gene expression, and immunological subsets, plays a pivotal role in determining prognoses. The evolving landscape includes promising systemic treatments, such as tebentafusp, a novel immune-modulating bispecific fusion protein, and targeted therapies. Combined regional and systemic approaches, including immune checkpoint inhibito...
Source: Cancer Journal - March 25, 2024 Category: Cancer & Oncology Authors: Mali Barbi Richard D Carvajal Craig E Devoe Source Type: research
Assessing the accuracy of health facility typology in representing the availability of health services: a case study in Mali
Conclusions
These results have significant implications for health policy and planning. The reliance on health facility types as indicators for health system policy and planning should be reconsidered. A more nuanced and evidence-based understanding of health service availability is crucial for effective health policy and planning, as well as for the assessment and monitoring of health systems. (Source: BMJ Open)
Source: BMJ Open - March 21, 2024 Category: General Medicine Authors: Petragallo, S., Timoner, P., Hierink, F., Fuhrer, C., Toure, O., Iknane, A., Coulibaly, Y., Fall, I.-S., Ray, N. Tags: Open access, Health services research Source Type: research
A droplet vitrification cryopreservation protocol for conservation of hops (Humulus lupulus) genetic resources
Cryobiology. 2024 Mar 15:104887. doi: 10.1016/j.cryobiol.2024.104887. Online ahead of print.ABSTRACTHops (Humulus lupulus L.) is essentially used in the brewing industry as it contributes to flavor, and aroma of beer. However, the genetic diversity of hops is increasingly threatened by diseases, environmental changes, and urbanization. Cryopreservation has emerged as a pivotal strategy for safeguarding and maintaining the genetic diversity of hops. The present work presents a comprehensive study on the cryopreservation of hops, focusing on the development and optimization of a droplet vitrification based cryopreservation p...
Source: Cryobiology - March 17, 2024 Category: Biology Authors: Era Vaidya Malhotra Suresh Chand Mali Shreya Sharma Sangita Bansal Source Type: research
A droplet vitrification cryopreservation protocol for conservation of hops (Humulus lupulus) genetic resources
Cryobiology. 2024 Mar 15:104887. doi: 10.1016/j.cryobiol.2024.104887. Online ahead of print.ABSTRACTHops (Humulus lupulus L.) is essentially used in the brewing industry as it contributes to flavor, and aroma of beer. However, the genetic diversity of hops is increasingly threatened by diseases, environmental changes, and urbanization. Cryopreservation has emerged as a pivotal strategy for safeguarding and maintaining the genetic diversity of hops. The present work presents a comprehensive study on the cryopreservation of hops, focusing on the development and optimization of a droplet vitrification based cryopreservation p...
Source: Cryobiology - March 17, 2024 Category: Biology Authors: Era Vaidya Malhotra Suresh Chand Mali Shreya Sharma Sangita Bansal Source Type: research
A droplet vitrification cryopreservation protocol for conservation of hops (Humulus lupulus) genetic resources
Cryobiology. 2024 Mar 15:104887. doi: 10.1016/j.cryobiol.2024.104887. Online ahead of print.ABSTRACTHops (Humulus lupulus L.) is essentially used in the brewing industry as it contributes to flavor, and aroma of beer. However, the genetic diversity of hops is increasingly threatened by diseases, environmental changes, and urbanization. Cryopreservation has emerged as a pivotal strategy for safeguarding and maintaining the genetic diversity of hops. The present work presents a comprehensive study on the cryopreservation of hops, focusing on the development and optimization of a droplet vitrification based cryopreservation p...
Source: Cryobiology - March 17, 2024 Category: Biology Authors: Era Vaidya Malhotra Suresh Chand Mali Shreya Sharma Sangita Bansal Source Type: research
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage
CONCLUSIONS: Preanalytical factors like needle thickness and storage time can affect the MVs' properties. Activation of platelets during blood collection or blood storage occurs; however, it is difficult to determine its effect on the physiological properties of EVs since the mechanisms of EVs` biogenesis and especially clearness are not precisely known.PMID:38492545 | DOI:10.1016/j.bcmd.2024.102842 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - March 16, 2024 Category: Hematology Authors: Ivica Mari ć Klemen Žiberna Ana Kolenc Elvira Mali čev Source Type: research
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage
CONCLUSIONS: Preanalytical factors like needle thickness and storage time can affect the MVs' properties. Activation of platelets during blood collection or blood storage occurs; however, it is difficult to determine its effect on the physiological properties of EVs since the mechanisms of EVs` biogenesis and especially clearness are not precisely known.PMID:38492545 | DOI:10.1016/j.bcmd.2024.102842 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - March 16, 2024 Category: Hematology Authors: Ivica Mari ć Klemen Žiberna Ana Kolenc Elvira Mali čev Source Type: research
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage
CONCLUSIONS: Preanalytical factors like needle thickness and storage time can affect the MVs' properties. Activation of platelets during blood collection or blood storage occurs; however, it is difficult to determine its effect on the physiological properties of EVs since the mechanisms of EVs` biogenesis and especially clearness are not precisely known.PMID:38492545 | DOI:10.1016/j.bcmd.2024.102842 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - March 16, 2024 Category: Hematology Authors: Ivica Mari ć Klemen Žiberna Ana Kolenc Elvira Mali čev Source Type: research
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage
CONCLUSIONS: Preanalytical factors like needle thickness and storage time can affect the MVs' properties. Activation of platelets during blood collection or blood storage occurs; however, it is difficult to determine its effect on the physiological properties of EVs since the mechanisms of EVs` biogenesis and especially clearness are not precisely known.PMID:38492545 | DOI:10.1016/j.bcmd.2024.102842 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - March 16, 2024 Category: Hematology Authors: Ivica Mari ć Klemen Žiberna Ana Kolenc Elvira Mali čev Source Type: research
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage
CONCLUSIONS: Preanalytical factors like needle thickness and storage time can affect the MVs' properties. Activation of platelets during blood collection or blood storage occurs; however, it is difficult to determine its effect on the physiological properties of EVs since the mechanisms of EVs` biogenesis and especially clearness are not precisely known.PMID:38492545 | DOI:10.1016/j.bcmd.2024.102842 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - March 16, 2024 Category: Hematology Authors: Ivica Mari ć Klemen Žiberna Ana Kolenc Elvira Mali čev Source Type: research
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage
CONCLUSIONS: Preanalytical factors like needle thickness and storage time can affect the MVs' properties. Activation of platelets during blood collection or blood storage occurs; however, it is difficult to determine its effect on the physiological properties of EVs since the mechanisms of EVs` biogenesis and especially clearness are not precisely known.PMID:38492545 | DOI:10.1016/j.bcmd.2024.102842 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - March 16, 2024 Category: Hematology Authors: Ivica Mari ć Klemen Žiberna Ana Kolenc Elvira Mali čev Source Type: research
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage
CONCLUSIONS: Preanalytical factors like needle thickness and storage time can affect the MVs' properties. Activation of platelets during blood collection or blood storage occurs; however, it is difficult to determine its effect on the physiological properties of EVs since the mechanisms of EVs` biogenesis and especially clearness are not precisely known.PMID:38492545 | DOI:10.1016/j.bcmd.2024.102842 (Source: Blood Cells, Molecules and Diseases)
Source: Blood Cells, Molecules and Diseases - March 16, 2024 Category: Hematology Authors: Ivica Mari ć Klemen Žiberna Ana Kolenc Elvira Mali čev Source Type: research
