Multidrug-resistant < em > Corynebacterium diphtheriae < /em > in people with travel history from West Africa to France, March to September 2023
We describe 10 unlinked cases of Corynebacterium diphtheriae infection (nine cutaneous, one respiratory) in France in 2023 in persons travelling from Guinea, Mali, Senegal, Niger or Nigeria and Central African Republic. Four isolates were toxigenic. Seven genomically unrelated isolates were multidrug-resistant, including a toxigenic respiratory isolate with high-level resistance to macrolides and beta-lactams. The high rates of resistance, including against first-line agents, call for further microbiological investigations to guide clinical management and public health response in ongoing West African outbreaks.PMID:379716...
Source: Euro Surveill - November 16, 2023 Category: Infectious Diseases Authors: Sylvie Br émont Virginie Passet M élanie Hennart Laure Fonteneau Julie Toubiana Edgar Badell Sylvain Brisse Source Type: research
Multidrug-resistant Corynebacterium diphtheriae in people with travel history from West Africa to France, March to September 2023
We describe 10 unlinked cases ofCorynebacterium diphtheriae infection (nine cutaneous, one respiratory) in France in 2023 in persons travelling from Guinea, Mali, Senegal, Niger or Nigeria and Central African Republic. Four isolates were toxigenic. Seven genomically unrelated isolates were multidrug-resistant, including a toxigenic respiratory isolate with high-level resistance to macrolides and beta-lactams. The high rates of resistance, including against first-line agents, call for further microbiological investigations to guide clinical management and public health response in ongoing West African outbreaks. (Source: Eurosurveillance)
Source: Eurosurveillance - November 16, 2023 Category: Infectious Diseases Authors: Sylvie Br émont, Virginie Passet, Mélanie Hennart, Laure Fonteneau, Julie Toubiana, Edgar Badell and Sylvain Brisse Source Type: research
Progress towards elimination of onchocerciasis transmission in Mali: A “pre-stop MDA” survey in 18 transmission zones
ConclusionThese data show that onchocerciasis prevalence in the five endemic regions has declined to levels that indicate that Stop-MDA surveys should be now carried out in most of the OTZ except for one in the Kayes Region. This latter site will need additional ivermectin treatment before reevaluation, and an OTZ in the Sikasso Region requires revaluation before possibly reinitiating MDA. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - November 15, 2023 Category: Tropical Medicine Authors: Housseini Dolo Source Type: research
Statistical analysis plan for the LAKANA trial: a cluster-randomized, placebo-controlled, double-blinded, parallel group, three-arm clinical trial testing the effects of mass drug administration of azithromycin on mortality and other outcomes among 1 –11-month-old infants in Mali
The Large-scale Assessment of the Key health-promoting Activities of two New mass drug administration regimens with Azithromycin (LAKANA) trial in Mali aims to evaluate the efficacy and safety of azithromycin ... (Source: Trials)
Source: Trials - November 15, 2023 Category: General Medicine Authors: Juho Luoma, Laura Adubra, Dagmar Alber, Per Ashorn, Ulla Ashorn, Elaine Cloutman-Green, Fatoumata Diallo, Camilla Ducker, Riku Elovainio, Yue-Mei Fan, Lily Gates, Gwydion Gruffudd, Tiia Haapaniemi, Fadima Haidara, Lotta Hallamaa, Rikhard Ihamuotila & hell Tags: Update Source Type: research
Gene expression analyses reveal differences in children's response to malaria according to their age
Res Sq. 2023 Oct 27:rs.3.rs-3487114. doi: 10.21203/rs.3.rs-3487114/v1. Preprint.ABSTRACTIn Bandiagara, Mali, children experience on average two clinical malaria episodes per season. However, even in the same transmission area, the number of uncomplicated symptomatic infections, and their parasitemia, vary dramatically among children. To examine the factors contributing to these variations, we simultaneously characterized the host and parasite gene expression profiles from 136 children with symptomatic falciparum malaria and analyzed the expression of 9,205 human and 2,484 Plasmodium genes. We used gene expression deconvolu...
Source: Cell Research - November 14, 2023 Category: Cytology Authors: Kieran Tebben Salif Yirampo Drissa Coulibaly Abdoulaye Kon é Matthew Laurens Emily Stucke Ahmadou Demb élé Youssouf Tolo Karim Traor é Ahmadou Niangaly Andrea Berry Bourema Kouriba Christopher Plowe Ogobara Doumbo Kirsten Lyke Shannon Takala-Harrison Source Type: research
